Metabolic reprogramming in lung cancer and its clinical implication by Qingqiu Huang, Lisha Fan, Mingjing Gong, Juntong Ren, Chen Chen, Shenglong Xie

“…In this study, the latest studies on lung cancer tumor metabolism were reviewed, including the impact of metabolic products and metabolic enzymes on the occurrence and development of lung cancer, as well as the progress in the field of lung cancer treatment targeting relevant metabolic pathways. …”
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Reprogramming of Thyroid Cancer Metabolism: from Mechanism to Therapeutic Strategy by Yuxuan Wan, Guoqing Li, Gaoyuan Cui, Saili Duan, Shi Chang

“…And metabolism-based therapies have advanced rapidly, for the exclusive metabolic profiling of thyroid cancer. In thyroid cancer cells, plenty of metabolic pathways are reprogrammed to accommodate tumor microenvironment. …”
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Interactions between the metabolic reprogramming of liver cancer and tumor microenvironment by Haoqiang Yang, Jinghui Li, Yiting Niu, Tao Zhou, Pengyu Zhang, Yang Liu, Yanjun Li, Yanjun Li

“…Metabolic reprogramming is one of the major biological features of malignant tumors, playing a crucial role in the initiation and progression of cancer. …”
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Epigenetic Reprogramming by Decitabine in Retinoblastoma by Lisa Gherardini, Ankush Sharma, Monia Taranta, Caterina Cinti

“…Introduction: Retinoblastoma (Rb) is a rare cancer, yet it is the most common eye tumor in children. …”
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Obesity reprograms the normal pancreas and pancreatic cancer microbiome in mice and humans by Raquel Santana da Cruz, Shravanthy Suguru, Sara P. C. Paiva, Ijeoma Nwugwo, Bhaskar Kallakury, Benjamin A. Weinberg, Katherine L. Cook, Sonia de Assis

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Alpha-linolenic acid-mediated epigenetic reprogramming of cervical cancer cell lines by Amrita Ulhe, Prerna Raina, Amol Chaudhary, Ruchika Kaul-Ghanekar

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Reprogramming of Glucose Metabolism by Nanocarriers to Improve Cancer Immunotherapy: Recent Advances and Applications by Jiang K, Liu H, Chen X, Wang Z, Wang X, Gu X, Tong Y, Ba X, He Y, Wu J, Deng W, Wang Q, Tang K

“…Finally, we discuss the limitations and future prospects of nanotechnology targeting glucose metabolism therapy, hoping to provide new directions and ideas to improve cancer immunotherapy. Keywords: nanoparticles, glycolysis, lactate metabolism, cancer immunotherapy, tumor microenvironment…”
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THEM6‐mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer by Arnaud Blomme, Coralie Peter, Ernest Mui, Giovanny Rodriguez Blanco, Ning An, Louise M Mason, Lauren E Jamieson, Grace H McGregor, Sergio Lilla, Chara Ntala, Rachana Patel, Marc Thiry, Sonia H Y Kung, Marine Leclercq, Catriona A Ford, Linda K Rushworth, David J McGarry, Susan Mason, Peter Repiscak, Colin Nixon, Mark J Salji, Elke Markert, Gillian M MacKay, Jurre J Kamphorst, Duncan Graham, Karen Faulds, Ladan Fazli, Martin E Gleave, Edward Avezov, Joanne Edwards, Huabing Yin, David Sumpton, Karen Blyth, Pierre Close, Daniel J Murphy, Sara Zanivan, Hing Y Leung

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Systemic mRNA aggregates elicit immunologic reprogramming that unlocks anti-cancer immunity by Hector R. Mendez-Gomez, John A. Ligon, Ashley P. Ghiaseddin, Elias J. Sayour

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Unravelling the Adiponectin Hallmark and Exploring the Therapeutic Potential of Its Receptor Agonists in Cancer Metabolic Reprogramming by Sanober Kafeel, Giuseppina Palmiero, Alessia Salzillo, Angela Ragone, Silvio Naviglio, Luigi Sapio

“…This review aimed at recapitulating the modulatory effects of adiponectin, as well as those of its synthetic receptor agonists, in driving metabolic alterations in cancerous cells. …”
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Ginsenoside 20(S)-Rg3 upregulates SQLE to reprogram cholesterol metabolism of ovarian cancer cells by Fang He, Yuanyuan Zhou, Jing Fu, ShiXue Chang, Xi Cui, Zhaozu Feng, Le Zhao, Xu Li

“…Summary: Ginsenoside 20(S)-Rg3 exhibits the anti-ovarian cancer activity by modulating aerobic glycolysis, but its role in reprogramming sterol metabolism remains unclear. …”
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The Mechanism and Dynamic Regulation of Epithelial to Mesenchymal Transition in Ovarian Cancer by Pande Kadek Aditya Prayudi, I Gde Sastra Winata, I Nyoman Bayu Mahendra, I Nyoman Gede Budiana, Kade Yudi Saspriyana, Ketut Suwiyoga

“…Cellular or non-cellular component of TME, external factors related to TME such as hypoxia, oxidative stress, mechanical forces, as well as exposure to chemotherapy, all play significant role to EMT induction. …”
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NSUN2 promotes colorectal cancer progression by stabilizing PHGDH mRNA to promote serine metabolism reprogramming by Hao Li, Tingyue Gong, Yongheng Zhao, Yang Luo, Shuibin Tang, Tingfeng Wang, Haiping Lin, Ming Zhong

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G-quadruplex structures regulate long-range transcriptional reprogramming to promote drug resistance in ovarian cancer cells by Jenna Robinson, Gem Flint, Ian Garner, Silvia Galli, Thomas E. Maher, Marina K. Kuimova, Ramon Vilar, Iain A. McNeish, Robert Brown, Hector Keun, Marco Di Antonio

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Immunosuppressive mechanisms and therapeutic targeting of regulatory T cells in ovarian cancer by Jing Li, Haojun Huang, Renxian Xie, Rongying Yang, Haitao Wang, Li Wan

“…This review synthesizes recent advances in understanding how the ovarian TME shapes Treg biology, highlighting mechanisms such as cytokine signaling, chemokine-driven recruitment, metabolic reprogramming, and immune checkpoint interactions, as well as the phenotypic and functional heterogeneity of tumor-infiltrating Tregs, including tissue-resident and follicular subsets, and their clonal expansion in response to tumor antigens. …”
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Lactylation-mediated miRNA regulation in cancer therapy resistance by Yiyi Shou, Ruiqi Liu, Hao Xiong, Xiaoyan Chen, Luanluan Huang, Ran Huang, Hailong Sheng, Haibo Zhang, Yanwei Lu, Haiwei Guo

“…Abstract Therapeutic resistance in cancer is increasingly understood as a dynamic outcome of the interplay among tumour metabolism, epigenetic regulation, and immune modulation, rather than a consequence of genetic mutations alone. …”
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Urea cycle dysregulation: a new frontier in cancer metabolism and immune evasion by Yiyi Shou, Ruiqi Liu, Hao Xiong, Keke Xu, Xiaoyan Chen, Luanluan Huang, Yitian Zhang, Hailong Sheng, Haibo Zhang, Yanwei Lu

“…Abstract Cancer cells experience metabolic reprogramming to enhance the synthesis of nitrogen and carbon, facilitating the production of macromolecules essential for tumor proliferation and growth. …”
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Reprogramming of hsa_circ_0008719 and its target miR-3615 induced by TOB1 in exosomes of gastric cancer cells: a contribution to inhibit gastric cancer progression by Na Qian, Tongtong Huang, Lulu Zhang, Li Zhang, Lijie Zhou, Dong Wang, Xiao Liang, Songbin Fu, Yingwei Xue, Jingcui Yu

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Sialylated IgG expressed in triple-negative breast cancer cells promotes cancer progression by promoting glycolysis by Chenyang Hu, Shenghua Zhang, Fugang Duan, Xinmei Huang, Jing Huang, Zhu Zhu, Xiaoning Mo, Weiyan Xu, Lina Wu, Zhimin Fan, Xiaoyan Qiu

“…Abstract Background Triple-negative breast cancer (TNBC) is among the most aggressive and lethal subtypes of breast cancer. …”
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Advances in MicroRNA-Mediated Reprogramming Technology by Chih-Hao Kuo, Shao-Yao Ying

“…MicroRNAs (miRNAs) have gained much attention over the past few years due to their pivotal role in many biological activites, including metabolism, host immunity, and cancer. Soon after the discovery of embryonic-stem-cell- (ESC-) specific miRNAs, researchers began to investigate their functions in embryonic development and differentiation, as well as their potential roles in somatic cell reprogramming (SCR). …”
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