Differentiating biomarker features and familial characteristics of B-SNIP psychosis Biotypes by David A. Parker, Rebekah L. Trotti, Jennifer E. McDowell, Sarah K. Keedy, Matcheri S. Keshavan, Godfrey D. Pearlson, Elliot S. Gershon, Elena I. Ivleva, Ling-Yu Huang, Kodiak Sauer, S. Kristian Hill, John A. Sweeney, Carol A. Tamminga, Brett A. Clementz

Get full text

Multi‐microRNA diagnostic panel for heart failure with preserved ejection fraction in preclinical and clinical settings by Reza Parvan, Natale Rolim, Andreas B. Gevaert, Alessandro Cataliotti, Emeline M. vanCraenenbroeck, Volker Adams, Ulrik Wisløff, Gustavo Jose Justo Silva, the OptimEx Study Group

Get full text

Macrophage transfer promotes intestinal mucosal healing by encouraging transit-amplifying cell expansion in mice by Dong su Kang, Dong su Kang, Young min Song, Young min Song, Yeon Ji Park, Yeon Ji Park, Hyeon Jong Jeong, Hyeon Jong Jeong, Jung Joo Hong, Seung Hyeok Seok, Seung Hyeok Seok, Seung Hyeok Seok, Yi Rang Na, Yi Rang Na, Yi Rang Na

“…However, challenges of stem cell therapy remain, such as Crohn’s disease with complex fistula, thus limiting its use and requiring another cellular therapy target for efficacy. …”
Get full text

Contribution à l’histoire de la boulangerie romaine : étude de « pains/galettes » découverts en Gaule by Andreas G. Heiss, Véronique Matterne, Nicolas Monteix, Margaux Tillier, Camille Noûs

“…Since the primary components of the preparations are no longer identifiable under a binocular magnifying glass, non-invasive imaging techniques are used to facilitate their analysis. …”
Get full text

Physics-enhanced machine learning for predicting strength of high-carbon chromium steel during thermomechanical processing and spheroidizing annealing by Changqing Shu, Shasha Zhang, Peiheng Ding, Yaxin Sun, Xuewei Tao, Xiaolin Zhu, Qiuhao Gu, Liukai Hua, Song Xue, Zhengjun Yao

“…However, conventional models struggle to capture the complex interactions between process parameters, microstructure, and strength. …”
Get full text

Laherradurin Inhibits Colorectal Cancer Cell Growth by Induction of Mitochondrial Dysfunction and Autophagy Induction by Izamary Delgado-Waldo, Svetlana Dokudovskaya, Yahir A. Loissell-Baltazar, Eduardo Pérez-Arteaga, Jossimar Coronel-Hernández, Mariano Martínez-Vázquez, Eloy Andrés Pérez-Yépez, Alejandro Lopez-Saavedra, Nadia Jacobo-Herrera, Carlos Pérez Plasencia

“…The changes in mitochondrial dynamics were observed through fluorescent imaging, while Western blot analysis was used to examine key autophagy and apoptosis markers. …”
Get full text

Peptide receptor radionuclide therapy for ectopic Cushing’s syndrome caused by metastatic neuroendocrine neoplasms by Emma Boehm, Terry Hung, Tim Akhurst, Ramin Alipour, Cherie Chiang, Rodney J Hicks, Michael S Hofman, Aravind S Ravi Kumar, Nirupa Sachithanandan, Javad Saghebi, Michael Michael, Grace Kong

“…Methods: Single-centre, retrospective analysis of imaging, biochemistry and outcomes of seven consecutive patients with ECS caused by metastatic GEPNEN treated with PRRT from 2006 to 2023. …”
Get full text

Divergent therapeutic and prognostic impacts of immunogenic features in undifferentiated pleomorphic sarcoma and myxofibrosarcoma by Siddh van Oost, Debora M. Meijer, Zeynep B. Erdem, Marieke E. IJsselsteijn, Jessica Roelands, Suk Wai Lam, Melissa S. Boejharat, Brendy E. W. M. van den Akker, Ruud van der Breggen, Inge H. Briare-de Bruijn, Lukas J. A. C. Hawinkels, Anouk A. Kruiswijk, Manon van der Ploeg, Pauline M. Wijers-Koster, Rick L. Haas, Michiel A. J. van den Sande, Noel F. C. C. de Miranda, Judith V. M. G. Bovee

“…Immune contextures were further evaluated in 14 UPS and 15 MFS using imaging mass cytometry. Characterization of T cell and macrophage infiltration in tumors was further assessed in 23 UPS and 22 MFS through multispectral immunofluorescence and immunohistochemical analysis. …”
Get full text

Reirradiation practices of Radiation Therapists (RePoRT) study by Neva Pang, Alvin Cuni, Amanda Caissie, Leigh Conroy, Aileen Duffton, Winnie Li, Brian Liszewski, Donna H. Murrell, Andrea Shessel, Fátima Silva, Yat Tsang, Michael Velec

“…The survey was distributed by email and data were analyzed with descriptive statistics or thematic analysis for free-text responses. Results: Responses from 214 RTTs revealed frequent and significant involvement in all steps of reirradiation pathway, ranging from pre-treatment imaging and positioning to patient supportive care. …”
Get full text

Identification of Ion-kinetic Instabilities in Hybrid-PIC Simulations of Solar Wind Plasma with Machine Learning by Viacheslav M. Sadykov, Leon Ofman, Scott A. Boardsen, Yogesh, Parisa Mostafavi, Lan K. Jian, Kristopher Klein, Mihailo Martinović

“…Analysis of ion-kinetic instabilities in solar wind plasmas is crucial for understanding energetics and dynamics throughout the heliosphere, as evident from spacecraft observations of complex ion velocity distribution functions (VDFs) and ubiquitous ion-scale kinetic waves. …”
Get full text

Endothelium-specific endoglin triggers astrocyte reactivity via extracellular vesicles in a mouse model of Alzheimer’s disease by Pingao Zhang, Chenghuan Song, Jiyun Shi, Zijie Wei, Jing Wang, Wanying Huang, Rui Zhang, Jintao Wang, Xiaoli Yang, Gang Wang, Xiaoling Gao, Yongfang Zhang, Hongzhuan Chen, Hao Wang

“…Abstract Background Alzheimer’s disease (AD) is a multifaceted neurodegenerative disorder with a complex etiology that extends beyond the well-documented amyloid-β and tau pathologies. …”
Get full text

Application of targeted next-generation sequencing for pathogens diagnosis and drug resistance prediction in bronchoalveolar lavage fluid of pulmonary infections by Qiugui Xu, Qiumei Chen, Wen Qiu, Lili Liu, Wan Zeng, Jinling Chen, Yangyang Li, Zhen Guo, Ling Rong, Bigui Chen, Jinxiu Yao, Liye Yang

“…Furthermore, two patients with complex infections were selected for tNGS microbiological surveillance to evaluate the efficacy of monitoring severe pneumonia.ResultsThis study included 205 confirmed infectious BALF specimens (two patients were tested twice). tNGS identified 56 putative pathogens, compared to 20 by CMTs, with a significantly higher positive rate (99.5% vs. 35.6%, P<0.0001). …”
Get full text

3D virtual reconstruction of the Gauzón Castle (Castrillón, Principado de Asturias) by Pablo Aparicio-Resco, Alejandro García Álvarez-Busto, Iván Muñiz-López, Noelia Fernández-Calderón

“…We believe that this analysis should be the basis of any scientific virtual reconstruction. …”
Get full text

Multisensor Data Fusion for Quantifying Agricultural Fire Impacts on Air Quality and Environmental Degradation by Pu Bu, Rana Waqar Aslam, Abdul Quddoos, Nazih Y. Rebouh, Muhammad Nasar Ahmad, Rana Muhammad Zulqarnain, Qaiser Abbas, Yahia Said

“…Our approach provides a scalable model for assessing ecological vulnerabilities in region, where multisensor synergy is critical to capture complex interactions between terrestrial and marine systems. …”
Get full text

Fine detection of floor water damage by three-dimensional direct current electric method based on cross-lane observation by Guanqun ZHOU, Hongda ZHAO, Weixin ZHANG, Xiaoping WU, Xikai LIANG, Zongtao WANG, Yafei WANG

“…In order to enhance the imaging accuracy of water damage inversion in the working face floor, through the analysis of the one-roadway electrical method, the two-roadway electrical method, and the comprehensive resistivity detection method that integrates both one-roadway and two-roadway method, a novel cross-roadway electrical observation method has been proposed. …”
Get full text

Intranasal Mitochondrial Transplantation Restores Mitochondrial Function and Modulates Glial–Neuronal Interactions in a Genetic Parkinson’s Disease Model of <i>UQCRC1</i> Mutation... by Jui-Chih Chang, Chin-Hsien Lin, Cheng-Yi Yeh, Mei-Fang Cheng, Yi-Chieh Chen, Chi-Han Wu, Hui-Ju Chang, Chin-San Liu

“…Both treatment groups showed significant locomotor improvements in open-field tests. PET imaging showed increased striatal tracer uptake, indicating enhanced dopamine synthesis capacity. …”
Get full text

The current state of knowledge on the role of NKG2D ligands in multiple sclerosis and other autoimmune diseases by Aleksandra Pogoda-Wesołowska, Nina Sługocka, Agnieszka Synowiec, Klaudia Brodaczewska, Marcin Mejer-Zahorowski, Maciej Ziękiewicz, Wojciech Szypowski, Piotr Szymański, Adam Stępień

“…The main tests used to support the diagnosis are magnetic resonance imaging (MRI) examination and cerebrospinal fluid (CSF) analysis. …”
Get full text

Surgical Outcomes of Olecranon Osteotomy Approach Combined With Submerged Kirschner Wires and Plate Fixation for Duckerley IIIB Distal Humeral Coronal Shear Fractures by Zhou‐Feng Song, Wei‐Qiang Zhao, Zeng‐Li Zhang, Jie‐Feng Huang

“…ABSTRACT Objective Duckerley type IIIB distal humerus fractures are rare and complex injuries that pose significant challenges in both diagnosis and treatment. …”
Get full text

Adapting the Germ Defence Web-Based Intervention to Improve Infection Prevention and Control in Care Homes: Interview Study Among Care Home Staff by Alex Hall, Johanna Aguilera-Muñoz, Lisa McGarrigle, Charlotte Eost-Telling, James Denison-Day, Christie Cabral, Merlin Willcox, Chris Todd

“…Ensuring good IPC practice is a perennial challenge in the varied and complex context of care homes. Behavior change interventions delivered via digital technology may be effective in improving IPC among care home staff. …”
Get full text

Exploring the nucleus accumbens circuit and oxytocin therapy in a Sapap3 knockout mouse model of trichotillomania by Yuan Wang, Jingjing Yu, Rui Ma, Yundong Chen, Shihao Lu, Jianqun Fang

“…WT, p < 0.05). Calcium imaging revealed NAc neuronal hypoactivity (peak ΔF/F 0 : 2.44 ± 1.67% vs. …”
Get full text