T-cell receptor dynamics in digestive system cancers: a multi-layer machine learning approach for tumor diagnosis and staging by Changjin Yuan, Bin Wang, Hong Wang, Fang Wang, Xiangze Li, Ya’nan Zhen

“…Across CRC stages, later stages (III–IV) showed higher clonal diversity (p-value < 0.05) and stage-specific V-J patterns, alongside distinct CDR3 amino acid preferences at N-terminal (positions 1–2) and central positions (positions 5–12). …”
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Left atrial stiffness index in the identification of heart failure with preserved ejection fraction by N. E. Shirokov, E. I. Yaroslavskaya, M. D. Kosterin, D. V. Krinochkin, E. A. Gorbatenko, T. N. Enina, N. A. Musikhina

“…According to ROC analysis, the largest area under the curve (AUC), optimal sensitivity and specificity in HFpEF diagnosis were observed in LASI (AUC=0,829, p<0,001; 77,8 and 74,5%, respectively). Lower classification quality was shown by the H2FPEF score (AUC=0,701, p=0,001; 66,7 and 69,1%), while the HFA-PEFF score was not significant in the pretest detection of HFpEF (AUC=0,608, p=0,065; 53,3 and 61,8%).Conclusion. …”
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Risk Factors of Positive Endocervical Curettage and Predictive Model Construction Based on Primary Human Papillomavirus Screening by Hangjing Gao MS, Guanxiang Huang MS, Binhua Dong MS, Ye Li MS, Hongning Cai MD, Xianqian Chen MS, Tingting Jiang MS, Kelvin Stefan Osafo MS, Dabin Liu MS, Jiancui Chen MS, Huihua Ge MS, Diling Pan MS, Huifeng Xue MS, Pengming Sun PhD, MD

“…Females with acetowhite changes on colposcopy, transformation zone (TZ) type II, TZ type III, colposcopic impression of high-grade squamous intraepithelial lesion, or cancer were at a high risk of positive ECC. …”
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Comparing Raman Spectroscopy-Based Artificial Intelligence to High-Definition White Light Endoscopy for Endoscopic Diagnosis of Gastric Neoplasia: A Feasibility Proof-of-Concept St... by Tse Kiat Soong, Guo Wei Kim, Daryl Kai Ann Chia, Jimmy Bok Yan So, Jonathan Wei Jie Lee, Asim Shabbbir, Jeffrey Huey Yew Lum, Gwyneth Shook Ting Soon, Khek Yu Ho

“…Objective: To compare the performance of the AI-enabled Raman spectroscopy with that of high-definition white light endoscopy (HD-WLE) for the risk classification of gastric lesions. Methods: This was a randomized double-arm feasibility proof-of-concept trial in which participants with suspected gastric neoplasia underwent endoscopic assessment using either the Raman spectroscopy-based AI (SPECTRA IMDx™) or HD-WLE performed by expert endoscopists. …”
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Implementing large language model and retrieval augmented generation to extract geographic locations of illicit transnational kidney trade by Zifu Wang, Meng-Hao Li, Patrick Baxter, Olzhas Zhorayev, Jiaxin Wei, Valerie Kovacs, Qiuhan Zhao, Chaowei Yang, Naoru Koizumi

“…Methods This study employed state-of-the-art technologies, including Bidirectional Encoder Representations from Transformers (BERT) and Generative Pre-Trained Transformers (GPT) model Llama3.3 from Meta in developing a kidney trade country database. …”
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Module Algebra Structures of Non-Standard Quantum Group <i>X</i>_q(<i>A</i>₁) on <inline-formula><math display="inline"><semantics><mrow><mi mathvariant="doubl... by Dong Su

“…The automorphism group of <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mi mathvariant="double-struck">C</mi><mi>q</mi></msub><mrow><mo>[</mo><mi>x</mi><mo>,</mo><mi>y</mi><mo>,</mo><mi>z</mi><mo>]</mo></mrow></mrow></semantics></math></inline-formula> is denoted by <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>Aut</mi><mo>(</mo><msub><mi mathvariant="double-struck">C</mi><mi>q</mi></msub><mrow><mo>[</mo><mi>x</mi><mo>,</mo><mi>y</mi><mo>,</mo><mi>z</mi><mo>]</mo></mrow><mo>)</mo></mrow></semantics></math></inline-formula>, and we give a complete classification of <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mi>X</mi><mi>q</mi></msub><mrow><mo>(</mo><msub><mi>A</mi><mn>1</mn></msub><mo>)</mo></mrow></mrow></semantics></math></inline-formula>-module algebra structures on <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mi mathvariant="double-struck">C</mi><mi>q</mi></msub><mrow><mo>[</mo><mi>x</mi><mo>,</mo><mi>y</mi><mo>,</mo><mi>z</mi><mo>]</mo></mrow></mrow></semantics></math></inline-formula>, where <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mi>K</mi><mn>1</mn></msub><mo>,</mo><msub><mi>K</mi><mn>2</mn></msub><mo>∈</mo><mi>Aut</mi><mrow><mo>(</mo><msub><mi mathvariant="double-struck">C</mi><mi>q</mi></msub><mrow><mo>[</mo><mi>x</mi><mo>,</mo><mi>y</mi><mo>,</mo><mi>z</mi><mo>]</mo></mrow><mo>)</mo></mrow></mrow></semantics></math></inline-formula>.…”
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Effects of thiamethoxam insecticide on sugarcane plant growth under chemical ripening at early and late harvest by Deise de Paula Silva, Josiane Viveiros, Lucas Moraes Jacomassi, Marcela Pacola, Letusa Momesso, Gabriela Ferraz de Siqueira, Jorge Martinelli Martello, Rodrigo Foltran, Rogério Peres Soratto, Leila Luci Dinardo-Miranda, Carlos Alexandre Costa Crusciol

“…However, given its classification as a neonicotinoid, further studies are needed to assess long-term safety. …”
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Predictive model for risk of gastric cancer using genetic variants from genome‐wide association studies and high‐evidence meta‐analysis by Lixin Qiu, Xiaofei Qu, Jing He, Lei Cheng, Ruoxin Zhang, Menghong Sun, Yajun Yang, Jiucun Wang, Mengyun Wang, Xiaodong Zhu, Weijian Guo

“…Multifactor dimensionality reduction (MDR) and classification and regression tree (CART) were applied to calculate the effect of high‐order gene‐environment interactions on risk of the cancer. …”
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Predicting rheumatoid arthritis progression from seronegative undifferentiated arthritis using machine learning: a deep learning model trained on the KURAMA cohort and externally v... by Takayuki Fujii, Koichi Murata, Hirohiko Kohjitani, Akira Onishi, Kosaku Murakami, Masao Tanaka, Wataru Yamamoto, Koji Nagai, Ayaka Yoshikawa, Yuki Etani, Yasutaka Okita, Naofumi Yoshida, Hideki Amuro, Tadashi Okano, Yo Ueda, Takaichi Okano, Ryota Hara, Motomu Hashimoto, Akio Morinobu, Shuichi Matsuda

“…Abstract Background Undifferentiated arthritis (UA) often develops into rheumatoid arthritis (RA), but predicting disease progression from seronegative UA remains challenging because seronegative RA often does not meet the classification criteria. This study aims to build a machine learning (ML) model to predict the progression from seronegative UA to RA using clinical and laboratory parameters. …”
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Detection of strawberry bloom phenology based on YOLO-RCMC and flower opening scale by Junquan Zhen, Yuke Wang, Xunhui Liu, Linfan Zhou, Shuqin Yang, Dong Wang

“…In addition, the RCM variants were integrated into the head of the model to reduce classification errors and improve detection accuracy. …”
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Concordance in diagnostic testing for respiratory pathogens of bighorn sheep by Daniel P. Walsh, E. Frances Cassirer, Michael D. Bonds, Daniel R. Brown, William H. Edwards, Glen C. Weiser, Mark L. Drew, Robert E. Briggs, Karen A. Fox, Michael W. Miller, Sudarvili Shanthalingam, Subramaniam Srikumaran, Thomas E. Besser

“…Despite differences in testing protocols, median agreement among laboratories and correct classification of controls for most agents was ≥0.80, meeting or exceeding the standard required by federal proficiency testing programs. …”
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Video capsule endoscopy in overt and occult obscure gastrointestinal bleeding: Insights from a single‐center, observational study in Japan by Anna Tojo, Tomohisa Sujino, Yukie Hayashi, Kenji J L Limpias Kamiya, Moe Sato, Sakurai Hinako, Yusuke Yoshimatsu, Satoshi Kinoshita, Hiroki Kiyohara, Yohei Mikami, Kaoru Takabayashi, Motohiko Kato, Haruhiko Ogata, Takanori Kanai, Naoki Hosoe

“…BAE was more frequently performed in P2 than in P1 VCE (83.0% vs. 35.3% in overt OGIB, 84.4% vs. 24.4% in occult OGIB). …”
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The malignant transformation of an atypical angiocentric glioma, MYB-altered by Oumaima Aboubakr, Annika K. Wefers, Volodia Dangouloff-Ros, Alice Métais, Philipp Sievers, Lauren Hasty, Raphaël Saffroy, Gaelle Pierron, Delphine Guillemot, Thomas Samoyeau, Nathalie Boddaert, Jacques Grill, Kevin Beccaria, Thomas Blauwblomme, Pascale Varlet, Arnault Tauziède-Espariat

“…Abstract According to the current World Health Organization classification of central nervous system tumors, the angiocentric glioma (AG) assigned a grade 1, characterized by recurrent MYB fusions. …”
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The Diagnostic Value of High-Frequency Ultrasound in Unclarified Lesions at the End of Extremities by Haojie Yang, Na Ni, Weiwei Ren, Qiao Wang, Mengyu Lu, Yincheng Gao, Guanqun Zhang, Yongxian Lai, Yujing Zhao, Lehang Guo, Dandan Shan, Liping Sun

“…For benign lesions (51.0% vs. 18.2%), subungual lesions (40.8% vs. 21.1%), non-subungual lesions (55.6% vs. 17.8%), and common cases (60.9% vs. 20.3%), the diagnostic correct rate of Mode B was also higher than that of Mode A (all <i>p</i> < 0.05). …”
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Improved Efficacy of a Predictive Model for Swallowing-Induced Breakthrough Pain Based on a Redefined Delineation Method in Locally Advanced Nasopharyngeal Carcinoma by Jian-Da Sun, MD, Ze-Kai Chen, MM, Shu-Peng Liu, PhD, Feng Ye, MD, Ting-Xi Tang, MD, Zhen-Hua Zhou, MD, Han-Bin Zhang, MM, Long-Shan Zhang, MD, Ting Xiao, BS, Lin-Lin Xiao, MM, Xiao-Qing Wang, MD, Jian Guan, MD

“…The random forest classification method was chosen to establish and validate the predictive models based on 3 contouring methods. …”
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eGFRCystatin C, difference between eGFRCystatin C and eGFRCre and heart failure: Insight from the NHANES 2001–2002 and Mendelian randomization analysis by Zhiyu Gu, Rui Zhang, Weihong Chang, Hongxuan Fan, Zixuan Dou, Peng Liu, Aman Liu, Boda Zhou

“…In participants without know HF, during a median follow-up of 17.3 years, those in the low eGFRCystatin C or low eGFRdiff groups showed significantly poorer survival. …”
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An analytical, mathematical annuloplasty ring curvature model for planning of valve-in-ring transcatheter mitral valve replacementCentral MessagePerspective by Matthew H. Park, MS, Mateo Marin-Cuartas, MD, Mark Sellke, PhD, Pearly K. Pandya, MS, Yuanjia Zhu, MD, PhD, Robert J. Wilkerson, BS, David M. Holzhey, MD, PhD, Michael A. Borger, MD, PhD, Y. Joseph Woo, MD

“…Our mathematical approach creates a foundation for extended classification of this practice, providing meaningful quantification of ring geometry.…”
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Factors associated with health-related quality of life in women with paid work at breast cancer diagnosis: a German repeated cross-sectional study over the first five years after p... by Batoul Safieddine, Siegfried Geyer, Stefanie Sperlich, Johannes Beller, Dorothee Noeres

“…Returning to work (RTW) after having been on sick leave was strongly associated with better HRQL as illustrated by higher sum scores for physical (at 3 weeks: ß=6.21; CI:3.36, 9.05; at 6 months: ß=5.40; CI:3.01, 1.80; at 1 year: ß=8.40; CI:5.31, 11.49) and mental wellbeing (at 6 months: ß=6.03; CI:33.25, 8.81; at 1 year: ß=7.71; CI:4.85, 10.58) until 1 year after primary surgery. …”
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Features of development and progression of colorectal cancer on a background of ulcerative colitis by I. L. Khalif, V. N. Kashnikov, A. V. Gusev, O. V. Golovenko, K. V. Bolikhov, L. L. Kapuller, A. N. Kuznetsov, A. V. Vasilchenko

“…According to ТNM classification tumor at Т4 stage was revealed in 48 (73,8%) patients, Т3 – in 15 (23,1%), Т2 – in 2 (3,1%); N0 – in 56 (86,2%), N + in 9 (13,8%). …”
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Gender Dysphoria and Scoliosis: Pediatric Orthopaedists Are Very Much Members of the Healthcare Team by Eden N. VanderHoek, BS, Jung U. Yoo, MD, Natalie L. Zusman, MD

“…Level of Evidence: III.…”
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