Cytokine-armed oncolytic herpes simplex viruses: a game-changer in cancer immunotherapy? by Howard L Kaufman, Hongbin Wang, Dipongkor Saha, Samuel D Rabkin, Mia Borlongan, Uyen Le, Hans J Nauwynck

“…A better understanding of cytokine delivery by oHSV can help improve clinical benefit from oncolytic virus immunotherapy in patients with cancer.…”
Get full text

Design and Optimization of a Hybrid Gas Generator for Hydrogen Peroxide Tank Pressurization by Mykhailo Vorobei, Mykola Bondarenko

“…This study presents a novel hybrid gas generator approach using hydrogen peroxide, showing how innovative materials enhance rocket system reliability and efficiency. Results benefit engineers seeking to improve space and defense systems. …”
Get full text

Assessment of Reductions in Emission-driven Air Pollution during the Beijing Olympic Games, Shanghai World Expo, Guangzhou Asian Games and Wuhan COVID-19 Lockdown by Ying Li, Haoxiang Xu

“…Comparison of these events show that shutdown or emission control measures applied to industries and power plants were generally benefit for PM2.5, SO2 and NO2 reduction, while those applied to on-road traffic control are less-effective for reducing NO2 and not works for the mean O3 reduction. …”
Get full text

Non-Linear Control of Interleaved Boost Converter Using Disturbance Observer-Based Approach by Avinash Mishra, Sanjoy Mandal, Jean-Yves Dieulot, Mrinal R. Bachute, Mohd Faizan, Anna Pinnarelli, Mehrdad Heidari, Alireza Soleimani

“…Applications such as fuel cell-based electric cars can benefit from the inherent characteristics of interleaved boost converters (IBCs), which include high voltage gain and minimal output voltage and input current ripples. …”
Get full text

THE IMPACT OF ARTIFICIAL INTELLIGENCE IN FOREIGN LANGUAGE LEARNING USING LEARNING MANAGEMENT SYSTEMS: A SYSTEMATIC LITERATURE REVIEW by Oke Oluwafemi Ayotunde, Dashty Ismil Jamil, Nadire Cavus

“…The most important finding in this systematic literature review is that the emergence of AI technology is helpful to both students and teachers in the learning of English as a foreign language using a learning management system as it improves and increases speaking, writing, reading, and listening skills processes and provides an easy, interesting, and personalized learning experience. The benefit of the study to shareholders; students and teachers, is to guide teachers on which AI tools to use and how they can be integrated or used into learning management systems to increase students’ reading, writing, speaking, and listening skills in teaching and learning foreign languages, especially the English language. …”
Get full text

Fast In-House Next-Generation Sequencing in the Diagnosis of Metastatic Non-small Cell Lung Cancer: A Hospital Budget Impact Analysis by Ubong Silas, Maximilian Blüher, Antonia Bosworth Smith, Rhodri Saunders

“…**Discussion:** Reducing testing turnaround time is a benefit of in-house NGS. It could contribute to fewer mNSCLC patients lost to second opinion and an increased number of patients on targeted therapy. …”
Get full text

Assessing the Fiscal Burden of Overweight and Obesity in Japan through Application of a Public Economic Framework by Ataru Igarashi, Cillian Copeland, Nikos Kotsopoulos, Riku Ota, Silvia Capucci, Daisuke Adachi

“…Policies aimed at reducing population-level obesity have the potential to benefit government accounts through increasing employment and reducing public spending, which can offset the cost of implementing these policies.…”
Get full text

Effect of intercropping Lolium perenne in Ziziphus jujuba orchards on soil quality in the canopy by Yao Ma, Bin Cao, Xiaojia Wang, Weijun Chen

“…The experiment assessed the impact on soil’s physical and chemical attributes beneath the jujube canopy, with a focus on correlating soil moisture, enzyme activity, and physical properties. …”
Get full text

Treatment Preferences for Acute Allergic Reactions: A Discrete Choice Experiment by Sofia Löfvendahl, Emelie Andersson, Sara Olofsson, Karin Wahlberg, Leif Bjermer, Göran Tornling, Jonas Hjelmgren

“…**Conclusion:** The findings show a substantial economic benefit of the oral film vs tablets for patients with AARs in Sweden. …”
Get full text

The Challenges of Social Work and Social Administration on Rural Development: A Case Study of Kabale District. by Sembure, Edson

“…Secondary methods are both participatory and non-participatory to be used for the benefit of society at large. Therefore role of social worker and social administration is widened for the betterment of individual, group and community. …”
Get full text

Rehabilitation Services and Disability in Buhara Sub-County Kabale District. by Orishaba, Joan

“…On the other hand, persons with intellectual disabilities could benefit from occupational therapy interventions to improve their ADL ability, even in the absence of any change in their awareness of disability. …”
Get full text

Role of Social Workers in Enhancing Chronic Care: A Case Study of Kabale Regional Referral Hospital Kabale District. by Musiimenta, Moureen

“…The primary methods of social work, which include participatory approaches with individuals, groups, and communities, are complemented by secondary methods that combine participatory and non-participatory strategies for societal benefit. Social workers fulfill diverse roles that evolve across different contexts and stages of their careers. …”
Get full text

E-Procurement and Procurement Performance of Central Government Procuring and Disposing Entities in Uganda: A Case Study of Kabale Regional Referral Hospital. by Kekitinisa, Privas

“…The study revealed the level of implementation of e-procurement in Kabale Regional Referral Hospital and these included, a lack of thorough cost-benefit analysis and effective communication of e-procurement benefits, mixed perceptions about management support, indicating the need for stronger and more consistent leadership, some suppliers may not be fully prepared for e-procurement, highlighting the need for additional support and training, although the ICT infrastructure is deemed adequate by the majority, there is still room for improvement to ensure seamless e-procurement operations. …”
Get full text

Public Procurement Practices and User Satisfaction in Kabale District: A Case Study of Kabale District Local Government. by Kyakunzire, Furumera

“…The study revealed the factors that the effect of non-discriminatory procurement practices on user satisfaction in Kabale District Local Government and these included the demand for enhanced Transparency and Trust, improved Quality of Services, enhanced Social Equity, regulatory Compliance, enhanced economic benefit, procurement system is robust and effective when it has a clear legal governing structure. …”
Get full text

Liver cancer risk and changes in lifestyle habits after successful hepatitis C virus therapy post-DAA HCV therapy: lifestyle changes and liver cancer risk by Núria Granel, Gemma Iserte, Concepció Bartres, Neus Llarch, Anna Pla, Víctor Sapena, Zoe Mariño, Sabela Lens, Ramón Vilana, Isabel Nuñez, Anna Darnell, Ernest Belmonte, Ángeles García-Criado, Alba Díaz, Marco Sanduzzi-Zamparelli, Carla Fuster, Sergio Muñoz-Martínez, Carmen Ayuso, Jordi Rimola, Alejandro Forner, Alexandre Soler, Ferran Torres, José Ríos, Jordi Bruix, Andrew M. Moon, Xavier Forns, María Reig

“…Post-SVR, patients may benefit from intensive counseling and pharmacotherapy to address obesity and alcohol use. …”
Get full text

Long-term real-world evidence of CPX-351 of high-risk patients with AML identified high rate of negative MRD and prolonged OS by Thomas Cluzeau, Fabio Guolo, Edmond Chiche, Paola Minetto, Ramy Rahme, Sarah Bertoli, Luana Fianchi, Jean-Baptiste Micol, Michele Gottardi, Pierre Peterlin, Sara Galimberti, Xavier Thomas, Giuliana Rizzuto, Olivier Legrand, Michela Rondoni, Emmanuel Raffoux, Giambattista Bertani, Alexis Caulier, Michelina D’Argenio, Caroline Bonmati, Atto Billio, Caroline Lejeune, Barbara Scappini, Arnaud Pigneux, Patrizia Zappasodi, Christan Recher, Francesco Grimaldi, Lionel Ades, Roberto M. Lemoli

Get full text

The Impacts of Breakthrough Drug Classes on Total Healthcare Expenditures by Zeynal Karaca, Steven N. Wiggins

“…**Background:** Pharmaceutical firms spend billions of dollars developing new therapies, which are often sold at a substantial premium over older therapies. The costs and benefits of these newer and more expensive drugs, however, are controversial. …”
Get full text

Recessive transition of rural residential land use from the perspective of value co-creation: A case study of Yiwu City, Zhejiang by ZHANG Cong, LONG Hualou, FENG Dedong

“…[Results] (1) Value co-creation of ural residential land follows the process model of “value consensus-value execution-value win-win” and the operational paradigm of “subject interaction - capacity embedding - benefit sharing”, driving the “element integration - structure reorganization - function optimization” of rural residential land use system, resulting in the dynamic evolution of diverse values such as residential security, economic property, production and operation, ecological protection, and cultural inheritance, and achieving the recessive rural residential land use transition. (2) Yiwu’s practice path of guiding multiple stakeholders to interact collaboratively, constructing “value consensus” for rural residential land, driving with multiple forces, and implementing “value execution” for rural residential land through multi-dimensional rule interaction is a successful model for realizing the recessive rural residential land use transformation through value co-creation. (3) Through the practice of value co-creation, Yiwu has achieved a transformation of the functional value of rural residential land from residential security orientation to economic property orientation, and then to a comprehensive and coordinated approach that encompasses residential security, production and operation, economic assets, and ecological protection, etc. …”
Get full text

Farmed fish welfare in Egypt: Surveying current practices and future directions for tilapia culture by Charlotte Flores, Christopher Bryant, Mohamed Bakr, Wasseem Emam

“…To this end, a survey was conducted of tilapia farmers across different regions, examining their level of training and knowledge as well as their farming practices including feeding, water changes and biosecurity measures.We found that just 11 % of the surveyed tilapia farmers had received any sort of training on the importance of animal welfare whilst 76 % said they could benefit from such training. Farmers perceived maintaining good water quality as the most important metric for achieving good tilapia welfare. …”
Get full text

Impact of the Timing of Enzyme Replacement Therapy Initiation and Cognitive Impairment Status on Outcomes for Patients with Mucopolysaccharidosis II (MPS II) in the United States:... by Karen S. Yee, David Alexanderian, Yidie Feng, Xiaowei Ren, Bernd Schweikert, Olulade Ayodele

“…**Conclusions:** Our findings reinforce previous recommendations for ERT to be initiated early to maximally benefit patients with MPS II, especially those younger than 3 years old. …”
Get full text