The Effect of Retatrutide on Kidney Parameters in Participants With Type 2 Diabetes Mellitus and/or Obesity by Hiddo J.L. Heerspink, Zeqing Lu, Yu Du, Kevin L. Duffin, Tamer Coskun, Axel Haupt, Mark L. Hartman

“…This study assessed changes in kidney parameters with retatrutide, an agonist of the glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), and glucagon receptors. Methods: A post hoc analysis of 2 retatrutide studies (dose range: 0.5–12 mg) was performed in participants (estimated glomerular filtration rate [eGFR] ≥ 45 ml/min per 1.73 m2) with T2D (n = 281) and with overweight or obesity without T2D (n = 338). …”
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An Overview of the Systematic Reviews About the Efficacy of Fluvoxamine on Depression by Luiz Henrique Junqueira Dieckmann, Michel Haddad, Thiago Wendt Viola, Franciele Franco Scarante, Naielly Rodrigues da Silva, Jair de Jesus Mari

“…<b>Results:</b> A total of 74 reviews were identified, of which 14 systematic reviews met the inclusion criteria after screening and full-text analysis. These reviews, published between 1994 and 2021, predominantly involved nine pairwise meta-analyses and five network meta-analyses, comparing fluvoxamine with placebo and various antidepressants. …”
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Comparison of Oral Pregabalin and Clonidine Premedication in Attenuating Pressor Response to Laryngoscopy and Intubation: A Prospective Interventional Study by Jyotsna Mulamoottil Jose, Basheer Padinjare Madathil Abdul, Minu Subramonian, Anto Abey Illickal

“…Results: Demographic variables and baseline parameters were comparable between the groups. A statistically significant reduction in HR was observed in the clonidine group compared to the pregabalin group (p<0.05) at multiple time intervals post-drug administration. …”
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Psychosocial outcomes of risk-adapted prevention for prostate cancer predisposition: study protocol for a longitudinal observational mixed-methods study by Dagmar Wieczorek, Tanja Fehm, Gerald Antoch, Günther Carl, Peter Albers, Andre Karger, Ralf Schäfer, Ulrike Dinger, Maike K Klett, Jale Lakes, Guenter Niegisch, Matthias Boschheidgen, Bernadette Jäger, Silke Redler

“…As part of this research project, this study (‘ProFam-Psych’ - risk-adapted prevention clinic for familial and genetic prostate cancer: psychosocial effects; funded by German Cancer Aid) aims to evaluate the longitudinal psychosocial trajectories associated with this novel prevention clinic.Methods and analysis In a longitudinal observational mixed-methods design, psychosocial outcomes will be assessed in participants of the prevention clinic (case group, CAG) and compared with urology patients without increased risk for PCa (control group, COG). …”
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TSLP pretreatment inhibits M1 macrophage polarization and attenuates LPS-induced iNKT cell-dependent acute lung injury by Ting Zhou, Ziyao Zhang, Yawen Zhan, Meiying Wang, Meiying Wang, Meiying Wang, Mi Wu, Xiufang Weng, Xiufang Weng, Xiufang Weng, Xiufang Weng, Younian Xu, Younian Xu, Younian Xu

“…Thymic stromal lymphopoietin (TSLP) is known to promote Th2 responses in allergic disease, however, its role in sepsis associated ARDS remains limited.MethodsTo investigate the role of TSLP in sepsis associated lung injury, we administered exogenous recombinant TSLP to wild-type mice, followed by lipopolysaccharide (LPS) challenge. At 24 hours post-treatment, bronchoalveolar lavage fluid (BALF) and lung tissues were collected for analysis. …”
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Postnatal prophylaxis and the use of presumptive HIV therapy for the prevention of vertical transmission of HIV in Canada 1997–2020 by Jeanne Brochon, Terry Lee, Jason Brophy, Joel Singer, Marie‐Elaine Metras, Jeannette Comeau, Alena Tse‐Chang, Athena McConnell, Deborah Money, Isabelle Boucoiran, Laura J. Sauve, Ari Bitnun, Fatima Kakkar

“…Neonatal prophylaxis and HIV transmission risk were compared between groups. Results A total of 4743 MIPs were included in the analysis. …”
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Ambulatory care management of 69 patients with acute severe ulcerative colitis in comparison to 695 inpatients: insights from a multicentre UK cohort study by Shaji Sebastian, Neeraj Bhala, Nicholas A Kennedy, Sreedhar Subramanian, Shameer Mehta, Matthew J Brookes, Alexandra J Kent, Jonathan P Segal, Christopher A Lamb, Gareth J Walker, Aamir Saifuddin, Thomas Edward Conley, Lucy Hicks, Kamal V Patel, Haidee Aleman Gonzalez

“…Forty per cent of patients treated as ambulatory from diagnosis required subsequent hospital admission.Conclusions In a post hoc analysis of one of the largest ASUC cohorts collected to date, we report an emerging UK ambulatory practice which challenges treatment paradigms. …”
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Investigation of suspected aneurysmal subarachnoid haemorrhage: a single-centre quality improvement project by Michael Abouyannis, Malka Reuben, Hannah Wilder, Jis B John, Shawn Miranda, Norman Main

“…Serious LP-related complications were post-LP headaches, which resulted in a prolonged hospital stay (n=2) or re-admission (n=3). …”
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Association between stroke and fracture and the mediating role of depression: a cross-sectional study from NHANES 2017 to 2020 by Yuqin Dan, Xuewen Pei, Danghan Xu, Zhaoxi Liu, Yuqi Wang, Meng Yin, Li Li, Gongchang Yu, Gongchang Yu

“…T-test and chi square test are conducted to compare the differences between fracture and non fracture subgroups. …”
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Effects of subjective stress levels on learning effectiveness in high-fidelity simulation among healthcare workers by Yoong-A Suh, Hoyeon Shim, Hae Jeong Lee, Jang Hoon Lee, Moon Sung Park, Seoheui Choi

“…Materials and methods: This study was conducted as a single-blind randomized controlled study with a pre–post design for health care workers, including paediatric residents and nurses in charge of neonatal care. …”
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Using a Social Application to Manage Women with Gestational Diabetes Mellitus: A Prospective Study by Hong Liu, Hongying Peng, Chunxia Cheng, Meng Wang, Chunmei Mi, Guo Feng, Jinru Wu, Hao Nie, Jiaoyang Wu, Yufang Luo, Min Liu

“…Among the 375 participants, 277 (73.9%) had completed post-partum 75 g OGTT, 202 (72.9%) had normal glucose levels, and 75 (27.1%) had impaired glucose regulation (IGR). …”
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ACTIVE, ACTUATED, AND ASSISTIVE: A SCOPING REVIEW OF EXOSKELETONS FOR THE HANDS AND WRISTS by Angel Galbert, Arjan Buis

“…Articles were included if the device was portable; supported the hands and wrist actively using an actuator; and could be used for assistive living during or post-rehabilitation period. FINDINGS: A total of 135 studies were included in the analysis of which 34 were clinical trials. …”
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Immunopathological features of highly pathogenic Korean Lineage B PRRSV-2: insights into virulence indicators and host immune responses by Gyeong-Seo Park, Gyeong-Seo Park, Seung-Chai Kim, Hwan-Ju Kim, Chang-Gi Jeong, Chang-Gi Jeong, Sang-Chul Kang, Go-Eun Shin, Seoung-Hee Kim, Hye-Young Jeong, Kyoung-Ki Lee, Sang-Myeong Lee, Won-Il Kim

“…Pigs were monitored, and blood and nasal swabs were collected. At 12- and 28 days post-infection (dpi), pigs were euthanized for histopathological analysis and tissue collection. …”
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Prognostic significance of preoperative CT-based sarcopenia in locally advanced rectal cancer: a multicenter retrospective study by Jiahong Zhu, Yan Gao, Chengjun Zhang, Yanbo Wu, Qian Wang, Weizhi Chen, Xiaohong Lyu, Xianglin Zhang, Zhen Liu, Shinong Pan

“…However, sarcopenic patients showed a higher risk of readmission (OR: 5.53, 95% CI: 1.57 ~ 19.5, P = 0.008) and a significant correlation with poorer CSS (HR: 2.78, 95% CI: 1.64 ~ 4.72, P < 0.001). Kaplan-Meier analysis showed that sarcopenic LARC patients had a significantly higher cumulative hazard of OS compared to non-sarcopenic patients (P < 0.001, log-rank test). …”
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Immunomodulatory and growth-promoting effects of Rauwolfia serpentina root powder in broiler chicks challenged with Salmonella Gallinarum by Yingyu Zhang, Hiba Rehman, Farina Khattak, Maryam Tariq, Bushra Nisar Khan, Sadia Chaman, Ayaesha Riaz, Muhammad Ovais Omer, Aqib Ali, Qamar un Nisa, Muhammad Muddassir Ali, Gulbeena Saleem

“…Additionally, histopathological assessments of gut and growth performance parameters including feed intake, body weight gain, and feed conversion ratio (FCR) were monitored throughout the experimental period.ResultThe gene expression analysis at 3 and 21 days post-challenge revealed that SGC birds had significantly higher SOCS3, P20K, and lower MHC class IIβ expression (p &lt; 0.001) in the caecum, liver, and spleen of broiler chickens. …”
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Alveolar bone loss is associated with oral cancer: a case-control study by Leah Trumet, Leah Trumet, Roman Fuchs, Roman Fuchs, Joy Backhaus, Bettina Grötsch, Kerstin Galler, Marco Kesting, Marco Kesting, Manuel Weber, Manuel Weber

“…Welch-test, Chi-Square-Test and a two-way Analysis of Covariance (ANCOVA) followed by a Bonferroni post-hoc test for multiple pairwise comparison were performed.ResultsSeveral statistically significant differences were identified between the two groups, with a greater than twofold prevalence of nicotine consumption among the OSCC group. …”
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Impact of Body Mass Index on the Outcomes of Cryoballoon Pulmonary Vein Isolation for Paroxysmal Atrial Fibrillation by Konstantinos A. Papathanasiou, Dimitrios A. Vrachatis, Charalampos Kossyvakis, Sotiria G. Giotaki, Gerasimos Deftereos, Maria Kousta, Ioannis Anagnostopoulos, Dimitrios Avramides, George Giannopoulos, Vaia Lambadiari, Gerasimos Siasos, Spyridon Deftereos

“…Both late and early (<3 months) AF recurrence rates were comparable across the three groups. Of note, obese patients showed greater improvement in their symptoms post-CBA, defined as improvement by at least one EHRA class, compared to normal weight patients; this might be explained by improved diastolic function. …”
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Virulence of fowl adenovirus (FAdV) serotype 4 strains impacts cell proliferation and immune response of primary chicken-embryo intestinal epithelial cells by Katharina Kau-Strebinger, Ursula Reichart, Taniya Mitra, Beatrice Grafl, Michael Hess, Dieter Liebhart

“…Cell growth and viral propagation were assessed at 4, 12, 24, and 48 hours post-infection (hpi) using immunofluorescence and automated image analysis. …”
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Effectiveness of Interval Versus Continuous Training on Blood Pressure Among Hypertensive Postmenopausal Women by Preeti Saini, Nitesh Malhotra

“…Blood pressure and BMI were recorded before and after the intervention. Data analysis involved ANOVA and post-hoc tests to examine intra-group and inter-group differences. …”
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The advantages of artificial intelligence-assisted total hip arthroplasty: A randomized controlled trial followed by 12 months by Gang Zhang, Zixuan Liu, Diaodiao Wang, Zhuang Tian, Qi Yao

“…The experimental group utilized AI planning, while the control group employed traditional two-dimensional X-ray planning. Statistical analysis was performed to compare the accuracy of prosthesis prediction, operation time, intraoperative blood loss, frequency of intraoperative model testing, length of hospital stay, postoperative imaging data, and postoperative hip function scores. …”
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