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Transcriptional regulatory network analysis identifies GRN as a key regulator bridging chemotherapy and immunotherapy response in small cell lung cancer
Published 2025-02-01“…GRN-high tumors, associated with non-neuroendocrine (non-NE) subtypes, had a higher level of macrophage infiltration, potentially contributing to immunotherapy resistance. These results highlight GRN as a critical regulator of chemo-resistance and a potential biomarker for immunotherapy resistance in SCLC. …”
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Desmoplastic reaction in the microenvironment of head and neck and other solid tumors: the therapeutic barrier
Published 2025-02-01“…DR also affects bone invasion and chemotherapy resistance by modulating stromal responses. Therapeutic strategies targeting DR and stromal components show promise in overcoming therapeutic resistance including resistance to immune checkpoint inhibitors. …”
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Elevated POSTN expression predicts poor prognosis and is associated with radioresistance in cervical cancer patients treated with radical radiotherapy
Published 2025-02-01“…Drug sensitivity analysis suggested that high POSTN expression may be linked to resistance to multiple chemotherapeutic agents. Furthermore, weighted correlation network analysis (WGCNA) and gene set enrichment analysis (GSEA) identified EMT as a top enriched pathway in patients with high POSTN expression, suggesting it may play a critical role in radiotherapy resistance. …”
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Unweaving the Technique
Published 2025-02-01“…These cosmotechni-cal manifestations enunciate singularity, resistance and emancipation. …”
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Innovative approaches to asthma treatment: harnessing nanoparticle technology
Published 2025-02-01“…Abstract In the domain of respiratory illnesses, asthma remains a critical obstacle. The heterogeneous nature of this chronic inflammatory disease poses challenges during its treatment. …”
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Jalaiah Effect: A Story of a Stolen Dance on TikTok and Trans-Platformization of Ignorance
Published 2025-02-01“…Employing new materialist feminist theory, Actor-Network Theory, and Critical Technocultural Discourse Analysis, this article operationalizes the concept of trans-platformization. …”
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Readiness of Christian Religious Education (CRE) Teachers and Implementation of Competence-Based Curriculum (CBC) in Nyakabande Sub-county Kisoro District.
Published 2024“…This study examines the readiness of CRE teachers in Nyakabande Sub-county, Kisoro District, to implement the CBC, addressing critical questions about their preparedness, the challenges they face, and potential strategies for improvement. …”
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Long non-coding RNA MIR4435-2HG modulates pancreatic cancer stem cells and chemosensitivity to gemcitabine by targeting the miR-1252-5p/STAT1
Published 2025-02-01“…Abstract Cancer stem cells (CSCs) are key drivers of cancer progression and therapeutic resistance. Long non-coding RNAs (lncRNAs) have emerged as critical regulators of CSC properties. …”
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Ludzkie zoo w percepcji dzieci
Published 2021-06-01“…The children’s statements show unequivocal resistance to the vision of exposure of the human body and strong species identification. …”
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Impact of developmental state, p53 status, and interferon signaling on glioblastoma cell response to radiation and temozolomide treatment.
Published 2025-01-01“…This was associated with increased resistance to TMZ, though not to RT, across all models. …”
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“Punk’s Not Dead, It Lives on The Football Terraces”: Tracing The Legacy of Punk in Subcultural Milieu of The Football Firms
Published 2021-12-01“…With the critical discourse analysis carried out in this context, the modern football phenomenon, which destroys the subjectivity of the fans, is investigated. …”
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Performance of Polyurethane Adhesive in Hardwood Cross-Laminated Timber
Published 2025-01-01“…These findings provide critical insights into selecting and optimizing adhesives for hardwood CLT production.…”
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Assessing the Durability Behaviour of Cement Stabilized Soil Bricks in Kabale Municipality.
Published 2025“…The results for water absorption show a reduction in water absorption with increasing cement content is a critical finding, as lower water absorption rates correlate with enhanced durability and resistance to moisture-related degradation. …”
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The Hippo pathway promotes platinum-based chemotherapy by inhibiting MTF1-dependent heavy metal response
Published 2025-02-01“…This resistance is mitigated by Hippo pathway-mediated phosphorylation of MTF1. …”
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Genome-wide identification and characterization of transcription factors involved in defense responses against Sclerotinia sclerotiorum in Brassica juncea
Published 2025-02-01“…Transcription factors (TFs) are recognized for their critical role in plant defense against S. sclerotiorum. …”
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Design and Analysis of a Serial Manipulator for Pick and Drop Objects for Material Handling at Uiri Metal Forming Workshop.
Published 2024“…The design process prioritized critical customer requirements, including maintainability, safety, usability, and adaptability. …”
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Construction of “Biomigration – Regional Cooling” Multi-functional Ecological Network in Wuhan Urban Agglomeration
Published 2025-01-01“…Based on the land cover and land surface temperature (LST) of Wuhan urban agglomeration, the research screens the biodiversity source sites and regional cold island source sites by morphological spatial pattern analysis (MSPA) and landscape connectivity. 2) Construction of two types of resistance surfaces. Based on land use type, elevation, slope, distance from road, distance from construction land, normalized difference vegetation index (NDVI) and other data, the resistance values of biomigration and cold island diffusion are calculated respectively, and raster resistance surfaces are generated in ArcGIS. 3) Based on minimum cumulative resistance (MCR) and circuit theory, biomigration corridors and regional cooling corridors are generated respectively by using the Linkage Mapper toolbox. 4) Two kinds of corridors are overlapped to form a multifunctional ecological network pattern, based on which the key areas for ecological protection and restoration are identified in Wuhan urban agglomeration.ResultsIn this research, Wuhan urban agglomeration is taken as the research area. …”
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Antimicrobial peptide AP2 ameliorates Salmonella Typhimurium infection by modulating gut microbiota
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