The development and evaluation of a tublysine-based antibody-drug conjugate with enhanced tumor therapeutic efficacy by Huihui Guo, Hongsheng Xie, Yuanyuan Huang, Junxiang Jia, Xiangfei Kong, Qingliang Yang, Shun Gai, Wenjun Li, Lu Bai, Lingli Zhang, Xiaoxiao Chen, Zhicang Ye, Hangbo Ye, Linyao Zhao, Yifang Xu, Yong Du, Xiuzhen Zhang, Miaomiao Chen, Xiaomai Zhou, Robert Y. Zhao

“…DX126-262, incorporating Tub114, a novel Tubulysin B analog, effectively mitigates the inherent hepatotoxicity associated with Tubulysin compounds while maintaining strong antitumor efficacy. …”
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Antifungal activity and biocompatibility assessment with molecular docking and dynamic simulations of new pyrazole derivatives by Basma T. Abd-Elhalim, Ghada G. El-Bana, Ahmed F. El-Sayed, Ghada E. Abdel-Ghani

“…The biocompatibility investigation showed that the 3b compound was completely safe with no IC50 dose obtained. …”
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Efficacy of Chinese traditional quadruple single pill combination versus valsartan/hydrochlorothiazide for the treatment of hypertension (COSPQ-BP): study protocol for randomised c... by Kai Liu, Yu Yan, Xin Zhang, Yanan Li, Yuanyuan Yao, Lu Liu, Runyu Ye, Si Wang, Xiangyu Yang, Xiaoping Chen, Shanshan Jia, Qingtao Meng, Xianghao Zuo

“…Introduction Hypertension constitutes the primary health burden of cardiovascular diseases, and the global control of blood pressure (BP) remains insufficient. Single pill combinations (SPCs) are employed as a means to streamline the management of poor BP control due to non-adherence and treatment inertia. …”
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Psilocybin-assisted therapy for reducing alcohol intake in patients with alcohol use disorder: protocol for a randomised, double-blinded, placebo-controlled 12-week clinical trial... by Claus Thorn Ekstrøm, Patrick MacDonald Fisher, Gitte Moos Knudsen, Dea Siggaard Stenbæk, Anders Fink-Jensen, Mathias Ebbesen Jensen, Tobias Søgaard Juul

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Physicochemical analysis and application of sardinella fimbriata-derived hydroxyapatite in toothpaste formulations by Ayub Irmadani Anwar, Muhammad Ruslin, Erni Marlina, H Hasanuddin

“…Results The calcium oxide content in fish bones was 60.25 m3/m%. The XRD of the natural fish bone hydroxyapatite compound has a crystallinity of 82.9%. …”
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Effectiveness of a novel amine + zinc + fluoride toothpaste in reducing plaque and gingivitis: results of a six-month randomized controlled trial by Dutmanee Seriwatanachai, Terdphong Triratana, Petcharat Kraivaphan, Norbert Huber, Tilo Poth, Luis R. Mateo, Melissa Stellitano, Yun-Po Zhang

“…Materials and methods In a randomized, double-blind, two-cell, parallel-group design on healthy adults from the Bangkok, Thailand area presenting with initial gingivitis (Löe-Silness gingival index ≥ 1) and visible plaque (Turesky Modification-Quigley-Hein index ≥ 1.5) were assigned test and negative control toothpastes and instructed to brush twice daily for two minutes. …”
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99mTc-labeled benzenesulfonamide derivative-entrapped gold citrate nanoparticles as an auspicious tumour targeting by Adli A. Selim, Tamer M. Sakr, Basma M. Essa, Galal H. Sayed, Kurls E. Anwer

“…Abstract Sulfonamide derivatives are a significant class of medicinal compounds. Gold nanoparticles (AuNPs) offer precise cancer treatment through targeted delivery, boasting high drug-loading capacity and low toxicity. …”
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Ornithine enantiomers modulate essential oil yield and constituents and gene expression of monoterpenes synthase in Salvia officinalis under well-watered and drought stress conditi... by Maryam Mohammadi-Cheraghabadi, Faezeh Ghanati, Naser Karimi, Mansour Ghorbanpour, Saeid Hazrati

“…The present results suggest that D-ornithine may serve as a stress-protecting compound, increasing total phenol and flavonoids content, thereby enhancing the capacity of the antioxidant system and increasing EO compounds under drought stress.…”
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Anti-inflammatory treatment using alpha melanocyte stimulating hormone (α-MSH) does not alter osteoblasts differentiation and fracture healing by Johanna Graue, Melanie Timmen, Katharina Schmitz, Daniel Kronenberg, Markus Böhm, Kishor K. Sivaraj, M. Gabriele Bixel, Richard Stange

“…However, its direct effect on bone cell differentiation or on bone regeneration, which is an inflammatory process, too, has not been investigated, yet. …”
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The effects of citral on the intestinal health and growth performance of American bullfrogs (Aquarana catesbeiana) by Xiaoting Zheng, Qiuyu Chen, Xueying Liang, Jingyi Xie, Alfredo Loor, Hongbiao Dong, Jinlong Yang, Jiasong Zhang

“…Antioxidant markers, including total antioxidant capacity (T-AOC) and glutathione (GSH), were highest at 2 mL/kg, while higher citral concentrations reduced superoxide dismutase (SOD) and catalase (CAT) activities, indicating potential oxidative stress at 8–16 mL/kg (P < 0.05). …”
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Tangeretin offers neuroprotection against colchicine-induced memory impairment in Wistar rats by modulating the antioxidant milieu, inflammatory mediators and oxidative stress in t... by Olalekan Bukunmi Ogunro, Mojisola Esther Karigidi, Gideon Ampoma Gyebi, Areej Turkistani, Ahmad H. Almehmadi

“…Results The biochemical analysis showed that chronic administration of tangeretin effectively reversed the colchicine-induced increase in the level/activity of lipid peroxidation, hydrogen peroxide (H2O2), myeloperoxidase (MPO), nitrite, reactive oxygen species (ROS), tumour necrosis factor-α (TNF-α), nuclear factor kappa B (NF-κB), interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-10 (IL-10), serotonin, dopamine, glutamate, amyloid beta (Aβ) peptide, and caspase-3. …”
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MICRO DETERMINATION OF DOPAMINE IN BIOLOGICAL SAMPLES BY COUPLING REACTION by AHMED JASSIM MUKLIVE AL-OGAIDI

“…As we study the nature of the azo dye by mole fraction method, from the practical value we found that the mole fraction of the dye compound is 1:1 (dopamine: 4- amino antipyrine) and the stability factor reach to 1.4x106 L.mol-1. …”
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Pengembangan Permainan Edukasi Berbasis Augmented Reality untuk Pembelajaran Senyawa Hidrokarbon bagi Siswa Sekolah Menengan Atas (SMA) by Carlista Naba, Muhammad Aminul Akbar, Ahmad Afif Supianto

“…The game will also detects the compound’s name. This study will be done with Iterative Rapid Prototyping design cycle. …”
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Poetic and theatrical occasionalisms: Creation of new morphologically complex words by Joseph von Eichendorff, Johann Nepomuk Nestroy, Peter Handke and Arno Schmidt by Wolfgang U. Dressler, Barbara Tumfart, Dietmar Kunisch, Vanessa Hannesschläger

“… This contribution characterises and differentiates the poetic occasionalisms in the form of new morphologically complex words created by the early romantic German lyrical poet Joseph von Eichendorff, by the Austrian Nobel Prize winner for literature Peter Handke and by the extravagant German prosaic author Arno Schmidt and the occasionalisms created by the most famous Austrian comedy writer Johann Nepomuk Nestroy.The concept and term occasionalism has been founded by the Russian pioneer of stylistics Erik J. …”
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Using a Financial Calculator to Make Financial Decisions by Josephine Turner

“…This publication shows you how. This document is FCS5263/FY442, one of a series of the Department of Family, Youth and Community Sciences, Florida Cooperative Extension Service, University of Florida, UF/IFAS, Gainesville, FL 32611. …”
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The anticancer properties, cell-cycle cytotoxicity and apoptosis of cissus rotundifolia, trema orientalis, and buddleja polystachya with ocular applications by Ali Hendi Alghamdi, Aimun A.E. Ahmed, Mahadi bashir, Haidar abdalgadir, Asaad khalid, Ashraf N. Abdalla, Mohamed E. elzubier, Riyad almaimani, Bassem refaat, Khalid alzahrani, Saleh MS. alghamdi, Sheraz gul

“…The GC–MS chromatogram of the leaf of C. rotundifolia extract (BEP-03B) revealed the presence of 17 compounds, as the main phytoconstituents representing 57.5 % of the total compounds present in BEP-03B Three steroidal components (12, 14 and 15) were the main components, while compound stigmast-5-en-3-ol (compound 15) was the main component. …”
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The drugs, interacting with opiate receptors, and their application in gastroenterological practice by S. A. Bulgakov

“…Article presents features of its synthesis, pharmacological effects, main directions of application: peptic ulcer of the stomach and duodenum, pancreatitis. Compounds of non-peptide nature, capable to interreact with opiate receptors are used now as well. …”
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Application of Laplace Transform For Solving Population Growth and Decay Models. by Natukunda, Pamellah

“…It is majorly concerned with the linearity property of the Laplace transform, How the Laplace transform is used in solving population growth and decay model, and How the Laplace transform is used in solving population growth and decay models demonstrated. …”
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The Hippo pathway promotes platinum-based chemotherapy by inhibiting MTF1-dependent heavy metal response by Hui Chen, Yue Xu, Dingshan Chen, Di Xiao, Bing Yang, Wenqi Wang, Han Han

“…In this study, we report the roles of heavy metal response and its associated Hippo pathway in regulating platinum-based chemotherapy. Our data show that the MTF1-dependent heavy metal response induces cancer cell resistance to platinum-based compounds both in vitro and in vivo. …”
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