A new statistical model for advanced modeling of cancer disease data

“…To address these limitations, the generalized odd beta prime Generalized (GOBP-G) class of distributions is introduced, along with an extension called the generalized odd beta prime-Weibull (GOBPW) distribution. …”
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On the study of solitary wave dynamics and interaction phenomena in the ultrasound imaging modelled by the fractional nonlinear system by Usman Younas, Jan Muhammad, Qasim Ali, Mirwais Sediqmal, Krzysztof Kedzia, Ahmed Z. Jan

“…These solutions are obtained by using two newly introduced techniques, namely modified generalized Riccati equation mapping method and modified generalized exponential rational function method. Moreover, breather, lump and other waves are extracted by the assistance of logarithmic transformation and different test functions. …”
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The Aβ42:Aβ40 ratio modulates aggregation in beta-amyloid oligomers and drives metabolic changes and cellular dysfunction by Annika Haessler, Stefanie Gier, Nathalie Jung, Maike Windbergs

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Beta‐Lactoglobulin for Water‐Based and Tunable Nanostructure Templating of Printed Titania Thin Films: The Influence of pH Value and Protein Concentration by Linus F. Huber, Kun Sun, Manuel A. Reus, Christian L. Weindl, Julian E. Heger, Stephan V. Roth, Peter Müller‐Buschbaum

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NADPH oxidase 1/4 dual inhibition impairs transforming growth factor-beta protumorigenic effects in cholangiocarcinoma cancer-associated fibroblasts by Josep Amengual, Ester Gonzalez-Sanchez, Mariana Yáñez-Bartolome, Laura Sererols-Viñas, Aashreya Ravichandra, Celia Guiton, Noel P. Fuste, Ania Alay, Sara Hijazo-Pechero, Beatriz Martín-Mur, Marta Gut, Anna Esteve-Codina, Ana Cantos-Cortes, Rut Espinosa-Sotelo, Emilio Ramos, Teresa Serrano, Mariona Calvo, Berta Laquente, Joana Ferrer, Gabriel Pons, Andrés Mendez-Lucas, Steven Dooley, Sumera I. Ilyas, Marie Vallette, Lynda Aoudjehane, Marie Lequoy, Laura Fouassier, Cédric Coulouarn, Silvia Affò, Alexander Scheiter, Diego F. Calvisi, Tian V. Tian, Isabel Fabregat, Javier Vaquero

“…In intrahepatic cholangiocarcinoma (iCCA), a highly aggressive malignancy of the biliary tract with poor prognosis, the latest clinical trials using TGF-β inhibitors have failed indicating that the specific actions carried out by TGF-β in iCCA are yet not well delineated. Here, we show that TGF-β signalling is highly active in iCCA and exerts a prominent suppressor effect on tumour cell lines and organoids established from iCCA metastases biopsies, that relies on a functional canonical SMAD2/3/4 signalling. …”
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ENERGIZE: A GLOBAL PHASE 3 STUDY OF MITAPIVAT DEMONSTRATING EFFICACY AND SAFETY IN ADULTS WITH ALPHA- OR BETA-NON–TRANSFUSION-DEPENDENT THALASSEMIA by AT Taher, H Al-Samkari, Y Aydinok, M Besser, G Luna, S Gheuens, A Glenthj, AS Goh, A Kattamis, SR Loggetto, KM Musallam, P Ricchi, E Salido-Fiérrez, S Sheth, V Viprakasit, MD Cappellini, KH Kuo

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Melatonin Modulates Endoplasmic Reticulum Stress and Akt/GSK3-Beta Signaling Pathway in a Rat Model of Renal Warm Ischemia Reperfusion by Kaouther Hadj Ayed Tka, Asma Mahfoudh Boussaid, Mohamed Amine Zaouali, Rym Kammoun, Mohamed Bejaoui, Sonia Ghoul Mazgar, Joan Rosello Catafau, Hassen Ben Abdennebi

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INDICATORS OF CYTOKINE ACTIVITY AND BETA-ENDORPHIN PRODUCTION LEVEL IN ARTERIAL HYPERTENSION ASSOCIATED WITH ASTHENIC/NEUROTIC DISORDERS IN YOUNG MEN EMPLOYED IN STRESSFUL PROFESSI... by A. V. Gertsev, V. N. Ischuk, Yu. N. Zakrevsky

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Calculator of some special mathematical functions by Lazić Sara, Iričanin Bratislav

“…For the time being, this application provides approximations for the following special mathematical functions: Bessel functions of the first kind, gamma and beta functions, and some orthogonal polynomials - Legendre, Laguerre, Hermite (physicist’s and probabilist’s) polynomials, Chebyshev polynomials of the first and the second kind, as well as Jacobi polynomials. …”
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Analytical methods for nebivolol quantification in pharmaceutical formulations and biological matrices: a comprehensive review by Kurdo A. Abdullah, Aryan Fathulla Qader, Rebaz Anwar Omer, Rebaz Obaid Kareem, Musher Ismael Salih

“…Abstract Nebivolol, a beta-blocker commonly prescribed for the treatment of hypertension and heart failure, functions by decelerating heart rate and promoting vasodilation, thereby enhancing blood flow and reducing blood pressure. …”
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Choosing therapeutic tactics in pregnant women with chronic arterial hypertension: the priorities by N. G. Pivonova, I. V. Fomin

“…To evaluate the pregnancy and delivery course, as well as fetal and newborn status, while achieving optimal blood  pressure (BP) levels with different regimens of antihypertensive therapy (AHT) in pregnant women with chronic arterial hypertension (AH). …”
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PO48 | Thrombotic risk evaluation and thrombophilia testing in beta-thalassemia patients: a retrospective cohort analysis from a reference regional center

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Prediction of secondary metabolites in hydroponically produced tomatoes: multivariate influence of abiotic climatic factors as well as photosynthesis and transpiration rates by Grigorij Devadze, Dennis Dannehl, Annika Nerlich, Uwe Schmidt, Stefan Streif, Stefan Streif

“…Considering a period of three weeks, we found that PPFD levels between 396.0 μmol/m2s and 511.2 μmol/m2s as well as transpiration rates ranging from 4.4 mg H2O/m2s to 7.47 mg H2O/m2s were observed as optimal for the contents of beta carotene, lutein, and lycopene. …”
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The effect of arsenic on mitochondrial fatty acid metabolism via inhibition of carnitine palmitoyltransferase 1B and choline kinase beta in C2C12 cells. by Fu-Lin Yu, Ming-Yan Zhang, Gang-Wei Song, Yang-Shan Ning, Xian Wu, Yan Gao

“…However, the metabolic mechanisms underlying arsenic's effects on muscle function and pathogenesis remain incompletely understood. …”
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Effects of Different Doses of Quercetin on Apoptotic Markers and Liver Enzymes in Liver Injury Induced by Interferon Beta-1b (Betaferon) in Male Rats in Comparison with Silymarin by Noor Kamel Obead, Inam Sameh Arif, Huda jaber waheed

“… The first disease-modifying drug for the treatment of multiple sclerosis (MS) was interferon beta 1b (IFN).this drug demonstrated efficacy in relapse MS, But There are many difficulties in treating multiple sclerosis, including the well-known side effect of betaferon(hepatotoxicity or liver injury), which present as brief, mild elevations in serum aminotransferase (ALT,AST) levels appear 3 to 12 months after starting treatment. …”
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Human iPSC-derived pericyte-like cells carrying APP Swedish mutation overproduce beta-amyloid and induce cerebral amyloid angiopathy-like changes by Ying-Chieh Wu, Šárka Lehtonen, Kalevi Trontti, Riitta Kauppinen, Pinja Kettunen, Ville Leinonen, Markku Laakso, Johanna Kuusisto, Mikko Hiltunen, Iiris Hovatta, Kristine Freude, Hiramani Dhungana, Jari Koistinaho, Taisia Rolova

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Promotion of neuroinflammation in select hippocampal regions in a mouse model of perimenopausal Alzheimer’s disease by Roberta Marongiu, Roberta Marongiu, Roberta Marongiu, Jimcy Platholi, Jimcy Platholi, Laibak Park, Fangmin Yu, Garrett Sommer, Clara Woods, Teresa A. Milner, Michael J. Glass

“…IntroductionAlzheimer’s disease, the most common form of dementia, is characterized by age-dependent amyloid beta (Ab) aggregation and accumulation, neuroinflammation, and cognitive deficits. …”
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Interferon-β and interleukin-6 exert opposing effects on Foxp3 acetylation to control regulatory T cell induction by Mehek Ningoo, Mehek Ningoo, Francisco Fueyo-González, Cayetana Gisbert-Vilanova, Cayetana Gisbert-Vilanova, Laura Espinar-Barranco, Laura Espinar-Barranco, Nada Marjanovic, Miguel Fribourg, Miguel Fribourg

“…Our studies reveal that, in contrast with its pro-inflammatory role in innate immune responses, IFNβ can counteract the well-described inhibitory effect of IL-6 on Treg induction. …”
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KCNE1 and KCNE3 beta-subunits regulate membrane surface expression of Kv12.2 K(+) channels in vitro and form a tripartite complex in vivo. by Sinead M Clancy, Bihan Chen, Federica Bertaso, Julien Mamet, Timothy Jegla

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Phospholipase C Beta 2 as a Key Regulator of Tumor Progression and Epithelial-Mesenchymal Transition via PI3K/AKT Signaling in Renal Cell Carcinoma by Shijin Wang, Deqian Xie, Hongzhe Yue, Guandu Li, Bowen Jiang, Yaru Gao, Zunwen Zheng, Xu Zheng, Guangzhen Wu

“…Despite its significant importance, the specific expression patterns and molecular mechanisms of <i>PLCB2</i> in the progression of RCC are not well understood. <b>Methods:</b> This investigation employed a combination of bioinformatics analyses, scRNA-seq, functional assays, transcriptome sequencing, real-time quantitative PCR (RT-PCR), immunofluorescence, rescue experiments, and Western blotting to explore the regulatory function of <i>PLCB2</i> in driving the epithelial-mesenchymal transition (EMT) in RCC through the PI3K/AKT signaling pathway. …”
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