Metabolic expression profiling analysis reveals pyruvate-mediated EPHB2 upregulation promotes lymphatic metastasis in head and neck squamous cell carcinomas by Jingjing Miao, Boyu Chen, Lu Zhang, Zhongming Lu, Rui Wang, Chunyang Wang, Xingyu Jiang, Qi Shen, Yue Li, Dongni Shi, Ying Ouyang, Xiangfu Chen, Xiaowu Deng, Siyi Zhang, Hequn Zou, Shuwei Chen

“…Abstract Lymphatic metastasis is a well-known factor for initiating distant metastasis of head and neck squamous cell carcinoma (HNSCC), which caused major death in most patients with cancer. …”
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Single-cell sequencing and machine learning reveal the role of dioxin-interacting genes in HCC prognosis and immune microenvironment by Senyan Wang, Qi Liu, Xiaoyan Sun, Minghui Hou, Wenjuan Wei, Hao Song, Jing Xu, Danyang Lu, Jing Fu, Xiaofang Zhao, Hongyang Wang

“…Although the carcinogenic potential of dioxins is well recognized, the molecular mechanisms driving hepatocellular carcinoma (HCC) development remain poorly understood. …”
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CYP51A1 in health and disease: from sterol metabolism to regulated cell death by Fangquan Chen, RuiRui Liang, Jieting Zhang, Rui Kang, Daolin Tang, Jiao Liu

“…Moreover, dysregulation of CYP51A1 has been implicated in a wide spectrum of diseases, such as cancer, cataracts, Antley-Bixler syndrome, autoimmune disorders, metabolic liver disease and neurodegeneration. …”
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Unravelling Shared Pathways Linking Metabolic Syndrome, Mild Cognitive Impairment, Dementia, and Sarcopenia by Daniela Ceccarelli Ceccarelli, Sebastiano Bruno Solerte

“…In AD, β-amyloid accumulation and hyperphosphorylated tau in neurofibrillary tangles can cause metabolic reprogramming in brain cells, shifting from oxidative phosphorylation to aerobic glycolysis, similar to the Warburg effect in cancer. …”
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A lncRNA-mediated metabolic rewiring of cell senescence by Elena Grossi, Francesco P. Marchese, Jovanna González, Enrique Goñi, José Miguel Fernández-Justel, Alicia Amadoz, Nicolás Herranz, Leonor Puchades-Carrasco, Marta Montes, Maite Huarte

“…However, the mechanisms behind this metabolic reprogramming are not well understood. We identify senescence-induced long noncoding RNA (sin-lncRNA), a previously uncharacterized long noncoding RNA (lncRNA), a key player in this response. …”
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The genetic interaction map of the human solute carrier superfamily by Gernot Wolf, Philipp Leippe, Svenja Onstein, Ulrich Goldmann, Fabian Frommelt, Shao Thing Teoh, Enrico Girardi, Tabea Wiedmer, Giulio Superti-Furga

“…Further exploration of an interaction between the mitochondrial citrate/malate exchanger SLC25A1 and the zinc transporter SLC39A1 revealed an unexpected role for SLC39A1 in metabolic reprogramming and anti-apoptotic signaling. This full-scale genetic interaction map of human SLC transporters is the backbone for understanding the intricate functional network of SLCs in cellular systems and generates hypotheses for pharmacological target exploitation in cancer and other diseases. …”
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The C/EBPβ antagonist peptide lucicebtide (ST101) induces macrophage polarization toward a pro-inflammatory phenotype and enhances anti-tumor immune responses by Claudio Scuoppo, Rick Ramirez, Siok F. Leong, Mark Koester, Zachary F. Mattes, Karen Mendelson, Julia Diehl, Franco Abbate, Erin Gallagher, Lila Ghamsari, Abi Vainstein-Haras, Gene Merutka, Barry J. Kappel, Jim A. Rotolo

“…Lucicebtide synergizes with anti-PD-1 therapy and overcomes resistance to checkpoint inhibition in anti-PD-1-refractory tumors, but in vivo responses are impaired by systemic macrophage depletion, indicating that macrophage reprogramming is integral to lucicebtide activity. These results identify lucicebtide as a novel immunomodulator that reprograms immunosuppressive macrophage populations to enhance anti-tumor activity and suggests its utility for combination strategies in cancers with poor response to ICIs.…”
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SLC25A35 enhances fatty acid oxidation and mitochondrial biogenesis to promote the carcinogenesis and progression of hepatocellular carcinoma by upregulating PGC-1α by Heng-Chao Yu, Lu Bai, Liang Jin, Yu-Jia Zhang, Zi-Han Xi, De-Sheng Wang

“…However, the role of SLC25A35 in mitochondrial metabolism reprogramming, development and progression in human cancers remains unclear. …”
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P4HA1 mediates YAP hydroxylation and accelerates collagen synthesis in temozolomide-resistant glioblastoma by Xueru Li, Gangfeng Yu, Xiao Zhong, Jiacheng Zhong, Xiangyu Chen, Qinglong Chen, Jinjiang Xue, Xi Yang, Xinchun Zhang, Yao Ling, Yun Xiu, Yaqi Deng, Hongda Li, Wei Mo, Yong Zhu, Ting Zhang, Liangjun Qiao, Song Chen, Fanghui Lu, Xuehong Zhang

“…Collagen remodeling has been shown to be a critical factor for therapy resistance in other cancers. This study aimed to investigate the mechanism of TMZ chemoresistance by GBM cells reprogramming collagens. …”
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Peroxisomal core structures segregate diverse metabolic pathways by Nils Bäcker, Julia Ast, Domenica Martorana, Christian Renicke, Jil Berger, Cristopher-Nils Mais, Marvin Christ, Thorsten Stehlik, Thomas Heimerl, Valentin Wernet, Christof Taxis, Jan Pané-Farré, Michael Bölker, Judith M. Klatt, Björn Sandrock, Kay Oliver Schink, Gert Bange, Johannes Freitag

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Untargeted Metabolomics Reveals Dysregulation of Glycine- and Serine-Coupled Metabolic Pathways in an ALDH1L1-Dependent Manner In Vivo by Grace Fu, Sabrina Molina, Sergey A. Krupenko, Susan Sumner, Blake R. Rushing

“…Serine and glycine play crucial roles in pathways linked to cancer initiation and progression, including one-carbon metabolism. …”
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Novel and Highly Potent Therapeutic Agent, Trametes Robiniophila Murr (Huaier), Mitigates Pulmonary Vascular Remodeling in Rodents by Huangshu Ye, Yue Zhang, Li Hu, Yuxin Feng, Tianfan Zhu, Qi Meng, Xiaoxuan Sun, Miaojia Zhang, Zhengsheng Mao, Feng Chen, Yanfang Yu, Qiang Wang, Jie Wang

“…Trametes robiniophila Murr (Huaier), a traditional Chinese medicine, inhibits cancer cell proliferation. Importantly, the aberrant proliferation of pulmonary artery smooth muscle cells (PASMCs) is a key contributor to increased pulmonary vascular resistance in PH. …”
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Bioengineering a Human Dermal Equivalent Using Induced Pluripotent Stem Cell-Derived Fibroblasts to Support the Formation of a Full-Thickness Skin Construct by Lucy Smith, David Bunton, Michael Finch, Stefan Przyborski

“…Pluripotent stem cell-derived populations offer a consistent supply, as well as the ability to model disease phenotypes through cell reprogramming using patient-derived cells. …”
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Identification of glycolysis-related gene signatures for prognosis and therapeutic targeting in idiopathic pulmonary fibrosis by Han Gao, Zhongyi Sun, Xingxing Hu, Weiwei Song, Yuan Liu, Menglin Zou, Menglin Zou, Minghui Zhu, Zhenshun Cheng, Zhenshun Cheng, Zhenshun Cheng

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Targeting myeloid cells for hematological malignancies: the present and future by Zihui Guan, Zhengqi Zhang, Kaiyan Wang, Shukai Qiao, Teng Ma, Lina Wu

“…Furthermore, we highlight emerging therapeutic approaches targeting myeloid cells, focusing on strategies to reprogram their functions, inhibit their suppressive effects, or eliminate pathological populations altogether, as well as the latest preclinical and clinical trials advancing these approaches. …”
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Dialog between mantle cell lymphoma cells and lymphoma-associated macrophages underlies ibrutinib resistance by Xiaoqing Sun, Caiqin Wang, Jianghua Cao, Jing Li, Gang Ma, Xianqiu Wu, Peng Sun, Yu Wang, Jiajia Huang, Robert Peter Gale, Zhiming Li

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Bispecific Antibody Targeting VEGF/TGF‐β Synergizes with Local Radiotherapy: Turning Tumors from Cold to Inflamed and Amplifying Abscopal Effects by Lijuan Lyu, Ming Yi, Ji Chen, Jing Zhang, Xiaobin Ma, Xiaojun Zhang, Liang Zeng, Yan Xue, Haimei Wen, Yujiao Deng, Pengfei Zhou, Kongming Wu, Huafeng Kang, Zhijun Dai

“…Abstract Beyond inherently killing cancer cells by directly inducing double‐strand DNA breaks, local radiotherapy (RT) can exert immune‐priming effects and reprogram the tumor microenvironment (TME) from immune‐cold tumors into inflamed, or “hot” tumors. …”
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siRNA micelleplexes-mediated glutamine metabolism re-engineering for vascular normalization-boosted photo-immunotherapy by Yunfei Yi, Zhangwen Peng, Yuanqi Liu, Huisong Hao, Liu Yu, Simin Wen, Shengjie Sun, Jianlin Shi, Meiying Wu, Lin Mei

“…This study provides a unique perspective on cancer treatments by focusing on the interrelations of metabolic characteristics and the biofunctions of various cell types within TME.…”
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Neural Differentiation of Human Pluripotent Stem Cells for Nontherapeutic Applications: Toxicology, Pharmacology, and In Vitro Disease Modeling by May Shin Yap, Kavitha R. Nathan, Yin Yeo, Lee Wei Lim, Chit Laa Poh, Mark Richards, Wei Ling Lim, Iekhsan Othman, Boon Chin Heng

“…In addition to the well-known potential therapeutic application of these cells in regenerative medicine, these are also various promising nontherapeutic applications in toxicological and pharmacological screening of neuroactive compounds, as well as for in vitro modeling of neurodegenerative and neurodevelopmental disorders. …”
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