Exploring the distinctive characteristics of gut microbiota across different horse breeds and ages using metataxonomics by Xinxi Qin, Li Xi, Longfei Zhao, Jincheng Han, Hongxia Qu, Yajun Xu, Weiping Weng

“…BackgroundGut microbiota exerts a pivotal function in host nutrient metabolism and maturation of the mucosal immunity. …”
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The Effect of Dapagliflozin, a Sodium–Glucose Co-Transporter 2 Inhibitor, on Vancomycin-Induced Nephrotoxicity in Rats by Seyhmus Tan, Bulent Kaya, Ercan Akburak, Cagri Avci, Kivilcim Eren Ates, Gulfiliz Gonlusen, Tugce Sapmaz Ercakalli, Burak Mete

“…<b>Methods</b>: Rats were randomly assigned to four groups: control, VA (vancomycin), DAPA (dapagliflozin), and VA+DAPA. Renal function was assessed by measuring serum urea and creatinine. …”
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Wildlife crossing database platform: A transdisciplinary approach to developing a tool for landscape connectivity planning and public engagement by Robert Newell, Nina‐Marie Lister, Ann Dale, Sabrina Careri

“…A research‐practitioner discussion was convened to discuss the beta version of the WCDP, as well as the key considerations and recommendations for its further development as an effective landscape connectivity planning tool. …”
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Chronical kidney disease in clinical practice: non progredi est regredi (lat. not to go forward is to go back) by A. L. Vertkin, N. A. Burakova, Yu. V. Sedyakina, S. S. Kurdzhieva, M. M. Shamuilova, E. M. Ledeneva

“…The purpose of describing this clinical case is to demonstrate the importance of assessing and considering the significance and modifiability of risk factors for the development of chronic kidney disease, as well as their timely correction. The clinical example illustrates the connection between impaired kidney function and the progression of cardiovascular pathology.Results. …”
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Creating a Full Multitenant Back End User Experience in Omeka S with the Teams Module by Alexander Dryden, Daniel G. Tracy

“…When Omeka S appeared as a beta release in 2016, it offered the opportunity for researchers or larger organizations to publish multiple Omeka sites from the same installation. …”
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Leptin And Ghrelin – The New Old Players In Obesity And Depression by Rositsa Sandeva, Stanislava Mihaylova, Gergana Sandeva

“…The participation of the anorexigenic peptide leptin and the orexigenic peptide ghrelin in the pathogenesis of metabolic syndrome and obesity is well studied. In this review, we are taking a look at the structure, anatomical expression, regulation, receptors and physiological functions of these two neuropeptides. …”
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Selecting of statins optimum dosage regimen in patients with acute Q-wave myocardial infarction after thrombolytic therapy by V. D. Syvolap, S. M. Kyselov, A. A. Alferov

“…In group of high-doses of statins in the subacute period of Q-wave myocardial infarction observed higher exercise tolerance against the backdrop of increasing the power of global LV systolic function. 4. The use of low-dose statin regimens accompanied by more severe violations of diastolic LV function. …”
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Osteitis in Chronic Rhinosinusitis: A State-of-the-Art Review by Wiyono Hadi, Widia Isa Aprillia Sujana

“…Hence, we summarize the essential yet well-established features of osteitis in CRS, including the updated definition, the role of biofilm formation along with cytokines and runt-related transcription factor 2 axis as its possible underlying pathogenesis, the transforming growth factor beta signaling pathway of the disease, histopathological bone changes, radiographic staging and scoring systems, disease impacts on the CRS severity and quality of life, as well as the most up-to-date treatment strategies for osteitis in CRS. …”
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Inflammatory cytokines and oral cancer risk: an integrated study combining two-sample Mendelian randomization with experimental validation by Yinhua Xia, Guanqun Wan, Simin Li, Shaonan Hu, Guohui Wu

“…The findings were further validated through expression analysis in TCGA database and clinical samples, as well as functional studies in oral cancer cells. …”
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Association of Recreational Physical Activity with Gut Microbiota Diversity and Composition, and Symptom Burden in Crohn&amp;rsquo;s Disease: A Cross-Sectional Study by Sun S, Chen Y, Zheng M, Zhou M, Weng C, Fan Y, Lv B

“…A total of 29 dominant gut microbial taxa, including Oscillospiraceae, Ruminococcus, and Eubacterium rectale, have been identified as associated with recreational PA and primarily function in the butyric acid metabolism pathway.Conclusion: Promoting the incorporation of recreational PA as an indicator of healthy lifestyle management for CD may improve patients’ subjective psychological and mental well-being, while also preserving intestinal microbial diversity. …”
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Software Implementation of the Epps-Pulley Criterion in Matlab Modeling Environment by A. A. Tipikin, A. A. Prusakov, N. A. Timoshenko

“…We used an approximation by a beta function of the third kind for a sample of over 1000 elements.Results. …”
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DETERMINATION OF LEVEL EXPRESSION OF mRNA SPLICING VARIANTS FOR DR3 IN BLOOD CELLS IN INFECTIOUS MONONUCLEOSIS by V. D. Cvetkova, N. A. Sakharnov, D. I. Knyazev, O. V. Utkin, N. V. Neumoina, N. F. Brusnigina

“…These variant transcripts encode membrane and soluble forms of the receptor which have different functions. Features of their expression and contribution of individual DR3 variants to the immune pathogenesis of infectious mononucleosis (IM) are poorely understood.The purpose of this work was to develop, validate and test the techniques of DR3 gene expression assays, as well as to evaluate the DR3 mRNA splice variants by means of real-time RT-PCR and RT-PCR in the IM patients.The original version of real-time RT-PCR allowed to determine relative amounts of DR3 mRNA, DR3 membrane variants (LARD1a + LARD8), and ratios of mRNAs encoding membrane and soluble forms of the receptor. …”
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X‐Linked Gene Dosage and SOX2 Act as Key Roadblocks for Human Germ Cell Specification in Klinefelter Syndrome by Wenteng He, Qing Luo, Jian Zhao, Mengting Wang, Allan Zhao, Luohua Feng, Ahmed Reda, Eva Lindgren, Jan‐Bernd Stukenborg, Jiayu Chen, Qiaolin Deng

“…This work reveals that X‐linked genes play a multifaceted role against the fate competency to hPGCLCs, with escape genes IGSF1 and CHRDL1 inhibiting the TGF‐beta/Activin A and BMP pathways, respectively. Notably, this work identifies a previously unrecognized role of SOX2, upregulated by the escape gene USP9X, elucidating a species‐specific function in the mammalian germline. …”
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Unraveling the causal role of TGF-βRII in osteoporosis and the potential of its associated differential genes as novel targets by Xinyu Zhu, Yueyang Fan, Wenyu Wang, Rui Wu, Chen Zhang, Ziquan Yang

“…The long-term care and rehabilitation required for OP-induced fractures and complications impose significant economic burdens on both individuals and society, as well as reducing their quality of life. Methods Recent studies have demonstrated an association between transforming growth factor-beta type II receptor (TGF-βRII) and OP through analysis of gene expression data sets and Mendelian randomization, suggesting potential causal relationships. …”
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Thyroid storm during the recovery phase after non-thyroid surgery in a hyperthyroid patient: a case report and literature review by Jiyu Zeng, Ting Yang, Li Wu

“…Perioperative management should emphasize: (1) rigorous preoperative optimization of thyroid function to achieve euthyroidism; (2) vigilant postoperative monitoring for early signs of thyroid storm; and 3) prompt diagnosis using the Burch-Wartofsky scale and guideline-based criteria, followed by combined therapy with beta-blockers, corticosteroids, and antithyroid drugs. …”
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Liraglutide alleviates high-fat diet-induced kidney injury in mice by regulating the CaMKKβ/AMPK pathway by Yingli Xuan, Ting-ting Ding, Xiao-lei Mao, Shiqing Pang, Ruibin He, Li Qin, Jiang zi Yuan

“…Enzyme-linked immunosorbent assay was employed to detect the levels of total cholesterol, triglycerides, low-density lipoprotein cholesterol, blood urea nitrogen, creatinine in serum, as well as urinary protein in urine. Besides, hematoxylin–eosin staining and periodic acid-Schiff staining were used to observe the pathological changes of kidney tissue; immunohistochemistry, western blot, and real-time quantitative PCR to assess the calmodulin-dependent protein kinase kinase beta (CaMKKβ)/AMPK signaling pathway activation.Results Liraglutide significantly reduced serum lipid loading, improved kidney function, and relieved kidney histopathological damage and glycogen deposition in the mouse model of obesity-related kidney disease induced by HFD. …”
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Longitudinal association between DNA methylation and type 2 diabetes: findings from the KORA F4/FF4 study by Liye Lai, Dave Laurence Juntilla, Monica Del C Gomez-Alonso, Harald Grallert, Barbara Thorand, Aiman Farzeen, Wolfgang Rathmann, Juliane Winkelmann, Holger Prokisch, Christian Gieger, Christian Herder, Annette Peters, Melanie Waldenberger

“…Linear mixed-effects models were employed to identify significant associations between methylation sites and diabetes status, as well as with fasting plasma glucose (FPG), hemoglobin A1c (HbA1c), homoeostasis model assessment of beta cell function (HOMA-B), and homoeostasis model assessment of insulin resistance (HOMA-IR). …”
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Epilepsy protein myoclonin1 interacts with inositol 1,4,5-trisphosphate receptor and reduces calcium ions stored in endoplasmic reticulum by Toshimitsu Suzuki, Kripamoy Aguan, Hideaki Mizuno, Ikuyo Inoue, Katsuhiko Mikoshiba, Atsushi Miyawaki, Kazuhiro Yamakawa

“…Results: Myoclonin1 was revealed to be well co-expressed with IP3R1 at choroid plexus and ependymal cells, and these two proteins bound to each other. …”
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Regional and aging-specific cellular architecture of non-human primate brains by Yun-Mei Wang, Wen-Chao Wang, Yongzhang Pan, Lin Zeng, Jing Wu, Zheng-Bo Wang, Xiao-Lin Zhuang, Ming-Li Li, David N. Cooper, Sheng Wang, Yong Shao, Li-Min Wang, Ying-Yin Fan, Yonghan He, Xin-Tian Hu, Dong-Dong Wu

“…Abstract Background Deciphering the functionality and dynamics of brain networks across different regions and age groups in non-human primates (NHPs) is crucial for understanding the evolution of human cognition as well as the processes underlying brain pathogenesis. …”
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Pathophysiological mechanisms in severe preeclampsia: role of upregulated proteins in blood pressure, extracellular matrix and immunity by Caroline Cristina Pinto-Souza, Julyane Natsumi Saito Kaihara, Bruno César Rossini, Ricardo de Carvalho Cavalli, Lucilene Delazari dos Santos, Valéria Cristina Sandrim

“…Functional enrichment and pathway analyses were carried out using Metascape. …”
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