Preliminary research indicates that mechanical force through Pioze1 enhances local immunity during NPWT treatment for spinal infections by Hao Xing, Junlin Pan, Huan Liu, Yanan Wang, Zhengqi Chang

“…Additionally, healing times and recurrence rates within two years post-surgery were assessed. In addition, lesion specimens were retained during surgery and changes in Piezo1, Interleukin-1β (IL-1β), IL-6, IL-8, and Tumor Necrosis Factor-α (TNF-α) in lesion tissues were observed before and after immunohistochemical analysis.ResultsAll 7 patients with spinal infections successfully underwent NPWT treatment and were ultimately cured. …”
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Evaluation of a domestic violence training and support intervention in Palestinian primary care clinics in the west bank: a mixed method study by Nagham Joudeh, Amira Shaheen, Loraine J. Bacchus, Manuela Colombini, Abdulsalam Alkaiyat, Helen Lambert, Rasha Hashlamoon, Gene Feder

“…Evaluation phase: Thematic analysis of post-intervention semi-structured interviews with (HCP) and trainers; observations of training sessions and field notes. …”
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Six‐Minute Walk Test Is Superior to Grip Strength as a Marker of Functional Recovery During Cancer Cachexia Rehabilitation by Addison Barber, Amber Willbanks, Kathryn Abplanalp, Christopher W. Lewis, Ben Binder‐Markey, Prakash Jayabalan, Richard L. Lieber, Ishan Roy

“…These two outcome measures have never been directly compared in the same cohort of cachexia patients regarding their ability to measure and relationship to functional independence. …”
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Europe's adaptation to the energy crisis: reshaped gas supply–transmission–consumption structures and driving factors from 2022 to 2024 by C. Zhou, B. Zhu, A. Halff, A. Halff, S. J. Davis, Z. Liu, S. Bowring, S. B. Arous, P. Ciais

“…On the supply side, Russian gas supply to the EU27&UK was cut by 87.8 % (976.8 TW h per winter) during the post-invasion winters compared to the previous winters. …”
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Incidence, risk factors, and clinical implications of enfortumab vedotin-related cutaneous toxicity in urothelial carcinoma: a large-scale, real-world study in Japan by Y. Kita, T. Hara, T. Kawahara, K. Hashimoto, Y. Matsushita, H. Ito, T. Abe, A. Igarashi, S. Shimura, T. Sazuka, A. Yokomizo, N. Takaoka, M. Kato, T. Hazama, M. Miyake, Y. Sugino, J. Mutaguchi, A. Takahashi, Y. Shiraishi, S. Tatarano, Y. Takai, T. Mochizuki, S. Nakanishi, K. Mori, T. Yoshida, T. Hayashi, H. Otsuka, T. Anami, K. Okasho, K. Daizumoto, M. Kobayashi, I. Kobayashi, J. Watanabe, N. Nishiyama, T. Shibuya, Y. Matsui, H. Nishiyama, H. Kitamura, T. Kobayashi

“…Patients with epEVRCTs demonstrated significantly improved PFS and OS compared with those without. Post-PSM analysis confirmed longer OS for patients with epEVRCTs, particularly those with mild (grade 1) toxicities, suggesting that these reactions may be significantly linked to favorable treatment outcomes. …”
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The Role of Atrial Fibrillation and Oral Anticoagulation Status in Health‐Related Quality of Life 12 Months After Ischemic Stroke or TIA by Manuel C. Olma, Lena Steindorf‐Sabath, Serdar Tütüncü, Claudia Kunze, Cornelia Fiessler, Paulus Kirchhof, Joanna Dietzel, Johannes Schurig, Patrick Oschmann, Ludwig Niehaus, Christian Urbanek, Götz Thomalla, Darius G. Nabavi, Joachim Röther, Ulrich Laufs, Roland Veltkamp, Peter U. Heuschmann, Karl Georg Haeusler, Matthias Endres, for the MonDAFIS Investigators

“…It is known that AF impairs health‐related quality of life (HRQOL) in the general population, but data on HRQOL in stroke patients with newly diagnosed AF are sparse. Methods Post hoc analysis of the prospective, investigator‐initiated, multicenter MonDAFIS study (NCT02204267) to analyze whether AF‐related oral anticoagulation (OAC), and/or AF‐symptom severity are associated with HRQOL after ischemic stroke or transient ischemic attack (TIA). …”
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Effect of IL4-589C>T, FCGR2A-166His>Arg, DEFB1-20G>A, DEFB1-52G>A gene polymorphisms on TNFα, IL-1β, IL-4, and IL-10 contents in the patients with primary hip osteoarthrosis by A. M. Miromanov, T. V. Zabello, N. A. Miromanova

“…The control group (n = 100), were local residents, comparable by age (60±8.3 years), gender, habitation place and nationality. …”
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Staphylococcus epidermidis uses the SrrAB regulatory system to modulate oxidative stress and intracellular survival in mouse macrophage cell line Ana-1 by Chunjing Zhao, Zongkai Bai, Xiaoting Chen, Shuangjie Shang, Baitong Shen, Li Bai, Di Qu, Yang Wu, Youcong Wu

“…A srrAB deletion mutant (∆srrAB) was constructed using S. epidermidis strain 1457 (SE1457) as the parent strain to study its regulatory function in oxidative stress. Compared to SE1457, the viable cell counts of the ∆srrAB mutant significantly decreased in the post-stationary phase culture, coinciding with a sharp increase in reactive oxidative species (ROS) accumulation. …”
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Effects of Wolbachia removal on microbial composition and diversity in Aedes albopictus: implication of using wAlbB for discriminating irradiation-based sterile and wild males by Paerhande Dilinuer, Ming Li, Datao Lin, Yu Wu, Zhongdao Wu, Xiaoying Zheng, Dongjing Zhang

“…Wolbachia was absent in GT mosquitoes, and Elizabethkingia was undetected in GUA males. qPCR further confirmed these trends. PCR analysis revealed that wAlbB exhibited higher stability in differentiating factory-reared GT males from their wild counterparts (96.7% infection in field males, n = 60) compared to wAlbA (61.7%, n = 60) or Enterococcus (65.8%, n = 120). …”
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Pharmacy Integrated Transitions (PIT) trial: a protocol for a pragmatic cluster-randomised crossover trial by Elizabeth Austin, Catherine Kim, Elizabeth J Austin, Giana H Davidson, Bryan A Comstock, Sarah E Monsell, Bryan Comstock, Mariam N Hantouli, Jocelyn Chaing, Arzu Ahmed Dervish, Nick J Gionet, Shalynn Howard, Nathalia Jimenez, Miriam Liberman, Edwin G Lindo, Zachary A Marcum, Thuan D Ong, Elina Serrano, Katherine Simons, Lydia S Sun, Oleg Zaslavsky

“…A rigorous, pragmatic trial is needed to assess the programme’s effectiveness in enhancing care transitions compared with standard practices.The PIT trial aims to evaluate the effectiveness of the PIT programme in improving patients’ care transitions from hospitals to SNFs compared with usual care, and to characterise multiple interest holders’ perspectives on its implementation fidelity, effectiveness and needed support for sustainment.Methods and analysis The PIT trial is a parallel cluster-randomised controlled crossover trial design, with randomisation occurring at the SNF cluster level. …”
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Comparison of eight weeks of resistance training and high-intensity intermittent aerobic training on the expression of microRNAs associated with adipose tissue angiogenesis and ant... by Hamid Sadeghian, Marefat Siahkohian, Mohsen Akbarpour Beni, Lotfali Bolboli

“…Scheffe post hoc test was used to compare the pairwise .Results: The miR-221, miR-222 and VEGF in the Normal diet + Resistance training, Normal diet + HIIT and High-fat diet + Resistance training groups a significant increase was observed compared to the control group (P ≥ 0.01). …”
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Comparison of [99mTc]Tc-FAPI SPECT/CT and [18F]FDG PET/CT as predictive biomarkers for immunotherapy response in gastrointestinal cancer by Yu Zhang, Hong Chen, Dajia Lin, Zhiyi Lin, Jiyun Shi, Hannan Gao, Chenshen Huang, Fangqing Xue, Fan Wang, Wenxin Chen

“…Abstract To explore the diagnostic performance of [99mTc]Tc-FAPI SPECT/CT for gastrointestinal cancer, compared to [18F]FDG PET/CT. In this analysis of a prospective trial, consecutively recruited patients from a single center with pathologically confirmed gastrointestinal cancer were prospectively enrolled from September 2022 to June 2024 and underwent paired v and [18F]FDG PET/CT examinations at intervals of more than 1 day and within 7 days of each other.The activity of tracer accumulation in lesions was assessed by maximum standardized uptake value(SUVmax) and TBR (lesions SUVmax/ascending aorta SUVmean). …”
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Mesenchymal stromal cells conditioned by peripheral blood mononuclear cells exert enhanced immunomodulation capacities and alleviate a model of Myasthenia Gravis by Alexandra C. Bayer, Natalia Pinzón, Axel You, Cinthia Bergman, Nadine Dragin, Aurélien Corneau, Frédérique Truffault, Danièle Noël, Christophe Martinaud, Rozen Le Panse, Sonia Berrih-Aknin, Jean-Thomas Vilquin

“…Comparatively, 2089 genes were differentially expressed between rMSC and γMSC, highlighting host defense, anti-viral response, NFκB signaling pathways modulated by IFN-γ. …”
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Effect of Faricimab versus Aflibercept on Hyperreflective Foci in Patients with Diabetic Macular Edema from the YOSEMITE/RHINE Trials by Usha Chakravarthy, FRCOphth, PhD, Varun Chaudhary, MD, FRCS(C), Srinivas R. Sadda, MD, Colin S. Tan, FRCOphth, FRCSEd (Ophth), Stela Vujosevic, MD, PhD, Sascha Fauser, MD, Kara Gibson, PhD, Carl Glittenberg, MD, Nancy Holekamp, MD, FASRS, Ben Lanza, PhD, Andreas Maunz, PhD, Jeffrey R. Willis, MD, PhD, Rishi P. Singh, MD

“…Design: A post hoc analysis of the randomized, double-masked, noninferiority YOSEMITE/RHINE (NCT03622580/NCT03622593) phase III trials. …”
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Utilizing rice-husk waste as an effective weed control mulch for Holy Basil (Ocimum sanctum ) production in a tropical environment by Vivian Ogechi Osadebe, Uchenna Noble Ukwu, Nathaniel Dauda, Ifesinachi M Nwamba, Amos Ejike Ede, Anthony I Onah

“…All data were subjected to analysis of variance. Results: The use of rice-husk mulch resulted in the most significant (p<0.05) increase in plant height (41.70 cm), leaf number (206.80), branch number (50.50), stem girth (2.76 cm), and leaf yield (7.15 t/ha) of Ocimum sanctum compared to the other weed control methods. …”
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Bariatric surgery for patients with type 2 diabetes mellitus requiring insulin: Clinical outcome and cost-effectiveness analyses. by Emma Rose McGlone, Iain Carey, Vladica Veličković, Prem Chana, Kamal Mahawar, Rachel L Batterham, James Hopkins, Peter Walton, Robin Kinsman, James Byrne, Shaw Somers, David Kerrigan, Vinod Menon, Cynthia Borg, Ahmed Ahmed, Bruno Sgromo, Chandra Cheruvu, Gul Bano, Catherine Leonard, Howard Thom, Carel W le Roux, Marcus Reddy, Richard Welbourn, Peter Small, Omar A Khan

“…Over 5 years, bariatric surgery was cost saving compared to BMT (total cost GBP£22,057 versus GBP£26,286 respectively, incremental difference GBP£4,229). …”
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Fully automatic quantification of pulmonary fat attenuation volume by CT: an exploratory pilot study by Luca Salhöfer, Mathias Holtkamp, Francesco Bonella, Lale Umutlu, Johannes Wienker, Dirk Westhölter, Matthias Welsner, Christian Taube, Kaid Darwiche, Judith Kohnke, Jannis Straus, Nikolas Beck, Marko Frings, Sebastian Zensen, Rene Hosch, Giulia Baldini, Felix Nensa, Marcel Opitz, Johannes Haubold

“…Statistical analyses were conducted using Kruskal–Wallis with Dunn’s post hoc tests. Results Patients with fILDs demonstrated a significant increase in CTpfav (median 71.0 mL, interquartile range [IQR] 59.7 mL, p < 0.001) and PFI (median 1.9%, IQR 2.4%, p < 0.001) when compared to the control group (CTpfav median 43.6 mL, IQR 16.94 mL; PFI median 0.9%, IQR 0.5%). …”
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Development of a clinical decision support tool for Primary care Management of lower Urinary tract Symptoms in men: the PriMUS study by Adrian Edwards, Ridhi Agarwal, Janine Bates, Alison Bray, Sarah Milosevic, Emma Thomas-Jones, Michael Drinnan, Marcus Drake, Peter Michell, Bethan Pell, Haroon Ahmed, Natalie Joseph-Williams, Kerenza Hood, Yemisi Takwoingi, Chris Harding

“…Age, post-void residual volume and median voided volume were included in detrusor overactivity main model, while age and storage symptoms subscore predicted detrusor overactivity sensitivity analysis 2. …”
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Clinical outcomes of cancer-associated isolated distal deep vein thrombosis: a comparison between asymptomatic and symptomatic thrombosis—findings from the ONCO DVT Study by Yoshito Ogihara, Yugo Yamashita, Takeshi Morimoto, Nao Muraoka, Michihisa Umetsu, Yuji Nishimoto, Takuma Takada, Tatsuya Nishikawa, Nobutaka Ikeda, Kazunori Otsui, Daisuke Sueta, Yukari Tsubata, Masaaki Shoji, Ayumi Shikama, Yutaka Hosoi, Yasuhiro Tanabe, Ryuki Chatani, Kengo Tsukahara, Naohiko Nakanishi, Kitae Kim, Satoshi Ikeda, Toru Sato, Takeshi Kimura, Kaoru Dohi

“…In this post hoc analysis, 601 patients were categorized into the asymptomatic (n = 479) and symptomatic (n = 122) groups based on IDDVT-related symptoms at diagnosis. …”
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Virtual Nephron: Evaluation of a Novel Virtual Reality Educational Tool by Georges N. Nakhoul, Jonathan J. Taliercio, Elias H. Bassil, Susana Arrigain, Jesse D. Schold, Richard Wardrop, John O’Toole, Joseph V. Nally, S. Beth Bierer, John R. Sedor, Ali Mehdi

“…Knowledge acquisition was assessed with a post-test administered at the end of the course and repeated within 6 to 12 weeks. …”
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