Transcriptional profiling of peripheral blood mononuclear cells identifies inflammatory phenotypes in Ataxia Telangiectasia by Sylvia N. Michki, Benjamin D. Singer, Javier V. Perez, Aaron J. Thomas, Valerie Natale, Kathryn A. Helmin, Jennifer Wright, Leon Cheng, Lisa R. Young, Howard M. Lederman, Sharon A. McGrath-Morrow

“…Finally, we showed that individuals with classic A-T exhibit higher SERPINE1 (PAI-1) mRNA and plasma protein levels, irrespective of age, and higher FLT4 (VEGFR3) and IL6ST (GP130) plasma protein levels compared with mild A-T and controls. …”
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Analysis of cause-specific atherothrombotic cardiovascular disease mortality in Mexico: 2011–2015 by Erwin Chiquete, Jorge Aldrete-Velasco, Sonia C. Juárez-Comboni, David Solar-Cafaggi, Salvador Durán-Coyote, Mercedes Scarlett Enríquez Ramos, Benjamín Camacho-Silva, Ana Ochoa-Guzmán, Carlos Cantú-Brito

“…Material and methods We analyzed 3,105,975 death certificates issued between January 2011 and December 2015. …”
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Revolutionizing climbing perch disease management: AI-Driven solutions for sustainable aquaculture by Kosit Sriputhorn, Rapeepan Pitakaso, Surasak Matitopanum, Peerawat Luesak, Surajet Khonjun, Rungwasun Kraiklang, Chakat Chueadee, Sarayut Gonwirat

“…We present the Climbing Perch Disease Detection and Classification System (CPDDCS), employing cutting-edge imaging and deep learning technologies to automate disease detection. …”
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Features of Celiac Disease in children and adolescents with Down syndrome: a single-center experience of annual screening by Martina Lattuada, Paola Rebora, Paola Rebora, Chiara Fossati, Alessandra Lazzerotti, Lucia Paolini, Alessandro Cattoni, Alessandro Cattoni, Roberto Panceri, Maria Grazia Valsecchi, Maria Grazia Valsecchi, Andrea Biondi, Andrea Biondi, Giovanna Zuin

“…Among patients with CD and DS, 93% had histological damage equal to 3rd grade of Marsh-Oberhuber classification at diagnosis. …”
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Detection of hypervirulent Klebsiella pneumoniae (hvKp) strains directly from spiked blood cultures using a commercial Loop-Mediated isothermal amplification (LAMP) assay by Domingo Fernández Vecilla, Jorge Rodríguez Grande, Nuria Fraile Valcárcel, Zaira Moure García, Sergio García Fernández, María Siller Ruiz, María Pía Roiz Mesones, José Luis Díaz de Tuesta del Arco, Mikel Joseba Urrutikoetxea Gutiérrez, María Catalina Lomoro, María Carmen Fariñas, Alain Ocampo-Sosa

“…However, limitations in the Kleborate scoring system indicate that additional virulence biomarkers may be needed to improve the accuracy of hvKp classification.…”
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Optimizing timing and cost-effective use of plasma biomarkers in Alzheimer’s disease by Hsin-I Chang, Mi-Chia Ma, Kuo-Lun Huang, Chung-Gue Huang, Shu-Hua Huang, Chi-Wei Huang, Kun-Ju Lin, Chiung-Chih Chang

“…Discussion The use of multiclass LR model enhances amyloid classification, particularly at earlier clinical stages. …”
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Low Cholinesterase Is a Potential Poor Prognostic Factor in Colorectal Cancer Presenting With Tumor Markers Negative by Tawfik Ali Hamood Alburiahi, Lei Liang, Weiqing Liu, Zhiyong Kou, Yunfei Zhang, Ning Xu, Jun Yang

“…Results (1) Among 1140 patients who met the criteria, the TMN group (n = 369) had a higher survival rate (89.7%) than the TMP group (n = 771, 83.3%; p = 0.035). (2) Among 1140 CHE, the low cholinesterase (CHELow) group (n = 165) had worse survival (73.9%) compared to the high cholinesterase (CHEHigh) group (n = 975, 87.3%; p < 0.001). (3) In the TMN group, CHELow (n = 48) had worse survival (79.2%) than CHEHigh (n = 321, 91.3%; p = 0.008). …”
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Ferroptosis Transcriptional Regulation and Prognostic Impact in Medulloblastoma Subtypes Revealed by RNA-Seq by Christophe Desterke, Yuanji Fu, Jenny Bonifacio-Mundaca, Claudia Monge, Pascal Pineau, Jorge Mata-Garrido, Raquel Francés

“…Despite multimodal therapies achieving a response rate of 70% in children older than 3 years, treatment remains challenging. Ferroptosis, a form of regulated cell death, can be induced in medulloblastoma cells in vitro using erastin or RSL3. …”
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Spatial Correlates of Dementia and Disability After Intracerebral Hemorrhage by Yutong Chen, Cyprien A. Rivier, Samantha A. Mora, Victor Torres Lopez, Sam Payabvash, Kevin Sheth, Andreas Harloff, Guido J. Falcone, Jonathan Rosand, Ernst Mayerhofer, Christopher D. Anderson

“…Development of disability after ICH was linked to the right cerebral peduncle (mean HR, 3.10 [95% CI, 2.44–3.94]), right pallidum (mean HR, 2.96 [95% CI, 1.99–4.25]), and right posterior limb of the internal capsule (mean HR, 2.54 [95% CI, 1.88–3.96]). …”
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Evaluation of Perceptual Realism and Clinical Plausibility of AI-Generated Colon Polyp Images by Andrei-Constantin Ioanovici, Andrei-Marian Feier, Marius-Ștefan Mărușteri, Vasile Florin Popescu, Daniela-Ecaterina Dobru

“…<b>Materials and Methods:</b> A total of 32 Romanian gastroenterologists (18 residents and 14 seniors) reviewed 24 images (8 real, 8 augmented, 4 CycleGAN, and 4 diffusion) via an online form. Classification accuracy, 95% confidence intervals (CI), class sensitivity and precision, 3 × 3 confusion matrices, and Fleiss’ κ were calculated. …”
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Cell-bound complement activation products associate with lupus severity in SLE by Richard A Furie, Daniel J Wallace, Judith A James, Susan Manzi, Amit Saxena, Rosalind Ramsey-Goldman, Chaim Putterman, John Conklin, Anca Askanase, Jill P Buyon, Elena Massarotti, Roberta Vezza Alexander, Sonali Narain, Cristina Arriens, Kenneth C Kalunian, Christopher E Collins, Ghalib A Bello, Joseph Ahearn

“…Objectives To evaluate the association between lupus severity and cell-bound complement activation products (CB-CAPs) or low complement proteins C3 and C4.Methods All subjects (n=495) fulfilled the American College of Rheumatology (ACR) classification criteria for SLE. …”
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Perfil inflamatorio del humor acuoso tras tratamiento asistido por láser de femtosegundo en casos de catarata nuclear by Claudia Palacio-Pastrana, Andric C. Perez-Ortiz, Bani Antonio-Aguirre, Cristina Mendoza-Velásquez, Azyadeh Camacho-Ordóñez, Manuel Ceballos-Reyes, Atzin Robles-Contreras, Virgilio Lima-Gómez

“…Method: We performed a study of 67 eyes of 67 patients diagnosed with nuclear cataracts (lens opacity classification system III NO3) undergoing phacoemulsification. …”
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Patients With Mild ADPKD by Kidney Imaging but Low Estimated GFR by Seung Heyck Lee, Mauricio Miranda Cam, Taher Dehkharghanian, Fatemah Nasri, Saima Khowaja, Amirreza Haghighi, Xuewen Song, Korosh Khalili, York Pei

“…Mayo Clinic Imaging Classification (MCIC) based on age and HtTKV was used to assess cystic disease severity. …”
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Mechanisms sensitive to different drugs mediate a pro-adhesive and pro-thrombotic platelet phenotype in anti-phospholipid syndrome by Marina Camera, Marta Brambilla, Paola Adele Lonati, Alessia Becchetti, Claudia Grossi, Kevin Nallio, Arianna Da Via, Laura Trespidi, Maria Orietta Borghi, Francesco Tedesco, Pier Luigi Meroni

“…All patients had medium/high aPL levels with vascular/obstetric symptoms according to the 2023 ACR/EULAR classification. In vivo, we evaluated by flow-cytometry platelet activation markers [P-selectin, activated GPIIbIIIa (aGPIIbIII)], Tissue Factor (TF), ApoER2 and β2GPI expression and plateletmonocyte and-granulocyte aggregates (PMA and PGA)]. …”
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A two-step automatic identification of contrast phases for abdominal CT images based on residual networks by Qianhe Liu, Jiahui Jiang, Kewei Wu, Yan Zhang, Nan Sun, Jiawen Luo, Te Ba, Aiqing Lv, Chuane Liu, Yiyu Yin, Zhenghan Yang, Hui Xu

“…Results In the internal test set, the overall accuracy of the two-step strategy was 98.3% (283/288; p < 0.001), significantly higher than that of the one-step strategy (91.7%, 264/288; p < 0.001). …”
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Clinical characteristics, outcomes, and predictive modeling of patients diagnosed with immune checkpoint inhibitor therapy-related pneumonitis by Antonious Hazim, Irene Riestra Guiance, Jacob Shreve, Gordon Ruan, Damian McGlothlin, Allison LeMahieu, Robert Haemmerle, Keith Mcconn, Richard C. Godby, Lisa Kottschade, Anna Schwecke, Casey Fazer-Posorske, Tobias Peikert, Eric Edell, Konstantinos Leventakos, Ashley Egan

“…Median overall survival was 2.3 years (95% CI: 1.8, NR). A higher grade of ICI pneumonitis was associated with inferior survival (HR 5.85, 95% CI: 2.27, 15.09; p < 0.001). …”
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Comprehensive methodology for the integrating of the organic rankine Cycle-ORC with diesel generators in off-grid areas: Application to a Colombian case study by Ana Lisbeth Galindo Noguera, Luis Sebastian Mendoza Castellanos, Hernán Darío Pedraza-Corzo, Dimas José Rua, Electo Eduardo Silva Lora, Vladimir Rafael Melian Cobas

“…The cost of electricity generation decreased by 4.3%, with investment payback periods not exceeding 14 years.…”
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Body composition parameters in initial CT imaging of mechanically ventilated trauma patients: Single‐centre observational study by Hans‐Jonas Meyer, Tihomir Dermendzhiev, Michael Hetz, Georg Osterhoff, Christian Kleber, Timm Denecke, Jeanette Henkelmann, Robert Werdehausen, Gunther Hempel, Manuel F. Struck

“…After adjustment for statistically significant univariable predictors age, body mass index, sarcopenic obesity, visceral obesity, American Society of Anesthesiologists classification ≥3, injury severity score and Glasgow Coma Scale ≤ 8 points, the Cox proportional hazard model identified sarcopenia as significant prognostic factor of 30‐day mortality (hazard ratio 2.84; 95% confidence interval 1.38–5.85; P = 0.004), which was confirmed in Kaplan–Meier survival analysis (log‐rank P = 0.006). …”
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Rare malignant primary spinal chondrosarcoma: A case report by Ahmad Fitrah, MD, Btari Magistra Pancaputri, MD, Andreas Klemens Wienanda, MD, Atta Kuntara, MD, Abdul Kadir Hadar, MD, Muhammad Naseh Sajadi Budi Irawan, MD, Ahmad Ramdan, MD, Anglita Yantisetiasti, MD

“…Swelling and pain have been felt for approximately 3 years. The symptoms gradually worsened. On thoracolumbal X-ray a lytic sclerotic expansile lesion on the right posterior aspect of thoracal T5-T6. …”
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The predictive role of lung clearance index on FEV1 decline in cystic fibrosis by Beste Özsezen, Ebru Yalçın, Nagehan Emiralioğlu, Hande Konşuk Ünlü, Dilber Ademhan Tural, Canan Caka, Birce Sunman, Deniz Doğru, Ugur Özçelik, Nural Kiper

“…The LCI value for predicting ppFEV1 decline >3.7% at the end of one year was 8.2 (area under the curve: 0.80) Multivariable regression analysis showed that the absence of the F508del mutation in at least one allele, LCI >8.2 and initial FEV1 z-score were predictors of a ppFEV1 decline >3.7 (p<0.001). …”
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