Stemness regulation in prostate cancer: prostate cancer stem cells and targeted therapy by Hao Liang, Bin Zhou, Peixin Li, Xiaoyi Zhang, Shijie Zhang, Yaozhong Zhang, Shengwen Yao, Sifeng Qu, Jun Chen

“…Background Increasing evidence indicates that cancer stem cells (CSCs) and cancer stem-like cells form a special subpopulation of cells that are ubiquitous in tumors. …”
Get full text

Epigenetic regulation of cancer stemness by Claudia Galassi, Gwenola Manic, Manel Esteller, Lorenzo Galluzzi, Ilio Vitale

“…Moreover, we critically evaluate the potential and limitations of targeting epigenetic modifiers as a means to eradicate cancer stem cells for therapeutic purposes.…”
Get full text

Cancer stem cells and mesenchymal stem cells in pancreatic ductal adenocarcinoma by V. O. Tumanskyi, I. S. Kovalenko

“…Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive types of cancer and chemotherapy resistant cancer, in the development of which poorly studied cancer stem cells (CSC) and mesenchymal stem cells (MSC) are of great importance. …”
Get full text

Cancer stem cells and differentiation therapy by Xiong Jin, Xun Jin, Hyunggee Kim

“…In this review, we describe the crucial features of cancer stem cells related to tumor relapse and drug resistance, as well as the new therapeutic strategy to target cancer stem cells named “differentiation therapy.”…”
Get full text

Anticancer effect of curcumin on breast cancer and stem cells by Hui-Tien Liu, Yuan-Soon Ho

Get full text

Cancer Stem Cells (CSCs) in Drug Resistance and their Therapeutic Implications in Cancer Treatment by Lan Thi Hanh Phi, Ita Novita Sari, Ying-Gui Yang, Sang-Hyun Lee, Nayoung Jun, Kwang Seock Kim, Yun Kyung Lee, Hyog Young Kwon

“…Cancer stem cells (CSCs), also known as tumor-initiating cells (TICs), are suggested to be responsible for drug resistance and cancer relapse due in part to their ability to self-renew themselves and differentiate into heterogeneous lineages of cancer cells. …”
Get full text

TREM1 is essential for maintaining stemness of liver cancer stem-like cells in hepatocellular carcinoma by Arsha Sreekumar, Ashwin Ajith, Kenza Mamouni, Daniel D. Horuzsko, Anatolij Horuzsko

“…Targeting TREM1 may therefore represent a promising dual-action therapeutic strategy to disrupt both cancer stem-like cell function and the pro-inflammatory tumor milieu in HCC.…”
Get full text

Strategies for the Isolation and Identification of Gastric Cancer Stem Cells by Jianhua Wang, Jie Qu, Qiang Hou, Xueping Huo, Xiangrong Zhao, Le Chang, Cuixiang Xu

“…Gastric cancer stem cells (GCSCs) originate from both gastric adult stem cells and bone marrow cells and are conspicuously present within the histological milieu of gastric cancer tissue. …”
Get full text

The interaction of Adipose Derived Stem Cells and Breast Cancer by Natasha Cunningham, Ava O'Meara, Cathy L. Brougham

“…Adipose derived stem cells have been used in breast reconstruction following surgical intervention in breast cancer patients. …”
Get full text

MicroRNA-21 as a Regulator of Cancer Stem Cell Properties in Oral Cancer by Milica Jaksic Karisik, Milos Lazarevic, Dijana Mitic, Maja Milosevic Markovic, Nicole Riberti, Drago Jelovac, Jelena Milasin

“…Oral squamous cell carcinoma (OSCC) is a highly aggressive malignancy with poor prognosis, mainly due to the presence of cancer stem cells (CSCs), a small subpopulation of cells that contribute to therapy resistance and tumor progression. …”
Get full text

Open access and data sharing in cancer stem cells research by Rut Lucas-Domínguez, Antonio Vidal-Infer, Adolfo Alonso-Arroyo, Beatriz Tarazona-Álvarez, Máxima Bolaños-Pizarro, Vanessa Paredes-Gallardo

“…Objective: Understanding and targeting cancer stem cells (CSC) are areas of active research in oncology and further dissemination of scientific results is urgently needed to accelerate the comprehension of their involvement in tumor heterogeneity, resistance to conventional therapies and metastasis. …”
Get full text

CD44 on cancer stem cell is a potential immunological and prognostic pan-cancer biomarker by Ya-Juan Zhu, Si-Ying Li, Shan-Shan Yang, Yang Du, Zhuo-Yuan Zhang, Ji-Yan Liu

“…Abstract Background CD44, a widely recognized cancer stem cell marker, displayed a vital participation in the cancer immune invasion and may related with the response to the immunotherapy. …”
Get full text

Experience in creating primary cultures of endometrial cancer and studying cells carrying phenotype of cancer stem cells by S. Yu. Filippova, I. V. Mezhevova, T. V. Chembarova, I. A. Novikova, E. V. Verenikina, O. E. Zhenilo, V. V. Polovodova, A. V. Shaposhnikov, E. V. Shalashnaya, A. A. Maslov, O. G. Ishonina

“…Was to investigate the possibility of applying the method of spheroid formation in culture for assessment of the endometrial cancer (EC) tumor stem cells (TSC) content in complex samples containing various tumor cells and microenvironment.Materials and methods. …”
Get full text

Cyclooxygenase-2: A Role in Cancer Stem Cell Survival and Repopulation of Cancer Cells during Therapy by Lisa Y. Pang, Emma A. Hurst, David J. Argyle

“…COX-2 is overexpressed in cancer cells and is associated with progressive tumour growth, as well as resistance of cancer cells to conventional chemotherapy and radiotherapy. …”
Get full text

Targeted photodynamic therapy as potential treatment modality for the eradication of colon cancer and colon cancer stem cells by Natasha Hodgkinson, Cherie A Kruger, Heidi Abrahamse

“…This review focuses on current photodynamic therapy treatments available for colorectal cancer and highlights proposed actively targeted photosynthetic drug uptake mechanisms specifically mediated towards colon cancer stem cells, as well as identify the gaps in research which need to be investigated in order to develop a combinative targeted photodynamic therapy regime that can effectively control colorectal cancer primary and metastatic tumour growth by eliminating colon cancer stem cells.…”
Get full text

Stem cell properties of cancer cells in ascitic fluid of patients with ovarian cancer: a key to control over cancer progression by O. I. Kovalev, S. V. Vtorushin, E. V. Kaigorodova

“…The review presents up-to-date information on the molecular and biological parameters of cancer stem cells in ovarian cancer, which are the cellular component of malignant ascites, as well as data from the authors’ studies. …”
Get full text

The number of cancer stem cells in the tumor tissue and perifocal tissue of non-muscle invasive bladder cancer by L. I. Belyakova, A. N. Shevchenko, A. B. Sagakyants, E. S. Bondarenko, O. G. Shulgina, E. P. Ulyanova, E. V. Filatova, I. A. Khomutenko

“…Determine the content of cancer stem cells (CSCs) in the tumor tissue (TT) and perifocal tissues (PT) in muscle-non-invasive bladder cancer.Materials and methods. …”
Get full text

Signaling pathways in the regulation of cancer stem cells and associated targeted therapy by Wang Manni, Wu Min

“…Abstract Cancer stem cells (CSCs) are defined as a subpopulation of malignant tumor cells with selective capacities for tumor initiation, self‐renewal, metastasis, and unlimited growth into bulks, which are believed as a major cause of progressive tumor phenotypes, including recurrence, metastasis, and treatment failure. …”
Get full text

Dynamism, Sensitivity, and Consequences of Mesenchymal and Stem-Like Phenotype of Cancer Cells by Petra Gener, Joaquin Seras-Franzoso, Patricia González Callejo, Fernanda Andrade, Diana Rafael, Francesc Martínez, Sara Montero, Diego Arango, Joan Sayós, Ibane Abasolo, Simó Schwartz

“…There are remarkable similarities in the description of cancer stem cells (CSCs) and cancer cells with mesenchymal phenotype. …”
Get full text

Cancer Stem Cells and Radioresistance: Rho/ROCK Pathway Plea Attention by Annapurna Pranatharthi, Cecil Ross, Sweta Srivastava

“…The cancer stem cell (CSC), which has better DNA repair capability, has been shown to contribute to tumor resistance and is an important target for treatment. …”
Get full text