Identification and validation of TSPAN13 as a novel temozolomide resistance-related gene prognostic biomarker in glioblastoma. by Haofei Wang, Zhen Liu, Zesheng Peng, Peng Lv, Peng Fu, Xiaobing Jiang

“…Glioblastoma (GBM) is the most lethal primary tumor of the central nervous system, with its resistance to treatment posing significant challenges. …”
Get full text

Extensively drug-resistant Acinetobacter baumannii lung abscess and empyema in a patient with fulminant mycoplasma pneumoniae pneumonia by Siyu Yang, Chaojie Wei

Get full text

Genomic characterization of antimicrobial-resistance and virulence factors in Salmonella isolates obtained from pig farms in Antioquia, Colombia. by María Isabel García-Álvarez, Juana L Vidal, Pilar Donado-Godoy, Jared Smith, Nikki Shariat, María Fernanda Valencia, Luis M Gómez-Osorio, Sara López-Osorio, Jenny J Chaparro-Gutiérrez

“…This research emphasizes the utmost importance of epidemiological tools to understand the presence and spreading of antimicrobial resistance genes in pig farms. Additionally, it highlights the critical need for developing educational programs and public policies to help reduce the spread of antimicrobial resistance in production systems.…”
Get full text

Study on the multidrug resistance and transmission factors of Staphylococcus aureus at the ‘animal–environment–human’ interface in the broiler feeding cycle by Fangyuan Hu, Fangyuan Hu, Yaopeng Liu, Yaopeng Liu, Lin Wang, Juan Wang, Na Liu, Yan Li, Xiaoxiao Duan, Junwei Wang, Mingzhe Lu, Junhui Liu, Zhina Qu, Keguang Han

“…This study revealed the critical impact of environmental residual and worker-carried S. aureus, as well as the transmission of antibiotic resistance in stage 1. …”
Get full text

Genomic analysis of Enterobacter cloacae complex from Southern Thailand reveals insights into multidrug resistance genotypes and genetic diversity by Thunchanok Yaikhan, Kamonnut Singkhamanan, Pawarisa Luenglusontigit, Arnon Chukamnerd, Natakorn Nokchan, Nutwadee Chintakovid, Sarunyou Chusri, Rattanaruji Pomwised, Monwadee Wonglapsuwan, Kittinun Leetanaporn, Surasak Sangkhathat, Komwit Surachat

“…We identified six isolates carrying the mcr-9 gene, highlighting a significant concern in antimicrobial resistance (AMR). These genes confer a reduced susceptibility to colistin, a critical last-resort drug for the treatment of multidrug-resistant (MDR) infection. …”
Get full text

Unmasking MRSA antibiotic resistance: the impact of environment, pollution, and healthcare quality—a nationwide exploration in China: a comprehensive analysis spanning 2014 to 2021... by Yi-Chang Zhao, Ming-Xuan Xiao, Zhi-Hua Sun, Jia-Kai Li, Huai-yuan Liu, Bi-Kui Zhang, Hua-Lin Cai, Wei Cao, Feng Yu, Miao Yan

“…Abstract Background The rise of antibiotic resistance has become a critical global health concern, resulting in numerous fatalities annually. …”
Get full text

Sepsis Management in a Case of Myasthenic Crisis: A Case Report by Hossein Karballaei Mirzahosseini, Ehsan Yousefi-Mazhin, Rezvan Hassanpour, Atabak Najafi, Mahsa Tofighi-Mohammadi, Hamidreza Sharifnia, Amirmahdi Mojtahedzadeh, Mojtaba Mojtahedzadeh

Get full text

Unveiling the wonders of bacteria-derived extracellular vesicles: From fundamental functions to beneficial applications by Mariam Rima, Mariam Dakramanji, Elie El Hayek, Tia El Khoury, Ziad Fajloun, Mohamad Rima

“…Extracellular vesicles (EVs), are critical mediators of intercellular communication and exhibit significant potential across various biomedical domains. …”
Get full text

Attitudes of healthcare workers at a District in KwaZulu-Natal regarding institutionalisation of antimicrobial stewardship by Andile P. Dlungele, Lehlohonolo J. Mathibe

“…Contribution: This study highlights the need for employment experience and adequate healthcare service providers as critical factors for the successful institutionalisation of AMS programmes in public health facilities.…”
Get full text

An outbreak within an outbreak: The impact of Infection Prevention and Control strategies on hospital-acquired infections and the occurrence of multi-drug resistant organisms durin... by B Mashigo, A Parker, U Lalla, B W Allwood, M S Moolla, T Lovelock, C F N Koegelenberg

“…We noted an upstroke in the occurrence of HAIs, specifically carbapenem-resistant Enterobacterales (CRE) and multidrug-resistant (MDR) Acinetobacter baumannii. …”
Get full text

Spireoside Controls Blast Disease by Disrupting Membrane Integrity of Magnaporthe oryzae by Xu Liting, He Kaiwei, Guo Chunyu, Quan Cantao, Ma Yahuan, Zhang Wei, Ren Lifen, Wang Long, Song Li, Ouyang Qing, Yin Junjie, Zhu Xiaobo, Tang Yongyan, He Min, Chen Xuewei, Li Weitao

“…In this study, we conducted a metabolomic analysis on both blast-resistant (Digu) and -susceptible (Lijiangxintuanheigu) rice varieties to uncover novel metabolites that enhance blast resistance. …”
Get full text

Interferon-free therapy of chronic hepatitis C: replacement of medications or new treatment paradigm? by S. N. Batskikh

“…The aim of review. A critical estimation of interferon-free modes of antiviral therapy (AVT) of chronic hepatitis C (CHC) according to the analysis of clinical studies.Key points. …”
Get full text

Impact of concrete compressive strength on the reliability and the plastic moment of steel-concrete composite beams by Nabil Daanoune, Nassim Kernou

“…The objective was to evaluate the impact of concrete strength variations on structural performance, with particular attention to the plastic resistance moment, which is critical to the safety and compliance of the composite beam. …”
Get full text

The potential of green roof strategies for reducing CO2 emissions and energy use in Moroccan office buildings by Abdessamad Idouanaou, Mustapha Malha, Abdellah Bah, Saïd Kardellass

“…This study evaluates the potential of green roofs in Moroccan office buildings across six climatic zones, focusing on three critical design parameters: Leaf Area Index (LAI), plant height, and minimum stomatal resistance (MSR). …”
Get full text

Clinical Characteristics and Optimization of Empirical Antimicrobial Therapy for Febrile Neutropenia in Patients With Hematologic Malignancies by Cui Y, Liu X, Feng S

“…Timely, evidence-based empirical therapy remains critical for improving outcomes in FN, and continued advancements in antimicrobial strategies are essential to optimizing care for this high-risk patient population.Keywords: hematological malignancy, febrile neutropenia, multidrug-resistant bacteria, empirical antibiotic treatment, fever of unknown origin…”
Get full text

The third dimension of alpine plant leaf traits is related to cold-tolerance by Yuan Wang, Ji Suonan, Kun Liu, Yanni Gao, Sihao Zhu, Qian Liu, Ning Zhao

“…Furthermore, a cold resistance experiment was conducted at one of these sites to estimate the lethal temperature causing 50% frost damage (LT50) of 11 alpine species. …”
Get full text

Acute Necrotizing Fasciitis Caused by Rhizopus Infection in a Patient with Diabetes and Pulmonary Tuberculosis: A Case Report by Huang X, Qiu J, Pan L, Wang C, Tang C

Get full text

Incidence and Implications of Culture-Positive Corneoscleral Rims in Corneal Transplantation by Meeraalam Z, Alreshidi SO, ALBalawi HB, Alali NM, Hashem F, Kirat OM

“…Zuheer Meeraalam,1 Shaker O Alreshidi,2 Hani B ALBalawi,3 Naif M Alali,3 Faris Hashem,3 Omar M Kirat4 1Ophthalmology Department, Prince Sultan Military Medical City, Riyadh, Saudi Arabia; 2Ophthalmology Division, Department of Surgical Specialties, College of Medicine, Majmaah University, Majmaah, Saudi Arabia; 3Division of Ophthalmology, Department of Surgery, Faculty of Medicine, University of Tabuk, Tabuk, Saudi Arabia; 4Anterior Segment Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi ArabiaCorrespondence: Hani B ALBalawi, Division of Ophthalmology, Department of Surgery, Faculty of Medicine, University of Tabuk, Tabuk, 71491, Saudi Arabia, Email hb.albalawi@ut.edu.saBackground: Corneal transplantation is a critical procedure for restoring vision affected by different corneal pathologies. …”
Get full text

Understanding the Difficulties in Diagnosing Neonatal Sepsis: Assessing the Role of Sepsis Biomarkers by Lungu Nicoleta, Jura Ana-Maria-Cristina, Popescu Daniela-Eugenia, Horhat Florin George, Manea Aniko Maria, Boia Marioara

Get full text