Hypoxic Upregulation of IER2 Increases Paracrine GMFG Signaling of Endoplasmic Reticulum Stress‐CAF to Promote Chordoma Progression via Targeting ITGB1 by Tao‐Lan Zhang, Bo‐Wen Zheng, Chao Xia, Peng‐Fei Wu, Bo‐Yv Zheng, Ling‐Xiang Jiang, Jing Li, Guo‐Hua Lv, Hong Zhou, Wei Huang, Ming‐Xiang Zou

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Exploring the role of ELOVLs family in lung adenocarcinoma based on bioinformatic analysis and experimental validation by Zihan Wang, Wenjing Cui, Long Liang, Jingge Qu, Yuqiang Pei, Danyang Li, Ying Luo, Yue Zhang, Yifan Qiu, Yongchang Sun

“…Abstract Background The role of lipid metabolic reprogramming in the development of various types of cancer has already been established. …”
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Mutually exclusive teams-like patterns of gene regulation characterize phenotypic heterogeneity along the noradrenergic-mesenchymal axis in neuroblastoma by Manas Sehgal, Sonali Priyadarshini Nayak, Sarthak Sahoo, Jason A Somarelli, Mohit Kumar Jolly

“…We observed that NOR-specific and MES-specific expression patterns are largely mutually exclusive, exhibiting a “teams-like” behavior among the genes involved, reminiscent of our earlier observations in lung cancer and melanoma. This antagonism between NOR and MES phenotypes was also associated with metabolic reprogramming and with immunotherapy targets PD-L1 and GD2 as well as with experimental perturbations driving the NOR-MES and/or MES-NOR transition. …”
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YAP enhances mitochondrial OXPHOS in tumor-infiltrating Treg through upregulating Lars2 on stiff matrix by Hui Li, Yuan Yao, Yang Qu, Yihan Xu, Peng Jin, Yuhan Zhang, Liling Niu, Jingchao Bai, Meinan Yan, Youhui Wang

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mTOR inhibition modulates vaccine-induced immune responses to generate memory T cells in patients with solid tumors by Li Yan, Nina Bhardwaj, Tibor Keler, Kunle Odunsi, Song Liu, Junko Matsuzaki, Takemasa Tsuji, Mark Long, Thinle Chodon, Emese Zsiros, Protul Shrikant, Jianming Wang, Alan Hutson, Stephanie Blank, Amit Lugade, Richard Koya, Spencer R Rosario, Henry G Withers, Shashikant B Lele

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Bone marrow microenvironment in myelodysplastic neoplasms: insights into pathogenesis, biomarkers, and therapeutic targets by Forouzan Bahmani, Maryam Shayanmanesh, Mahdi Safari, Amirarsalan Alaei, Yasaman Pouriafar, Zahra Rasti, Farhad Zaker, Shahrbano Rostami, Fatemeh Damerchiloo, Majid Safa

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Glioblastoma metabolomics: uncovering biomarkers for diagnosis, prognosis and targeted therapy by Susan Costantini, Elena Di Gennaro, Giulia Fanelli, Palmina Bagnara, Chiara Argenziano, Carmen Maccanico, Marco G. Paggi, Alfredo Budillon, Claudia Abbruzzese

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LRP11 promotes stem-like T cells via MAPK13-mediated TCF1 phosphorylation, enhancing anti-PD1 immunotherapy by Zhishui Chen, Gang Chen, Li Chen, Xiangli Zhao, Lingjuan Sun, Zhibo Ma, Xiaosheng Tan, Yuhao Tu, Jingzeng Wang, Peixiang Lan

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HDL-cholesterol confers sensitivity of immunotherapy in nasopharyngeal carcinoma via remodeling tumor-associated macrophages towards the M1 phenotype by Yan Huang, Li Zhang, Ting Yang, Hongyun Zhao, Yunpeng Yang, Ting Zhou, Jianhua Zhan, Xue Bai, Fan Luo, Qun Chen, Wenjuan Ma, Jiaxin Cao, Lusha Liu, Chaozhuo Lin

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Initial dose of oncolytic myxoma virus programs durable antitumor immunity independent of in vivo viral replication by Eric Bartee, Erica B Flores, Bulent A Aksoy

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PSMB10 maintains the stemness of chemotherapeutic drug-resistant leukemia cells by inhibiting senescence and cytotoxic T lymphocyte-mediated killing in a ubiquitinated degradation... by Xiao Ma, Yingnan Li, Di Wang, Jialan Niu, Qian Li, Ying Chen, Mengyuan Wang, Jin Wen, Chenxi Liao, Nan Wang, Xiaolan Zhang, Jiwei Chang, Jiayi Yang, Lei Li, Jing Zou, Danyue Peng, Lingbo Liu

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Enhanced lipid biosynthesis in human tumor-induced macrophages contributes to their protumoral characteristics by Mihai G Netea, Katrin Rabold, Gosse J Adema, Anna Aschenbrenner, Christoph Thiele, Collins K Boahen, Alexander Schiltmans, Johannes W A Smit, Joachim L Schultze, Romana T Netea-Maier

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Single-cell transcriptomic analysis reveals gut microbiota-immunotherapy synergy through modulating tumor microenvironment by Minyuan Cao, Yun Deng, Qing Hao, Huayun Yan, Quan-Lin Wang, Chunyan Dong, Jing Wu, Yajiao He, Li-Bin Huang, Xuyang Xia, Yongchao Gao, Hai-Ning Chen, Wei-Han Zhang, Yan-Jing Zhang, Xiaozhen Zhuo, Lunzhi Dai, Hongbo Hu, Yong Peng, Feng Zhang, Zhaoqian Liu, Weihua Huang, Huiyuan Zhang, Li Yang, Yang Shu, Wei Zhang, Yan Zhang, Heng Xu

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Epithelial-mesenchymal transition orchestrates tumor microenvironment: current perceptions and challenges by Yuqi Xie, Xuan Wang, Wenquan Wang, Ning Pu, Liang Liu

“…This review discusses the mechanisms by which EMT coordinates TME dynamics, including secretion of soluble factors, direct cell contact, release of exosomes and enzymes, as well as metabolic reprogramming. Recent evidence also indicates that cells undergoing EMT may differentiate into cancer-associated fibroblasts, thereby establishing themselves as functional constituents of the TME. …”
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Autocrine INSL5 promotes tumor progression and glycolysis via activation of STAT5 signaling by Shi‐Bing Li, Yan‐Yan Liu, Li Yuan, Ming‐Fang Ji, Ao Zhang, Hui‐Yu Li, Lin‐Quan Tang, Shuo‐Gui Fang, Hua Zhang, Shan Xing, Man‐Zhi Li, Qian Zhong, Shao‐Jun Lin, Wan‐Li Liu, Peng Huang, Yi‐Xin Zeng, Yu‐Ming Zheng, Zhi‐Qiang Ling, Jian‐Hua Sui, Mu‐Sheng Zeng

“…In conclusion, INSL5 enhances NPC progression by regulating cancer cell metabolic reprogramming and is a potential diagnostic and prognostic marker as well as a therapeutic target for NPC.…”
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A high throughput assay for phosphoribosylformylglycinamidine synthase by Nandini Sharma, Yuka Otsuka, Louis Scampavia, Timothy P. Spicer, Jarrod B. French

“…Metabolic reprogramming of purine biosynthesis is a hallmark of cancer metabolism and represents a critical vulnerability. …”
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Mesothelin-directed protein-drug conjugates for mesothelin-low solid tumor therapy by Ying Wang, Jiayao Yan, Lin Li, Tianran Chen, Jingyi Guo, Lei Lei, Siwen Wu, Lijing Zhu, Xiaotong Chen, Baorui Liu

“…Notably, M7GA-DC demonstrates enhanced tumor control and improved survival benefits in pancreatic cancer models with limited MSLN expression. Combination therapy with PD-1 blockade further promotes long-term immunological memory formation by activation of dendritic cells and reprogramming of the tumor microenvironment. …”
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Therapeutic potential of tumor-associated neutrophils: dual role and phenotypic plasticity by Yanting Zhou, Guobo Shen, Xikun Zhou, Jing Li

“…The discussion on promising therapy encompasses five key areas: inhibition of the tumor-promoting effect of TANs, enhancement of the antitumor effect of TANs, targeting the interaction between TANs and the TME, reprogramming of TANs, and drug delivery carriers. Finally, we discuss the potential of TANs and their related markers as emerging biomarkers for predicting the prognosis of cancer patients.…”
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Redox regulation: mechanisms, biology and therapeutic targets in diseases by Bowen Li, Hui Ming, Siyuan Qin, Edouard C. Nice, Jingsi Dong, Zhongyan Du, Canhua Huang

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Spatial protein redistribution: wandering but not lost by Faiza Amterat Abu Abayed, Laila Abu Madegam, Ayelet Gilad, Gal Twito, Suad Sheikh Suliman, Suma Biadsy, Aeid Igbaria

“…This dynamic aspect of proteostasis allows proteins to acquire novel functions based on their subcellular localization, enabling the cell to adapt to both physiological and pathological challenges. Such spatial reprogramming is especially pronounced under stress conditions, including those associated with cancer, neurodegenerative diseases and viral infection, where widespread remodeling of the proteome facilitates survival and adaptation. …”
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