Distinct mechanisms of electroacupuncture and manual acupuncture in modulating hypothalamic GnRH–tanycyte unit function of polycystic ovary syndrome by Yu Wang, Yicong Wang, Yuning Chen, Wenhan Lu, Xiaoyu Tong, Jiajia Li, Wenhao Gao, Rui Huang, Wei Hu, Yi Feng

“…Abstract Background Polycystic ovary syndrome (PCOS) is a complex neuroendocrine disorder characterized by dysregulation of the hypothalamus. …”
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ddPCR Enhances early diagnosis, treatment, prognosis, and pathogen verification in elderly BSI by Jiayi Peng, Huili Bai, Ying Li, Huating Luo, Jiajun Li, Haifeng Dai, Hongmei Wang, Tao Meng, Jia Zhang, Zhijian Wang, Xuanxin Chen, Wei Cheng, Yan Peng, Wenxiang Huang

“…Patients were stratified into BSI and non-BSI groups, with data collected on ddPCR and BC results, imaging and laboratory findings, medication response, and discharge outcomes. …”
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Knockout of the inhibitory receptor TIGIT enhances the antitumor response of ex vivo expanded NK cells and prevents fratricide with therapeutic Fc-active TIGIT antibodies by Dean A Lee, Jeremiah L Oyer, Md Faqrul Hasan, Tayler J Croom-Perez, Liza D Robles-Carrillo, Sanjana Kumar, Brendan W Andersen, Brian P Tullius, Alicja J Copik, Amanda R Campbell, Thomas A Dieffenthaller, Catherine A Cash, Jonathan E Eloriaga, Meisam Naeimi Kararoudi

“…TIGIT KO NK cells upregulated mTOR complex 1 (mTORC1) signaling and had better metabolic fitness with an increased basal glycolytic rate when co-cultured with cancer cells compared with WT NK cells. …”
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Original drugs approved by the Food and Drug Administration (Center for Drug Evaluation and Research) in 2024 by D. V. Kurkin, N. A. Osadchenko, A. R. Makarova, D. A. Galkina, D. A. Bakulin, O. V. Shatalova, A. V. Strygin, V. I. Petrov, O. V. Marincheva, Yu. V. Gorbunova, Yu. A. Kolosov, A. V. Zaborovsky, D. V. Yunina, K. N. Koryanova, E. I. Morkovin, M. A. Dzhavakhyan, V. I. Zvereva, R. V. Drai, I. E. Makarenko, A. S. Shuvaeva

“…The annual review of new medicines approved by the FDA is an important tool for analyzing current trends in pharmacology and medicine, reflecting progress in the treatment of complex diseases, including cancers, orphan diseases, and infections. …”
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MODELS OF SYNTACTIC STRUCTURES IN OLD GERMANIC CONCESSIVE SENTENCES by Oleksandra M. Tuhai

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Cerebrospinal fluid pressure dynamics as a biomechanical marker for quantification of spinal cord compression: Conceptual framework and systematic review of clinical trials by Najmeh Kheram, Madeleine A. Bessen, Claire F. Jones, Benjamin M. Davies, Mark Kotter, Mazda Farshad, Markus Hupp, Daniel Nanz, Patrick Freund, Martin Schubert, Vartan Kurtcuoglu, Armin Curt, Carl M. Zipser

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Deviations From Normative Functioning Underlying Emotional Episodic Memory Revealed Cross-Scale Neurodiverse Alterations Linked to Affective Symptoms in Distinct Psychiatric Disord... by Yang Xiao, Mingzhu Li, Xiao Zhang, Yuyanan Zhang, Yuqi Ge, Zhe Lu, Mengying Ma, Yuqing Song, Hao-Yang Tan, Dai Zhang, Weihua Yue, Hao Yan

“…The microscale cellular signatures underlying macroscale variations were identified using imaging transcriptomic analysis and associated with affective symptoms. …”
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Role of late gadolinium enhancement in the risk stratification of pediatric hypertrophic cardiomyopathy: based on a Chinese cohortResearch in context by Xingrui Chen, Wei Xiangli, Xuan Ma, Yun Tang, Jiaxin Wang, Zhixiang Dong, Kankan Zhao, Zhuxin Wei, Xi Jia, Pengyu Zhou, Yujie Liu, Yanyan Song, Chen Cui, Minjie Lu, Kai Yang, Xiuyu Chen, Shujuan Yang, Shihua Zhao

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Prediction of canopy mean traits in herbaceous plants by the UAV multispectral data: The quest for a better leaf-to-canopy upscaling method by Yuanqi Shan, Yunlong Yao, Lei Wang, Zhihui Wang, Huaihu Yi, Yi Fu, Weineng Li, Xuguang Zhang, Wenji Wang, Zhongwei Jing

“…Accurate trait prediction is critical for biodiversity conservation, yet research on canopy traits in heterogeneous wetlands with complex species mixtures remains scarce. While the Community-Weighted Mean (CWM) method has been widely used for upscaling leaf traits to the canopy level, it often suffers from low model precision, and the suitability of alternative upscaling methods for predicting canopy mean traits using imaging spectroscopy remains uncertain. …”
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Preclinical validation of human recombinant glutamate-oxaloacetate transaminase for the treatment of acute ischemic stroke by María Pérez-Mato, Antonio Dopico-López, Yunus Akkoc, Sonia López-Amoedo, Clara Correa-Paz, María Candamo-Lourido, Ramón Iglesias-Rey, Esteban López-Arias, Ana Bugallo-Casal, Andrés da Silva-Candal, Susana B. Bravo, María del Pilar Chantada-Vázquez, Susana Arias, María Santamaría-Cadavid, Ana Estany-Gestal, Ahlem Zaghmi, Marc A. Gauthier, María Gutiérrez-Fernández, Abraham Martin, Jordi Llop, Cristina Rodríguez, Ángeles Almeida, Martina Migliavacca, Ester Polo, Beatriz Pelaz, Devrim Gozuacik, Naouale El Yamani, Tanima SenGupta, Elise Rundén-Pran, José Vivancos, Mar Castellanos, Exuperio Díez-Tejedor, Tomás Sobrino, Aharon Rabinkov, David Mirelman, José Castillo, Francisco Campos

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Brain tumor segmentation using deep learning: high performance with minimized MRI data by Jacky Huang, Banu Yagmurlu, Powell Molleti, Richard Lee, Abigail VanderPloeg, Humaira Noor, Rohan Bareja, Yiheng Li, Michael Iv, Haruka Itakura

“…Our findings may ultimately help mitigate human labor intensity of a complex task integral to medical imaging analysis.…”
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Cognitive interference elicits developmental sex differences in inhibitory control by Jake J. Son, Abraham D. Killanin, Mikki Schantell, Yasra Arif, Thomas W. Ward, Maggie P. Rempe, Grace C. Ende, Hannah J. Okelberry, Danielle L. Rice, Anna T. Coutant, Julia M. Stephen, Yu-Ping Wang, Vince D. Calhoun, Alex I. Wiesman, Tony W. Wilson

“…MEG data were transformed into the time-frequency domain and significant oscillatory responses were imaged using a beamformer. Whole-brain analysis of flanker interference maps (i.e., incongruent - congruent trials) revealed age-related decreases in theta power in the supplementary motor area and cerebellum. …”
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Approaches used to prevent and reduce the use of restrictive practices on adults with learning disabilities: a realist review by Joy Duxbury, Alina Haines-Delmont, John Baker, Peter Baker, Gary Bourlet, Elaine Craig, James Ridley, Rachel Whyte, Beth Morrison, Michaela Thomson, Anthony Tsang, Tella Lantta

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Unsupervised Spectral-Spatial Feature Selection-Based Camouflaged Object Detection Using VNIR Hyperspectral Camera by Sungho Kim

“…Camouflaged objects can be detected better with less computational complexity by optical spectral-spatial feature analysis.…”
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Clinical and cost-effectiveness of detailed anomaly ultrasound screening in the first trimester: a mixed-methods study by Jehan N Karim, Helen Campbell, Pranav Pandya, Edward C F Wilson, Zarko Alfirevic, Trish Chudleigh, Elizabeth Duff, Jane Fisher, Hilary Goodman, Lisa Hinton, Christos Ioannou, Edmund Juszczak, Louise Linsell, Heather L Longworth, Kypros H Nicolaides, Anne Rhodes, Gordon Smith, Basky Thilaganathan, Jim Thornton, Gillian Yaz, Oliver Rivero-Arias, Aris T Papageorghiou

“…Design Systematic review and meta-analysis. Nationwide survey. Analysis of National Congenital Anomaly Disease Registry data. …”
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Neuroprotective effects of healthful plant-based diets on retinal structure: insights from a large cohort by Qian Zhu, Xiaoxin Liu, Yuan Qu, Yan Jiang, Xinyi Liu, Yu Xiao, Kangjia Lv, Yupeng Xu, Kun Liu

“…Retinal sublayers measured included macular retinal nerve fiber layer (mRNFL), macular ganglion cell-inner plexiform layer (mGCIPL), macular ganglion cell complex (mGCC), retinal pigment epithelium (mRPE), the outer nuclear layer of the central subfield (ONL), photoreceptor inner segment of the central subfield (IS) and total macular thickness. …”
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Diagnostic criteria for proximal left bundle branch block and their significance in predicting the success of cardiac resynchronization therapy by E. M. Rimskaya, S. Yu. Kashtanova, Kh. F. Salami, E. V. Kukharchuk, T. A. Malkina, S. A. Gaman, A. E. Komlev, N. A. Mironova, O. V. Stukalova, T. E. Imaev, R. S. Akchurin, S. P. Golitsyn

“…Patients in the DCM group underwent contrast-enhanced cardiac magnetic resonance imaging (MRI) before device implantation.Results. …”
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Primary and metastatic cellular landscapes in human pancreatic cancer by Nina G. Steele, Veerin R. Sirihorachai, Ahmed M. Elhossiny, Ian M. Loveless, Padma Kadiyala, Monica Bonilla, Emily L. Lasse-Opsahl, Carinna Solano Vargas, Katelyn L. Donahue, Samantha B. Kemp, Valerie Gunchick, Yatrik M. Shah, Timothy L. Frankel, Filip Bednar, Arvind Rao, Benjamin L. Allen, Jiaqi Shi, Vaibhav Sahai, Howard C. Crawford, Eileen S. Carpenter, Marina Pasca di Magliano

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Modeling the hillside movement in the area of Sattarkhan dam reservoir using by predictive models Logistic Regression and Neural Network by soghra andaryani, Nasrin Samandar, Ohammadreza Nikjoo

“…1-Introduction Evaluation of slope instabilities such as many of the most complex issues of environmental hazards are considered as the important factors in the occurrence of slope instability, mostly due to the variety of issues. …”
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Development and retrospective validation of an artificial intelligence system for diagnostic assessment of prostate biopsies: study protocol by Martin Eklund, Brett Delahunt, Lars Egevad, Hemamali Samaratunga, Mattias Rantalainen, Marcello Gambacorta, Einar Gudlaugsson, Bodil Ginnerup Pedersen, Xiaoyi Ji, Karina Dalsgaard Sørensen, Kelvin Szolnoky, Nita Mulliqi, Anders Blilie, Henrik Olsson, Matteo Titus, Geraldine Martinez Gonzalez, Sol Erika Boman, Masi Valkonen, Svein Reidar Kjosavik, José Asenjo, Paolo Libretti, Marcin Braun, Radzislaw Kordek, Roman Łowicki, Kristina Hotakainen, Päivi Väre, Benedicte Parm Ulhøi, Pekka Ruusuvuori, Toyonori Tsuzuki, Emilius Adrianus Maria Janssen, Kimmo Kartasalo

“…Many pathology departments are also facing an increasingly unsustainable workload due to rising prostate cancer incidence and a decreasing pathologist workforce coinciding with increasing requirements for more complex assessments and reporting. Digital pathology and artificial intelligence (AI) algorithms for analysing whole slide images show promise in improving the accuracy and efficiency of histopathological assessments. …”
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