Impact of intermediate-dose tertiary prophylaxis on quality of life and psychological aspects of adult patients with severe/moderate hemophilia A by Hua Gao, Jia Liu, Shiqiu Zhou, Jing Gao, Jing Tan, Rong Chen

“…Haemophilia Quality of Life Questionnaire for Adults (HAEMO-QoL-A), Patient Health Questionnaire-9 (PHQ-9), and Generalized Anxiety Disorder-7 (GAD-7) were compared before and after prophylaxis. Additionally, functional independence and joint status were analyzed at the end of the 3-year prophylaxis period, as well as their correlations with HAEMO-QoL-A, PHQ-9, and GAD-7.Results The HAEMO-QoL-A total score decreased after prophylaxis (pre-prophylaxis: 88.90 ± 33.38 vs. post-prophylaxis: 79.59 ± 22.89) (P = 0.016). …”
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Study protocol of short versus long-term levetiracetam in brain tumors (LIBRA): a phase 3 randomized controlled trial by Archya Dasgupta, Shakthivel Mani, Abhishek Chatterjee, Sadhana Kannan, Aliasgar Moiyadi, Prakash Shetty, Vikas Singh, Nandini Menon, Arpita Sahu, Amitkumar Choudhary, Kajari Bhattacharya, Ameya Puranik, Indraja Dev, Sridhar Epari, Ayushi Sahay, Aekta Shah, Nazia Bano, Farnaz Shaikh, Tejpal Gupta

“…However, the incidence of seizures post antitumoral treatment is relatively low, and the duration of use is not well defined. …”
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Succession characteristics and assembly process of soil microbiome at reclaimed farmlands in coal mining area by Jianhua Li, Jianhua Li, Zixu Li, Yanwen Sun, Jinjing Lu, Jinjing Lu, Qiang Zhang, Xinhua He, Xinhua He, Xinhua He, Minggang Xu, Minggang Xu

“…We analyzed soil microbial diversity, composition, co-occurrence network structure, and assembly processes using 16S rDNA/ITS sequencing and null models at 0 (R0), 1 (R1), 6 (R6), and 10 (R10) years of post-reclamation. Results showed that (1) Compared to R0, the R10 treatment resulted in significant increases in soil organic matter (SOM), total nitrogen (TN), available phosphorus (AP), and available potassium (AK) by 2.1-fold, 1.3-fold, 1.5-fold, and 0.4-fold, and also in activities of β-glucosidase (BG), N-acetyl-β-glucosaminidase (NAG), and leucine aminopeptidase (LAP), by 17-fold, 8.7-fold, and 1.8-fold, respectively (p < 0.05). (2) Rising bacterial diversity (Shannon, Chao1) over time, contrasting with fungal diversity that declined initially before recovering. (3) As the reclamation progressed, the network complexity was increased for both bacteria and fungi, improving stability. …”
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Validation of the role of apolipoproteins in coronary artery disease patients with impaired kidney function for prognosis: a prospective cohort study in China by Zixiang Ye, Enmin Xie, Zhangyu Lin, Chenxi Song, Rui zhang, Haoyu Wang, Yongbao Zhang, Kefei Dou

“…ROC curve analyses indicated comparable predictive performances to traditional risk factors like LDL cholesterol. …”
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The relationship of baseline high-sensitivity C-reactive protein with incident cardiovascular events and all-cause mortality over 20 yearsResearch in context by Adam Hartley, Somayeh Rostamian, Amit Kaura, Paris Chrysostomou, Paul Welsh, Cono Ariti, Naveed Sattar, Peter Sever, Ramzi Khamis

“…The objectives of this post-hoc analysis of a randomised controlled trial were to investigate the usefulness of baseline serum hsCRP for predicting very long-term cardiovascular events in patients with hypertension in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) Legacy Study. …”
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tRNA-derived small RNA 3’ tRF-Ala CGC obstructs NK cytotoxicity via cleavage of membrane protein MICA in colorectal cancer by Jing Zhang, Chunlin Ou, Xin Li, Li Fu, Qizhi Luo, Jie Wang, Yizhou Zou

“…The Cell Counting Kit-8 assay, colony formation assay, and apoptosis analysis were used to evaluate tumor heterogeneity. …”
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Impact of 16/8 time-restricted eating on body composition and lipolytic hormone regulation in female DanceSport dancers by Xinxin Li, Xian Guo, Yanbing Zhou, Guoxia Cao, Mengmeng Chen, Jinhao Mu

“…In contrast, no significant changes were observed in TC, TG and LDL-C (p>0.05). Hormonal analysis revealed significant changes in the TRE group. …”
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Real-world treatment patterns for patients with non-infectious uveitis in Japan: a descriptive study using a large-scale claims database (J-CAT study) by Sentaro Kusuhara, Koh-Hei Sonoda, Toshikatsu Kaburaki, Tachie Fujita, Saki Katayama, Misako Makishima, Takao Nakamura, Mariko Nio, Takashi Omoto, Yukari Matsuo-Tezuka, Tomoki Yoshizaki, Kensuke Sasaki, Kairi Ri, Keiko Sato, Hiroshi Goto

“…Sankey diagrams were used to describe treatment transitions. Post-treatment ocular complications, potentially related surgeries, and fundus findings associated with uveitis were determined. …”
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The impact of cell density variations on nanoparticle uptake across bioprinted A549 gradients by Luigi Di Stolfo, Wang Sik Lee, Dimitri Vanhecke, Sandor Balog, Patricia Taladriz-Blanco, Alke Petri-Fink, Alke Petri-Fink, Barbara Rothen-Rutishauser

“…SiO2 NP uptake per cell was around 50% higher in low-density regions compared to high-density areas across all time points, i.e., 6, 24, and 48 h post-exposure. …”
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The impact of paraspinal muscle morphology on functional outcome in patients with degenerative lumbar spine disease undergoing surgery - A prospective observational study by Niraj Ghimire, Prashant Lakhe, Anil Kumar, Nisha Ghimire, Chayanika Kutum, Deepak Choudhary, Bhanu Pratap Singh Chauhan, Poonam Narang, Hukum Singh, Daljit Singh

“…Research question: Can the degree of paraspinal muscle atrophy be a reliable prognostic indicator of post-operative functional outcome in patients undergoing surgery for degenerative lumbar spine disease? …”
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Choice of optimal therapeutic sequence in treatment of patients with progressive / metastatic squamous cell cancer of the head and neck in the light of TPEx study results by A. M. Mudunov

“…Pembrolizumab as a monotherapy gives positive effect only in patients with certain level of PD-L expression (CPS >20) in total population. Post-hoc analysis of TPExtreme study demonstrated the most benefit results until now for patients who received consequently cetuximab contained chemotherapy regimens as a first line followed by immunotherapy for the second line in this patients group (overall survival 19.4 months for EXTREME arm and 21.9 months for TPEx arm).Thus TPExtreme study results demonstrates opportunity for better disease control in patients receiving cetuximab in first line and immunotherapy as second line treatment in total population for patients with recurrent / metastatic SCCHN.…”
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Prognostic factors for stent restenosis in patients with coronary artery disease undergoing percutaneous coronary intervention by M. А. Meshkova, I. A. Starodubtseva, A. A. Pashkova

“…In CAD patients 1-2 months post-PCI for ACS, restenosis development is associated with longer CAD duration, CKD stage 3A, use of BMS, and elevated Lp(a) levels >30 mg/dL, irrespective of achieving the target LDL-C level <1.4 mmol/L. …”
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Sex‐related pathophysiological mechanisms may be present before symptoms of HFpEF develop by B. Wong, J.D. Dodd, J. Gallagher, B. Dyer, C. Ryan, K. McDonald, M. Ledwidge

“…Methods and results This post hoc analysis of the PARABLE trial enrolled 250 patients with pre‐HFpEF. …”
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Hyrax versus transverse sagittal maxillary expander: An assessment of arch changes on dental casts. A retrospective study by C. Maspero, D. Cavagnetto, A. Fama, L. Giannini, G. Galbiati, M. Farronato

“…Objective: The aim of this study was to compare arch changes before and after maxillary expansion with Transverse Maxillary Sagittal Expander (TSME) and Hyrax Palatal Expander (HPE), in growing patients with diagnosis of maxillary hypoplasia. …”
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Development and validation of a pathological model predicting the efficacy of neoadjuvant therapy for breast cancer based on RCB scoring by Huan Li, Xianli Ju, Chuanfei Zeng, Zhengzhuo Chen, LinXin Yu, Ge Ke, Ziyin Huang, Youping Wang, Jingping Yuan, Mingkai Chen

“…We thoroughly validated the PBCS and compared it to a Pathomics Signature (PS) prediction model. …”
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A study on the prediction of targeted therapy efficacy in advanced lung adenocarcinoma patients with EGFR mutations using CT-based delta-radiomics model by Zekai Wu, Zekai Wu, Peiyan Hua, Xiuying Chen, Jie Lei, Laian Zhang, Peng Zhang

“…We segmented tumor regions on pre-and post-treatment CT scans using ITK-SNAP, then extracted radiomic features and applied mRMR-LASSO (Minimum Redundancy Maximum Relevance–Least Absolute Shrinkage and Selection Operator). …”
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Study on the Relationship between Swallowing-Related Muscle Activity and Respiratory Muscle Function in Stroke Patients with Dysphagia by SU Panpan, HE Chuan, FENG Min, JIA Yuanyuan, WANG Tiantian, MENG Dianhuai

“…The root mean square values and peak amplitudes were compared among the three groups and between the healthy and affected sides, and a correlation analysis was performed between the sEMG signals and respiratory muscle function in the study group.ResultsMIP and MEP of the respiratory muscle weakness group were significantly lower than those of the non-respiratory muscle weakness group and the control group (<italic>P</italic>&lt;0.05). …”
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Survival outcomes of hybrid total hip replacement following failed proximal femoral nail antirotation: a retrospective study with a median 10-year follow-up by Yannan Chen, Zhifen Lai, Weiguang Yu, Xianshang Zeng, Mingdong Zhao, Guangquan Zhu

“…Stratified survival analysis by age groups (50–60 years and 60–70 years) revealed that the 50–60-year group had significantly higher survival rates compared to the 60–70-year group (p = 0.00026). …”
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Effects of integrating Feldenkrais method with dynamic neuromuscular stabilization exercises on clinical outcomes in older women with nonspecific chronic low back pain: A randomize... by Farzaneh Saki, Marziyeh Ziya

“…Assessments were conducted at baseline and post-intervention. Between-group differences were analyzed using analysis of covariance (ANCOVA) adjusted for baseline values, and paired t-tests were used to assess within-group changes (P≤0.05). …”
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Spirituality-based palliative care education on quality of life, death anxiety, and resilience of heart failure patients: Randomized controlled clinical trial by Roghayeh Balaghi Inaloo, Mostafa Bijani, Leila Nikrouz, Azizallah Dehghan, Abdulhakim Alkamel, Ali Taghinezhad, Zahra Khiyali

“…Both groups completed these assessments at baseline, immediately post-intervention, and at a three-month follow-up. …”
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