Comparison of Shear Bond Strength for Onestep Self-etch versus Universal Adhesives on Contaminated and Decontaminated Dentin Surfaces: An In-vitro Study by Asritha Kondapaneni, Anila Bandlapally Sreenivasa Guptha, Sayesh Vemuri, Roopadevi Garlapati, Mayana Aameena Banu, Niharika Halder

“…Shear bond strength at the dentin-composite interface was evaluated using a Universal Testing Machine (UTM). One-way Analysis of Variance (ANOVA) for intergroup comparison followed by Tukey’s post-hoc test for multiple comparisons was performed. …”
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Cluster Training plus creatine supplementation on body composition and physical performance in older adults: A study protocol by Alejandro Romero-Reyes, Luis Mario Gómez-Miranda, Melinna Ortiz-Ortiz, Marco Antonio Hernández-Lepe, Roberto Espinoza-Gutiérrez, María A. Agudelo-Martínez, Diego A. Bonilla

“…Body composition will be assessed using dual-energy X-ray absorptiometry (DXA), physical performance with the Short Physical Performance Battery (SPPB), and maximal strength using a one-repetition maximum (1RM) test following ACSM and NSCA guidelines. Statistical analysis will include an ANCOVA with pre-test scores as a covariate, followed by post hoc tests and effect size calculations. …”
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The association between neostigmine and postoperative atelectasis in elderly patients undergoing laparoscopic pancreaticoduodenectomy: a retrospective single-center propensity scor... by Rong Luo, Yunfen Ge, Yue Chen, Huizi Liu

“…Secondary endpoints included the incidence of pneumonia, pleural effusion, acute respiratory distress syndrome (ARDS), time to extubation, length of stay in the post-anesthesia care unit (PACU) and hospital, reintubation, postoperative blood gas analysis, 30-day readmission, and 30-day mortality. …”
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Exosomes derived from hypoxia-preconditioned M2 macrophages alleviate degeneration in knee osteoarthritis through the miR‑124‑3p/STAT3 axis by Hao Li, Yuze Yang, Yuanpeng Gao, Bo Li, Jiaju Yang, Pengyu Liu, Min Zhang, Guangzhi Ning

“…The underlying molecular mechanism is associated with increased delivery of miR-124-3p to chondrocytes, which subsequently inhibits the post-transcriptional expression of STAT3. This provides a promising therapeutic strategy for the clinical intervention of OA.…”
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Intervención psicomotriz en el trauma infantil: efectos en la reactividad del cortisol (Psychomotor intervention for childhood trauma: the effects on cortisol reactivity) by Talía Morillo Lesme, Pedro Abreu González, Josefa Sánchez Rodríguez, Miguel Llorca Llinares

“…Cortisol levels decreased in all sessions, with a high level of significance obtained in the Wilcoxon analysis when comparing cortisol levels before the first session and after finishing the fourth one. …”
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Successful implementation of a risk assessment and mitigation program to control bovine digital dermatitis at the herd-level by Jim Weber, Marina Hillen, Torsten Seuberlich, Andreas Fürmann, Corinne Gurtner, Jens Becker, Claudia Syring, Maria Welham Ruiters, Maher Alsaaod, Lina Mazurek, Gertraud Schüpbach, Adrian Steiner

“…A significant decline in bulk milk anti-Treponema antibodies over the 1-year period was found in INT as compared to CTR farms. Considering the results of the histopathological examination, of 16S metagenomic sequencing and of the Fluorescence in situ hybridization as indicators for healing, 6/7 (85.7%) selected lesions were cured 2 months post completion of treatment. …”
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IMPACT OF LENALIDOMIDE MAINTENANCE DOSAGE ON SURVIVAL OUTCOMES IN MULTIPLE MYELOMA by Zeynep Kürüm, Ayfer Gedük

“…Methodology: A retrospective analysis was conducted on 82 MM patients who underwent lenalidomide maintenance therapy on a 21/28-day cycle post-ASCT. …”
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The incremental value of aspartate aminotransferase/alanine aminotransferase ratio combined with CURB-65 in predicting treatment outcomes in hospitalized adult community-acquired p... by Huamei Zhou, Xuelei Zhu, Yi Zhang, Wenjuan Xu, Shiqun Li

“…An AST/ALT ratio of ≥ 1.625 conferred a 74% post-test probability of poor treatment outcome, while < 1.625 predicted 21%. …”
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Measuring cytokines in Eurasian tundra reindeer (Rangifer tarandus tarandus) with a bovine bead-based multiplex immunoassay and real-time PCR by Tuva Løken Frøvoll, Kari Lybeck, Hege Lund, Shokouh Makvandi-Nejad, Unni Grimholt, Carlos G. das Neves, Morten Tryland, Ingebjørg Helena Nymo, Siv Klevar

“…Although cytokine concentrations were generally higher in bovine samples, analysis of reindeer supernatants demonstrated significantly increased IL-10, IL-17, TNF-α and IFN-γ concentrations in supernatants from stimulated compared to unstimulated PBMCs. …”
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Increased tau-induced inflammatory responses are associated with a greater degree of atherosclerosis in progressive supranuclear palsy by Yi-Xin He, Yi-Xin He, Rui Zhang, Rui Zhang, Chen Xie, Si-Fan Ji, Wen-Jing Deng, Wen-Jing Deng, Jun-Fang Teng, Jun-Fang Teng

“…To further investigate the mechanism, we established a mouse model using repeated tail vein injections of tau-preformed fibrils (tau-PFFs), followed by histological and biochemical analysis after 3 months.ResultsCompared to controls, patients with PSP exhibited significantly higher atherosclerotic burden across most measured vascular parameters. …”
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Correlation between Pre-procedural Ultrasound-estimated and Actual Procedural Epidural Depth in Lumbar Epidural Anaesthesia Taking BMI into Consideration: An Observational Study by Minu Thomas, Derlin Thomas, John Varghese Thoppil, Paul Ovungal Raphael, Deo Mathew

“…However, the variability in the distance between the skin and the epidural space can make it difficult to accurately locate the space, thereby increasing the risk of complications such as nerve injuries, paresthesia, haematoma formation, and post-dural puncture headache. Aim: To evaluate the skin-to-epidural space distance using Ultrasound-derived (UD) measurements compared to the conventional Needle Depth (ND) using the Loss of Resistance (LOR) technique, and to investigate their correlation with Body Mass Index (BMI). …”
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Does constipation affect the effectiveness of washed microbiota transplantation in treating autism spectrum disorders? by Zihao Pan, Zheng Gao, Junyi Chen, Yongxi Quan, Jiating Xu, Xiaofeng Liang, Wenrui Xie, Xingxiang He, Xingxiang He, Lihao Wu, Lihao Wu

“…After one course of WMT, constipation group showed an obvious increase in microbial diversity and a significant increase in the relative abundance of Bifidobacteria compared to non-constipation group.ConclusionPost WMT, core symptoms and sleep disorders were significantly improved in both groups. …”
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Feasibility of a Web-Based and Mobile-Supported Follow-Up Treatment Pathway for Adult Patients With Orthopedic Trauma in the Netherlands: Concurrent Mixed Methods Study by Gijs J A Willinge, Jelle F Spierings, Kim A G J Romijnders, Elke G E Mathijssen, Bas A Twigt, J Carel Goslings, Ruben N van Veen

“…Semistructured interviews were performed at 10‐12 weeks post injury. Anonymous data from a pre-existing database were used to compare health care resource use between the digital treatment pathways and traditional treatment. …”
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Comparison of circulating immune signatures across different consensus molecular subtypes (CMS) and between left- and right-sided lesions in stage II colorectal cancer using single... by Pin Gao, Chuanyong Zhou, Hong Yang, Shunyu Deng, Beihai Jiang, Zaozao Wang, Jiabo Di, Xiangqian Su

“…Krustal–Wallis analysis with post-hoc Dunn test was used to assess differences across multiple CMS groups. …”
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Platelet inhibition strategies in rescue stenting after failed thrombectomy: a large retrospective multicenter registry by Aikaterini Anastasiou, Alex Brehm, Johannes Kaesmacher, Adnan Mujanovic, Marta de Dios Lascuevas, Tomás Carmona Fuentes, Alfonso López-Frías, Blanca Hidalgo Valverde, Ansgar Berlis, Christoph J. Maurer, Thanh N. Nguyen, Mohamad Abdalkader, Piers Klein, Guillaume Thevoz, Patrik Michel, Bruno Bartolini, Marius Kaschner, Daniel Weiss, Andrea M. Alexandre, Alessandro Pedicelli, Paolo Machi, Gianmarco Bernava, Shuntaro Kuwahara, Kazutaka Uchida, Jason Wenderoth, Anirudh Joshi, Grzegorz Karwacki, Manuel Bolognese, Agostino Tessitore, Sergio Lucio Vinci, Amedeo Cervo, Claudia Rollo, Ferdinand Hui, Aaisha Siddiqua Mozumder, Daniele Giuseppe Romano, Giulia Frauenfelder, Nitin Goyal, Vivek Batra, Violiza Inoa, Christophe Cognard, Matúš Hoferica, Riitta Rautio, Daniel P. O. Kaiser, Johannes C. Gerber, Julian Clarke, Michael R. Levitt, Marcel N. Wolf, Ahmed E. Othman, Luca Scarcia, Erwah Kalsoum, Diana Melancia, Diana Aguiar de Sousa, Maria Porzia Ganimede, Vittorio Semeraro, Flavio Giordano, Massimo Muto, Aristeidis Katsanos, Umesh Bonala, Anil M. Tuladhar, Sjoerd F. M. Jenniskens, Victoria Hellstern, Ilka Kleffner, Paolo Remida, Susanna Diamanti, Leonardo Renieri, Elena Ballabio, Luca Valvassori, Nikki Rommers, Mira Katan, Victor Schulze-Zachau, Marios-Nikos Psychogios

“…Stent occlusion is associated with worse clinical outcomes, and the first 24 h post-RS are critical for stent patency. Compared to SAPT, DAPT was associated with better functional outcome, lower mortality, and lower stent occlusion rates.…”
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Biocontrol effect of ginger glycoprotein and essential oil against Vicia faba damping-off caused by Fusarium solani and Rhizoctonia solani by Hossam S. El-Beltagi, Ali Osman, Mahmoud Sitohy, Hayfa Habes Almutairi, Eman Eldesouky, Entsar Abbas, Ahmed Mahmoud Ismail, Hazem S. Elshafie, Ippolito Camele

“…Whereas, the in vivo trial evaluated the efficacy of ginger EO and glycoprotein at 50 and 100 μg/mL, compared to Rizolex-T 50 WP at 50 μg/mL, in reducing pre- and post-emergence damping-off percentages. …”
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Outcomes of Different Lifestyle Approaches in a Multicentre, Open-Label, Parallel-Group, Randomised Controlled Trial of the Effectiveness of Integrating a Pragmatic Pathway for Pre... by Werd Al-Najim, Babak Dehestani, Ahmed W. Al-Humadi, Danielle H. Bodicoat, Dimitris Papamargaritis, Michael Lean, Barbara McGowan, David R. Webb, John PH Wilding, Melanie J. Davies, Carel W. le Roux

“…<b>Background/Objectives:</b> The STRIVE study was a multicentre, open-label, real-world clinical trial evaluating the effectiveness of a targeted prescribing pathway for liraglutide 3.0 mg as an adjunct to standard care versus standard care alone in people with obesity attending Specialist Weight Management Services (SWMS) in the UK and Ireland. This post hoc analysis focuses on the standard care arm to explore differences in outcomes between sites, particularly the potential impact of offering meal replacements as part of usual care. …”
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Safety and Efficacy of Different Stent Strategies in Percutaneous Coronary Intervention by Waqas Ullah, MD, RPVI, Harigopal Sandhyavenu, MD, Syeda Ramsha Zaidi, MD, Mileydis Alonso, MD, Muhammad Atif Khan, MD, Irfan Ullah, MBBS, Farah Yasmin, MD, Aravind Reddy Polam, MD, Salman Zahid, MD, Arnav Kumar, MD, MSCR, Ewout W. Steyerberg, MSc, PhD, Mohammad Murtaza, MD, Chadi Alraiesm, MD, MPH, Jeffrey J. Rade, MD

“…Objectives: The purpose of this study was to compare the efficacy of different DES strategies in post-PCI patients. …”
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Efficacy of irreversible electroporation combined with immunotherapy versus irreversible electroporation alone in locally advanced pancreatic cancer: a propensity score-matched ret... by Pu Xi, Peng Sun, Miao Chen, Zehui Yao, Qi Zhu, Shengping Li, Chaobin He

“…This study aimed to evaluate the efficacy and safety of IRE combined with anti-PD-1 immunotherapy versus IRE alone in patients with LAPC.MethodsIn this retrospective study, LAPC patients treated either with IRE plus toripalimab (240 mg administered 7 days post-IRE) or with IRE alone were included. Propensity score matching (PSM) analyses were employed for analysis. …”
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Prognostic Value of Genetic Markers for Efficacy Estimation of Induction Treatment Including Autologous Hematopoietic Stem Cell Transplantation in Multiple Myeloma Patients by EL Nazarova, NV Minaeva, MN Khorobrykh, EE Sukhorukova, VI Shardakov, IV Paramonov, NA Zorina

“…The study showed that group 2 had no AA mutant homozygotes of IL10 in the G-1082A polymorphic locus compared to group 3 and no TT mutant homozygotes of TLR6 (Ser249Pro) compared to group 1. …”
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