Combination gemcitabine and PD-L1xCD3 bispecific T cell engager (BiTE) enhances T lymphocyte cytotoxicity against cholangiocarcinoma cells by Methi Wathikthinnakon, Piriya Luangwattananun, Nunghathai Sawasdee, Chutipa Chiawpanit, Vannajan Sanghiran Lee, Piyarat Nimmanpipug, Yingmanee Tragoolpua, Siriphorn Rotarayanont, Thanich Sangsuwannukul, Nattaporn Phanthaphol, Yupanun Wutti-in, Chalermchai Somboonpatarakun, Thaweesak Chieochansin, Mutita Junking, Jatuporn Sujjitjoon, Pa-thai Yenchitsomanus, Aussara Panya

“…Two recombinant PD-L1xCD3 BiTEs (mBiTE and sBiTE contain anti-PD-L1 scFv region from atezolizumab and from a published sequence, respectively) were able to specifically bind to both CD3 on T lymphocytes, and to PD-L1 overexpressed after gemcitabine treatment on CCA (KKU213A, KKU055, and KKU100) cells. mBiTE and sBiTE significantly enhanced T lymphocyte cytotoxicity against CCA cells, especially after gemcitabine treatment, and their magnitudes of cytotoxicity were positively associated with the levels of PD-L1 expression. …”
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CONSTRUCTIVE GEOMETRY IN IMPLEMENTATIONS OF MODERN 3D GRAPHICS by Ivan G. Lenchuk, Oleksandr O. Mosiiuk

“…The importance of planimetric constructions in the process of performing high-precision polygonal modeling is also emphasized. The article contains many figures that illustrate the essential stages of modeling. …”
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Meniran (Phyllanthus niruri Linn) Extract Potential on Texel Sheep Feed Consumption, Body Weight Gain and Feed Conversion by Rara Irbah Fitriana Karimah, Sri Hidanah, Mohammad Anam Al-Arif, Kadek Rachmawati, Emy Koestanti Sabdoningrum, Suwarno

“…Meniran contains phytochemical compounds that are efficacious for productivity. …”
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Immunoexpression of P16 and Ki 67 in oral squamous cell carcinoma: Association with clinicopathological parameters. by Shadan Mohamad Omer, Payman Anwar Rashid

“…The use of p16 and Ki67 as biomarkers of biological behavior of oral squamous cell carcinoma is contro-versial. This study aimed to determine immunoexpression of P16 and Ki67 in oral squamous cell carcinoma and to evaluate their association with various clinicopathological parameters. …”
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Knowledge of mothers on diaper dermatitis management and associated factors in Ethiopia by Atoma Negera, Midekso Sento, Gemechu Tola

“…Abstract Diaper dermatitis is an inflammatory reactions of the skin under a diaper due to prolonged skin contact with irritants (urine and faeces), seborrhoea, allergic reaction, fungal (candida), and bacterial infections. …”
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Social Acceptance of Smart Glasses in Health Care: Model Evaluation Study of Anticipated Adoption and Social Interaction by Niek Zuidhof, Oscar Peters, Peter-Paul Verbeek, Somaya Ben Allouch

“…ObjectiveAssuming that smart glasses mediate contact between the health care provider and patient, the objectives of this research are two-fold: (1) to develop an instrument that combines the adoption and mediation perspectives, and (2) to gain insights into how the intention to use is influenced through aspects of adoption and social interaction. …”
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Effect of cardanol on the physical and chemical properties of sodium caseinate-coated papers for packaging applications by Jihyeon Hwang, Yeon-Ji Jo, Dowan Kim

“…Consequently, with increasing CL content, the hydrophobicity of the CasNa/CL-coated papers is enhanced with a reduction in the water-vapor transmittance rate from 461.3 ± 2.0 to 389.8 ± 3.9 g/m2·day and an increase in the water contact angle from 56.6 ± 2.4° to 72.9 ± 1.1°. Notably, the taste and flavor of coffee packaged with commercial and CasNa/CL (100 %)-coated coffee drip bags are similar, possibly owing to the good gas barrier properties of the CasNa/CL-coated papers. …”
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Evaluation of cellular and physiological alterations of cells from Mytilus galloprovincialis exposed to benzisothiazolinone by Federica Impellitteri, Kristian Riolo, Giorgia Zicarelli, Miriam Porretti, Cristiana Roberta Multisanti, Giuseppe Piccione, Alessia Giannetto, Caterina Faggio

“…This extensive use is reflected in a vast amount of this compound in the environment, which may cause toxic effects in organisms that come in contact with it. In light of the aforementioned context, this work aims to investigate the potential cellular and physiological impact on aquatic organisms through in vitro tests, utilising haemocytes and digestive gland (DG) cells derived from the Mediterranean mussel (Mytilus galloprovincialis). …”
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Genesis of the term "savilaida": from collections of avant-garde poetry till Lithuanian neologism by Egidijus Jaseliūnas

“…A part of press publishers, multipliers, and distributors contributed to the partisan press or came in contact with it in 1944-1953; therefore, the entire press circumventing the Soviet censorship and published without the knowledge of the authorities was generally referred to as the "underground press". …”
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Metode Deteksi Intrusi Menggunakan Algoritme Extreme Learning Machine dengan Correlation-based Feature Selection by Sulandri Sulandri, Achmad Basuki, Fitra Abdurrachman Bachtiar

“…This research analyzes the network traffic to find out whether the packet contains intrusion or is a normal packet. Traffic data used for intrusion detection in this study were taken from the KDD Cup dataset. …”
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Probiogenomic analysis of Limosilactobacillus fermentum SD7, a probiotic candidate with remarkable aggregation abilities by Thunchanok Yaikhan, Monwadee Wonglapsuwan, Nuntiya Pahumunto, Natakorn Nokchan, Rawee Teanpaisan, Komwit Surachat

“…In addition, L. fermentum SD7 genome contains four strain-specific putative CRISPR-associated genes and lacks antimicrobial resistance and virulence genes. …”
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Compressibility characteristics and modification effect of coal reservoirs in Longtan Formation, Nanchuan area, southeast Chongqing by Jinxian LIU, Tao GUO, Yatong ZHOU, Dongyang LI, Xiaobo JIN

“…Mudstone roof plates with high clay mineral content are brittle, prone to fracturing, and susceptible to swelling upon water contact, which are the major causes for spalling risks and impact horizontal well drilling rate. (4) Irregular natural fractures can lead to fracture propagation and fracture height control failure, while regular fractures that align with the direction of maximum principal stress facilitate artificial fracture propagation and contribute to effective reservoir modification.…”
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Produção de um curso de especialização em Medicina de Família e Comunidade by Alysson Feliciano Lemos, Paula Zeni Miessa Lawall, Rodrigo Luciano Bandeira de Lima, Sara Shirley Belo Lança, Edinalva Neves Nascimento

“…Método: Nesse contexto, foi concebido, produzido e ofertado um curso de Especialização em Medicina de Família e Comunidade, direcionado a médicos participantes de um Programa de Provimento. A iniciativa contou com a colaboração de especialistas da área, da Sociedade Brasileira de Medicina de Família e Comunidade e de instituições de ensino superior (IES) vinculadas ao Sistema Universidade Aberta do SUS (UNA-SUS). …”
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Community Caregivers’ Perspectives on Health IT Use for Children With Medical Complexity: Qualitative Interview Study by Farah Elkourdi, Onur Asan

“…They are often the first point of contact for the families of children with medical complexity, particularly in vulnerable communities, including families in rural areas, low-income households, and non–English-speaking immigrant populations. …”
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Kabale University Policy on Promoting Staff Academic Growth and Professional Development by Kabale University

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Implementasi Weighted Product untuk memberikan Rekomendasi Prospek Pelanggan bagi Sales Marketing Berdasarkan Web Analytics by Fajar Pradana, Fitra Abdurrachman Bachtiar, Mochammad Dearifaldi Al Ikhsan

“…Marketing activities currently developing are not only done conventionally through face-to-face contact with customers. One of the marketing activities done by companies is digital marketing. …”
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Codon usage patterns and genomic variation analysis of chloroplast genomes provides new insights into the evolution of Aroideae by Xinbi Jia, Jiaqi Wei, Yuewen Chen, Chenghong Zeng, Chan Deng, Pengchen Zeng, Yufei Tang, Qinghong Zhou, Yingjin Huang, Qianglong Zhu

“…Abstract Aroideae is an important subfamily of the Araceae family and contains many plants with medicinal and edible value. …”
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Phytochemical study and evaluation of the antidiabetic and antihyperglycemic activities of the fruit extracts of Physalis peruviana L. (Solanaceae) by Damien S.T. Tshibangu, Fortune S. Kavugho, Carlos N. Kabengele, Adrien T. Masunda, Gédéon N. Bongo, Giresse N. Kasiama, Domaine T. Mwanangombo, Clément L. Inkoto, Clément M. Mbadiko, Benjamin Z. Gbolo, Désiré M. Musuyu, Dorothée D. Tshilanda, Jean Paul K.N. Ngbolua, Pius T. Mpiana

“…Mineralogical analysis showed that the species contains minerals, essential for the organism and for the survival of the plant at significant concentrations (K, P, Ca, Mg, Na, Zn, etc.). …”
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