Can virtual reality replace conventional vestibular rehabilitation tools in multisensory balance exercises for vestibular disorders? A non-inferiority study by Gaël Le Perf, Guillaume Thebault, Claire Duflos, Fanchon Herman, Sylvie Cauquil-Gleizes, Isabelle Laffont

“…However, the VR program did not meet the non-inferiority criterion compared to the conventional program. The primary outcome analysis revealed a difference of − 13.36 (95% CI − 29.84 to 3.11), with the lower bound of the confidence interval (− 29.84) falling below the non-inferiority margin of -2.01. …”
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Urinary NephroCheck® test, as a marker of subclinical postoperative AKI, correlates with long-term GFR decline in patients undergoing partial nephrectomy: a prospective bicentric o... by Marco Allinovi, Margarete Teresa Walach, Micaela Anna Casiraghi, Marc Weidenbusch, Samantha Innocenti, Lorenzo Tofani, Laura Paparella, Alessandra Fanelli, Gianluca Villa, Philipp Nuhn

“…Samples were collected pre- and post-operatively; renal function was re-assessed up to 24 months. …”
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Bridging the gaps in detection of structural cardiotoxicity in stem cell-derived cardiomyocytes: promise of miR-133b, miR-184 and miR-208b-3p by M. Cherubin, M. Cherubin, A. Delaunois, J. P. Valentin, M. Alaerts, P. J. Guns, V. Gryshkova

“…Although miRNAs could be useful for detection of cardiotoxicity, they are not routinely assessed in preclinical drug development.MethodsThe current study aimed to investigate dysregulation of miRNAs in human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) and their culture media after exposure to a set of cardiotoxic agents known to cause structural cardiotoxicity by different mechanisms of action. Dose-response analysis of intracellular miRNA expression was conducted after 72-hour incubation with 29 drugs, while the presence of miRNAs in the culture media was evaluated at 24-, 48-, and 72-hour post-treatment in response to 7 selected treatments.ResultsAs a result, we confirmed the upregulation of the following intracellular miRNAs across various drug classes: hsa-miR-96-5p, hsa-miR-126-3p, hsa-miR-133b, hsa-miR-146b-5p, hsa-miR-182-5p, hsa-miR-187-3p and hsa-miR-365a-5p. …”
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Faricimab in the Treatment of Exudative Neovascular Age-Related Macular Degeneration and Diabetic Macular Edema in Italy: The FARIT Real World Study by Marco Lupidi, Cristiana Iaculli, Luisa Marco, Settimio Rossi, Emilia Sicari, Giulia Villa, Vittorio Pirani

“…After a full loading phase, the median number of injections administered during the post-loading follow-up period (12 months for nAMD, 10 months for DME) was three for nAMD and two for DME. …”
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Lower expression of miR-218 in human breast cancer is associated with lymph node metastases, higher grades, and poorer prognosis by Fereshteh Ahmadinejad, Seyed Javad Mowla, Mohammad-Amin Honardoost, Mostafa Gholami Arjenaki, Mohammad Moazeni-Bistgani, Soleyman Kheiri, Hossein Teimori

“…Finally, to better understand biological function of miR-218 in breast cancer, we performed in silico Gene Ontology and signaling pathway enrichment analysis on miR-218 targetome. According to our data, significant elevation of the expression of miR-218 and downregulation of BMI1 were observed in clinical breast cancer specimens compared with normal tissues ( p  < 0.0001). …”
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Effect of DMARD Therapy on Inflammatory Biomarkers and Disease Activity in Rheumatoid Arthritis Patients by Hardik Kharbanda, Manish Khanna, Krunal Thakrar, Manojit Basak, Manish Dwivedi, Partha Pratim Das

“…Materials and Methods: The study aims to evaluate and compare pre- and post-therapy outcomes retrospectively of patients with seropositive and seronegative RA undergoing DMARD therapy. …”
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Enhancement of the Bio-Responsiveness of PCL Nanofibers via the Combination of a Thiol Plasma-Polymerized Coating and Fibronectin Immobilization by Pegah Zahedifar, Rino Morent, Sheida Aliakbarshirazi, Rouba Ghobeira, Nathalie De Geyter

“…The thiol-coated substrates demonstrated superior protein immobilization and significantly improved cell responses. Post-fibronectin immobilization, these substrates exhibited the highest cell viability, adhesion, and proliferation. …”
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Outcomes and risk factors associated with in-hospital mortality in patients undergoing coronary artery bypass grafting with low ejection fraction by Yang Zhao, Xu Yu, Xiaolong Ma, Liang Zhang, Zehui Wang, Zehui Wang, Zehui Wang

“…The patients were categorized into a in-hospital mortality group (n = 38) and a in-hospital survival group (n = 727), based on whether they died within 30 days post-operation. Univariate and multivariate logistic regression analyses were employed to identify risk factors for in-hospital mortality. …”
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Effects of Acute Coordinative vs. Endurance Exercise on Cortisol Concentration in Healthy Women and Men by Henning Budde, Mirko Wegner, Christiane Ahrens, Bruna Velasques, Pedro Ribeiro, Sergio Machado, Thomas Gronwald, Sandra Amatriain-Fernández, Marcelle Schaffarczyk, Anett Mueller-Alcazar

“…Until now there have been no studies comparing the acute effects of endurance and coordinative exercise on cortisol. …”
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Qualidade do café natural e despolpado após diferentes tipos de secagem e armazenamento Quality of natural and washed coffee after different types of drying and storage by Paulo C. Coradi, Flávio M. Borém, João A. Oliveira

“…Os resultados obtidos no presente trabalho permitem concluir que: a acidez graxa aumenta ao longo do tempo de armazenamento nas condições de 60 e 80% de umidade relativa; a descoloração do café é mais intensa ao longo do tempo de armazenamento para as condições de 80% de umidade relativa; aos 180 dias de armazenamento, a análise sensorial do café é menos afetada pela interação secagem, processamento e armazenamento, nas condições de 60% de umidade relativa.<br>For comparing the alterations in the quality of natural and washed coffee under 60 to 80% relative humidity conditions from and controlled temperature of 23 &deg;C at 90 and 180 days of storage, this work was accomplished in the Engineering Department and Coffee Post-Harvest Technology Centre of the Federal University of Lavras. …”
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Well-being trajectories and dynamic resource shifts in the transitions of retirement: a longitudinal study of Taiwanese older adults by Wan-Chen Hsu, Nuan-Ching Huang, Nuan-Ching Huang, Susan C. Hu

“…Compared with the “Low-Decline” group, individuals in the “High-Increase” group exhibited better health, stronger economic status, greater social participation, more family support, and higher educational attainment. …”
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Histomorphometric evaluation of bone regeneration using autogenous bone and beta-tricalcium phosphate in diabetic rabbits by Živadinović Milka, Andrić Miroslav, Milošević Verica, Manojlović-Stojanoski Milica, Prokić Branislav, Prokić Bogomir, Dimić Aleksandar, Ćalasan Dejan, Brković Božidar

“…All parameters were statistically evaluated by Friedman Test and post hock Wilcoxon Singed Ranks Test with a significance of p < 0.05. …”
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Integrative machine learning model for subtype identification and prognostic prediction in lung squamous cell carcinoma by Guangliang Duan, Qi Huo, Wei Ni, Fei Ding, Yuefang Ye, Tingting Tang, Huiping Dai

“…An online tool for predicting survival probabilities for LUSC patients up to 10 years post-treatment is available at https://hznuduan.shinyapps.io/LCSP/ . …”
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Electroacupuncture Alleviates Neuropathic Pain and Negative Emotion in Mice by Regulating Gut Microbiota by Feng C, Pan H, Zhang Y, Ye Z, Zhou Y, Zou H, Wang K

“…Starting from the 8th day post-CCI induction, the EA group underwent EA treatment once every two days, for a total of 20 sessions. …”
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Effectiveness Test of Granulated Bioinsecticide Formulation from Avocado Seed Extract Against Aedes aegypti Larvae by Rahmi Amir, Amrin, Bastiana, Tatiana, Fitriana, Nirwana, Faisal Syarief

“…Larval mortality was assessed at 24 and 48-hour intervals. Statistical analysis was performed using ANOVA, followed by post-hoc tests to determine significant differences. …”
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Healthcare utilization patterns before and after a long COVID diagnosis: a case-control study by Rick DeVoss, Elizabeth J. Carlton, Sarah E. Jolley, Marcelo C. Perraillon

“…The objective of this study is to examine the characteristics and healthcare utilization patterns of Long COVID patients in Colorado pre- and post-diagnosis compared to controls. Methods Retrospective, longitudinal case-control study using a 100% sample of Colorado’s All-Payer Claims Database. …”
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Impact of the conflict interactions and social learning on the hierarchy structure in captive males of Moschus chrysogaster (Moschidae) by Xiaolong Wang, Jiayi Wu, Xiaoping Lu, Vasili Shakun, Irena Solovej, Xiuxiang Meng

“…In addition, we found a significant surge in socially learning behaviours among musk deer post-conflict, indicative of the essential spread of information on individual rank and fighting capabilities within the captive population. …”
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Rational design of allosteric inhibitors targeting C797S mutant EGFR in NSCLC: an integrative in silico and in-vitro study by Jian Wang, Feiyang Yuan, Mahadevi Kendre, Zhijin He, Shaowei Dong, Abhinandan Patil, Kausing Padvi

“…MD simulations over 100 ns confirmed the stability of the MK1-EGFR complex, with RMSD values stabilizing post-50 ns and RMSF values consistently below 3 Å. …”
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The impact of gamma interferon on BK virus candidate microRNAs and related miRNAs in kidney transplant patients with BK infection by Maryam Changizi, Gholamreza Motalleb, Ramin Yaghobi, Afsoon Afshari, Jamshid Roozbeh

“…Thus, we investigated these modifications as putative biomarkers for evaluating viral infection and the regulatory web that arises from their expression during infection and the emergence of post-transplant problems. This study was carried out on KTRs. …”
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Indication of Economic Populism in Local Governance: A New Approach for Classifying Populist Behaviour by Pavel Zdražil, Jan Fuka, Bohuslav Pernica, Robert Baťa

“…Findings: Examination of 6,240 municipalities in post-communist Czechia between 2002 and 2021 reveals indications of economic populism in 6.2 % of cases. …”
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