Sodium glucose cotransporter 2 inhibitors are associated with renal stabilization in heart transplantation by Lisa M. Raven, MBBS, FRACP, Jerry R. Greenfield, MBBS (Hons 1), PhD, FRACP, Andrew Jabbour, BSc (Med), MBBS (Hons), PhD, FRACP, Peter S. Macdonald, MBBS, MD, PhD, FRACP, Christopher A. Muir, MBBS (Hons), FRACP, PhD

“…Heart transplant (HTx) recipients are at increased risk of diabetes and CKD, and both are independently associated with increased mortality. In a retrospective analysis of 104 HTx recipients with diabetes (23 exposed to SGLT2i, 81 not exposed), SGLT2i treatment was associated with stable renal function at 3 years post-HTx, measured by estimated glomerular filtration rate change from baseline (median change of 0 ml/min/1.73 m2 (interquartile range [IQR] −13 to +11)), compared to a change of −15 ml/min/1.73 m2 (IQR −27 to +1) in patients not exposed to SGLT2i (p = 0.02). …”
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Comparison of Escitalopram Alone versus in Combination with Jacobson’s Progressive Muscle Relaxation in Patients with Neurotic, Stress Related and Somatoform Disorders: A Randomise... by Piyush Mahajan, Malvika Dahuja, Pranjal Tripathi, Shashank Saurabh Sinha

“…Paired t-tests were conducted to compare pre- and post-treatment HAM-A scores within each group, while independent t-tests were used to compare scores between the groups. …”
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Promoting smoking cessation and preventing relapse to tobacco use following a smoke-free mental health inpatient stay (SCEPTRE feasibility study): a multicentre randomised controll... by Simon Gilbody, Catherine Hewitt, John Britton, Lion Shahab, Tim Coleman, Elena Ratschen, Judith Watson, Alex Mitchell, Gregor Russell, Steve Parrott, Lesley Sinclair, Peter A Coventry, Paul Galdas, Michelle Horspool, Samantha Brady, Emily Shoesmith, Petal Petersen Williams, Lisa Huddlestone, Victoria Exley, Fraser Wiggins, Jodi Pervin, Moira Leahy, Claire Paul, Lesley Colley, Simon Hough

“…The aim of this trial is to determine the feasibility of a large-scale clinical trial to test the effectiveness and cost-effectiveness of the SCEPTRE intervention, compared with usual care.Methods and analysis This feasibility study will be an individually randomised, controlled trial in eight National Health Service mental health Trusts recruiting adults (≥18 years) admitted to an acute adult mental health inpatient setting who smoke tobacco on admission, or at any point during their inpatient stay. …”
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Effects of nutritional counseling on dietary patterns in patients with mild cognitive impairment: insights from the BrainFit-Nutrition study by Etienne Hanslian, Etienne Hanslian, Melanie Dell’Oro, Julia K. Schiele, Julia K. Schiele, Farid I. Kandil, Farid I. Kandil, Dzenita Hasanbasic, Dzenita Hasanbasic, Cirus Henn, Elmar Graessel, Julia-Sophia Scheuermann, Petra Scheerbaum, Andreas Michalsen, Andreas Michalsen, Michael Jeitler, Michael Jeitler, Michael Jeitler, Michael Jeitler, Christian S. Kessler, Christian S. Kessler, Christian S. Kessler

“…IntroductionThis study examines the effects of a structured nutritional counseling intervention for individuals with mild cognitive impairment (MCI) via synchronized online courses conducted bi-weekly over six months.MethodsThis work presents a secondary analysis of the BrainFit-Nutrition study, which explored the impacts of both 1) dietary counseling interventions (comparing a Whole Food Plant-Based (WFPB) diet with a diet based on the German Nutrition Association guidelines or Deutsche Gesellschaft für Ernährung, DGE) and 2) standardized versus individualized computer-based cognitive training, within a 2x2 factorial randomized controlled trial design for participants with MCI. …”
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Modified drought propagation under a changing environment: A case study in the Dongting Lake basin, China by Lina Jin, Tao Peng, Tianyi Fan, Vijay P. Singh, Qingxia Lin, Xiaohua Dong, Ji Liu, Jiali Guo, Dan Yu, Gaoxu Wang

“…Study focus: The “pre-post-disturbance” method was employed to assess the impact of environmental variation on propagation from meteorological drought (MD) to hydrological drought (HD) in the DLB. …”
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Biopsy-Proven T-Cell Mediated Rejection After Belatacept Rescue Conversion: A Multicenter Retrospective Study by Dominique Bertrand, Nathalie Chavarot, Jérôme Olagne, Clarisse Greze, Philippe Gatault, Clément Danthu, Charlotte Colosio, Maïté Jaureguy, Agnès Duveau, Nicolas Bouvier, Yannick Le Meur, Léonard Golbin, Eric Thervet, Antoine Thierry, Arnaud François, Charlotte Laurent, Mathilde Lemoine, Dany Anglicheau, Dominique Guerrot

“…Out of 47 patients with TCMR, death-censored graft survival was 70.1%, 55.1% and 50.8% at 1 year, 3 years and 5 years post-rejection, respectively. Eight patients died after rejection, mainly from infectious diseases. …”
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Sintilimab and anlotinib with gemcitabine plus cisplatin in advanced biliary tract cancer: SAGC a randomized phase 2 trial by Jingjing Li, Shurui Zhou, Xiaoqing Xu, Qinhong Zheng, Fabiao Zhang, Cong Luo, Da Li, Xing Sun, Zhe Han, Wei Wu, Junrong Yan, Yang Shao, Yuhua Zhang, Bingchen Wu, Qing Wei, Xinbao Wang, Yiwen Zhou, Weijing Sun, Qi Xu, Jieer Ying

“…At 13.4-month median follow-up, SAGC significantly improved median progression-free survival (8.5 vs. 6.3 months; HR 0.48, 95% CI 0.22–0.64, p = 0.005) and objective response rate (51.4% vs. 29.4%), with higher grade 3/4 adverse events (75.0% vs. 43.6%). Post hoc analysis showed enhanced efficacy with anlotinib 8 mg versus 10 mg (ORR 54.5% vs. 38.8%). …”
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Epigenetic memory of radiotherapy in dermal fibroblasts impairs wound repair capacity in cancer survivors by Xiaowei Bian, Minna Piipponen, Zhuang Liu, Lihua Luo, Jennifer Geara, Yongjian Chen, Traimate Sangsuwan, Monica Maselli, Candice Diaz, Connor A. Bain, Evelien Eenjes, Maria Genander, Michael Crichton, Jenna L. Cash, Louis Archambault, Siamak Haghdoost, Julie Fradette, Pehr Sommar, Martin Halle, Ning Xu Landén

“…This is further confirmed by single-cell RNA-sequencing and spatial transcriptomic analysis of human wounds. Notably, fibroblasts in both murine and human post-radiation wound models show heightened and sustained THBS1 expression, impairing fibroblast motility and contractility. …”
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PSMB10 maintains the stemness of chemotherapeutic drug-resistant leukemia cells by inhibiting senescence and cytotoxic T lymphocyte-mediated killing in a ubiquitinated degradation... by Xiao Ma, Yingnan Li, Di Wang, Jialan Niu, Qian Li, Ying Chen, Mengyuan Wang, Jin Wen, Chenxi Liao, Nan Wang, Xiaolan Zhang, Jiwei Chang, Jiayi Yang, Lei Li, Jing Zou, Danyue Peng, Lingbo Liu

“…The specific high expression of PSMB10 in post-chemotherapy nonsenescent LSCs predicts a poor AML prognosis. …”
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Soil Physical Properties, Root Distribution, and “Ponkan” Tangerine Yield Across Different Rootstocks in a Deep Tillage Ultisol by Pedro Antônio Namorato Benevenute, Laura Beatriz Batista Melo, Samara Martins Barbosa, Mariany Isabela Soares Domingues, Isabela Cristina Filardi Vasques, Everton Geraldo de Morais, Lucas Roberto de Castro, Geraldo César de Oliveira, Ester Alice Ferreira, Bruno Montoani Silva

“…Under the Ultisol preparation, these rootstocks were compared to a native forest area (FA). Three years post-initial tillage, soil samples were collected at depths of 0–0.05, 0.35–0.40, and 0.45–0.50 m from the pre-established positions. …”
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Apobec-1 complementation factor regulates cell migration and apoptosis through Dickkopf1 by acting on its 3′ untranslated region in MCF7 cells by Xin Yan, Qianyin Li, Dongsheng Ni, Yajun Xie, Qingling He, Qianya Wan, Yamin Liu, Zhongshi Lyu, Zhaomin Mao, Qin Zhou

“…Previous researches mainly focused on its post-transcriptional cytidine to uridine RNA editing. …”
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An Inducible CYP19A1 Excision Model for Sexual Differentiation in Chicken (<i>Gallus gallus</i>) via the CRISPR/Cas9 System by Guangzheng Liu, Yixiu Peng, Zeyu Li, Xilin Zhu, Hongyan Sun, Guohong Chen, Qisheng Zuo, Yingjie Niu, Jiuzhou Song, Wei Han, Wanhong Wei, Bichun Li, Kai Jin

“…Western blotting showed decreased protein expression of CYP19A1 and FOXL2, and increased SOX9 expression in female embryos post-DOX induction. Elisa detection further confirmed lower estradiol levels in the gonads of induced female embryos compared to normal and non-induced females. …”
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Conversion study of hepatocellular carcinoma using HAIC combined with lenvatinib and PD-1/L1 immunotherapy under the guidance of BCLC staging by Weihao Zhang, Weihao Zhang, Weihao Zhang, Xiaohui Zhao, Xiaohui Zhao, Xiaohui Zhao, Wei Gao, Wei Gao, Wei Gao, Tongguo Si, Tongguo Si, Tongguo Si, Qiang Zou, Qiang Zou, Qiang Zou, Xueling Yang, Xueling Yang, Xueling Yang, Wenge Xing, Wenge Xing, Wenge Xing, Haipeng Yu, Haipeng Yu, Haipeng Yu

“…Subgroup analysis revealed that BCLC-B stage patients who achieved successful conversion therapy demonstrated significantly superior outcomes compared to those who did not undergo successful conversion therapy (median OS: 29.3 months [95% CI: 24.3-NA] vs. 19.7 months [95% CI: 17.2-24.6], P = 0.0013). …”
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Sex-specific effects of gastrointestinal microbiome disruptions on Helicobacter pylori-induced gastric carcinogenesis in INS-GAS mice by Chao Peng, Xin Li, Yu Li, Xinbo Xu, Yaobin Ouyang, Nianshuang Li, Nonghua Lu, Yin Zhu, Cong He

“…Gastric mucosal and fecal samples were collected for microbiota analysis using 16S rRNA gene sequencing. Results Following H. pylori infection, male mice showed heightened inflammatory infiltration and notably greater intestinal metaplasia compared to female mice. …”
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Pre-procedural abnormal von Willebrand factor function predicts clinical outcomes after Transcatheter Aortic Valve Implantation: a prospective cohort study by Haitham Abu Khadija, Mohammad Alnees, Mohammad Alnees, Omar Ayyad, Gera Gandelman, Nizar Abu Hamdeh, Amir Haim, Yazan Hamdan, Ramon Cohen, Duha Najajra, Alena Kirzhner, Tal Schiller, Jacob George, Alex Blatt

“…While, patients with abnormal von Willebrand factor function presented an Coef of 1.841 (p = 0.022; 95% CI: 0.271–3.410) for complications compared to those without AVWS. ROC curve analysis indicated an AUC of 0.7417 for the DPC model and 0.8025 for the AVWS model in predicting major vascular complications. …”
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Impact of the COVID-19 pandemic on outcomes of acute ischemic stroke patients treated with endovascular therapy: A multicenter Canadian study. by Shenghua Zhu, Ammar Alam, Rebecca Thornhill, Vered Tsehmaister-Abitbul, Grant Stotts, Hailey Pettem, Richard Aviv, Ronit Agid, Aleksandra Pikula, Jai Jai Shiva Shankar, Genevieve Milot, Brian Van Adel, Samuel Yip, Manraj Heran, Robert Fahed, Fabio Settecase, Marlise P Dos Santos

“…This patient cohort was compared to pre-pandemic patients consecutively treated with EVT from March 11, 2019 to March 10, 2020. …”
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Sample preparation using multiple microbial pattern recognition proteins and magnetic bead ratcheting by Jessica Martinez, Dong Jin M. Park, Samantha Abate, James Hill, George Downey, Craig Galligan, Tyler Hammond, Michael T. McCurdy, Surekha Gurung, Shanjana Shawon, Ralf Lenigk, Kuangwen Hsieh, Michael Super, Erik Kvam, Tza-Huei Wang, Coleman Murray, Chris Puleo

“…The flow-through system was operated up to 1 mL per minute and enabled pathogen isolation from 10 mL samples in <30 min. Demonstration of post-ratcheting PCR-based microbe analysis was also performed, showing that the technology may have applicability across different infectious agents, sample types/volumes, and analytical assays. …”
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The Impact of As-Built Surface Characteristics of Selective-Laser-Melted Ti-6Al-4V on Early Osteoblastic Response for Potential Dental Applications by Muhammad Hassan Razzaq, Olugbenga Ayeni, Selin Köklü, Kagan Berk, Muhammad Usama Zaheer, Tim Tjardts, Franz Faupel, Salih Veziroglu, Yogendra Kumar Mishra, Mehmet Fatih Aycan, O. Cenk Aktas, Tayebeh Ameri, Sinan Sen

“…This study investigates the potential of Selective Laser Melting (SLM) to tailor the surface characteristics of Ti6Al4V directly during fabrication, eliminating the need for post-processing treatments potentially for dental implants. …”
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Evaluating the multitargeted potency of Pixuvri against cell cycle regulation proteins in cervical cancer by Mohammed Ali Alshehri, Hadil Alahdal, Akram Ahmed Aloqbi, Afnan Mohammed Shakoori, Ghadir Sindi, Rehab M. Bagadood, Nida Alsaffar, Mohammad Ahmad Alobaidy, Noof Abdulrahman Alrabiah, Md Khursheed, Abeer Al Tuwaijri, Abeer Al Tuwaijri

“…Pixuvri is approved for non-Hodgkin lymphoma and exhibits minimal cardiotoxicity compared to anthracyclines. Interaction fingerprints highlighted key residues (4GLN, 4GLU, 3TRP), while pharmacokinetics, DFT computations, and WaterMap hydration site analysis supported its potential. …”
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Growth Factor Comparison in Cortical Demineralized Bone Matrix that Demineralized Using Chloric and Acetic Acid by Mouli Edward, Ferdiansyah Mahyudin, Mohammad Hardian Basuki, Heri Suroto, Ferdiansyah Danang Perwira

“…Conclusion: DBM demineralized with acetic acid yielded higher average IGF-1 levels compared to hydrochloric acid. However, BMP-2 and TGF-β levels were higher with hydrochloric acid. …”
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