Cardiac MRI of differing ischemia and reperfusion times in a myocardial infarction pig model by David Boll, Simon Reiss, Heidi R. Cristina Schmitz, Christian Weber, Julien Thielmann, Felix Spreter, Kian Tadjalli Mehr, Diana Chiang, Markus Jäckel, Lukas Heger, Jonathan Rilinger, Dirk Westermann, Constantin von zur Mühlen, Timo Heidt, Michael Bock, Alexander Maier

“…Occlusion durations of 60–90 min resulted in LGE and T1 and T2 values both increased compared to 30–45 min of ischemia (p < 0.001 for T1 and p = 0.021 for T2). …”
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Impulsivity and aggression in suicide across age and sex: case–control study by Sergio Sanz-Gómez, Constanza Vera-Varela, Diego de-la-Vega-Sánchez, María Luisa Barrigón, Adrián Alacreu-Crespo, Julio A. Guija, Ana Sánchez, Santiago de León, Enrique Baca-García, Lucas Giner

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UVC-PURGE: A Novel Cost-Effective Disinfection Robot for Combating COVID-19 Pandemic by Akib Zaman, Mohammad Shahjahan Majib, Shoeb Ahmed Tanjim, Shah Md. Ahasan Siddique, Shafayetul Islam, Md Shadman Aadeeb, Nafiz Imtiaz Khan, Riasat Haque, Md Rashid Ul Islam, M. Rayhan Ferdous Faisal, Siddharth Malik, Muhammad Nazrul Islam

“…Moreover, the usability evaluation yields an above-average SUPR-Q score of 81.91&#x0025; with significant scores in all the criteria (usability, trust, loyalty, and appearance) and the number of positive themes from the subjective evaluation using thematic analysis is twice the number of negative themes. Additionally, compared with the prevailing UVC disinfection robots in the market, UVC-PURGE is cost-effective with a price of less than 800 USD. …”
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At-home Breast Oncology care Delivered with EHealth solutions (ABODE) study protocol: a randomised controlled trial by Wei Xu, Eitan Amir, Madeline Li, Gary Rodin, Toni Zhong, Raymond H Kim, Allan Okrainec, Michael Reedijk, David McCready, Emily Thain, Kelly Metcalfe, Siba Haykal, Jeanna Mccuaig, Robin Forbes, Jaime Escallon, Janet Papadakos, Erin Kennedy, Amanda Mac, Dalia Schaffer, Mohini Kalia, Emma Reel, Adina Isenberg, C Anne Koch, Sarah Rotstein, Tulin D Cil, Jordan Cleland, Alexandra Easson, Sheila Jarvis, Wey Leong, Daniel Santa Mina, Larissa Peck, Sharmy Sarvanantham, Fahreen Walimohamed

“…Among newly diagnosed patients with breast cancer, we will compare changes in patient activation, other patient-reported outcomes and health service outcomes over 1 year between those using the app and Fitbit, and those receiving standard care and Fitbit only.Methods and analysis This randomised controlled trial will include 200 patients with breast cancer seen at a tertiary care cancer centre in Ontario, Canada. …”
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The association between hepatic steatosis, vitamin D status, and insulin resistance in adolescents with obesity by Emir Tas, Amanda Flint, Ingrid Libman, Radhika Muzumdar, Xiawei Ou, David K. Williams, Elisabet Børsheim, Eva C. Diaz

“…This study examined the relationship between changes in vitamin D status and markers of IR in adolescents, with a focus on the modifying effect of liver fat. Methods: A post-hoc analysis was performed using data from 44 adolescents participating in a 6-month observational study evaluating biomarkers of hepatosteatosis. …”
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Preoperative partial breast reirradiation and repeat breast-conserving surgery in patients with recurrent breast cancer: the prospective single-arm REPEAT trial – a study protocol... by Ellis Barbé, Joost Verhoeff, Nina Bijker, Philip Meijnen, Yasmin Civil, Lisca Wurfbain, Lysanne Jonker, Maurice van der Sangen, Arlene Oei, Katya Duvivier, Zdenko van Kesteren, Miguel Palacios, Willemien Menke-van der Houven van Oordt, Gwen Diepenhorst, Victor Thijssen, Berend Slotman, Robert-Jan Schipper, Desirée van den Bongard

“…This approach can downstage the tumour and may possibly reduce toxicity and improve cosmetic outcomes compared with postoperative radiotherapy. This study aims to evaluate the feasibility of single-dose preoperative PBI and second breast-conserving surgery (BCS) for patients with an ipsilateral recurrent breast event (IRBE) after previous BCT.Methods and analysis The REPEAT trial is a multicentre, prospective, single-arm trial investigating ablative single-dose preoperative PBI in patients with an IRBE. …”
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Team climate, job satisfaction, burnout and practice performance: results of a national survey of staff in general practices in England by Peter Williams, Heather Gage, Bridget Jones, Carole Aspden, Jessica Smylie, Thomas Bird, Morro M. L. Touray, Phelim Brady, John Campbell, Rupa Chilvers, Catherine Marchand, Stephen Peckham, Suzanne H. Richards, Karen Spilsbury, Mark Joy, Simon de Lusignan

“…Staff outcomes (job satisfaction, likelihood of remaining in post, less burnout) were associated with a better practice team climate, as were patient experience ratings. …”
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Collaborative tailoring of the Reach Out, Stay Strong Essentials (ROSE) program for pregnant veterans in the U.S. Veterans Health Administration: a qualitative case study of contex... by Erin P. Finley, Alison B. Hamilton, Ismelda Canelo, La Shawnta S. Jackson, Rachel Lesser, Rebecca S. Oberman, Julia Yosef, Joya G. Chrystal, Erica H. Fletcher, Bevanne Bean-Mayberry, Tannaz Moin, Melissa M. Farmer, Ariel J. Lang

“…Abstract Background Reach Out, Stay Strong Essentials (ROSE) is an evidence-based intervention for preventing post-partum depression being implemented across U.S. …”
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Feeding amylolytic and fibrolytic exogenous enzymes in feedlot diets: effects on ruminal parameters, nitrogen balance and microbial diversity of Nellore cattle by Igor Machado Ferreira, Hilario Cuquetto Mantovani, Fiorella Viquez-Umana, Yury Tatiana Granja-Salcedo, Luiz Fernando Costa e Silva, Anne Koontz, Vaughn Holder, James Eugene Pettigrew, Arlan Araújo Rodrigues, Aline Naime Rodrigues, Mateus José Inácio de Abreu, Saulo Teixeira Rodrigues de Almeida, Pedro Marcus Pereira Vidigal, Gustavo Rezende Siqueira, Flávio Dutra de Resende

“…The experimental period lasted 19 d and included total urine and feces collection (d 15 to 18) and rumen fluid sampling (d 19) at 0, 4, 8, 12, and 16 h post-feeding for ammonia, volatile fatty acids (VFA), pH and microbiome analysis. …”
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The efficacy and safety of sodium‐glucose cotransporter 2 inhibitors in patients aged over 80 years with heart failure by Kenji Nakano, Kenji Kanenawa, Akihiro Isotani, Takashi Morinaga, Kaori Yamamoto, Norihisa Miyawaki, Euihong Ko, Miho Nakamura, Yuichi Tanaka, Kenichi Ishizu, Toru Morofuji, Masaomi Hayashi, Masato Fukunaga, Makoto Hyodo, Shinichi Shirai, Kenji Ando

“…A multivariate Cox regression model was used to compare the risk of primary composite outcome (all‐cause death and HFH) and secondary safety composite outcome (ischaemic stroke, urinary tract infection and dehydration) at 1 year post‐discharge between the two groups. …”
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Neoadjuvant in situ vaccination with cowpea mosaic virus as a novel therapy against canine inflammatory mammary cancer by Daniel Alonso-Miguel, Guillermo Valdivia, Diego Guerrera, Maria Dolores Perez-Alenza, Stanislav Pantelyushin, Angela Alonso-Diez, Veronique Beiss, Steven Fiering, Nicole F Steinmetz, Maria Suarez-Redondo, Johannes vom Berg, Laura Peña, Hugo Arias-Pulido

“…In the TME, higher neutrophilic infiltration and MPO expression, lower tumor Ki-67 PI, increase in CD3+ lymphocytes, decrease in FoxP3+/CD3+ ratio (p&lt;0.04 for all comparisons), and no changes in CC-3+ immunostainings were observed in post-treatment tumor tissues when compared with pretreatment tumor samples. eCPMV-treated IMC patients had a statistically significant (p=0.033) improved overall survival than patients treated with medical therapy.Conclusions Neoadjuvant in situ eCPMV immunotherapy demonstrated anti-tumor efficacy and improved survival in IMC patients without systemic adverse effects. eCPMV-induced changes in immune cells point to neutrophils as a driver of immune response. …”
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Good Arts, Good Mental Health®: the effectiveness of an Australian health promotion media campaign in promoting community mental wellbeing via the arts by Christina R. Davies, Melanie T. Pescud, Rhonda Clifford, Richard McGrath, Annie Thomson, Mia Jeffrey, Melissa Stoneham, Terri Pikora, Peter Wright, Sonya Girdler, Sonya Girdler, Loretta Baldassar, Stephen Clift

“…For paid media channels, the highest reach (948,106 people) and best cost-per-reach ($0.02) were delivered by Meta (Facebook and Instagram).Measured as both (1) a proportion of total respondents and (2) a sub-set analysis of each preceding level in the cognitive impact hierarchy, post-campaign, one-in-four respondents were aware of Good Arts, Good Mental Health®. …”
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Prolonged versus single dose in penicillin oral challenge testing: protocols for a pilot and definitive randomised controlled trial (PROSPECTOR studies) by Vito Sabato, Jason Trubiano, Sara Vogrin, Richard Sullivan, Michael Lane, Suran Fernando, Fiona James, Jonathan Grant Peter, Morgan Rose, Amy Legg, Irvin Ng, Ana Copaescu, Elise Mitri, Jack Godsell, Lene Heise Garvey, Philip Li

“…PROSPECTOR-2 will commence immediately post completion of PROSPECTOR-1 in a vanguard design, with adjustments to the projected sample size for superiority made following completion of PROSPECTOR-1. …”
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Paleogeography and regional interpretation of facies in Tirgan Formation, west of Kopet-Dagh sedimentary basin, northeast of Iran by Atefeh Chenarani, Meysam Shafiee Ardestani, Mohamad Vahidinia

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Dynamic cardiac changes in low cardiovascular risk patients with triple negative breast cancer treated with chemo-immunotherapy by Jean Philippe Nesseler, Katrina D. Silos, Olivia Peony, Asneh Singh, Patrick Belen, Mitchell R. Kamrava, Julie K. Jang, Stephen L. Shiao, Alan C. Kwan, Cody Ramin, Raymond H. Mak, Andriana P. Nikolova, Katelyn M. Atkins

“…Methods Retrospective analysis of 85 women with early-stage TNBC treated with chemotherapy-pembrolizumab between 2018 and 2023 and had ≥ 1 transthoracic echocardiogram (TTE) available. …”
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Medical follow-up and long-term survival of patients with cerebrovascular accident: data from the REGION-M registry by S. N. Tolpygina, M. I. Chernysheva, A. V. Zagrebelny, V. P. Voronina, N. P. Kutishenko, N. A. Dmitrieva, O. V. Lerman, Yu. V. Lukina, M. M. Lukyanov, E. Yu. Okshina, N. E. Parsadanyan, S. Yu. Martsevich, O. M. Drapkina

“…The lower mortality among those visited the local clinic in the first year after CVA and among those who were visited by a doctor at home, compared with patients who were not observed, confirms the important role of medical supervision in the post-hospital period.…”
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Infant Parent Support (IPS): a multidisciplinary intervention to improve the mental health of children with a social worker - a study protocol for a feasibility randomised controll... by Jaycee Pownall, Karen Crawford, Lindsay Dalgarno, Judith Fisher, Sharon Graham, Fiona Turner, Helen Minnis, Kathleen Boyd, Abril Seyahian, Alex McConnachie, Nicola Cosgrave, Matt Forde, Carol Atkinson, Janet McCullough, Kapil Sayal, Dennis Ougrin

“…We will utilise a pre-post and 3/6-month follow-up design with embedded mixed-method process evaluation and exploratory economic analysis. …”
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Value of synthetic MRI in predicting treatment response to neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer by WANG Kangning, ZHU Lan, FENG Weiming, XIA Yihan, SHI Bowen, ZHANG Huan

“…Logistic regression analysis showed that mrEMVI and elevated T2RT_Fat_P90 were independent risk factors for predicting mesorectal lymph node metastasis. …”
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CYP1B1 knockout enhanced IFN-γ production is required but not sufficient for protection of cigarette smoke-exposed mice against lethal influenza virus infection by Wenxin Wu, Jeremy S. Alexander, J. Leland Booth, Magdalena Chlebicz, Craig A. Miller, Chao Xu, Susan Kovats, Susan Kovats, Jordan P. Metcalf, Jordan P. Metcalf, Jordan P. Metcalf

“…We used an in-vivo mouse model to assess the hypothesis that CYP1B1 modifies innate immune responses to CS and alters survival during IAV infection.MethodsWe measured CYP1B1 induction in bronchial epithelial cells in smokers and nonsmokers obtained by bronchoscopy by whole transcriptome analysis. To determine whether CYP1B1 knockout (CYP KO) improves mortality and reduces lung injury in CS-exposed mice, we compared the survival rates, host immune responses, and lung-to-body weight ratio of CYP KO mice with the wild-type (WT) mice following challenge with IAV with or without CS exposure.ResultsCYP1B1 is one of the most highly upregulated genes in human lung epithelia derived from cigarette smokers. …”
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Transcatheter edge‐to‐edge repair of atrial secondary mitral regurgitation positively influences atrial remodelling by Aniela Petrescu, Martin Geyer, Julian Andres Gelves Meza, Omar Hahad, Tobias Ruf, Valeria Maria deLuca, Lukas Hobohm, Theresa Gößler, Felix Kreidel, Philipp Lurz, Ralph Stephan vonBardeleben

“…A significant reduction in LA volume compared with baseline, both at end‐systole (151.4 ± 64 vs. 113 ± 64 mL, P < 0.001) and at end‐diastole (119.8 ± 56 vs. 91.2 ± 56.9 mL, P < 0.001) could be observed. …”
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