An Experimental Dynamic Investigation of the Influence of Melatonin, Serotonin and Tryptophan on the Stability of the DNA Structure by Cristina Manuela Drăgoi, Anca Zanfirescu, Ion-Bogdan Dumitrescu, Anca Ungurianu, Denisa Marilena Margină, Alina-Crenguţa Nicolae

“…Tryptophan, an essential amino acid, serves as a vital structural element in proteins and a precursor for bioactive compounds like serotonin and melatonin, which impact various physiological functions. …”
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Synergistic and Antagonistic Mechanisms of <i>Arctium lappa</i> L. Polyphenols on Human Neutrophil Elastase Inhibition: Insights from Molecular Docking and Enzymatic Kinetics by Yixun Sun, Mingbo Zhang, Yating Zhang, Yu Zheng, Jing Li, Qian Cai, Anqi Wang, Yang Qu

“…Molecular docking techniques were employed to predict the binding patterns and inhibition types between polyphenolic components and HNE, complemented by in vitro enzymatic tests to validate inhibitory efficacy. …”
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Physical and drug- releasing properties of a cement containing simvastatin (SimCeram) by Iman Parisay, Morva Moodi, Marzieh Boskabady, Hossein Bagheri, Roshanak Salari, Melika Hoseinzadeh

“…Abstract Background This in vitro study compared the physical characteristics and drug release patterns of a bioactive cement containing with 0.1 μM Simvastatin (SimCeram) with mineral trioxide aggregate (MTA; Angelus, Brazil). …”
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Relationship between Changes in Physicochemical Properties with Antioxidant and Antitumor Activity Changes in Vitro of Different Purified Fractions of Pu-erh Tea Polysaccharides by Yilong WU, Zaikun SHUI, Yan WANG, Zhenhao LIU, Xuanjun WANG, Chengting ZI

“…The results of this study may provide theoretical support for the application of PTPS in the field of bioactive polysaccharides and functional foods.…”
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Food Toxicology and Safety: Evaluating Dietary Risks and Functional Ingredients by Sujaritha Jayaraj, Lavanya Kothandan, Vijay Babu Murugan, Saravana Kumar Prakash, Vandhana Vijayakumar, Elizabeth Rani

“…This review critically examines the multifaceted relationship between dietary patterns, food‐derived carcinogens, metabolic health outcomes, and technological innovations in the modern food system. …”
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Development of κ-Carrageenan Films Reinforced with Magnesium Oxide Nanoparticles for the Potential Treatment of Chronic Wounds: In Vitro and In Vivo Insights by Lesly Rodríguez-Vicens, Jorge L. Mejía-Méndez, Edgar R. López-Mena, Sergio A. Bernal-Chávez

“…Even though this work provides innovative insights into the optimal design of bioactive structures, further approaches are required to improve the biological performance of the synthesized κ-C-PEO films.…”
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NeXtMD: a new generation of machine learning and deep learning stacked hybrid framework for accurate identification of anti-inflammatory peptides by Chengzhi Xie, Yijie Wei, Xinwei Luo, Huan Yang, Hongyan Lai, Fuying Dao, Juan Feng, Hao Lv

“…NeXtMD systematically extracts four functionally relevant sequence-derived descriptors—residue composition, inter-residue correlation, physicochemical properties, and sequence patterns—and utilizes a two-stage prediction strategy. …”
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Histone deacetylases repress the accumulation of licochalcone A by inhibiting the expression of flavonoid biosynthetic pathway-related genes in licorice (Glycyrrhiza inflata) by Jiangyi Zeng, Xiaoling Ma, Yuping Li, Lijun Zhou, Jingxian Fu, Hongxia Wang, Yongliang Liu, Ling Yuan, Ying Wang, Yongqing Li

“…Abiotic stresses and plant hormones were found to influence flavonoid compound accumulation, correlating with altered expression patterns of HDAC genes and global histone H3 acetylation (H3ac) levels. …”
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Box-Behnken Design Assisted Optimization and Characterization of Chitosan Film for Simultaneous Topical Delivery of Ascorbic Acid and Metronidazole by Bilawal Khan, Pakorn Kraisit, Supaporn Santhan, Namon Hirun

“…Moreover, in vitro release studies revealed a co-release pattern, delivering both bioactive compounds simultaneously. …”
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A classical genetic solution to enhance the biosynthesis of anticancer phytochemicals in Andrographis paniculata Nees. by Alireza Valdiani, Daryush Talei, Soon Guan Tan, Mihdzar Abdul Kadir, Mahmood Maziah, Mohd Yusop Rafii, Sreenivasa Rao Sagineedu

“…Nevertheless, there is still a huge gap in knowledge on the genetic pattern of the biosynthesis of these bioactive compounds. …”
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Acyloxyacyl hydrolase promotes the resolution of lipopolysaccharide-induced acute lung injury. by Benkun Zou, Wei Jiang, Han Han, Jing Li, Weiying Mao, Zihui Tang, Qian Yang, Guojun Qian, Jing Qian, Wenjiao Zeng, Jie Gu, Tianqing Chu, Ning Zhu, Wenhong Zhang, Dapeng Yan, Rui He, Yiwei Chu, Mingfang Lu

“…Innate immune responses induced by Microbe-Associated Molecular Pattern (MAMP) molecules are essential for lung defense but can lead to tissue injury. …”
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Metabolite profile and antioxidant activities of Trikatu, black pepper, Javanese long pepper, and red ginger essential oils by Dewa Ayu Ika Pramitha, Tati Herlina, Iman Permana Maksum, Ari Hardianto, Abd. Wahid Rizaldi Akili, Jalifah Latip

“…PCA showed different patterns of compound abundance across the samples. …”
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Differential exosome miRNA expression in oral cancer stem cells by M. Shoff, T. Booker, B. Leavitt, D. Harmon, K. Kingsley, K. M. Howard

“…Differential expression of miR-21, miR-34 and miR-155 were observed with patterns observed among the cancer cell lines which were distinct from the corresponding AiTS isolates. …”
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Retinol and Hydroxyasiaticoside Synergistically Relieve Histamine-Induced Atopic Dermatitis Activity by Repressing TRPV1, L1R1, and CD130 Targets by Qin Liu, Peng Shu, Qingle Song, Zhenhai Huang, Jiyu Weng, Lanyue Zhang, Yuan Wang, Qingqing Liu

“…Quantitative RNA-seq analysis revealed that the gene expression patterns were similar in different concentration groups. …”
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Component specific responses of the microbiomes to common chemical stressors in the human food chain by Wasimuddin, Aurea Chiaia-Hernandez, Céline Terrettaz, Lisa Thoenen, Veronica Caggìa, Pierre Mateo, Miquel Coll-Crespi, Matheus Notter, Mohana Mukherjee, Teresa Chavez-Capilla, Francesca Ronchi, Stephanie C. Ganal-Vonarburg, Martin Grosjean, Moritz Bigalke, Sandra Spielvogel, Andrew Macpherson, Adrien Mestrot, Siegfried Hapfelmeier, Matthias Erb, Klaus Schlaeppi, Alban Ramette

“…Microbial co-occurrence patterns significantly shifted with either decreased (water, sediment, plant, animal) or increased (soil) network sparsity and numbers of keystone taxa following stress treatments. …”
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Functional properties and toxicological analysis of nanocellulose-based aerogels loaded with polyphenols from Hyeronima macrocarpa berries by Andrés Felipe Alzate-Arbeláez, Farid B. Cortés, Benjamín A. Rojano

“…In this study, the nutraceutical properties of ethanolic extract of Hyeronima macrocarpa fruits, immobilized on nanocellulose-based aerogels (NCAG) synthesized from the seeds were studied. Specifically, bioactives with antioxidant properties of the pulp were determined, NCAG and homologs of acetate (NCAG-A) and sulfate (NCAG-S) were obtained, and characterized from the seed, the aerogels loaded with antioxidants were studied to determine the anti-radical activity, digestion patterns, protein oxidation inhibition, and toxicological properties. …”
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Green synthesis of silver nanoparticles using cocoon extract of Bombyx mori L.: therapeutic potential in antibacterial, antioxidant, anti-inflammatory, and anti-tumor applications by Ahmed H. Elsaffany, Ahmed E. M. Abdelaziz, Abdullah A. Zahra, Alsayed E. Mekky

“…This study expands the range of biological materials used in AgNP synthesis and provides deeper insight into how different bioactive components influence their functional properties. …”
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In Silico Prediction of Maize microRNA as a Xanthine Oxidase Inhibitor: A New Approach to Treating Hyperuricemia Patients by Manas Joshi, Mohd Mabood Khan

“…Conclusion: Therefore, we propose that zma-miR-156 variants may be a promising new bioactive compound against hyperuricemia and related diseases.…”
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Retention and Survival Optimization of Juvenile Green Mussel (Perna Viridis) by Using Substrate from Seaweed Extract by Dyahruri Sanjayasari, Maria Dyah Nur Meinita, Tjahjo Winanto

“…The result indicated a variation pattern on the retention of juvenile mussels according to the experimental substrate. …”
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Eco-friendly silver nanoparticles from garlic: a novel therapeutic approach for treating Escherichia fergusonii wound infections by Sozan M. Abdelkhalig, Arwa Gamal Ali, Mohamed Farouk Ghaly, Nada K. Alharbi, Maha Alharbi, Mahmoud M. Bendary, Amira I. Abousaty

“…Antimicrobial susceptibility testing revealed that all identified E. fergusonii strains exhibited MDR patterns. Garlic extract, analyzed using GC-MS and UPLC-ESI-MS/MS, identified sulfur-containing bioactive compounds such as allyl methyl trisulfide, dimethyl trisulfide, and allicin, which facilitated the biosynthesis of AgNPs. …”
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