Comparison of torch with electric arc casting in the lost wax technique for the cast dental stud protocol. by Víctor Hugo Gonzalo Quispe Mamani, César Alberto Luna Castillo, Dina Miryan Alanoca Sejje, Luis Alexander Orrego-Ferreyros

“…The results reveal a significant advantage for the EAC technique. In Essay 1, EAC posts exhibited a mean compressive strength of 206.102 MPa, compared to 157.207 MPa for TC posts. …”
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Quality of life issues in rural settlements: assessment by social media users by Evgeniy V. Shchekotin, Viacheslav L. Goiko, Darya O. Dunaeva, Polina A. Basina, Julia K. Aleksandrova

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Personalized brain functional sectors guided theta burst transcranial magnetic stimulation for treatment-resistant depression: a study protocol for a multi-centre, randomised, doub... by Ling Zhang, Ping Zhang, Wuxiang Xie, Hao Cheng, Kai Wang, Yongbo Hu, Qiyong Gong, Weihong Kuang, Meiyun Wang, Gang Wang, Liang Li, Wen Qin, Weihua Yue, Dai Zhang, Lijuan Chen, Gongjun Ji, Hesheng Liu, Meiling Li, Chunshui Yu, Ziqiang Li, Yuyanan Zhang, Yansheng Jiang, Sixiang Liang, Xiaoyue Sun, Zekun Yang

“…This trial aims to evaluate the clinical efficacy of iTBS as an additional treatment to a stable antidepressant regimen in patients with treatment-resistant depression (TRD) by modulating brain circuits identified through personalized brain functional sectors compared with sham treatment. This work is a part of the China Study to Predict Optimised Treatment bioMarkers of Individualised Neuromodulation in Depression project.Methods and analysis This is a multi-centre, double-blind, sham-controlled randomised trial, with a 2:1 allocation ratio to 21 days of active or sham iTBS. …”
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A standards-based application for improving platelet transfusion workflow by William Gordon, Maria Aguad, Layne Ainsworth, Samuel Aronson, Jane Baronas, Edward Comeau, Rory De La Paz, Justin B.L. Halls, Vincent T. Ho, Michael Oates, Adam Landman, Wen Lu, Shawn N. Murphy, Fei Wang, Indira Guleria, Sean R. Stowell, Melissa Y. Yeung, Edgar L. Milford, Richard M. Kaufman, William J. Lane

“…Our model, which included 376 patients in the final analysis, did not demonstrate a significantly decreased odds that a patient would have a complicated thrombocytopenia course after application deployment as compared to before application deployment. …”
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Potency of Lacticaseibacillus paracasei as an alternative to antibiotic growth promoter in broiler chicken challenged with avian pathogenic Escherichia coli by Widya Paramita Lokapirnasari, Lilik Maslachah, Amung Logam Saputro, Efi Rokana, Andreas Berny Yulianto, Zulfi Nur Amrina Rosyada, Muhammad Aviv Firdaus, Himatul Ilma Silfia, Ertika Fitri Lisnanti, Zein Ahmad Baihaqi, Tabita Dameria Marbun, Aswin Rafif Khairullah, Muhammad Shakeel

“…Treatments were administered from day 15 to 35 post-hatch, following a 2-week adaptation period. …”
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Socio‐economic status and the effect of guideline‐directed medical therapy in the STRONG‐HF study by Albertino Damasceno, Hadiza Saidu, Gad Cotter, Beth Davison, Christopher Edwards, Jelena Celutkiene, Marianna Adamo, Mattia Arrigo, Marianela Barros, Jan Biegus, Kamilė Čerlinskaitė‐Bajorė, Ovidiu Chioncel, Alain Cohen‐Solal, Benjamin Deniau, Rafael Diaz, Gerasimos Filippatos, Etienne Gayat, Antoine Kimmoun, Carolyn S.P. Lam, Marco Metra, Maria Novosadova, Matteo Pagnesi, Peter S. Pang, Piotr Ponikowski, Jozine M. Ter Maaten, Daniela Tomasoni, Adriaan A. Voors, Koji Takagi, Alexandre Mebazaa, Karen Sliwa

“…Conclusions In this post hoc analysis of the STRONG‐HF study, lower SES was associated with milder acute HF but similar 180‐day outcomes. …”
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Validation of POD24 as a robust early clinical indicator of poor survival in mantle cell lymphoma from 1280 patients on clinical trials, a LYSA study by Clémentine Sarkozy, Loïc Chartier, Vincent Ribrag, Remy Gressin, Christian H. Geisler, Hanneke C. Kluin-Nelemans, Catherine Thieblemont, Franck Morschhauser, François Lemonnier, Violaine Safar, Benoît Tessoulin, Lucie Oberic, Ghandi Damaj, Hervé Ghesquières, Krimo Bouabdallah, René Olivier Casasnovas, Roch Houot, Wolfram Klapper, Barbara Burroni, Christiane Pott, Marie-Hélène Delfau-Larue, Elizabeth Macintyre, Mary Callanan, Mats Jerkeman, Michael Unterhalt, Eva Hoster, Martin Dreyling, Steven Le Gouill, Olivier Hermine, Morgane Cheminant

“…Patients with a POD24 event had a median OS of 9.3 months (95% CI 8.4–11.8) versus not reached (95% CI 97.8–NR) for those without POD24 events. The median post-relapse OS of patients with a late relapse was also significantly longer at 49.4 months (HR = 0.39; 95% CI 0.31–0.48; P < 0.001) as compared to POD24 patients. …”
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Early introduction of IL-10 weakens BCG revaccination’s protection by suppressing CD4+Th1 cell responses by Qing Lei, Hui Fu, Zongjie Yao, Zijie Zhou, Yueqing Wang, Xiaosong Lin, Yin Yuan, Qi Ouyang, Xinyue Xu, Jinge Cao, Mengze Gan, Xionglin Fan

“…BCG-revaccinated IL-10 −/− mutant mice were compared with wild-type mice to evaluate antigen-specific IgG antibody and T cell responses. …”
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Long-term follow-up of BCMA CAR-T cell therapy in patients with relapsed/refractory multiple myeloma by Yok-Lam Kwong, Tingting Yang, Guoqing Wei, He Huang, Zhen Cai, Mingming Zhang, Fengmei Song, Yongxian Hu, Yanlei Zhang, Simao Huang, Huijun Xu, Alex H Chang, Jingjing Feng, Jiazhen Cui, Chunxiang Jin, Rongrong Chen, Shan Fu, Yuanyin Teng, Ruimin Hong, Thomas Sau Yan Chan

“…Notably, patients with prior ASCT exhibited significantly lower CAR-T cell expansion compared with those without prior ASCT (p&lt;0.001). …”
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Predicting Coronavirus Pandemic in Real-Time Using Machine Learning and Big Data Streaming System by Xiongwei Zhang, Hager Saleh, Eman M. G. Younis, Radhya Sahal, Abdelmgeid A. Ali

“…Twitter is a virtual social network where people share their posts and opinions about the current situation, such as the coronavirus pandemic. …”
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Immunotherapy with nebulized pattern recognition receptor agonists restores severe immune paralysis and improves outcomes in mice with influenza-associated pulmonary aspergillosis by Jezreel Pantaleón García, Sebastian Wurster, Nathaniel D. Albert, Uddalak Bharadwaj, Keerthi Bhoda, Vikram K. Kulkarni, Mbaya Ntita, Paris Rodríguez Carstens, Madeleine Burch-Eapen, Daniela Covarrubias López, Jania Foncerrada Lizaola, Katherine E. Larsen, Lauren M. Matula, Seyed J. Moghaddam, Yongxing Wang, Dimitrios P. Kontoyiannis, Scott E. Evans

“…Additionally, transcriptional analysis of lung tissue homogenates revealed induction of pattern recognition receptor signaling and several key effector cytokine pathways after Pam2ODN therapy. …”
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Impact of Y chromosome loss on the risk of Parkinson's disease and progressionResearch in context by Junhao Wang, Xinyi Chen, Wenxuan Du, Cha Lin, Yu Liao, Jean-Christophe Corvol, Jodi Maple-Grødem, Meghan C. Campbell, Alexis Elbaz, Suzanne Lesage, Alexis Brice, Michael A. Schwarzschild, Pille Taba, Sulev Kõks, Guido Alves, Ole-Bjørn Tysnes, Joel S. Perlmutter, Baijayanta Maiti, Jacobus J. van Hilten, Roger A. Barker, Caroline H. Williams-Gray, Clemens R. Scherzer, Ganqiang Liu, Ganqiang Liu, Rebecca R. Valentino, Zhixiang Liao, Joseph J. Locascio, Jean-Christophe Corvol, Xianjun Dong, Jodi Maple-Grødem, Meghan C. Campbell, Alexis Elbaz, Suzanne Lesage, Alexis Brice, Graziella Mangone, John H. Growdon, Albert Y. Hung, Michael A. Schwarzchild, Michael T. Hayes, Anne-Marie Wills, Todd M. Herrington, Bernard Ravian, Ira Shoulson, Pille Taba, Sulev Kõks, Thomas G. Beach, Florence Cormier-Dequaire, Guido Alves, Ole-Bjørn Tysnes, Joel S. Perlmutter, Peter Heutink, Jacobus J. van Hilten, Meike Kasten, Brit Mollenhauer, Claudia Trenkwalder, Christine Klein, Roger A. Barker, Caroline H. Williams-Gray, Johan Marinus, Clemens R. Scherzer

“…Additionally, we assessed the LOY status in single-nucleus RNA sequencing (snRNA-seq) data, which included 1,303,531 cells from 279 post-mortem samples across five brain regions, and performed temporal dynamic gene expression analysis. …”
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Gamma-irradiated fowl cholera vaccines formulated with different adjuvants induced antibody response and cytokine expression in chickens by Eyerusalem Belay, Molalegne Bitew, Saddam Mohammed Ibrahim, Bereket Dessalegn, Solomon Lulie Abey, Haileyesus Dejene, Mastewal Birhan, Dawit Duffera, Eyob Asefa, Liyuwork Tesfaw, Takele Abayneh, Kedir Sherefa, Wubet W/Medhin, Yeneneh Tesfaye, Keyru Tuki, Esayas Gelaye, Richard Thiga Kangethe, Viskam Wijewardana, Carla Bravo De Rueda

“…PBMC proliferation was compared between vaccinated and unvaccinated controls. …”
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SLC31A1 promotes chemoresistance through inducing CPT1A-mediated fatty acid oxidation in ER-positive breast cancer by Xudong Li, Jingjing Ge, Mengdi Wan, Tongtong Feng, Xiaoqian Li, Haibo Zhang, Zhangyan Wang, Yongsheng Gao, Meiting Chen, Fei Pan

“…Significantly, ER-positive breast cancer tissues in patients with recurrence post-TAM treatment exhibited considerably stronger SLC31A1 expression levels. …”
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MiR‐146a engineered extracellular vesicles derived from mesenchymal stromal cells more potently attenuate ischaemia–reperfusion injury in lung transplantation by Xiucheng Yang, Shanchao Hong, Tao Yan, Mingzhao Liu, Mingyao Liu, Jin Zhao, Bingqing Yue, Di Wu, Jingbo Shao, Man Huang, Jingyu Chen

“…Bulk‐RNA sequencing, single‐cell sequencing analysis, immunofluorescence and Western blot techniques were employed to assess NLRP3 inflammasome activation and inflammation. …”
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Characterization of Rotavirus strains responsible for break-through diarrhoeal disease among Zambian children using whole genome sequencing by Prof Corena De Beer, Mr Innocent Mwape, Ms Natasha Makabilo Laban, Dr Kennedy Chibesa, Mr Andrew Moono, Mr Suwilanji Silwamba, Dr Moffat Mulemena Malisheni, Ms Caroline Chisenga, Mr Adriace Chauwa, Dr Paul Simusika, Mr Mabvuto Phiri, Mr Michelo Simuyandi, Mr Roma Chilengi, Mr David Ojok

“…Conclusion: This study confirmed the importance of post-market surveillance of vaccines, in identifying and characterising Rotavirus strains responsible for breakthrough infections to monitor viral evolution and inform next generation of vaccines. …”
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Níveis de ruído em Unidade Terapia Intensiva Neonatal antes e após intervenção educativa [Noise levels in a Neonatal Intensive Care Unit before and after an educational interventio... by Vitória Eugenia Martins, Maria Paula Custódio Silva, Camila dos Santos Machado, Cinthia Lorena Silva Barbosa Teixeira, Divanice Contim, Jesislei Bonolo do Amaral Rocha

“…Data were collected in three stages – pre-intervention noise measurement, educational intervention, and post-intervention noise measurement – and were examined by descriptive analysis. …”
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Approaches used to prevent and reduce the use of restrictive practices on adults with learning disabilities: a realist review by Joy Duxbury, Alina Haines-Delmont, John Baker, Peter Baker, Gary Bourlet, Elaine Craig, James Ridley, Rachel Whyte, Beth Morrison, Michaela Thomson, Anthony Tsang, Tella Lantta

“…Organisations should ensure that there is training for post-incident reviews including debriefing and post-incident support. …”
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Clinical Outcomes and Health Care Utilization in Patients with Advanced Chronic Kidney Disease not on Dialysis After the Onset of the COVID-19 Pandemic in Ontario, Canada by Carol Wang, Yuguang Kang, Stephanie N. Dixon, Nivethika Jeyakumar, K. Scott Brimble, Amit X. Garg, Peter G. Blake, Therese A. Stukel, Matthew J. Oliver, Ahmed Al-Jaishi, Kristin K. Clemens, Longdi Fu, Jane Ip, Susan McKenzie, Louise Moist, Amber O. Molnar, Flory Muanda-Tsobo, Marian Reich, Pavel Roshanov, Samuel A. Silver, Ronald Wald, Matthew A. Weir, Kevin Yau, Ann Young, Kyla L. Naylor

“…Similarly, the monthly rates of acute kidney injury requiring dialysis initiation showed little variation compared with pre-pandemic levels. Limitations: Due to data availability at the time of analysis, we did not examine the impact of the COVID-19 pandemic on patients with advanced CKD beyond December 2021. …”
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Triage test for all-oral drug-resistant tuberculosis (DR-TB) regimen: a phase IV study to assess effectiveness, feasibility, acceptability and cost-effectiveness of the Xpert MTB/X... by Kogieleum Naidoo, Derek J Sloan, Wilber Sabiiti, Bariki Mtafya, Stephen H Gillespie, Aderonke Agbaje, Nyanda Elias Ntinginya, Morten Ruhwald, Agnes Gebhard, Anushka Naidoo, Rubeshan Perumal, Getachew Tollera, Evaezi Okpokoro, Alash'le G Abimiku, Everdina W Tiemersma, Sabine M Hermans, Sophia B Georghiou, Kalkidan Yae, Shewki Moga, Hannelise Feyt, Takondwa Kachoka, Marothi P Letsoalo, Andrea M Cabibbe, Letitia Shunmugam, Daniela M Cirillo, Salah Foraida

“…Introduction The TriAD study will assess the Xpert MTB/XDR (Xpert XDR; Cepheid) assay to detect tuberculosis (TB) drug resistance in sputum testing positive for TB to rapidly triage and treat patients with a short all-oral treatment regimen.Methods and analysis In this study, approximately 4800 Xpert MTB/RIF or Ultra MTB-positive patients (irrespective of rifampicin (RIF) resistance (RR) status) from several clinical sites across South Africa, Nigeria and Ethiopia will be enrolled over 18–24 months and followed-up for approximately 6 months post-TB treatment completion. …”
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