2024 Update on Position Statement by Experts from the Polish Society of Allergology and the Polish Respiratory Society on the Evaluation of Efficacy and Effectiveness of Single Inh... by Paweł Śliwiński, Adam Antczak, Adam Barczyk, Adam J. Białas, Małgorzata Czajkowska-Malinowska, Karina Jahnz-Różyk, Marek Kulus, Piotr Kuna, Maciej Kupczyk

“…Medication non-adherence remains a substantial obstacle in asthma care, prompting the exploration of novel therapeutic modalities that prioritize rapid symptom relief, anti-inflammatory activity, and facilitate patients’ compliance. This task is well-served by the following new form of therapy: inhaled triple-combination medications ICS/LABA/LAMA (inhaled glucocorticosteroid/long-acting beta2-agonist/long-acting muscarinic antagonist). …”
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Neuroimaging Insights into the Public Health Burden of Neuropsychiatric Disorders: A Systematic Review of Electroencephalography-Based Cognitive Biomarkers by Evgenia Gkintoni, Apostolos Vantarakis, Philippos Gourzis

“…Inclusion criteria focused on EEG-based investigations in clinical populations with neuropsychiatric diagnoses, emphasizing studies that assessed associations with cognitive function, symptom severity, treatment response, or functional outcomes. …”
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The protective role of omentin-1 in IL-1β-induced chondrocyte senescence by Bin Chai, Zi-Hui Zheng, Xiang Liao, Kang-Yang Li, Jiang-Shan Liang, Yong-Xiang Huang, Chang-Jun Tong, Di-Jun Ou, Jun Lu

“…In this study, we examined the biological function of omentin-1 in cultured chondrocytes. The presence of omentin-1 potently suppresses IL-1β-induced cellular senescence as revealed by staining with senescence-associated beta-galactosidase (SA-β-Gal). …”
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I-alowCD11bhigh DC Regulates the Immune Response in the Eyes of Experimental Autoimmune Uveitis by Yu Zhao, Jingwen Wang, Zhang Min, Li Peng, Shuhong Qi, Wei Lin

“…These cells expressed lower levels of CD80, CD86, and CD54 than the mature DCs and expressed interleukin 10 (IL-10), indoleamine 2,3-dioxygenase (IDO), and transforming growth factor beta (TGF-β) as well. Moreover, these DCreg can regulate the development of EAU by promoting CD4+CD25+Foxp3+ regulatory T cells. …”
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Characterization of growth differentiation factor 15 (GDF15) as a neurotropic adipokine permeable to the brain by Andreas Schmid, Emily Wilfurth, Alexandra Höpfinger, Manuel Behrendt, Edita Islami, Thomas Karrasch, Martin Berghoff, Andreas Schäffler

“…Abstract GDF15 (growth/differentiation factor-15) belongs to the superfamily of transforming growth factor-beta. Little is known about adipocytic regulation of GDF15, its concentrations in serum and cerebrospinal fluid (CSF), its permeability to the brain, and its correlation with neurological diseases. …”
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Comparative Analysis of Gut Microbiota Between Wild and Captive Guizhou Snub‐Nosed Monkey (Rhinopithecus brelichi) by Xiaolong Huang, Haibo Li, Lan Zhang, Xu Zhang, Shaochuan Cheng, Yuying Yan, Wei Yang, Bingshun Meng, Zuobo Wang, Juanjuan Zhao, Jingcheng Ran

“…However, changes in the feeding environment and food can affect the composition and function of the gut microbiota in R. brelichi, ultimately impacting its health and adaptation. …”
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The Role of Prion Protein in Reelin/Dab1 Signaling: Implications for Neurodegeneration by Irene Giulia Rolle, Anna Burato, Merve Begüm Bacınoğlu, Fabio Moda, Giuseppe Legname

“…PrP^C has also been implicated in several physiological functions. The protein is abundant in the nervous system, and it is critical for cell signaling in cellular communication, where it acts as a scaffold for various signaling molecules. …”
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Improved mental health outcomes and normalised spontaneous EEG activity in veterans reporting a history of traumatic brain injuries following participation in a psilocybin retreat by Grace Blest-Hopley, Giuseppe Pasculli, Giuseppe Pasculli, Simon G. D. Ruffell, WaiFung Tsang, Olateju Emmanuel, Kathryn M. Pate, Hannes Kettner, Hannes Kettner, Leor Roseman, David Erritzoe, Robin Carhart-Harris, Robin Carhart-Harris

“…Enhanced coherence in alpha and beta bands suggested improved neural communication.DiscussionThe study suggests that psilocybin retreats might provide improvements in psychological well-being and brain connectivity in veterans with TBI. …”
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Effect of hulled Cannabis sativa L. seeds in a home-made diet for adult dogs by Sara Frazzini, Paola Cremonesi, Elena Scaglia, Bianca Castiglioni, Filippo Biscarini, Valeria Besana, Luciana Rossi

“…Homemade diets integrated with functional ingredients may help to ensure that companion animals have a good life quality given the rise in their average lifespan. …”
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Unveiling Synergies Among University Partners in Developing a Dairy App in Uganda: An In-Depth Exploration of the Design Thinking Process from Ideation to Prototyping and Testing by Alice Sheila Nanyanzi, Leo Van Audenhove, Justice Mugenyi Kintu, Mark Kaahwa, Ivo De Pauw, Chang Zhu

“…Faculty and farmers first developed app content during the ideation stage, then created and pre-tested a usable “Beta1” prototype app. The prototype was then iteratively tested in workshops with the farmers, gathering feedback on the app’s content and functionality, as well as the farmer’s perceived value of cocreating it. …”
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Effect of Mifepristone Preconditioning on Stress Response and Sex Hormone Levels after Combined Laparoscopic Treatment for Cesarean Scar Pregnancy: A Prospective Randomized Trial by Yan Chen, LiXiu Peng, Quan Shou, Hong Song, Qian Wang

“…The ovarian hemodynamic indices, stress indices, and sex hormone levels were measured, and the incidence of complications such as postoperative infection and liver function impairment was calculated. Results: There was no significant difference in the surgical success rate between the two groups (97.96% vs 95.92%), as well as the thickness and proportion of residual muscle layer, the width, length, and depth of scars, and the incidence of postoperative complications (p > 0.05). …”
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Software Implementation of the Epps-Pulley Criterion in Matlab Modeling Environment by A. A. Tipikin, A. A. Prusakov, N. A. Timoshenko

“…We used an approximation by a beta function of the third kind for a sample of over 1000 elements.Results. …”
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Pyridostigmine Mitigates Methotrexate-Induced Liver Fibrosis in Rats: Association with Changes in BMP-9, SIRT1, and Endoglin Expression by Mehmet Ulusan, Mumin Alper Erdogan, Ozkan Simsek, Hilal Ustundag, Zafer Dogan, Bertug Bekir Ciftci, Mesih Kocamuftuoglu, Imdat Orhan, Oytun Erbas

“…Additionally, pyridostigmine treatment resulted in reduced levels of transforming growth factor-beta (<i>p</i> < 0.05), bone morphogenetic protein-9 (<i>p</i> < 0.001), and endoglin levels (<i>p</i> < 0.05), as well as increased sirtuin 1 level (<i>p</i> < 0.05). …”
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Hampered AMPK-ULK1 cascade in Alzheimer’s disease (AD) instigates mitochondria dysfunctions and AD-related alterations which are alleviated by metformin by Arnaud Mary, Samantha Barale, Fanny Eysert, Audrey Valverde, Sandra Lacas-Gervais, Charlotte Bauer, Sabiha Eddarkaoui, Luc Buée, Valérie Buée-Scherrer, Frédéric Checler, Mounia Chami

“…Furthermore, in the 3xTgAD brains, it reduces the early accumulation of APP C-terminal fragments (APP-CTFs) as well as amyloid beta (Aβ) burden, microgliosis and astrogliosis occurring at a later disease stage. …”
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Cdkn1a silencing restores myoblast differentiation by inducing selective apoptosis in senescent cells by Sujin Kim, Bonsang Gu, Chan-Young So, Keren Esther Kristina Mantik, Seung-Hyun Jung, Sohee Moon, Dong-Ho Park, Hyo-Bum Kwak, Jinkyung Cho, Eun-Jeong Cho, Jae-Seon Lee, Ju-Hee Kang

“…Abstract Background Sarcopenia, characterized by a progressive loss of skeletal muscle mass and function, is associated with the accumulation of senescent muscle stem cells, which impair muscle regeneration and contributes to the decline in muscle health. …”
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Integrated meta-analysis and network pharmacology analysis: evaluation of Zhigancao decoction as treatment for diabetic cardiomyopathy by Kangshou Ji, Kangshou Ji, Meizi Han, Mingqian Yang, Qian Xu, Yan Zhang, Yan Zhang

“…ZGCD not only significantly reduces blood pressure, but also enhances cardiac function while producing fewer adverse effects. The therapeutic effects of ZGCD on DCM can likely be ascribed to its capacity to modulate the AGEs-RAGE signaling pathway, as well as its efficacy in enhancing lipid metabolism and mitigating atherosclerosis.Systematic Review Registrationidentifier (INPLASY202430133).…”
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LRP1 Mediates Endocytosis Activity and Is a Potential Therapeutic Target in Osteoarthritis by Yuangang Wu, Kaibo Sun, Mingyang Li, Yang Yang, Yuan Liu, Limin Wu, Yang Ding, Yi Zeng, Bin Shen

“…Emerging therapies targeting LRP1, such as gene interventions, exosome‐based therapies, and small‐molecule modulators, show potential in restoring LRP1 function, reducing cartilage degradation, and promoting joint repair. …”
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Association of rs780094 in GCKR with metabolic traits and incident diabetes and cardiovascular disease: the ARIC Study. by Mark Bi, Wen Hong Linda Kao, Eric Boerwinkle, Ron C Hoogeveen, Laura J Rasmussen-Torvik, Brad C Astor, Kari E North, Josef Coresh, Anna Köttgen

“…Moreover, the T-allele was independently associated with higher HDL cholesterol levels (p = 0.022), metabolic syndrome prevalence (p = 0.043), and lower beta-cell function measured as HOMA-B (p = 0.011). …”
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Long term exposure to multiple environmental stressors induces mitochondrial dynamics imbalance in testis: Insights from metabolomics and transcriptomics by Shiqin Jiang, Tianli Nong, Ting Yu, Zhiyan Qin, Junyuan Huang, Zhaokun Yin, Shiqi Luo, Yating Lai, Jing Jin

“…Comprehensive multi-omics analysis revealed that long-term exposure to environmental stressors disrupted the BTB and testes, which was associated with mitochondrial metabolism disorders, including oxidative phosphorylation and fatty acid beta-oxidation, as well as glutathione and lipid metabolism alterations. …”
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Nintedanib alleviates hyperoxia-induced lung injury via targeting NF-κB signalling pathway in rat model of bronchopulmonary dysplasia by Rui Hao, Yuping Li, Junhui Li, Zirui Guo, Zhi Yang, Wei Lu

“…Western blotting was applied to detect level changes of inflammatory factors IL-1β (interleukin-1 beta), CXCL-1 (C-X-C motif chemokine ligand 1), MCP-1 (monocyte chemotactic protein-1), as well as the phosphorylation of IkB (NF kappa B inhibitor) and NF-kB (nuclear factor kappa-B) in lung samples. …”
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