Notch3 Targeting: A Novel Weapon against Ovarian Cancer Stem Cells by Simona Ceccarelli, Francesca Megiorni, Diana Bellavia, Cinzia Marchese, Isabella Screpanti, Saula Checquolo

“…Notch signaling is frequently activated in ovarian cancer (OC) and contributes to the proliferation and survival of cultured OC cells as well as to tumor formation and angiogenesis in xenograft models. …”
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Double-sided niche regulation in skin stem cell and cancer: mechanisms and clinical applications by Trang Thao Quoc Pham, Yung-Che Kuo, Wei-Ling Chang, Hao-Jui Weng, Yen-Hua Huang

“…Abstract The niche microenvironment plays a crucial role in regulating the fate of normal skin stem cells (SSCs) and cancer stem cells (CSCs). Therapeutically targeting the CSC niche holds promise as an effective strategy; however, the dual effects of shared SSC niche signaling in CSCs have contributed to the aggressive characteristics of tumors and poor survival rates in skin cancer patients. …”
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Role of Hyperbaric Oxygen Therapy in Prostate Tumor Microenvironment and Cancer Stem Cell Niche by Pranathi Konda, Merrel Holley, Vinoth Kumar Lakshmanan

“…We have succinctly captured the multifaceted role of HBOT in modifying the TME and comprehensive overview focuses on the advanced approaches to eliminate prostate cancer stem cells (PCSCs) and exploration of their role in anti-androgen resistance, as well as stemness-related signaling pathways and growing body of evidence supporting the potential benefits of HBOT in prostate cancer treatment. …”
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Cancer stem-like cells stay in a plastic state ready for tumor evolution by Jiali Xu, Houde Zhang, Zhihao Nie, Wenyou He, Yichao Zhao, Zhenhui Huang, Lin Jia, Zhiye Du, Baotong Zhang, Siyuan Xia

“…Cancer stem-like cells (CSCs) are considered the root of cancer. …”
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Cytokines secreted from bone marrow-derived mesenchymal stem cells promote apoptosis of CD34+ leukemic stem cells as anti-cancer therapy by Raheleh Farahzadi, Ezzatollah Fathi, Somayeh Vandghanooni, Behnaz Valipour

“…Objective: The effect of mesenchymal stem cells (MSCs) on the immortal characteristics of malignant cells, particularly hematologic cancer cells, remains a topic of debate, with the underlying mechanisms still requiring further elucidation. …”
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Role of noncoding RNA as a pacemaker in cancer stem cell regulation: a review article by Yasmin M. Attia, Samer A. Tadros, Sally A. Fahim, Doaa M. Badr

“…Abstract Accumulated evidence supported the crucial role of a tiny population of cells within the tumor called cancer stem cells (CSCs) in cancer origination, and proliferation. …”
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The role of the mTOR pathway in breast cancer stem cells (BCSCs): mechanisms and therapeutic potentials by Chen Zhang, Shu Xu, Chuanzheng Yin, Shaobo Hu, Pian Liu

“…Central to its pathogenesis and therapeutic resistance are breast cancer stem cells (BCSCs), which possess unique properties such as self-renewal, differentiation, and resistance to conventional therapies, contributing to tumor initiation, metastasis, and recurrence. …”
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Crosstalk between thyroid CSCs and immune cells: basic principles and clinical implications by Xiaoxiao Li, Hengtong Han, Kaili Yang, Shouhua Li, Libin Ma, Ze Yang, Yong-xun Zhao

“…A fresh viewpoint on the oncological aspects of thyroid cancer, including proliferation, invasion, recurrence, metastasis, and therapeutic resistance, has been made possible by the recent thorough understanding of the defining and developing features as well as the plasticity of thyroid cancer stem cells (TCSCs). …”
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The cancer stem cells characteristics analysis of LGR5 + cells that influence lung cancer risk by using single cell RNA-seq analysis by Ge Wen, Shaoqing Niu, Shiqi Mei, Senming Wang

“…Abstract Lung adenocarcinoma (LUAD) is the most popular lung cancer type with highly mortality. We performed a single cell RNA-seq analysis to explore characteristic of cancer stem cells in LUAD. …”
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Valproic acid improves the efficacy of oxaliplatin/fluoropyrimidine-based chemotherapy by targeting cancer stem cell via β-Catenin modulation in colorectal cancer by Maria Serena Roca, Rita Lombardi, Cristina Testa, Federica Iannelli, Laura Grumetti, Tania Moccia, Veronica Barile, Laura Addi, Domenico Memoli, Alessandra Leone, Simone Di Franco, Giorgio Stassi, Antonio Avallone, Francesca Bruzzese, Biagio Pucci, Alfredo Budillon, Elena Di Gennaro

“…Cancer stem cells (CSCs) play central roles in drug resistance and CRC recurrence. …”
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Acute symptomatic seizures during haematopoietic stem cell transplantation by Ya. B. Skiba, A. Yu. Polushin, M. Yu. Prokudin, M. D. Vladovskaya, A. D. Kulagin

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BIN1 inhibited tumor growth, metastasis and stemness by ALDH1/NOTCH pathway in bladder carcinoma by Si-yu Chen, Ya-long Zhang, Xiao-ran Li, Ji-rong Wang, Kun-peng Li, Shun Wan, Jian-wei Yang, Hao Wang, Jin-long Cao, Chen-yang Wang, Xin-peng Fan, Sheng-jun Fu, Li-yun Ding, Tuan-jie Che, Li Yang

“…Bridging integrator 1 (BIN1), a well-characterized tumor suppressor that interacts with and inhibits oncogenic Myc transcription factors, has demonstrated crucial roles in various cancer types. …”
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Molecular signatures of prostate stem cells reveal novel signaling pathways and provide insights into prostate cancer. by Roy Blum, Rashmi Gupta, Patricia E Burger, Christopher S Ontiveros, Sarah N Salm, Xiaozhong Xiong, Alexander Kamb, Holger Wesche, Lisa Marshall, Gene Cutler, Xiangyun Wang, Jiri Zavadil, David Moscatelli, E Lynette Wilson

“…<h4>Background</h4>The global gene expression profiles of adult and fetal murine prostate stem cells were determined to define common and unique regulators whose misexpression might play a role in the development of prostate cancer.…”
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Evaluation of Tinospora cordifolia stem extract bioactive content and anticancer activity against breast cancer cells by Annisa Yuslinda, Rosyadah Nuraini, Kamila Fairuz Sarah, Ulfa Siti Mariyah, Lestari Sri Rahayu, Widodo Nashi

“…This study aims to explore the bioactive potential of Tinospora cordifolia stem extract by investigating the content of flavonoids, phenols, terpenoids and alkaloids as well as the cytotoxic and apoptotic effects on T47D breast cancer cells. …”
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Regulatory Mechanism of C1q-Like Protein 4 in Characteristics of Breast Cancer Stem Cells by Xiao LI, Shenglin ZHANG, Chanchan HU, Lu BAI, Fan XU

“…ObjectiveTo investigate the role and underlying mechanism of C1q-like protein 4 (C1ql4) in regulating the characteristics of breast cancer stem cells. MethodsqRT-PCR was used to detect the expression of C1ql4 in breast cancer and normal breast epithelial cell lines, as well as to verify the transfection efficiency of C1ql4. …”
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Unlocking the Role of OCT4 in Cancer Lineage Plasticity: A Cross-Cancer Perspective with an Emphasis on Prostate Cancer by Mohammad Esfini Farahani, Yanquan Zhang, Amos Olalekan Akinyemi, Fatemeh Seilani, Md Rakibul Alam, Xiaoqi Liu

“…OCT4, in coordination with SOX2 and NANOG, acts as a master regulator of stemness and is frequently upregulated in prostate cancer stem cells (PCSCs). …”
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Possible pathogenetic types of sporadical ovarian cancer by L. A. Ashrafyan

“…This article in question dwells on a possible pathogenetic model ovarian cancer, it’s histogenesis speciality, the role of ovulation, chronic in- flammation and stem cells. …”
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Isolation and Characterization of Cervical Cancer-Associated Mesenchymal Stem Cells From Primary Tumors Using Explant Culture by Surbhi Singla, Sanchita Khurana, Rashmi Bagga, Radhika Srinivasan, Shalmoli Bhattacharyya

“…Cancer-associated mesenchymal stem cells (Ca-MSCs), an integral part of the tumor microenvironment, play a major role in modulating tumor progression; they have been reported to progress as well as inhibit various cancers, including cervical cancer. …”
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miR-142-3p attenuates breast cancer stem cell characteristics and decreases radioresistance in vitro by Fabian M Troschel, Nicolas Böhly, Katrin Borrmann, Timo Braun, Alexander Schwickert, Ludwig Kiesel, Hans Theodor Eich, Martin Götte, Burkhard Greve

“…Levels of BRCA1, BRCA2, and Bod1 in miR-142-3p–overexpressing cells as well as expression of miR-142-3p, Bod1, KLF4, and Oct4 in sorted CD44 + /CD24 –/low cells were determined by quantitative polymerase chain reaction. miR-142-3p overexpression resulted in a strong decline in breast cancer stem cell characteristics with a decrease in CD44, CD133, ALDH1, Bod1, BRCA2, and mammosphere formation as well as reduced survival after irradiation. miR-142-3p expression was strongly reduced in sorted CD44 + /CD24 –/low stem cells, while Bod1, Oct4, and KLF4 were overexpressed. β-catenin levels strongly decreased after miR-142-3p overexpression, but not after anti–miR-142-3p treatment. …”
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Targeting AMP‐activated kinase impacts hepatocellular cancer stem cells induced by long‐term treatment with sorafenib by Alicia Bort, Belén G. Sánchez, Pedro A. Mateos‐Gómez, Diana Vara‐Ciruelos, Nieves Rodríguez‐Henche, Inés Díaz‐Laviada

“…Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide. HCC treatment is hindered by the frequent emergence of chemoresistance to the multikinase inhibitor sorafenib, which has been related to the presence of cancer stem cells (CSCs) that self‐renew and often escape therapy. …”
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