Epigenomic preconditioning of peripheral monocytes determines their transcriptional response to the tumor microenvironment by Máté Kiss, Laszlo Halasz, Eva Hadadi, Wilhelm K. Berger, Petros Tzerpos, Szilard Poliska, Daliya Kancheva, Aurélie Gabriel, Romina Mora Barthelmess, Ayla Debraekeleer, Jan Brughmans, Yvon Elkrim, Liesbet Martens, Yvan Saeys, Bence Daniel, Zsolt Czimmerer, Damya Laoui, Laszlo Nagy, Jo A. Van Ginderachter

“…Abstract Background Monocytes are recruited to tumors and undergo transcriptional reprogramming resulting in tumor-promoting functions. …”
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Remodeling tumor immunosuppressive microenvironment through dual activation of immunogenic panoptosis and ferroptosis by H2S-amplified nanoformulation to enhance cancer immunothera... by Yingli Luo, Maoyuan Linghu, Xianyu Luo, Dongdong Li, Jilong Wang, Shaojun Peng, Yinchu Ma

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Sphingosine-1-phosphate stimulates colorectal cancer tumor microenvironment angiogenesis and induces macrophage polarization via macrophage migration inhibitory factor by Fang Wu, Zhaode Feng, Xuan Wang, Yingcong Guo, Bingcong Wu, Shuheng Bai, Ning Lan, Min Chen, Juan Ren

“…BackgroundColorectal cancer (CRC) is the most common gastrointestinal malignancy with extensive reprogramming of sphingolipid metabolism. …”
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Cancer stem cells and tumor-associated macrophages as mates in tumor progression: mechanisms of crosstalk and advanced bioinformatic tools to dissect their phenotypes and interacti... by Francesco Verona, Sebastiano Di Bella, Roberto Schirano, Camilla Manfredi, Francesca Angeloro, Giulia Bozzari, Matilde Todaro, Matilde Todaro, Giuseppe Giannini, Giuseppe Giannini, Giorgio Stassi, Veronica Veschi

“…On the other hand, CSCs exhibited their capacity to influence immune cells, creating a favorable microenvironment for cancer progression. Interestingly, the bidirectional influence of CSCs and TME leads to an epigenetic reprogramming which sustains malignant transformation. …”
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NLRP12 decreases TRIM25-mediated HK2 degradation to promote glycolysis and H3K18la in gastric cancer by Linsen Zhou, Zhiqiang Wang, Yang Huang, Xinyi Zhang, Haohai Jiang, Zhiyuan Guo, Guangjun Zhou, Haofeng Liu

“…The present study revealed that NLRP12 was highly expressed in gastric cancer tissues and cells, as well as positively correlated with poor patient prognosis and survival. …”
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Latency, microenvironment, and the priming of a precancerous senescent cell for malignant transformation by April Kirkendoll

“…This report reexamines existing data to provide insights into the conditions necessary to prime a relatively benign and latent cell with malignant potential to respond to a stimulus and transform into cancer. I propose that normal, well-established reactions to cellular insults over time induce conditions within the affected cell which predispose it to malignant transformation. …”
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Enhancing radiotherapy-induced anti-tumor immunity via nanoparticle-mediated STING agonist synergy by Qian Zeng, Min Liu, Ziqi Wang, Rongrong Zhou, Kelong Ai

“…Abstract Radiotherapy (RT) remains a cornerstone treatment for over 50% of cancer patients, primarily via ionizing radiation-induced DNA damage to exert therapeutic effects. …”
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Aristolochic acid I orchestrates multi-organ carcinogenesis through apoptotic pathway in bladder, kidney, and liver cancers: a multi-omics dissection by Bitian Zhang, Ping-Chung Leung, Chun-Kwok Wong, Dongjie Wang

“…Abstract Aristolochic acid I (AA-I), a naturally occurring compound derived from plants of the genus Aristolochia, is a well-documented nephrotoxin and carcinogen linked to bladder (BLCA), kidney (KIRC), and liver (LIHC) cancers. …”
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Vagus nerve stimulation: Novel concept for the treatment of glioblastoma and solid cancers by cytokine (interleukin-6) reduction, attenuating the SASP, enhancing tumor immunity by Steven Brem

“…Immuno-oncology, specifically immune checkpoint inhibitors (ICIs), has revolutionized cancer care with dramatic, long-term responses and increased survival, including patients with metastatic cancer to the brain. …”
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Targeting myeloid cells in pancreatic ductal adenocarcinoma: from primary tumors to liver metastasis by Ruining Gong, Ying Chen, Chang Li, Huan Zhang, Zimin Liu, Qian Yu

“…Checkpoint-based immunotherapy has largely been ineffective for most pancreatic cancer patients. This ineffectiveness is not well understood, as clinical trials often involve patients with advanced diseases, such as liver and peritoneal metastases, while most preclinical studies focus on primary tumors. …”
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DLAT is involved in ovarian cancer progression by modulating lipid metabolism through the JAK2/STAT5A/SREBP1 signaling pathway by Hui Wang, Shen Luo, Yue Yin, Yang Liu, Xiaomei Sun, Ling Qiu, Xin Wu

“…Abstract Background Ovarian cancer (OC) remains a lethal gynecological malignancy with an alarming mortality rate, primarily attributed to delayed diagnosis and a lack of effective treatment modalities. …”
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The context-dependent epigenetic and organogenesis programs determine 3D vs. 2D cellular fitness of MYC-driven murine liver cancer cells by Jie Fang, Shivendra Singh, Brennan Wells, Qiong Wu, Hongjian Jin, Laura J Janke, Shibiao Wan, Jacob A Steele, Jon P Connelly, Andrew J Murphy, Ruoning Wang, Andrew Davidoff, Margaret Ashcroft, Shondra M Pruett-Miller, Jun Yang

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Single-Cell and Single-Nuclei transcriptomics profiling reveals dynamic cellular features in tumor-related adipose microenvironment of breast cancer patients with high BMI by Xiaoxiao Hu, Fang Jia, Lili Li, Wuzhen Chen, Leyi Zhang, Jun Pan, Sangsang Zhu, Zhen Wang, Jian Huang

“…Objectives: High body mass index (BMI), encompassing overweight and obesity, is a well-established risk factor for developing breast cancer (BC). …”
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Immunocytes in the tumor microenvironment: recent updates and interconnections by Jiyao Yu, Jiyao Yu, Li Fu, Li Fu, Rui Wu, Rui Wu, Linyi Che, Linyi Che, Guodong Liu, Qinwen Ran, Zhiwei Xia, Xisong Liang, Xisong Liang, Guanjian Zhao

“…By integrating recent molecular insights and clinical advancements, the review underscores the importance of deciphering the interplay between immunocytes and the TME to develop more effective cancer immunotherapies.…”
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Fibroblast Growth Factor Receptor 4 Promotes Triple‐Negative Breast Cancer Progression via Regulating Fatty Acid Metabolism Through the AKT/RYR2 Signaling by Jinhui Ye, Song Wu, Qiang Quan, Feng Ye, Jinhui Zhang, Cailu Song, Yidan Fan, Huijiao Cao, Hailin Tang, Jianfu Zhao

“…Additionally, Oil Red O staining, fatty acid metabolite detection, and Western blot analysis were used to investigate the impact of FGFR4 and its inhibitor fisogatinib, as well as the AKT activator SC79, on the metabolic reprogramming of fatty acids in TNBC cells. …”
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FNDC5 and ACOX1 as Biomarkers of Peroxisomal Activity with Contrast Outcomes in Colon Adenocarcinoma by Yuan Hepei, Zeng Jun, Khan Muhammad, Wang Baiyao, Hu Xiaoshan, Wei Hao, Wang Zhaotong, Yuan Yawei

“…Abstract Background Colorectal cancer progression and immune evasion are closely linked to mitochondrial and peroxisomal metabolic reprogramming, yet the role of peroxisomes remains underexplored. …”
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Pathogenic Mechanisms of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)-Associated Hepatocellular Carcinoma by Toru Nakamura, Atsutaka Masuda, Dan Nakano, Keisuke Amano, Tomoya Sano, Masahito Nakano, Takumi Kawaguchi

“…Hepatocellular carcinoma (HCC) is the sixth most common cancer and the third leading cause of cancer deaths worldwide. …”
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The significance of miR-142 in tumor progression of diffuse large B-cell lymphoma by E. N. Voropaeva, O. B. Seregina, M. S. Voytko, T. N. Babaeva, N. V. Skvortsova, V. N. Maksimov, T. I. Pospelova

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Integration of Untargeted Metabolomics, Network Pharmacology, Single-Cell RNA Sequencing, and Molecular Dynamics Simulation Reveals GOT1, CYP1A2, and CA2 as Potential Targets of Hu... by Tiegang Li, Zheng Yan, Mingxuan Zhou, Wenyi Zhao, Fang Zhang, Silin Lv, Yufang Hou, Zifan Zeng, Liu Yang, Yixin Zhou, Zengni Zhu, Xinyi Ren, Min Yang

“…<b>Background:</b> Huang Qin Decoction (HQD) is a well-established Traditional Chinese Medicine (TCM) formulation recognized for its application in the treatment of colorectal cancer (CRC). …”
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Integrated transcriptomics and machine learning reveal REN as a dual regulator of tumor stemness and NK cell evasion in Wilms tumor progression by Qingfei Cao, Junyi Li, Yunfei Zou, Changwen Xu, Huihui Tang, Meixue Chen

“…IntroductionWilms tumor (WT) is the most common pediatric kidney cancer, which presents significant therapeutic challenges, particularly in high-risk cases, due to chemotherapy resistance and immunosuppressive tumor microenvironments (TMEs). …”
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