PGC-1α Promotes mitochondrial biosynthesis and energy metabolism of goose fatty liver by Jiahui Li, Mengqing Lv, Zijin Yuan, Jing Ge, Tuoyu Geng, Daoqing Gong, Minmeng Zhao

“…But the activity of MRCC Ⅴ, as well as the levels of ADP and ATP in fatty liver were reduced. …”
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Chinese herbal foot baths as a new strategy for diabetic foot with Wagner grade of 0 or 1: a meta-analysis and data mining by Ruifang Lin, Yunfeng Yu, Yuman Yin, Xiu Liu, Yongjun Wu, Qin Xiang, Yaoyue Luo, Rong Yu

“…Schmidt].ConclusionChinese herbal foot-baths can improve clinical symptoms as well as vascular and nerve functions in diabetic foot patients with Wagner grades 0 or 1, without increasing the incidence of adverse events. …”
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Exon Sequencing of HNF1β in Chinese Patients with Early-Onset Diabetes by Siqian Gong, Hong Lian, Yating Li, Xiaoling Cai, Wei Liu, Yingying Luo, Meng Li, Si-min Zhang, Rui Zhang, Lingli Zhou, Yu Zhu, Qian Ren, Xiuying Zhang, Jing Chen, Jing Wu, Xianghai Zhou, Xirui Wang, Xueyao Han, Linong Ji

“…Background Maturity-onset diabetes of the young (MODY) due to variants of hepatocyte nuclear factor 1-beta (HNF1β) (MODY5) has not been well studied in the Chinese population. …”
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Domestication of different varieties in the cheese-making fungus Geotrichum candidum by Bennetot, Bastien, Vernadet, Jean-Philippe, Perkins, Vincent, Hautefeuille, Sophie, Rodríguez de la Vega, Ricardo C., O’Donnell, Samuel, Snirc, Alodie, Grondin, Cécile, Lessard, Marie-Hélène, Peron, Anne-Claire, Labrie, Steve, Landaud, Sophie, Giraud, Tatiana, Ropars, Jeanne

“…Domestication is an excellent model for studying adaptation processes, involving recent adaptation and diversification, convergence following adaptation to similar conditions, as well as degeneration of unused functions. Geotrichum candidum is a fungus used for cheese making and is also found in other environments such as soil and plants. …”
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Chemical Composition, Free Radicals and Pathogenic Microbes in the Extract Derived from <i>Dictyota dichotoma</i>: In Silico and In Vitro Approaches by Fouad Oumassi, Khalid Chebbac, Naouar Ben Ali, Soundouss Kaabi, Zineb Nejjar El Ansari, Amira Metouekel, Azeddin El Barnossi, Abdelfattah El Moussaoui, Mohamed Chebaibi, Loubna Bounab, Ibrahim Mssillou, Abdelaaty Abdelaziz Shahat, Brahim El Bouzdoudi, Mohammed L’bachir El Kbiach

“…Marine algae are renowned for their health benefits due to the presence of functional bioactive compounds. In this context, this study aims to valorize the extract of a seaweed, <i>Dictyota dichotoma</i> (<i>D. dichotoma</i>), through phytochemical characterization using liquid chromatography–mass spectrometry (HPLC-MS), as well as in vitro and in silico evaluation of its biological activities (antioxidant and antimicrobial). …”
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Combining single-cell analysis and molecular docking techniques to construct a prognostic model for colon adenocarcinoma and uncovering inhibin subunit βb as a novel therapeutic ta... by Qinqing Wu, Qinqing Wu, Lu Ye, Yuwei Wu, Mengyu Zhao, Mengyu Zhao, Jiaxin Lu, Yanping Yu, Yanping Yu, Yixiao Niu, Yixiao Niu, Luxiao Zhang, Peijun Zuo, Peijun Zuo

“…Additionally, we employed molecular docking techniques to evaluate the potential of inhibin subunit beta B (INHBB) as therapeutic targets and to assess the binding affinity of candidate drugs. …”
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HCAR2 Exerts Anti-Depressive Effects on Corticosterone-Induced Depression in Mice by Modulating Microglial Activity by Zhao Pan, Li Jiang, Jiacheng Chen, Sicong Xu, Ping Zhang, Yili Yi, Yangzhi Xie, Yongjun Chen

“…Hydroxy-carboxylic acid receptor 2 (HCAR2) functions as a receptor for various diet-derived metabolites. …”
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PREPARATION OF 1-[18F]FLUORO-2-IODOETHANE AS A PROSTHETIC GROUP FOR [18F]FLUOROETILATION by Marcelle Vitória Carreira Dos Santos, Gabriela Viana de Souza, Helio Alexandre Stefani, Fabio Luiz Navarro Marques

“…Introduction/Justification: [18F]Fluorine is of considerable importance in radiochemistry for positron emission tomography (PET) due to its decay characteristics (18F; beta+ 96.7%, T1 = 2. 109:8 min). Numerous methods for introducing 18F into organic molecules have been developed, with alkylation being one of the methods. …”
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Could the Microbial Profiling of Normal Pancreatic Tissue from Healthy Organ Donors Contribute to Understanding the Intratumoral Microbiota Signature in Pancreatic Ductal Adenocarc... by Francesca Tavano, Alessandro Napoli, Domenica Gioffreda, Orazio Palmieri, Tiziana Latiano, Matteo Tardio, Fabio Francesco di Mola, Tommaso Grottola, Markus W. Büchler, Marco Gentile, Anna Latiano, Tommaso Mazza, Francesco Perri

“…Future prospective studies on larger populations, also including patients in advanced tumor stages and considering all potential existing confounding factors, as well as further functional investigations, are needed to prove the role of microbiota-mediated pathogenicity in PDAC.…”
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Some growth factors in neoplastic tissues of brain tumors of different histological structure by O. I. Kit, E. M. Frantsiyants, E. E. Rostorguev, I. V. Balyazin-Parfenov, N. D. Cheryarina, L. S. Kozlova, Yu. A. Pogorelova

“…VEGF-induced tumor vasculature has a number of structural and functional features that provide growth and progression of tumors, including increased permeability of blood vessels and their chaotic arrangement.Objective: to study in comparative aspect the level of certain growth factors in the following tissues: glioblastomas, brain metastasis of the breast cancer, meningiomas as well as corresponding peritumoral areas.Materials and methods. …”
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A preliminary study of the pathological characteristics of the internal orifice and the local mucosal microbial community in complex anal fistula by Zhu Jingyi, Zhang Ling, He Li, Zhang Jun, Mei Zubing, Wang Zhenyi, Chen Qiyi, Wang Qingming

“…[Objectives] To observe the histological morphology and Mucoprotein 2 (MUC2) expression in the internal orifice of complex anal fistula, as well as to compare the difference of the composition and structure of the microbial community in the mucosal tissue of the internal orifice of patients with complex anal fistula with the anal sinus mucosa of the healthy population. …”
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Transcriptomic profiles of monocyte-derived macrophages exposed to SARS-CoV-2 VOCs reveal immune-evasion escape driven by delta by Alessia Gallo, Josè Camilla Sammartino, Roberta Vazzana, Roberto Giambruno, Claudia Carcione, Nicola Cuscino, Salvatore Castelbuono, Vitale Miceli, Matteo Bulati, Daniele Lilleri, Irene Cassaniti, Pier Giulio Conaldi, Fausto Baldanti

“…The success of each VOC, as well as the virus fitness, were enabled by altered intrinsic functional properties and, reasonably, to virus antigenicity changes, conferring the ability to evade a primed immune response. …”
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Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in miceResearch in context by Farooq Syed, Olivia Ballew, Chih-Chun Lee, Jyoti Rana, Preethi Krishnan, Angela Castela, Staci A. Weaver, Namratha Shivani Chalasani, Sofia F. Thomaidou, Stephane Demine, Garrick Chang, Alexandra Coomans de Brachène, Maria Ines Alvelos, Eugenia Martin Vazquez, Lorella Marselli, Kara Orr, Jamie L. Felton, Jing Liu, John S. Kaddis, Piero Marchetti, Arnaud Zaldumbide, Donalyn Scheuner, Decio L. Eizirik, Carmella Evans-Molina

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3D genomic features across &gt;50 diverse cell types reveal insights into the genomic architecture of childhood obesity by Khanh B Trang, Matthew C Pahl, James A Pippin, Chun Su, Sheridan H Littleton, Prabhat Sharma, Nikhil N Kulkarni, Louis R Ghanem, Natalie A Terry, Joan M O'Brien, Yadav Wagley, Kurt D Hankenson, Ashley Jermusyk, Jason Hoskins, Laufey T Amundadottir, Mai Xu, Kevin Brown, Stewart Anderson, Wenli Yang, Paul Titchenell, Patrick Seale, Klaus H Kaestner, Laura Cook, Megan Levings, Babette S Zemel, Alessandra Chesi, Andrew D Wells, Struan FA Grant

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Hybrid closed-loop systems for managing blood glucose levels in type 1 diabetes: a systematic review and economic modelling by Asra Asgharzadeh, Mubarak Patel, Martin Connock, Sara Damery, Iman Ghosh, Mary Jordan, Karoline Freeman, Anna Brown, Rachel Court, Sharin Baldwin, Fatai Ogunlayi, Chris Stinton, Ewen Cummins, Lena Al-Khudairy

“…It is the result of an autoimmune process that leads to the destruction of the insulin-producing beta cells in the pancreas. Treatment with insulin is aimed at replicating the function of the pancreas to manage hyperglycaemia and avoid hypoglycaemia. …”
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Establishing the best step-up treatments for children with uncontrolled asthma despite inhaled corticosteroids: the EINSTEIN systematic review, network meta-analysis and cost-effec... by Sofia Cividini, Ian Sinha, Giovanna Culeddu, Sarah Donegan, Michelle Maden, Katie Rose, Olivia Fulton, Dyfrig Hughes, Stephen Turner, Catrin Tudur Smith

“…Conclusions Overall, we conclude that ICS Medium + LABA would be the recommended step-up treatment for children with asthma that is not well controlled on ICS and that LTRA alone should be avoided. …”
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