Networking the nucleus by Indika Rajapakse, David Scalzo, Stephen J Tapscott, Steven T Kosak, Mark Groudine

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From Biomarker Discovery to Clinical Applications of Metabolomics in Glioblastoma by Neja Šamec, Gloria Krapež, Cene Skubic, Ivana Jovčevska, Alja Videtič Paska

“…Background/Objectives: In recent years, interest in studying changes in cancer metabolites has resulted in significant advances in the metabolomics field. …”
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Chemotherapy reprograms miRNA expression profiles in apoptotic extracellular vesicles from medulloblastoma cells, regulating pro- and anti-proliferative effects on recipient drug-n... by Rosa Mistica C. Ignacio, Helen Forgham, Zerong Ma, Anya Jensen, George Sharbeen, Juanfang Ruan, David S. Ziegler, Maria Tsoli, Phoebe A. Phillips, Chelsea Mayoh, Maria Kavallaris, Joshua McCarroll

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Classification of the LC4 Primarily-like Cell Line—Recapitulating a CDK4 Overexpressing Immune Evasive HIV-HCV-Induced HCC by Janine Kah, Lisa Staffeldt, Tassilo Volz, Kornelius Schulze, Asmus Heumann, Götz Rövenstrunk, Meike Goebel, Sven Peine, Maura Dandri, Stefan Lüth

“…Results: LC4 cells reflect the characteristics of the parental cancer region, including immunosuppression and metabolic reprogramming, characterized by the downregulation of drug-metabolizing enzymes compared to healthy individuals, indicating a transition to alternate metabolic pathways. …”
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Cancer immunotherapy in routine cost‐effective cancer care? by Sir Marc Feldmann

“…Abstract Therapy‐triggered autoimmunity and inflammation in many cancer patients, as well as treatment costs, hamper the success of cancer immunotherapy. …”
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Natural killer cells from endurance-trained older adults show improved functional and metabolic responses to adrenergic blockade and mTOR inhibition by Luciele Guerra Minuzzi, Helena Batatinha, Christopher Weyh, Vidya Srokshna Balasubramanian Lakshmi, Carmen Fiuza-Luces, Beatriz G. Gálvez, Alejandro Lucia, Ana Maria Teixeira, Natascha Sommer, José Cesar Rosa-Neto, Fabio Santos Lira, Karsten Krüger

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Iron-loaded cancer-associated fibroblasts induce immunosuppression in prostate cancer by Kai Zhang, Kaiyuan Liu, Benxia Hu, Genyu Du, Xinyu Chen, Lingling Xiao, Yingchao Zhang, Luyao Jiang, Na Jing, Chaping Cheng, Jinming Wang, Penghui Xu, You Wang, Pengfei Ma, Guanglei Zhuang, Huifang Zhao, Yujiao Sun, Deng Wang, Qi Wang, Wei Xue, Wei-Qiang Gao, Pengcheng Zhang, Helen He Zhu

“…We report the presence of FerroCAFs in prostate cancer from both mice and human, as well as in human lung and ovarian cancers, and identify a conserved cell surface marker, the poliovirus receptor. …”
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MODIFICATION OF BREAST CANCER CELLS' SENSITIVITY TO METFORMIN DUE TO CO-CULTIVATION WITH B. ANIMALIS by T.P. Kozak, O.O. Lykhova, P.A. Virych, V.F. Chekhun

Subjects: “…glucose metabolism (gm) disturbances are well-known risk factors for the development of breast cancer (bc). the gm regulator metformin is used as an adjunctive therapy for bc. another potent modulator of gm in bc cells is the microbiota…”
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Multiple roles of branched-chain amino acid metabolism in tumour progression by Lin Wang, Feng Shi, Ya Cao, Longlong Xie

“…In this review, we describe the role of BCAA metabolism in the progression of different tumours. As well as discuss how BCAA metabolic reprogramming drives tumour therapy resistance and evasion of the antitumour immune response, and how these pro-cancer effects are achieved in part by activating the mTORC signalling pathway. …”
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Potentiation of cancer immunogenicity by targeting PARP by Victoria Klepsch, Gottfried Baier, Dominik Humer

“…This finding strongly supports PARPi targeting as a promising approach to alleviate intratumoral effector T cell immune dysfunction, particularly in the context of immunotherapy resistance. In conclusion, this well-defined relationship between PARPi-based chemotherapy and ICD of tumor cells may offer substantial potential as a valuable sensitizer for future combinatorial cancer immunotherapy, which together with immune checkpoint therapy, but potentially also with others including cancer vaccines, is likely to be more effective against defined solid tumors and better promote host-protective cancer immune control (see related article by Xia et al, 2024).…”
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A Review of Advances in Mitochondrial Research in Cancer by Zhiru Li BS, Wu Zhang BS, Shaowei Guo MS, Guoyan Qi MD, Jiandi Huang BS, Jin Gao MS, Jing Zhao MD, Lin Kang MS, Qingxia Li PhD, MD

“…Purpose Explore the major role of mitochondria in cancer, as well as targeted mitochondrial therapies and mitochondria-associated markers. …”
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Features of aminothiol metabolism and progression of breast cancer by A. V. Markovsky

“…Determination of serum markers of the redox state in patients with breast cancer, especially during antitumor therapy, can serve for an objective assessment of the effectiveness of treatment and the adaptive capabilities of the body, as well as predicting tumor growth and optimizing the program for screening and preventing cancer.…”
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NAD+ metabolism enzyme NNMT in cancer-associated fibroblasts drives tumor progression and resistance to immunotherapy by modulating macrophages in urothelial bladder cancer by Jian Huang, Bo Wang, Dong Yan, Tianxin Lin, Lu Pei, Hao Yu, Wang He, Kaiwen Li, Meihua Yang, Weibin Hou, Honghui Zeng, Xin-Ke Zhang, Long Huang, Haide Qin

“…Background This study comprehensively investigates the association between the expression of nicotinamide N-methyltransferase (NNMT) and clinical outcomes of urothelial bladder cancer (UBC), as well as the molecular mechanisms by which NNMT in cancer-associated fibroblast (CAF) modulates tumor progression and immunotherapy resistance in UBC.Methods Single-cell transcriptomic analyses, immunohistochemical and immunofluorescence assays were performed on bladder cancer samples to validate the relationship between NNMT expression and clinical outcomes. …”
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The new insight into the role of hydroxyproline in metabolism of cancer cells by Magda Chalecka, Justyna Magdalena Hermanowicz, Jerzy Palka, Arkadiusz Surazynski

“…Therefore, Hyp is involved in several critical metabolic processes regulating DNA synthesis, gene expression, apoptosis/survival, angiogenesis, metastasis and energy production, suggesting a key role of Hyp in reprogramming metabolism of cancer cells. It suggests that Hyp metabolism could be considered as a target in novel experimental strategy for cancer treatment.…”
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Primary and metastatic cellular landscapes in human pancreatic cancer by Nina G. Steele, Veerin R. Sirihorachai, Ahmed M. Elhossiny, Ian M. Loveless, Padma Kadiyala, Monica Bonilla, Emily L. Lasse-Opsahl, Carinna Solano Vargas, Katelyn L. Donahue, Samantha B. Kemp, Valerie Gunchick, Yatrik M. Shah, Timothy L. Frankel, Filip Bednar, Arvind Rao, Benjamin L. Allen, Jiaqi Shi, Vaibhav Sahai, Howard C. Crawford, Eileen S. Carpenter, Marina Pasca di Magliano

“…In cancer-associated fibroblasts, we identified a unique upregulation of metabolic genes, including UPP1, in metastasis. …”
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The role and mechanism of fatty acid oxidation in cancer drug resistance by Yun Lei, Shuang Cai, Jia-Kui Zhang, Si-Qi Ding, Zhan-He Zhang, Chun-Dong Zhang, Dong-Qiu Dai, Yong-Shuang Li

“…The mechanisms underlying cancer drug resistance are complex and may involve genetic mutation, immune escape, and metabolic reprogramming, amongst others. …”
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Research progress on mechanisms of endocrine therapy resistance in prostate cancer by QI Zihao,  WANG Leijie, WU Linjie, BAI Xiaojie, FAN Jiuming, WANG Tiankun, HAN Yutong, YU Ying, GUO Zhongqiang, ZENG Xiantao

“…Prostate cancer (PCa) is one of the most prevalent malignancies among men worldwide and a leading cause of cancer-related deaths. …”
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Ferroptosis and Metabolic Dysregulation: Emerging Chemical Targets in Cancer and Infection by Marta Pawłowska, Jarosław Nuszkiewicz, Dorian Julian Jarek, Alina Woźniak

“…It also discusses metabolic reprogramming as a factor that modifies the levels of cell-sensitizing polyunsaturated fatty acids (PUFAs), iron dysregulation, and oxidative stress in aggressive cancers and inflammatory diseases such as sepsis, tuberculosis, and COVID-19. …”
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Centromere Protein F in Tumor Biology: Cancer's Achilles Heel by Zitong Wan, Miaomiao Wen, Chunlong Zheng, Ying Sun, Yinxi Zhou, Yahui Tian, Shaowei Xin, Xuejiao Wang, Xiaohong Ji, Jie Yang, Yanlu Xiong, Yong Han

“…Objective This review aims to systematically summarize the molecular structure, subcellular localization, expression regulation, intracellular transport mechanisms, biological functions, and carcinogenic mechanisms of CENP‐F, as well as explore its potential value in cancer diagnosis and therapy. …”
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Biomarkers for modeling of cancer-specifc tumor-associated macrophages ex vivo by T. S. Sudarskikh, I. V. Larionova, M. A. Rakina, J. G. Kzhyshkowska

“…Tumor-associated macrophages (TAMs) are essential innate immune cells in the tumor microenvironment. TAMs can stimulate cancer cell proliferation and primary tumor growth, angiogenesis, lymphangiogenesis, cancer cell invasiveness in vessels and metastatic niche formation as well as support chemotherapy resistance. …”
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