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28341
Women's economic empowerment and poverty: Specification empirics examining global data
Published 2025-06-01Get full text
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28342
Downregulation of DNAJC12 Expression Predicts Worse Survival for ER-Positive Breast Cancer Patients
Published 2025-02-01“…Using IHC analysis, we showed that low DNAJC12 protein-level expression is also associated with a worse prognosis in patients with all subtypes of BC and patients with Luminal BC, and its expression is significantly different between patients with different tumor size classifications (T1/T2 vs T3/T4; P = .013) or with different lymph node involvement (N0 vs N+; P = .005). …”
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28343
Ferroptosis: a novel pharmacological mechanism against multiple myeloma
Published 2025-07-01“…It aims to provide novel insights and strategies for MM research and clinical therapy.MethodsWe systematically retrieved data from PubMed, Web of Science, ScienceDirect, SciFinder, Scopus, and the China National Knowledge Infrastructure (CNKI) spanning database inception to March 2025, followed by taxonomic integrative analysis of NPs’ and antitumor compounds’ echanistic classifications.ResultsNPs and antitumor compounds exert anti-MM effects via ferroptosis modulation, mechanistically mediated through: 1) lipid metabolism reprogramming; 2) ferritinophagy-driven iron homeostasis regulation; 3) Reactive oxygen species (ROS)-mediated oxidative stress potentiation; 4) autophagic activation; 5) Genes and proteins regulation.ConclusionNPs and antitumor compounds demonstrate therapeutic potential against MM through multi-dimensional ferroptosis modulation, yet clinical translation faces two critical hurdles: 1) predominant focus on single-target mechanisms lacking systems pharmacology-level network analysis; 2) overreliance on in vitro models with insufficient clinical validation. …”
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28344
Stratifying Breast Lesion Risk Using BI-RADS: A Correlative Study of Imaging and Histopathology
Published 2025-07-01“…This study assessed the diagnostic performance of BI-RADS 3, 4, and 5 classifications and their association with tumor grade and markers such as ER, PR, HER2, and Ki-67. …”
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28345
Understanding Postpartum Psychosis: Current Perspectives and Clinical Implications
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28346
Correlation of Histopathological and Radiological Response Patterns and Their Prognostic Implications in Breast Cancer After Neoadjuvant Chemotherapy
Published 2024-12-01“…Concordance between radiological and histopathological classifications was assessed using the kappa statistic. …”
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Diagnostic and Therapeutic Challenges in Pregnancy-Associated Breast Cancer: A Literature Review
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28352
The Clinical and Economic Burden of Idiopathic Hypersomnia: Results from the Real-World Idiopathic Hypersomnia Total Health Model (RHYTHM) Study
Published 2025-07-01“…Ragy Saad,1 Sarah C Markt,1 Prasheel Lillaney,1 Deb A Profant,1 Douglas S Fuller,2 Elizabeth M Poole,1 Trevor Alvord,3 Patricia Prince,3 Shaina Desai,3 Marisa Whalen,2 Weiyi Ni,1 Jed Black1,4 1Jazz Pharmaceuticals, Palo Alto, CA, USA; 2Jazz Pharmaceuticals, Philadelphia, PA, USA; 3Aetion, Inc, New York, NY, USA; 4Stanford University Center for Sleep Sciences and Medicine, Palo Alto, CA, USACorrespondence: Jed Black, Stanford University Center for Sleep Sciences and Medicine, 401 Quarry Road, #3301, Palo Alto, CA, 94304, USA, Email jed.black@jazzpharma.comPurpose: Limited research describes the clinical and economic burden of idiopathic hypersomnia. …”
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Chikungunya: From Hypothesis to Evidence of Increased Severe Disease and Fatalities
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Madelung's disease: combined surgical approach of lipectomy and liposuction
Published 2022-03-01Get full text
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Soft Electronic Switches and Adaptive Logic Gates Based on Nanostructured Gold Networks
Published 2025-05-01Get full text
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L2D2: A Novel LSTM Model for Multi-Class Intrusion Detection Systems in the Era of IoMT
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Visual Deepfake Detection: Review of Techniques, Tools, Limitations, and Future Prospects
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Pulmonary Embolism Treatment: Current Developments and Approaches
Published 2024-04-01Get full text
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Agent-based modeling of spreading infectious diseases: state-of-the-art
Published 2024-09-01Get full text
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