Improving pain, function and quality of life in end-stage knee osteoarthritis: a patient-preference cohort study on whole-body vibration and exercise as bridging therapies for tota... by Kendrew Yu-Hei Choi, Wai-Wang Chau, Linda Man-Kuen Li, Sammie Yuk-Lam Ng, Boie Po-Yee Lo, Michael Tim-Yun Ong, Patrick Shu-Hang Yung

“…Outcomes were assessed at baseline and after the final treatment session. Statistical analysis included ANOVA with post-hoc Bonferroni correction for baseline comparisons and paired t-tests for longitudinal comparisons. …”
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Relationship between venous thromboembolism and inflammatory bowel disease in Taiwan: a nationwide retrospective cohort study by Yi-Jen Fang, Hui-Hsia Hsieh, Heng-Jun Lin, Cheng-Li Lin, Wan-Yi Lee, Chi-Hua Chen, Fuu-Jen Tsai, Bang-Jau You, Ni Tien, Yun-Ping Lim

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The N-6 methyladenosine dynamics in STEMI and the effect of IL-6 inhibition - a hypothesis generating sub-study of the ASSAIL-MI trial by Tuva B. Dahl, Tuva B. Dahl, Ana Quiles-Jiménez, Kaspar Broch, Kaspar Broch, Anne Kristine Anstensrud, Anne Kristine Anstensrud, Lars Gullestad, Lars Gullestad, Lars Gullestad, Geir Ø. Andersen, Geir Ø. Andersen, Ola Kleveland, Jonas Øgaard, Jonas Øgaard, Vigdis Bjerkeli, Vigdis Bjerkeli, Azita Rashidi, Kuan Yang, Kirsten B. Holven, Kirsten B. Holven, Pål Aukrust, Magnar Bjørås, Magnar Bjørås, Camilla Huse, Camilla Huse, Camilla Huse, Bente Halvorsen, Bente Halvorsen

“…RNA was isolated, and m6A sites were analyzed using human m6A single nucleotide resolution microarray analysis. mRNA levels were analyzed using RNA sequencing analysis.ResultsCompared with controls, patients with STEMI had a strikingly different pattern of m6A deposition. …”
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Individual responses to encapsulated caffeine and caffeine chewing gum on strength and power in strength-trained males by Hamed Teimouri-Korani, Mohammad Hemmatinafar, Mark ET Willems, Rasoul Rezaei, Babak Imanian

“…Responders to the caffeine conditions were identified using the smallest worthwhile change (SWC) analysis.Results In knee extensors, 1) average peak torque and power at 60°/s were higher in CC (p = 0.045; + 11.2% and p = 0.038; + 14.1%) and CG (p = 0.044; + 7.3% and p = 0.015; + 11.4%) compared to PLA with a co-response rate of 60% and 66%, 2) maximum voluntary isometric contraction at 45° (MVIC-45°) was higher in CC compared to PLA (p = 0.031; + 10.1%), and 3) MVIC-60° was higher in CG compared to PLA (p = 0.037; + 10.1%) with a co-response rate of 60%. …”
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Cyborg Adolescents and Digital Data: Examining Education and Revenue Generation in the Digital Lives of Youth through More-than-Human Ethnography by Davood Zahrani, Ali Hashemianfar, Ahmad Mehrshad

“…Materials & Methods Ethnography is a prominent method in post-human studies and new materialism (Berry, 2019: 48). …”
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Knowledge and perception of a clinical trial among the participants: An experience from oral cholera vaccine study in Koshi Province, Nepal by Shipra Chaudhary, Surendra Uranw, Basant Rai, Nisha Keshary Bhatta, Gauri Shankar Shah, Prakash Poudel, Basudha Khanal, Rosan Prasad Shah Kalawar, Nikita Rai, Jenisha Shrestha, Merina Shrestha, Shalu Parajuli, Birendra Prasad Gupta, Sridhar Vemula, Katerina Rok Song, Julia Lynch, Tarun Saluja

“…Most participants (467; 75.1%) had participated in CT to get protection from the particular disease from the provided vaccine and (603; 96.9%) believed CT to benefit mankind. Further studies comparing pre- and post-participation knowledge and perception might be helpful for planning and better management of CTs in such settings.…”
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Evidence for reduced torsional resistance of rotary files under curved position by Ahmed Jamleh, Raghad Almedlej, Rasha Alomar, Nouf Almayouf, Abdulmohsen Alfadley, Khalid Alfouzan

“…Torque failure values were recorded, and fractured surfaces were tested using a scanning electron microscopy (SEM). Statistical analysis of the data was completed using one-way ANOVA and post-hoc test (LSD) in order to compare between the tested systems in each file position. …”
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The Mechanism Involved in High-Lycopene Tomato Mutants for Broomrape Resistance by Lianfeng Shi, Xin Li, Jinrui Bai, Xiaoxiao Lu, Chunyang Pan, Junling Hu, Chen Zhang, Can Zhu, Yanmei Guo, Xiaoxuan Wang, Zejun Huang, Yongchen Du, Lei Liu, Junming Li

“…Both pot experiment and in vitro seed germination assays demonstrated that the mutants exhibited reduced susceptibility to <i>P. aegyptiaca</i> and triggered lower germination rates in broomrape seeds compared to the wild-type cultivar AC. Quantitative RT-PCR analysis revealed a significant downregulation of SL biosynthesis genes (<i>SlD27</i>, <i>SlCCD7</i>, <i>SlCCD8</i>, <i>SlMAX1</i>, <i>SlP450</i>, <i>SlDI4</i>) in <i>hp-1</i> at various parasitic stages post-inoculation, with a more pronounced suppression observed in <i>hp-1</i> than in <i>og^c</i>. …”
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In-depth assessment of BRAF, NRAS, KRAS, EGFR, and PIK3CA mutations on cell-free DNA in the blood of melanoma patients receiving immune checkpoint inhibition by Isabel Heidrich, Charlotte Rautmann, Cedric Ly, Robin Khatri, Julian Kött, Glenn Geidel, Alessandra Rünger, Antje Andreas, Inga Hansen-Abeck, Finn Abeck, Anne Menz, Stefan Bonn, Stefan W. Schneider, Daniel J. Smit, Christoffer Gebhardt, Klaus Pantel

“…Persistent or re-emerging ctDNA positivity post-therapy correlated with shorter progression-free survival (PFS, p = 0.003), while ctDNA-negative patients showed significantly improved outcomes. …”
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Derivation and internal–external validation of clinical prediction model for postoperative clinically important hypotension in patients undergoing noncardiac surgery: an internatio... by Stephen Su Yang, German Malaga, Maria Lazo-Porras, Patricia Busta-Flores, Aida del Carmen Rotta-Rotta, Pavel S. Roshanov, Daniel I. Sessler, Amal Bessissow, Thomas Schricker, Vicky Tagalakis, Diane Heels-Ansdell, Shirley Pettit, P.J. Devereaux

“…The postoperative period was defined from the Post-Anesthesia Care Unit to hospital discharge. …”
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Verification of Lactobacillus brevis tolerance to simulated gastric juice and the potential effects of postbiotic gamma-aminobutyric acid in streptozotocin-induced diabetic mice by Amro Abdelazez, Heba Abdelmotaal, Smith Etareri Evivie, Maha Bikheet, Rokayya Sami, Hassan Mohamed, Xiangchen Meng

“…The body weight and hyperglycemia in the blood were assessed weekly, post-euthanasia blood plasma parameters, insulin, and histological examination were evaluated. …”
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Epitope Variation in Hemagglutinin and Antibody Responses to Successive A/Victoria A(H1N1) Strains in Young and Older Adults Following Seasonal Influenza Vaccination: A Pilot Study by Mónica Espinar-García, Isabel María Vallejo-Bermúdez, María Ángeles Onieva-García, Irene Reina-Alfonso, Luis Llapa-Chino, Pablo Álvarez-Heredia, Inmaculada Salcedo, Rafael Solana, Alejandra Pera, Alexander Batista-Duharte

“…Antibody responses were measured pre- and 28 days post-Vaxigrip Tetra vaccination in young (18–35) and older (>65) adults, stratified by cytomegalovirus (CMV) serostatus. …”
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Improved overall survival with checkpoint inhibition and allogeneic transplantation in relapsed Hodgkin lymphoma by Nadeem Tabbara, Marianna Zahurak, Cole H. Sterling, Iris Margalit Trutzer, Jaroslaw Jedrych, Lode J. Swinnen, Ephraim J. Fuchs, Javier Bolaños-Meade, Nina Wagner-Johnston, Richard J. Jones, Richard F. Ambinder, Ravi Varadhan, Suman Paul

“…In this retrospective analysis, we report the 5-year overall survival (OS), PFS, and graft-versus-host disease (GVHD) incidence in patients with cHL treated with ICI before alloBMT with post-transplantation cyclophosphamide GVHD prophylaxis. …”
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Formative research to optimize pre-eclampsia risk-screening and prevention (PEARLS): study protocol by Nicole Minckas, Alim Swarray-Deen, Sue Fawcus, Rosa Chemwey Ndiema, Annie McDougall, Jennifer Scott, Samuel Antwi Oppong, Ayesha Osman, Alfred Onyango Osoti, Katherine Eddy, Mushi Matjila, George Nyakundi Gwako, Joshua P. Vogel, A. Metin A. Gülmezoglu, Adanna Uloaku Nwameme, Meghan A. Bohren, the PEARLS Trial collaborative group

“…Data will be analyzed using thematic analysis and triangulated across sources and participant groups. …”
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Determination of the optimal ejaculate concentration of a buffalo bull for successful semen cryopreservation by Krishna Bansal, Krishna Bansal, Dinesh Jhamb, Usha Yadav, Usha Yadav, Mamta Meel, Mamta Meel, Akanksha Gupta, Akanksha Gupta, Renu Bala, Meenakshi Virmani, Meeti Punetha, Dharmendra Kumar, Pradeep Kumar

“…Remarkably, it was found that sperm motility, integrity of plasma and acrosome membrane, and mitochondrial membrane potential (MMP) significantly decreased (p &lt; 0.05) when the ejaculates of category &lt;300 were cryopreserved, despite being qualified in subjective motility analysis compared to the other categories. Except for the category &lt;300, in all the other three categories, there was no significant difference (p &gt; 0.05) in the percentage of spermatozoa in MMP. …”
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Surface electromyography character of upper limb muscle after open reduction combine with ulnar osteotomy in children with neglected Monteggia fracture by Hailing Qiu, Hailing Qiu, Tingzhi Li, Fanling Li, Siqi Zhang, Xiangling Wu, Jing Yang, Xin Li, Ke Fang, Jie Wen, Sheng Xiao

“…The root mean square (RMS) values of sEMG signals, co-contraction ratio, and elbow joint function scores were compared between pre- and post-operation periods as well as between the affected side and unaffected side.ResultsThe preoperative maximum grip strength, as well as the average RMS values of flexor carpi radialis and average RMS value of extensor carpi ulnaris on the affected side were significantly lower. …”
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Association of Estimated Plasma Volume Status With Invasive Hemodynamics and All‐Cause Mortality in Patients With Liver Cirrhosis by Esteban Kosak Lopez, Phuuwadith Wattanachayakul, Jose Manuel Martinez Manzano, Andrew Geller, Simone A. Jarrett, John Malin, Raul Leguizamon, Tara A. John, Rasha Khan, Ian McLaren, Alexander Prendergast, Kevin Bryan Lo, Zurab Azmaiparashvili

“…Estimated plasma volume status (ePVS) was calculated using the Strauss‐derived Duarte formula, with patients classified into high (> 5.5%) and low‐ePVS (≤ 5.5%) groups. Cox‐multivariable analysis was used to determine if ePVS was associated with all‐cause mortality within 1 year post‐RHC among transplant‐free patients. …”
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Development and internal validation of a depressive symptoms prediction model among the patients with cardiovascular disease who have recovered from SARS-CoV-2 infection in Wuhan,... by Zhenwei Dai, Xin Liu, Shu Jing, Hao Wang, Yiman Huang, Jiaqi Fu, Yijin Wu, Ling Zhang, Bicheng Han, Xiaoyou Su

“…The prediction model included age, stethalgia after recovery, insomnia after recovery, post-traumatic stress disorder (PTSD), anxiety, fatigue, and perceived social support as predictors. …”
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Are Urethral Pressure Profile Measurements Effective in Diagnosing Urodynamic Stress Incontinence in Women Presenting with Stress or Mixed Urinary Incontinence? Results from a Cros... by Konstantinos Pantazis, Themistoklis Mikos, Sofia Tsiapakidou, Iakovos Theodoulidis, Stamatios Petousis, Konstantinos Dinas, Antonio Schiattarella, Antonio Simone Laganà, Apostolos P. Athanasiadis

“…However, the women in Group 2 had a significantly lower MUCP, FUL, and post-void residual after pressure flow compared to the women in Group 1 (<i>p</i> = 0.038, 0.003, and 0.04, respectively, upon Student’s <i>t</i> test for independent parameters). …”
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Design and Evaluation of Real-Time Data Storage and Signal Processing in a Long-Range Distributed Acoustic Sensing (DAS) Using Cloud-Based Services by Abdusomad Nur, Yonas Muanenda

“…The results show latencies of 40 ms per batch of access with low standard deviations of a few milliseconds, and latency per sample decreases for increasing the sample size, paving the way toward the development of scalable, cloud-based data storage services integrating additional post-processing for more precise feature extraction. …”
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