Diagnostic Performance of Clinical and Routine Laboratory Data in Acute Mesenteric Arterial Occlusion—An International Multicenter Study by Yasmin Soltanzadeh-Naderi, Annika Reintam Blaser, Martin Björck, Alexandre Nuzzo, Joel Starkopf, Alastair Forbes, Marko Murruste, Kadri Tamme, Peep Talving, Anna-Liisa Voomets, Merli Koitmäe, Miklosh Bala, Zsolt Bodnar, Dumitru Casian, Zaza Demetrashvili, Mario D’Oria, Virginia Dúran Muñoz-Cruzado, Hanne Fuglseth, Moran Hellerman Itzhaki, Benjamin Hess, Karri Kase, Kristoffer Lein, Matthias Lindner, Cecilia I. Loudet, Damian J. Mole, Sten Saar, Maximilian Scheiterle, Kenneth Voon, Jonas Tverring, Stefan Acosta

“…This study aimed to find differences in clinical and laboratory markers between arterial occlusive AMI and other acute abdominal diseases where AMI was initially suspected. Methods: This was a post hoc study of an international prospective multicenter study where data on patients with suspected AMI were collected. …”
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Frailty, Pitavastatin, and Major Adverse Cardiovascular Events Among People With HIV by Kristine M. Erlandson, MD, MS, Ariela R. Orkaby, MD, Triin Umbleja, MSc, Heather J. Ribaudo, PhD, Todd T. Brown, MD, PhD, Markella V. Zanni, MD, Marissa R. Diggs, AB, Sarah M. Chu, MSN, Kathleen V. Fitch, MSN, Carl J. Fichtenbaum, MD, Carlos Malvestutto, MD, MPH, Judith A. Aberg, MD, Gerald S. Bloomfield, MD, MPH, Judith S. Currier, MD, Karen T. Tashima, MD, Marcus Vinícius Guimarães de Lacerda, MD, PhD, Sonya L. Heath, MD, Michael T. Lu, MD, MPH, Alan Landay, PhD, George A. Kuchel, MD, Pamela S. Douglas, MD, Steven K. Grinspoon, MD

“…Methods: We conducted a post hoc analysis of the REPRIEVE trial, a randomized, blinded trial of pitavastatin 4 mg vs placebo. …”
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Characterization of a Natural Accession of <i>Elymus sibiricus</i> with <i>In Situ</i> Hybridization and Agronomic Evaluation by Yizhuo Liu, Jiarui Ding, Chunfei Wu, Weiwei Song, Xinyu Zhao, Haibin Zhao, Yunfeng Qu, Hui Jin, Rui Zhang, Mingyao Li, Xinyu Yan, Liangyu Zhu, Yaqi Bao, Dianhao Liu, Xinling Li, Lei Cui, Hongjie Li, Yanming Zhang

“…Using morphological and cytogenetic methods, this study evaluated the cold tolerance, post-harvest regeneration capacity, and perennial characteristics of the <i>E. sibiricus</i> accession 20HSC-Z9 in the Harbin region of China from 2020 to 2023. …”
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Pediatric autoimmune diseases in the light of COVID-19 pandemic, A retrospective observational big data study by Rim Kasem Ali Sliman, Hilla Cohen, Shereen Shehadeh, Reut Batcir, Yigal Elenberg Alter, Keren Cohen, Ilana Koren, Inbal Halabi, Hussein Sliman, Mohamad Hamad Saied

“…Methods: A retrospective cross-sectional study analyzed data from Clalit Health Services, Israel's largest healthcare provider, examining the IR of different autoimmune diseases in children aged 0–18. The study compared pre-pandemic (2019) with pandemic/post-pandemic periods (2020–2023), encompassing a cohort of over 1.5 million children. …”
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Neoadjuvant Aumolertinib for unresectable stage III EGFR-mutant non-small cell lung cancer: a single-arm phase II trial by Dongliang Bian, Shuyu Ji, Yue Liu, Zhida Huang, Lei Jiang, Ming Liu, Xiao Bao, Jie Yang, Yirui Zhou, Junjie Hu, Liangdong Sun, Yingzhi Zheng, Jie Huang, Jing Liu, Xinsheng Zhu, Jing Zhang, Lele Zhang, Xiaogang Liu, Wenxin He, Dong Xie, Yuming Zhu, Chunyan Wu, Deping Zhao, Liang Duan, Gening Jiang, Peng Zhang

“…RNA-sequencing based analysis revealed increased infiltration of CD8 + T-cells in post-treatment tumors compared to baseline, particularly in responsive and Ex19-Del mutation tumors. …”
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Concordance and agreement between different activity scores in polymyalgia rheumatica by Bruno Fautrel, Eric Toussirot, Renaud Felten, Emmanuel Nowak, Christophe Richez, Jacques-Eric Gottenberg, Isabelle Chary-Valckenaere, Alain Saraux, Aleth Perdriger, Emanuelle Dernis, Thierry Marhadour, Marie-Elise Truchetet, Divi Cornec, Valérie Devauchelle-Pensec, Daniel Wendling, Guillaume Direz, Anne Lohse, Laurent Chiche, PASCAL HILLIQUIN, Guillermo Carvajal Alegria, Dewi Guellec, Justine D'Agostino, Aghiles Souki, Catherine Le Henaff, Benjamin Dervieux

“…Our secondary objective was to evaluate the concordance between different cutoffs of the PMR-ASs.Method Data from the Safety and Efficacy of tocilizumab versus Placebo in Polymyalgia rHeumatica With glucocORticoid dEpendence (SEMAPHORE) trial, a superiority randomised double-blind placebo-controlled trial, were subjected to post hoc analysis to compare the efficacy of tocilizumab versus placebo in patients with active PMR. …”
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Left Atrial Remodeling Identification and Catheter Ablation Outcomes With 18F‐Fluorodeoxyglucose Positron Emission Tomography in Persistent Atrial Fibrillation by Tristan Raoult, Bernhard L. Gerber, Quentin Garnir, Christophe Scavée, Varnavas Varnavas, Aurélien Wauters, Damien Gruson, Eric Nellessen, Michel Hesse, Christophe Beauloye, Véronique Roelants, Sébastien Marchandise

“…Patients were followed for up to 24 months post CA to assess AF recurrence. Results Global LGU extent was 16.8% (7.6–42.6) and correlated with left atrial volume index (R2=0.20, P=0.039) and low voltage area during AF and right atrial pacing (R2=0.54 and R2=0.35 respectively, both P<0.001). …”
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Prognostic Significance of Nutritional Scores in Patients With Heart Failure: Insights From the PARAGON‐HF Trial by Henri Lu, Brian L. Claggett, Masatoshi Minamisawa, John W. Ostrominski, Alberto Foà, Maria A. Pabón, Arzu Kalayci, Muthiah Vaduganathan, Maja Cikes, Amil M. Shah, Akshay S. Desai, John J. V. McMurray, Pardeep S. Jhund, Milton Packer, Martin Lefkowitz, Jean L. Rouleau, Michael R. Zile, Faiez Zannad, Sheila M. Hegde, Scott D. Solomon, Hicham Skali

“…Methods and Results The CONUT score and GNRI were serially analyzed in this post hoc analysis of the PARAGON‐HF (Prospective Comparison of Angiotensin Receptor–Neprilysin Inhibitor With Angiotensin‐Receptor Blockers Global Outcomes in Heart Failure With Preserved Ejection Fraction) trial. …”
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Protocol for a phase IV double-blind randomised controlled trial to investigate the effect of the 13-valent pneumococcal conjugate vaccine and the 23-valent pneumococcal polysaccha... by Tao Chen, Duolao Wang, Konstantinos Liatsikos, Stephen B Gordon, Hassan Burhan, Ben Morton, Tinashe K Nyazika, Bradford D Gessner, Helen Hill, Andrea Collins, Josh Hamilton, Kelly Davies, Fred Fyles, Phoebe Hazenberg, Elizabeth Begier, Angela Hyder-Wright, Sherin Pojar, Christopher Myerscough, Jesus Reine, Ryan E Robinson, Britta Urban, Elena Mitsi, Carla Solorzano, Angela Quinn, Kaijie Pan, Annaliesa S Anderson, Christian Theilacker, Daniela M Ferreira, Kelly Convey, James Court, Madlen Farrar, Lisa Hitchins, Ashleigh Howard, Lauren Kerruish, Samuel Latham, Annabel Murphy, Elissavet Nikolaou, Angelina Peterson

“…Here, we summarise an ethically approved protocol for a double-blind, randomised controlled trial investigating the effect of the 13-valent pneumococcal conjugate vaccine (PCV13) and the 23-valent pneumococcal polysaccharide vaccine (PPV23) on pneumococcal nasopharyngeal colonisation acquisition, density and duration using experimental human pneumococcal challenge (EHPC).Methods and analysis Healthy adult participants aged 18–50 years will be randomised to receive PCV13, PPV23 or placebo and then undergo one or two EHPCs involving intranasal administration of SPN at 1-month post-vaccination with serotype 3 (SPN3) and 6 months with serotype 6B (SPN6B). …”
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Differentially expressed microRNAs in pre-transplant lung biopsies target immune checkpoint proteins and can predict primary graft dysfunction in lung transplantation by Vitale Miceli, Pia Ferrigno, Claudio Centi, Claudia Carcione, Gioacchin Iannolo, Valentina Agnese, Giovanna Lo Iacono, Rosa Liotta, Pier Giulio Conaldi, Massimo Pinzani, Lavinia De Monte, Alessandro Bertani

“…Our analysis revealed differential miRNA expression in donor lung tissues, potentially associated with PGD onset, targeting immune regulatory pathways. …”
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Molecular insights into the relationship between sustained CRP elevation and endothelial dysfunction in axial spondyloarthritis by Clementina López-Medina, Nuria Barbarroja, Alejandro Escudero-Contreras, Chary López-Pedrera, Carlos Perez-Sanchez, Pedro Segui, Eduardo Collantes, Jerusalem Calvo, Lourdes Ladehesa-Pineda, Desiree Ruíz-Vilchez, Laura Cuesta-López, Iván Arias-de la Rosa, Jesús Eduardo Martín-Salazar, Antonio Manuel Barranco, Miriam Ruiz-Ponce, María Ángeles Puche Larrubia, Rafaela Ortega, María Carmen Ábalos-Aguilera, Elena Moreno-Caño, Pedro Ortiz-Buitrago

“…Carotid intima-media thickness (CIMT) and microvascular endothelial function (post-ischaemic reactive hyperaemia) were measured. …”
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Effectiveness of different physical activity programs in improving older adults’ physical capacities: a randomized controlled trial by Carolina A. Cabo, Carolina A. Cabo, Carolina A. Cabo, Carolina A. Cabo, Víctor Hernández-Beltrán, Orlando Fernandes, Orlando Fernandes, Cláudia Mendes, Cláudia Mendes, Cláudia Mendes, José M. Gamonales, José M. Gamonales, José M. Gamonales, Mário C. Espada, Mário C. Espada, Mário C. Espada, Mário C. Espada, Mário C. Espada, José A. Parraca, José A. Parraca

“…Data were collected pre- and post-intervention. To analyze the changes, we used Student’s T-test and Cohen’s d for effect size (ES), with statistical significance set at p &lt; 0.05. …”
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Identification and preclinical efficacy evaluation of two lytic bacteriophages targeting highly virulent and multidrug-resistant Klebsiella pneumoniae by Ai Guo, Dianbao Zuo, Li Shi, Ming Guo, Jinquan Li, Caili Li, Puqing Wang, Xiaodong Sun, Ming Sang

“…The bacterial concentration markedly decreased at 2 h post-treatment, reaching its biological nadir by 6 h. …”
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The effects of dance intervention on clinical symptoms and cognitive deficits in hospitalized patients with chronic schizophrenia: a randomized controlled trial by Gujing Li, Hui He, Kexin Gao, Yuanyuan Yu, Yayun Liu, Tianhuan Li, Ping Xi, Frank Pollick, Jing Lu, Lixue Yin, Dezhong Yao, Mingjun Duan, Li Mi, Cheng Luo

“…Results The PANSS total scores (P < 0.01**), PANSS negative scores (p < 0.001**), NOISE score (p < 0.001**), MCCB cognitive scores, and physiological indicators were significantly changed after the intervention in both groups compared with baseline. Post-hoc analysis revealed notable improvements in the specific cognitive subscales, including the Continuous Operation Test-identical pairs (CPT-IP, p = 0.026*), Hopkins Verbal Learning Test-Revised (HVLT-R, p = 0.019*) and the physiological indicators Cystatin C (CYS-C, p = 0.037*) in the dance intervention group. …”
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Trained human bone marrow mesenchymal stem cells restore tissue immuno-microenvironment in fulminant hepatic failure mice by Bingqi Li, Xiaofei Zeng, Jing Jiang, Qian Zhou, Li Tong, Xi Liang, Jiaojiao Xin, Xi Chen, Xiao Wu, Yuheng Kong, Shiwen Ma, Jinjin Luo, Wei Qiang, Bing Zhu, Xinhua Luo, Jun Li, Dongyan Shi

“…The therapeutic potential of T-hBMSC was evaluated through transplantation into FHF mice. Transcriptomic analysis was performed to elucidate the mechanism of liver regeneration post-transplantation of T-hBMSC. …”
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Glucose metabolism in heterozygous familial hypercholesterolemia with a founder effect and a high diabetes prevalence: a cross-sectional study by Ana María González-Lleó, Yeray Brito-Casillas, Virginia Martín-Santana, Yaiza Gil-Quintana, Antonio Tugores, Roberto Scicali, Marta Riaño, Luisa Hernández-Baraza, Roberto Jiménez-Monzón, Josefa Girona, Francesco Di Giacomo Barbagallo, Luis Masana, Mauro Boronat, Ana M. Wägner, Rosa M. Sánchez-Hernández

“…Normoglycemic HeFH-GC individuals had elevated HOMA-IR [2.0 (1.3–2.9) vs. 1.3 (1.0–1.9); p = 0.008]. Compared with HeFH-It patients, HeFH-GC individuals had higher fasting glucose levels (99 vs. 92.5 mg/dL; p = 0.004) and lower 120-min post-OGTT glucose levels (115 vs. 136.5 mg/dL; p = 0.001). …”
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Late recurrent gastric carcinoma 12 years after surgery with attenuation of CD44 variant 9 expression by Hirokatsu Hayashi, Itaru Yasufuku, Toshiya Higashi, Wakana Chikaishi, Ryoma Yokoi, Masahiro Fukada, Yuta Sato, Ryuichi Asai, Jesse Yu Tajima, Chiemi Saigo, Akitaka Makiyama, Yoshihiro Tanaka, Naoki Okumura, Katsutoshi Murase, Takao Takahashi, Manabu Futamura, Tamotsu Takeuchi, Nobuhisa Matsuhashi

“…Abstract Background Late recurrence of gastric cancer at 10 years post-gastrectomy is extremely rare, and the underlying mechanism remains unclear. …”
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Breaking prolonged sitting with high-intensity interval training to improve cognitive and brain health in middle-aged and older adults: a protocol for the pilot feasibility HIIT2SI... by Charles Hillman, Talha Syed, Dominika M Pindus, Tomasz S Ligeza, Jin Kuang, Scott Paluska, Joseph So, Miroslaw Wyczesany, Jesus Sarol, Flor B Quiroz, Ramiya Shanmugam, Maciej Kos, Naiman Khan, Art Kramer

“…This pilot randomised crossover feasibility trial capitalises on PA intensity as the major limiting factor in peripheral catecholamine increase and tests the effects of interrupting prolonged sitting every 30 min with 6 min high-intensity interval training (HIIT) compared with low-intensity interval training (LIIT) bouts. …”
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Efficacy of danhong injection adjuvant therapy in patients with acute ischemic stroke: a real-world, multicenter, retrospective study by Danping Pan, Haitong Wan, Haitong Wan, Yu He, Jiehong Yang, Yilei Guo, Li Yu, Feihu Zhang, Guoqing Zheng, Bin Xu, Yaohong Song, Mingjun Zhao, Xiangzhe Liu, Jianhe Liu, Gang Sun, Yaming Lin

“…After treatment, the NIHSS score in the DHI group was 2.01 ± 3.10, compared with 2.50 ± 3.26 in the Non-DHI group, indicating significantly lower scores in the DHI group (adjusted RR = 0.81, 95% CI: 0.74–0.88, P &lt; 0.001). …”
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Optical properties, inclusions, and chemical composition of blue corundum from the Stazh-2 deposit, South-Western Pamir by A. K. Litvinenko, D. B. Vandanova, O. A. Shilova, S. B. Pakhomova

“…The Stazh-2 deposit of blue corundum is a representative object in the post- Soviet territory with prospects for mining of jewelry crystal raw materials. …”
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