Harnessing the Power of Nanocarriers to Exploit the Tumor Microenvironment for Enhanced Cancer Therapy by Bandar Aldhubiab, Rashed M. Almuqbil, Anroop B. Nair

“…The tumor microenvironment (TME) has a major role in malignancy and its complex nature can mediate tumor survival, metastasis, immune evasion, and drug resistance. Thus, reprogramming or regulating the immunosuppressive TME has a significant contribution to make in cancer therapy. …”
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Combination of potassium oxonate with anti-PD-1 for the treatment of colorectal cancer by Yuanyuan Wang, Chenxi Hu, Tianpeng Du, Jiawen Li, Kaiyuan Hui, Xiaodong Jiang

“…IntroductionIdentification of effective therapies for colorectal cancer (CRC) remains an urgent medical need, especially for the microsatellite stable (MSS) phenotype. …”
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The distinct landscape of tumor immune microenvironment in homologous recombination deficient cancers by Qiuyang Xu, Yuanjia Wen, Taiyuan Huang, Huayi Li, Xingzhe Liu, Shen-nan Shi, Wenjian Gong, Gordon B. Mills, Ding Ma, Qinglei Gao, Yong Fang

“…This intricate network reprograms cancer biology in multiple aspects and serves as a potential target for cancer treatment. …”
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Mathematical modeling links Wnt signaling to emergent patterns of metabolism in colon cancer by Mary Lee, George T Chen, Eric Puttock, Kehui Wang, Robert A Edwards, Marian L Waterman, John Lowengrub

“…Abstract Cell‐intrinsic metabolic reprogramming is a hallmark of cancer that provides anabolic support to cell proliferation. …”
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The role of transcription factors in the crosstalk between cancer-associated fibroblasts and tumor cells by Xiaoyan Zhang, Meng Zhang, Hui Sun, Xu Wang, Xin Wang, Weiqi Sheng, Midie Xu

“…Background: Transcription factors (TFs) fulfill a critical role in the formation and maintenance of different cell types during the developmental process as well as disease. It is believed that cancer-associated fibroblasts (CAFs) are activation status of tissue-resident fibroblasts or derived from form other cell types via transdifferentiation or dedifferentiation. …”
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Menin maintains lysosomal and mitochondrial homeostasis through epigenetic mechanisms in lung cancer by Jun-Bo Yuan, Gui-Xin Gu, Bang-Ming Jin, Qing Han, Bing-Hui Li, Li Zhang, Bin Xu, Xuan Zhu, Guang-Hui Jin

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ANKRD22 participates in the proinflammatory activities of macrophages in the colon cancer tumor microenvironment by Xiaoying Wang, Keqing Yang, Bin Yang, Rui Wang, Yongliang Zhu, Tianhui Pan

“…A significant decrease in ANKRD22 expression in macrophages cocultured with colon cancer cell culture supernatant as well as in macrophages directly derived from colorectal cancer tissues was observed. …”
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Overcoming immunosuppression in cancer: how ketogenic diets boost immune checkpoint blockade by Victoria E. Stefan, Daniela D. Weber, Roland Lang, Barbara Kofler

“…Ketogenic diets (KDs), i.e., high-fat low-carbohydrate diets, have been shown to have antiproliferative and immunomodulatory effects in various preclinical cancer studies. Here, we review current knowledge of the complex interplay of KDs and the anti-tumor immune response in the context of ICB therapy, to update our understanding of diet-induced immunometabolic reprogramming in cancer. …”
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SREBP2 as a central player in cancer progression: potential for targeted therapeutics by Ruiqi Chen, Tianyu Chen, Xiang Li, Junfeng Yu, Min Lin, Siqi Wen, Man Zhang, Jinchi Chen, Bei Yi, Huage Zhong, Huage Zhong, Zhao Li

“…Furthermore, we summarize that SREBP2 plays a crucial role in various cancers and tumor microenvironment primarily by regulating cholesterol, as well as through several non-cholesterol pathways. …”
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Glutamate transporter SLC1A6 promotes resistance to immunotherapy in cancer by Chenchen Li, Yi Lin, Haoran Zheng, Hengda Zeng, Longhao Xu, Daqin Wu, Jianwen Lao, Peicong Cai, Shuai Liang, Chunhui Wang, Tianxin Lin, Wenlong Zhong

“…The clinical prognostic value of SLC1A6 in cancer was validated using publicly available lung cancer single-cell datasets, as well as transcriptomic data from both bladder and lung cancer cohorts. …”
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Ketone drink enhances therapeutic efficacy in prostate cancer by targeting EZH2 by Chaehyun Yum, Richard A. Schaefer, Rui Wang, Ting-You Wang, Xiaotong Lu, Qi Liu, Yanan Ren, Qingshu Meng, Yongyong Yang, Xin Zhang, Yan Xiong, Xufen Yu, Xiaoyu Zhang, Jian Jin, Xuesen Dong, Yang Yi, Rendong Yang, Qi Cao

“…Abstract It is well established that EZH2, a lysine methyltransferase, is upregulated in most aggressive cancers, highlighting the importance of EZH2 in cancer progression. …”
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Bridging viral hepatitis and liver cancer: Emerging concepts in pathogenesis and therapeutic innovation by Keyin Zheng, Aimin Jiang, Zhengrui Li, Li Chen, Kailai Li, Junyi Shen, Hank Z. H. Wong, Quan Cheng, Jian Zhang, Anqi Lin, Peng Luo

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Bladder cancer subtypes exhibit limited plasticity across different microenvironments and in metastases by Carina Bernardo, Subhayan Chattopadhyay, Natalie Andersson, Pontus Eriksson, Benjamin Medle, Lena Tran, Nour al dain Marzouka, Adam Mattsson, Aymeric Zadoroznyj, Malin Larsson, Fredrik Liedberg, Mattias Höglund, Gottfrid Sjödahl

“…Conclusions Our results suggest that invasive bladder cancers have a strong intrinsic tumor identity that is not easily reprogrammed by the microenvironment.…”
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Deciphering the mechanistic roles of ADARs in cancer pathogenesis, tumor immune evasion, and drug resistance by Xiaoke Wang, Fei Yin, Yangfang He, Yue Qiao, Yan Yan, Jingru Ma

“…Beyond their catalytic editing function, ADARs also regulate cancer-relevant pathways through editing-independent mechanisms, including RNA binding and protein-protein interactions. …”
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Immunotherapy resistance in non-small cell lung cancer: from mechanisms to therapeutic opportunities by Huiyu Wang, Xiaomin Niu, Zhenning Jin, Shaoxing Zhang, Rong Fan, Hua Xiao, Shen S. Hu

“…Abstract This review provides a comprehensive synthesis of current knowledge on immunotherapy resistance in non-small cell lung cancer (NSCLC), a disease that accounts for approximately 85% of all lung cancer cases and remains the leading cause of cancer-related death worldwide. …”
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Arid1a deficiency sensitises pancreatic cancer to fatty acid synthase inhibition by Tzu‐Lei Kuo, Ya‐Chin Hou, Yan‐Shen Shan, Li‐Tzong Chen, Wen‐Chun Hung

“…Collectively, ARID1A deficiency upregulates fatty acid metabolism to accelerate pancreatic tumourigenesis and FASN is a potential therapeutic target for ARID1A‐deficient pancreatic cancer. Key points ARID1A mutations drive metabolic reprogramming in pancreatic cancer. …”
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Myeloid targeting antibodies PY159 and PY314 for platinum-resistant ovarian cancer by Afshin Dowlati, Judy Wang, Siqing Fu, Amita Patnaik, Minal Barve, Shivaani Kummar, Abdul Rafeh Naqash, Patricia LoRusso, Michael Gordon, Debra L Richardson, Ira Winer, Christos Kyriakopoulos, Joleen Hubbard, Marc Chamberlain, Oladapo O Yeku, Winston W Tan, Sarah K Lynam

“…Background Novel treatment options are required in patients with platinum-resistant ovarian cancer (PROC). Myeloid-derived suppressor cells promote a hostile tumor microenvironment and are associated with worse clinical outcomes in PROC. …”
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SPRY4-IT1: A novel oncogenic long non-coding RNA in human cancers by Jianfa Li, Yincong Chen, Zhicong Chen, Anbang He, Haibiao Xie, Qiaoxiao Zhang, Zhiming Cai, Yuchen Liu, Weiren Huang

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Functionally enriched epigenetic clocks reveal tissue-specific discordant aging patterns in individuals with cancer by Chiara M. S. Herzog, Elisa Redl, James Barrett, Sepideh Aminzadeh-Gohari, Daniela D. Weber, Julia Tevini, Roland Lang, Barbara Kofler, Martin Widschwendter

“…Results Our findings offer insights into the association of functionally enriched groups of age-related DNAme changes with cancer, identify sites perturbed earliest during carcinogenesis, as well as those distinct between cancer and reprogramming that could inform strategies to prevent teratoma formation upon in vivo reprogramming. …”
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Targeting amino acid in tumor therapy by Mingpai Ge, Yuan Xu, Lu Cui, Enyuan Huang, Zhaorui Liu, Kai Yin

“…This review provides an in-depth analysis of the biological roles of amino acids in cancer, identifies vulnerabilities associated with amino acid dependency, and discusses strategies to leverage these weaknesses for enhanced cancer treatment. …”
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