Persistence of Ebola virus in semen among Ebola virus disease survivors in Sierra Leone: A cohort study of frequency, duration, and risk factors. by A E Thorson, G F Deen, K T Bernstein, W J Liu, F Yamba, N Habib, F R Sesay, P Gaillard, T A Massaquoi, S L R McDonald, Y Zhang, K N Durski, S Singaravelu, E Ervin, H Liu, A Coursier, J E Marrinan, A Ariyarajah, M Carino, P Formenty, U Ströher, M Lamunu, G Wu, F Sahr, W Xu, B Knust, N Broutet, Sierra Leone Ebola Virus Persistence Study Group

“…Participants were matched with the Sierra Leone EVD case database to retrieve cycle threshold (Ct) values from the qRT-PCR analysis done in blood during acute disease. A purposive sampling strategy was used, and the included sample composition was compared to the national EVD survivor database to understand deviations from the general male survivor population. …”
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PATIENTS WITH COMBINATION OF CHRONIC HEART FAILURE, HYPERTENSION AND HISTORY OF MYOCARDIAL INFARCTION: CLINICAL AND ANAMNESTIC CHARACTERISTICS, ADMINISTRATION OF ACE INHIBITORS, AN... by M. M. Loukianov, A. N. Kozminsky, S. Yu. Martsevich, S. S. Yakushin, A. N. Vorobyev, A. V. Zagrebelnyy, R. P. Myasnikov, K. G. Pereverzeva, E. A. Pravkina, E. Yu. Andreenko, E. N. Belova, A. D. Deev, V. G. Klyashtorny, E. V. Kudryashov, S. A. Boytsov

“…Patients with a combination of CHF, HT and post-infarction cardiosclerosis (PICS) compared with patients without PICS significantly more often had CHF class 3-4 NYHA (62% vs 47.9%, respectively), HT of degree 3 (92.5% vs 84.2%, respectively), stable angina class 3-4 (84.4% vs 66.4%, respectively). …”
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The natural immune molecules urinary Tamm–Horsfall protein and pentraxin 3 as predictors for recurrent urinary tract infection severity: a single-center self-control study by Zongping Li, Yingru Xu, Qian Wang, Gang Yuan, Jing Shu, Shiwei Liu, Xuezhong Gong

“…All patients received consistent lifestyle guidance. Descriptive analysis was performed on the RUTI cohort.Results Urinary THP levels were significantly lower in RUTI patients (TLF and CLAT groups) compared to the non-RUTI, whereas PTX3 levels showed a tendency toward elevation. …”
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LEO or LEO baby within enterprise overlapping stents combined with coil embolization treatment for ruptured vertebrobasilar artery dissecting aneurysms by Zengbao Wu, Minghui Zhou, Ali Abdi Maalim, Yang Han, Xiao Guo, Cao Chen, Ting Lei, Kai Shu, Mingxin Zhu

“…One patient (5.00%) required ventriculoperitoneal shunt placement. Immediate post-operation angiography revealed Raymond grade I, II, and III occlusions in 55.00%, 30.00%, and 15.00% of cases, respectively. …”
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Delta radiomics modeling based on CTP for predicting hemorrhagic transformation after intravenous thrombolysis in acute cerebral infarction: an 8-year retrospective pilot study by Xiaxia Wu, Xiaxia Wu, Jinfang Yang, Jinfang Yang, Xianqun Ji, Yingjian Ye, Ping Song, Lina Song, Peng An, Peng An

“…These were combined with baseline patient data (e.g., age, sex, NIHSS score, medical history) to establish various models for predicting HT-ACI through multivariable logistic regression analysis. The predictive performance of the models was compared using DeLong curves, clinical net benefit was assessed using decision curves, and model predictions were validated using the XGboost algorithm. …”
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Efficacy of corticosteroids addition to multimodal cocktail periarticular injection in total knee arthroplasty with hemophilic arthropathy by Hai Su, Shenxu Yu, Lei Chen, Haojing Zhou, Yichen Gong, Hua Huang, Shuaijie Lv, Peijian Tong, Xun Liu, Jun Ying

“…We conducted a retrospective analysis of clinical data from 98 HA patients who underwent TKA at our institution between January 2015 and January 2024. …”
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Faster efficacy and reduced nodule occurrence with PLLA (poly-l-lactic acid) porous microspheres by Qihua Cao, Qihua Cao, Qihua Cao, Jiayu Chen, Jiayu Chen, Jiayu Chen, Jiayu Chen, Zijun Zhang, Yufei Xiong, Jinxia Ma, Wei Sun, Xin Chen, Qilei Lou, Kaijia Tang, Kaijia Tang, Kaijia Tang, Kaijia Tang, Feng Lin, Feng Lin, Feng Lin, Yueliang Zhu, Yueliang Zhu, Yueliang Zhu, Xiaohua Yu, Xiaohua Yu, Xiaohua Yu, Xiaohua Yu

“…At predetermined experimental time points, subjects were humanely euthanized. Post-euthanasia, tissue sections underwent histological examination through hematoxylin and eosin (H&E) staining and Masson’s trichrome technique, with subsequent statistical analysis of the observational data.ResultsThe PLLA porous microsphere group demonstrated significantly faster onset of action compared to the control, with observable collagen deposition as early as week 2, enhanced inflammatory cell infiltration, more homogeneous tissue distribution, and substantially fewer microaggregates upon histological examination.DiscussionStructural modification of PLLA microspheres has successfully accelerated their onset of action while reducing nodule formation, thereby providing novel insights for clinical applications.…”
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Evaluating Interlaboratory Variability in Wastewater-Based COVID-19 Surveillance by Arianna Azzellino, Laura Pellegrinelli, Ramon Pedrini, Andrea Turolla, Barbara Bertasi, Sandro Binda, Sara Castiglioni, Clementina E. Cocuzza, Fabio Ferrari, Andrea Franzetti, Maria Giovanna Guiso, Marina Nadia Losio, Marianna Martinelli, Antonino Martines, Rosario Musumeci, Desdemona Oliva, Laura Sandri, Valeria Primache, Francesco Righi, Annalisa Scarazzato, Silvia Schiarea, Elena Pariani, Emanuela Ammoni, Danilo Cereda, Francesca Malpei

“…A two-way ANOVA framework within Generalized Linear Models was applied, and multiple pairwise comparisons among laboratories were performed using the Bonferroni post hoc test. The statistical analysis revealed that the primary source of variability in the results was associated with the analytical phase. …”
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Nosocomial lower respiratory tract infections in patients with immunosuppression: a cohort study by Luis Felipe Reyes, Natalia Sanabria-Herrera, Saad Nseir, Otavio T. Ranzani, Pedro Povoa, Emilio Diaz, Marcus J. Schultz, Alejandro Rodríguez, Cristian C. Serrano-Mayorga, Gennaro De Pascale, Paolo Navalesi, Szymon Skoczynski, Mariano Esperatti, Luis Miguel Coelho, Andrea Cortegiani, Stefano Aliberti, Anselmo Caricato, Helmut J. F. Salzer, Adrian Ceccato, Rok Civljak, Paolo Maurizio Soave, Charles-Edouard Luyt, Pervin Korkmaz Ekren, Fernando Rios, Joan Ramon Masclans, Judith Marin, Silvia Iglesias-Moles, Stefano Nava, Davide Chiumello, Lieuwe D. J. Bos, Antonio Artigas, Filipe Froes, David Grimaldi, Mauro Panigada, Fabio Silvio Taccone, Massimo Antonelli, Antoni Torres, Ignacio Martin-Loeches, for the European Network for ICU-Related Respiratory Infections (ENIRRIs) European Respiratory Society-Clinical Research Collaboration Investigators

“…Abstract Background This post-hoc analysis of a multinational, multicenter study aimed to describe and compare clinical characteristics, microbiology, and outcomes between immunosuppressed and non-immunosuppressed patients with nosocomial lower respiratory tract infections (nLRTI). …”
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The effects of TiO2 nanotubes on bond strength and radiopacity of a self-adhesive resin cement in self-curing mode by Leandro Edgar Pacheco, Ana Paula Rodrigues Magalhães, Carla Muller Ramos-Tonello, Ligia Saraiva Bueno, Orisson Ponce Gomes, Lucas José Azevedo Silva, Adilson Yoshio Furuse, Paulo Noronha Lisboa-Filho, Carmem Silva Costa Pfeifer, Ana Flavia Sanches Borges, Paulo Afonso Silveira Francisconi

“…The bond strength to bovine root dentin and fiberglass posts was assessed with the push out bond strength test and was evaluated in three thirds (cervical, middle and apical) (n=10), followed by failure mode analysis (SEM), and the ISO standard 9917-2 was followed for radiopacity test (n=10). …”
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Alterations in the intestinal fungal microbiome of patients with severe fever with thrombocytopenia syndrome by Meng-Yu Liu, Sheng-Fu He, Yu-Yao Li, Jiao-Jiao Shen, Jia-Jia Li, Ya-Sheng Li, Yan-Yan Liu, Ting Wu, Jia-Bin Li, Li-Fen Hu

“…R statistical software (version 3.5.1) was used for data processing and analysis. Results: The intestinal mycobiomes of SFTS patients showed strong alterations characterized by increased Aspergillus species, and a highly heterogeneous mycobiome configuration compared to healthy controls. …”
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The unreversible reduced but persistent activated NK and CD8+ T cells in severe/critical COVID-19 during omicron pandemic in China by Ling Qin, Xinmin Duan, Jay Zengjun Dong, Yue Chang, Yang Han, Yan Li, Wei Jiang, Hongwei Fan, Xiufeng Hou, Wei Cao, Huadong Zhu, Taisheng Li

“…The subsequent analysis showed in contrast to the M/M group, NK and CD8+ T cell counts remained low-level after therapy in the S/C group. …”
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Lymphodepletion, tumor-infiltrating lymphocytes, and high versus low dose IL-2 followed by pembrolizumab in patients with metastatic melanoma by Merve Hasanov, Simin Kiany, Marie-Andrée Forget, Roland Bassett, Michael A. Davies, Adi Diab, Jeffrey E. Gershenwald, Isabella C. Glitza, Jeffrey E. Lee, Anthony Lucci, Jennifer L. McQuade, Sapna P. Patel, Merrick I. Ross, Hussein A. Tawbi, Jennifer A. Wargo, Michael K. Wong, Chantale Bernatchez, Patrick Hwu, Cara Haymaker, Rodabe N. Amaria

“…Patients received pembrolizumab 200 mg IV starting 21 days post-TIL infusion, and every 3 weeks for up to 2 years. …”
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HLA-mismatched stem cell microtransplant prolonged overall survival and promoted immunological reconstitution for multiple myeloma by Yangyang Lei, Yangyang Lei, Bo Cai, Zhiqing Liu, Anli Xie, Jianhui Qiao, Yi Wang, Xinrui Chen, Fei Peng, Yingxin Zhao, Jiaxin Chen, Wei Guan, Changlin Yu, Xiao Lou, Kaixun Hu, Ang Zhang, Qiyun Sun, Yajing Huang, Yajing Huang, Huisheng Ai, Mei Guo

“…Although microtransplant (MST) has proved promising results in treating several hematological malignancies, it has not been studied in multiple myeloma.MethodsWe performed a retrospective analysis of multiple myeloma patients treated with MST at our institution. …”
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Association of Pulmonary Hypertension With Outcomes in Kidney Transplant Recipients by Isabel G. Scalia, Juan M. Farina, Milagros Pereyra Pietri, Nima Baba Ali, Mohammed Tiseer Abbas, Kamal Awad, Ahmed K. Mahmoud, Niloofar Javadi, Nadera N. Bismee, Samy Riad, Hani Wadei, Byron Smith, D. Eric Steidley, Timothy Barry, Robert L. Scott, Yeoungjee Cho, David W. Johnson, Chadi Ayoub, Reza Arsanjani, Girish Mour

“…Clinical outcomes were compared between patients with and without pretransplant PHTN, including mortality and allograft failure (overall and censored by mortality). …”
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Precision laser acupuncture at back-shu points enhances growth performance, feed efficiency, and hormonal regulation in rabbits by Mudhita Zikkrullah Ritonga, Ertika Fitri Lisnanti, Widya Pramita Lokapirnasari, Sri Hidanah, Saifur Rehman, Muhammad Fajar Amrullah, Rico Anggriawan, Mutasem Abuzahra, Denny Irmawati Hasan, Aamir Shehzad, Siti Rani Ayuti

“…Data were statistically evaluated using a one-way analysis of variance followed by Duncan’s post hoc test. …”
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Early Rituximab as an Add-On Therapy in Children With the Initial Episode of Nephrotic Syndrome by Jialu Liu, Fang Deng, Xiaowen Wang, Cuihua Liu, Shuzhen Sun, Ruifeng Zhang, Aihua Zhang, Xiaoyun Jiang, Weili Yan, Yalan Dou, Yi Zhang, Li Xie, Biyun Qian, Qian Shen, Hong Xu

“…The post hoc analysis revealed a higher 24-month relapse-free survival and a lower incidence of FRNS/SDNS at the 12-month follow-up. …”
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Beyond first-line therapy: efficacy and safety outcomes of continuing immunotherapy in extensive stage small cell lung cancer after PD-L1 inhibitor progression by Jianfeng Peng, Xueying Zhai, Xiaomei Liu, Zhaoqin Huang, Yimeng Wang, Peizhu Wu, Ran Gao, Xiangjiao Meng

“…Results: In a cohort of 150 ES-SCLC patients evaluated post-progression following first-line PD-L1 inhibitors, second-line treatment regimens varied: 86 patients received immunotherapy beyond progression (IBP) and 64 did not proceed to second-line immunotherapy (non-IBP). …”
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Inter-assay variability in the measurement of urinary C-terminal cross-linked telopeptide of type II collagen following anterior cruciate ligament reconstruction by Lachlan M. Batty, Kate E. Webster, Natasha Vassileff, Jereme G. Spiers, Haydn J. Klemm, Brian Devitt, Timothy S. Whitehead, Andrew F. Hill, Julian A. Feller

“…The specific assay used is critical to consider when interpreting results and has implications for pooling data and meta-analysis.…”
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Honeybees fed D-galactose exhibit aging signs with changes in gut microbiota and metabolism by Guanzhou Zhou, Jiabin Hu, Mengqi Xu, Yiyuan Li, Ruqi Chang, Jiaqi Zeng, Wanyue Dan, Lihua Peng, Zikai Wang, Gang Sun, Fei Pan, Yunsheng Yang

“…A comprehensive assessment was conducted on day 15 post-treatment, including survival analysis, starvation test, motor, learning and memory ability tests, malondialdehyde test, and Smurf test. …”
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