Bedside cerebral microvascular imaging of patients with disorders of consciousness: a feasibility study by Qianqian Ge, Lijie Huang, Qiang Fu, Shuai Han, Rui Wang, Jianghong He, Changhui Li, Changhui Li, Jianwen Luo, Long Xu

“…Notably, uPDI demonstrates high sensitivity and imaging depth, revealing microvessels as small as 320 μm in diameter at 4 cm depth, and detecting blood flow signals up to 6 cm beneath the scalp.ConclusionThrough the decompressive cranial windows of DoC patients, we obtained cerebral microvascular images with significantly higher sensitivity without the need for contrast agents.SignificanceOur research provides a novel bedside cerebral microcirculation imaging method for patients with DoC, offering convenient neurofunctional assessment to improve the clinical management of DoC patients.…”
Get full text

Comparing the Fiscal Consequences of Controlled and Uncontrolled Osteoarthritis Pain Applying a UK Public Economic Perspective by Rui Martins, Nikos Kotsopoulos, Melodi Kosaner Kließ, Craig Beck, Lucy Abraham, Samuel Large, Patricia Schepman, Mark P. Connolly

“…Social benefit rules were applied to calculate government financial support to individuals. …”
Get full text

Gender disparity in living organ donation: a qualitative analysis of experiences and perceptions of female donors in Pakistan by Muhammad Ishaq, Javeria Saleem, Ruhma Binte Shahzad, Mahrukh Iqbal, Abida Tehreem, Raja Sajjad Asghar, Aleena Touqeer, Gul Mehar Javaid Bukkhari

“…The study resulted in the following themes emerging: (1) female donation as a consequence of economic vulnerability; (2) comorbidities impacting donor eligibility; (3) altruism among female donors; (4) social and self-benefit of the donors and (5) social obligation on the female donors. …”
Get full text

Adolescent girls’ explanations of high rates of low mood and anxiety in their population: a co-produced qualitative study by Ola Demkowicz, Rebecca Jefferson, Pratyasha Nanda, Lucy Foulkes, Jo Lam, Steven Pryjmachuk, Rhiannon Evans, Bernadka Dubicka, Liz Neill, Laura Anne Winter, Georgina Nnamani

“…Conclusions The study offers a critically important contribution to evidence on gendered inequalities in low mood and anxiety, drawing attention to the interwoven and complex nature of girls’ lives and illuminating various aspects that would benefit from greater research. The insights gained through exploration with girls themselves hold policy and practical relevance to enhance systems to meet girls’ needs.…”
Get full text

Home-based transcranial direct current stimulation paired with cognitive training to reduce fatigue in multiple sclerosis by Leigh Charvet, Judith D. Goldberg, Xiaochun Li, Pamela Best, Matthew Lustberg, Michael Shaw, Lana Zhovtis, Josef Gutman, Abhishek Datta, Marom Bikson, Giuseppina Pilloni, Lauren Krupp

“…This suggests that tDCS does not provide any additional benefit over cognitive training alone in reducing fatigue, but confirms the feasibility and tolerance of this home-based intervention.…”
Get full text

Efficacy and safety of antifibrotic drugs for interstitial lung diseases other than IPF: A systematic review, meta-analysis and trial sequential analysis. by Mei Yang, Yuying Tan, Ting Yang, Dan Xu, Mei Chen, Lei Chen

“…However, based on two studies with 324 patients, benefit of antifibrotic drugs in FVC was not shown in the subgroup taking mycophenolate (mean difference 17.08; 95% CI -56.22 to 90.37), which also had higher risk of SAEs (RR 1.71; 95% CI 1.09 to 2.70), although both were contested by TSA.…”
Get full text

Modeling and Planning a Transmission Network Expansion System in a Regulated Electricity Market by Considering Demand-Side Management via a Developed Fuzzy-Salp Optimization Algori... by Yuying Zhang, Lei Xu, Ji Li, Long Zhang, Zhi Yuan

“…With the daily rise in power demand, the penetration of dispersed generations (DG) such as wind turbines, the operation of series reactive compensator devices, and the progress of reconfiguration in power system management, there is a dire need for optimally planning the expansion of transmission network lines. …”
Get full text

Advanced NGS analysis of cell-free tumor DNA supports clonal relation to primary high-grade B-cell lymphoma lesion and CNS relapse despite MRI negativity by Veronika Navrkalova, Andrea Mareckova, Jakub Porc, Samuel Hricko, Viera Hrabcakova, Jarmila Kissova, Sona Kundova, Marie Jarosova, Sarka Pospisilova, Jana Kotaskova, Andrea Janikova

“…This case report demonstrates the relevance of cerebrospinal fluid (CSF) cell-free DNA testing by integrative next-generation sequencing (NGS) panel. The benefit of this approach resided in tumor genotyping alongside the proof of CNS progression despite MRI negativity, revealing a clonal relationship with the primary tumor lesion. …”
Get full text

Efficacy of high-dose steroids versus low-dose steroids in the treatment of immune checkpoint inhibitor-associated myocarditis: a case series and systematic review by Xiuyue Man, Hong Wang, Chen Chen, Xiaofeng Cong, Lemeng Sun, Xueru Sun, Chen Chen, Jing Zhang, Lei Yang

“…In cases of steroid resistance, combination therapies may provide additional benefit.…”
Get full text

Effect of probiotic and prebiotics supplementation on hemoglobin levels and iron absorption among women of reproductive age and children: a systematic review and meta-analysis by Aditi Apte, Ashwini Parge, Radhika Nimkar, Anju Sinha

“…However, the current evidence does not conclusively show the benefit of these interventions in improving hemoglobin levels in women and children.…”
Get full text

Venetoclax added to CLAG regimen might improve the outcome of patients with relapsed/refractory acute myeloid leukemia by Yu Zhang, Zhao Yin, Zurong Yao, Dan Xu, Xuejie Jiang, Xiaqi Nie, Dandan Chen, Hongsheng Zhou, Pengcheng Shi, Hui Liu, Qifa Liu, Guopan Yu

“…Subgroup analysis showed that patients without response after two courses of induction therapy, or patients with FLT3 mutations seemed to benefit more from CLAG ± Ida/Mito + Ven than CLAG ± Ida/Mito in acquiring CRc. …”
Get full text

Pulmonary Nuclear protein in Testis (NUT) carcinoma: clinical, molecular characteristics, and treatment strategies by Jingjing Qu, Zhen Chen, Yanping Zhu, JinYan Huang, Qian Shen

“…Immunotherapy demonstrated limited benefit, likely attributable to low PD-L1 expression and an immunologically “cold” tumor microenvironment. …”
Get full text

The evolving roles of geophysics in environmental assessment, monitoring, and management of landfill leachate contaminant plumes: An overview by Joseph Omeiza Alao

“…This review highlights the crucial involvement of geophysics as a powerful tool to peer beneath the surface and unravel the mysteries of LLPs to address these challenges, showcasing its ability to detect, map, characterize, and monitor LLPs with unprecedented detail. …”
Get full text

TNBC response to paclitaxel phenocopies interferon response which reveals cell cycle-associated resistance mechanisms by Nicholas L. Calistri, Tiera A. Liby, Zhi Hu, Hongmei Zhang, Mark A. Dane, Sean M. Gross, Laura M. Heiser

“…Abstract Paclitaxel is a standard of care neoadjuvant therapy for patients with triple negative breast cancer (TNBC); however, it shows limited benefit for locally advanced or metastatic disease. …”
Get full text

Modeling optimal combination of breast and cervical cancer screening strategies in China by Xuewei Liu, Yanbo Wang, Bei Gao, Xinlin Lu, Yuan Wang, Wenli Lu

“…Conclusions From a social cost–benefit perspective, biennial BUS and MAM in parallel screening, and quinquennial HPV screening is the most efficient combination strategy with limited budget, while annual CBE, BUS and MAM in series screening and biennial TCT and HPV in series screening are the most efficient combination strategy with sufficient budget.…”
Get full text

Financial Inclusion and Refugees’ Self-Reliance: An Assessment for Women’s Economic Empowerment at Nakivale Refugee Settlement, Southwestern Uganda. by Mugisha, Abbas, Kaaya, Siraje

“…While self-reliance and economic inclusion are increasingly centralized in the international refugee regime as tools of empowerment that benefit women refugees, policy makers largely fail to consider the distribution and availability of local resources in promoting these ideas. …”
Get full text

Customer Relationship Management and Performance of Agro¬business Organizations in Uganda: A Case Study of Green Firm Africa-Uganda Limited in Kabale Municipality. by Muzoora, Alleluyah

“…The study findings on the relationship between customer relationship management and the performance of agro-business organizations were; customer relationship management strategy enables an organization to recruit and retain profitable clients who benefit the organization, customer relationship management leads to improved targeting of profitable consumers which enhances the performance of agro-business organizations, customer relationship management leads to reduced direct cost of marketing leading to business performance, customer relationship management leads to relationship building between the business owners and customers which leads to increased sales hence performance and customer relationship management leads to customer loyalty and brand values are built and enhanced through marketing strategies. …”
Get full text

Social Work Practice and Rural Development. A Case Study of Kyanamira Sub-County Kabale District. by Ssembure, Edson

“…Secondary methods are both participatory and non-participatory to be used for the benefit of society at large. Therefore the role of social workers and social administration is widened for the betterment of individuals, groups, and communities. …”
Get full text

Evaluation of Local Organic Materials as Source of Organic Pesticides for Pest Control in Carrots. by Kanyesigye, Arozious

“…The highest value of carrot fruit weight was obtained under tobacco extracts followed by wood ash, the mixture of wood ash and tobacco leaf extract, cypermethrin, and control respectively leading to an increase in profit margins and benefit-cost ratio in these treatments respectively except under cypermethrin where the variable cost was higher than gross income. …”
Get full text

Debt Management and Financial Performance of SACCOs in Karamoja Region: A Case of Kamukoi, Thurr and Lotuke SACCOs. by Apio, Brenda

“…The study suggests that SACCOs in the Karamoja region’s financial performance is significantly impacted by the benefits of debt management. This implies that if people are sensitized about the benefits of paying debts to the SACCOs, financial performance will increase. …”
Get full text