iPSC-derived exosomes as amphotericin B carriers: a promising approach to combat cryptococcal meningitis by Jingyu Zhao, Jingyu Zhao, Wei Fang, Yangjie Gao, Jiquan Chen, Guizhen Wang, Julin Gu

“…Amphotericin B (AmB) serves as the cornerstone treatment for CM; however, its clinical application is restricted due to limited penetration of the blood–brain barrier and associated nephrotoxicity.ObjectiveThis study investigates the use of exosomes derived from induced pluripotent stem cells (iPSC-Exos) as carriers for AmB in treating CM, aiming to enhance therapeutic efficacy and safety and reduce AmB toxicity.MethodsExosomes were extracted from iPSC culture supernatants using ultrafiltration and ultracentrifugation. …”
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Assessment of in vitro skin permeation and accumulation of phenolic acids from honey and honey-based pharmaceutical formulations by Anna Nowak, Anna Muzykiewicz-Szymańska, Magdalena Perużyńska, Edyta Kucharska, Łukasz Kucharski, Karolina Jakubczyk, Paulina Niedźwiedzka-Rystwej, Justyna Stefanowicz-Hajduk, Marek Droździk, Juraj Majtan

“…The inclusion of honey in the vehicle, in particular hydrogel increased the penetration of phenolic acids through the skin.…”
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Efficacy and cost-effectiveness of an ACT and compassion-based intervention for women with breast cancer: study protocol of two randomised controlled trials {1} by Inês A. Trindade, Andreia Soares, David Skvarc, Diogo Carreiras, Joana Pereira, Óscar Lourenço, Filipa Sampaio, Bruno de Sousa, Teresa C. Martins, Paula Boaventura, Joana Marta-Simões, Mind Project Team, Helena Moreira

“…Results will likely support the potential benefits of the Mind programme for breast cancer patients and highlight the clinical relevance of integrative and holistic interventions in oncology. …”
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An Integrated Approach for Conducting long-term PM2.5 Exposure and Health Impact Assessments for Residents of a City-scale by Ming-Shing Ho, Ming-Yeng Lin, Chih-Da Wu, Jung-Der Wang, Li-Hao Young, Hui-Tsung Hsu, Bing-Fang Hwang, Perng-Jy Tsai

“…Abstract This study aims to show the benefits of integrating the mobile monitoring system (MMS), hybrid land use regression (h_LUR), and air quality monitoring station (AQMS) data in both conducting long-term PM2.5 exposure assessment (EA) and health impact assessment (HIA) for residents in a city-scale. …”
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Sistem Pakar untuk Diagnosis Penyakit Tiroid dengan Gejala Psikologis Beserta Pengobatan Etnobotaninya by Rosyid Ridlo Al-Hakim, Yanuar Zulardiansyah Arief, Muhammad Haikal Satria, Agung Pangestu, Hexa Apriliana Hidayah, Glagah E. Setyowisnu, Prihantini Prihantini, Antonius Darma Setiawan, Esa Rinjani Cantika Putri

“…Abstract The role of an expert system can help an expert solve problems in a particular field. One of the benefits of the expert system is that it is used to diagnose a specific disease or symptom of a disease. …”
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Analisis Faktor-Faktor Penentu Kepuasan Pengguna Layanan Paylater Dengan Pendekatan Regresi Linier by Kastaman, Siska Komala Sari, Tora Fahrudin, Heru Nugroho

“…We conclude that if there is an engineering and non-engineering study programme background, with an awareness of paylater meaning that the knowledge of paylater both in terms of benefits and risks increases, customer satisfaction will be achieved. …”
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Tobacco control research in South Africa from 1978 to 2022: A scoping review by C O Egbe, C Dare, S Gwambe, C van Walbeek

“…A total of 79% of the studies used cross-sectional survey design, followed by randomised controlled trials (3.6%; n=8), time series studies (3.1%; n=7) and longitudinal and qualitative studies (2.2%; n=5 each), while costs and benefits analysis (0.4%; n=1) was used much less. Most were published in the South African Medical Journal, and three of the top international tobacco control journals: Tobacco Control, Nicotine and Tobacco Research and Tobacco Induced Diseases. …”
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Pemanfaatan Internet Of Things (Iot) Dalam Proses Pengeringan Rimpang Dengan Menggunakan Platform Node-Red by Gaguk Suprianto

“…So the industry will gain benefits starting from improving rhizome quality, shorter drying time, increasing production capacity and reducing production costs. …”
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Framework for smartphone-based grape detection and vineyard management using UAV-trained AI by Sergio Vélez, Mar Ariza-Sentís, Mario Triviño, Antonio Carlos Cob-Parro, Miquel Mila, João Valente

“…Viticulture benefits significantly from rapid grape bunch identification and counting, enhancing yield and quality. …”
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Which patients received a ReSPECT form, what was documented and what were the patient outcomes? A protocol for a retrospective observational study investigating the impact of the C... by Lucy Selman, Charlotte Chamberlain, Adam McDermott, Claire A Woodall, Lucy Victoria Pocock

“…Patterns of clinical recommendations documented on ReSPECT forms during the first year of its implementation may also have changed, particularly with reference to the pandemic.To determine the equity and potential benefits of implementation of the ReSPECT form process in BNSSG and contribute to the ACP evidence base, this study will describe the characteristics of patients in the BNSSG area who had a completed ReSPECT form recorded in their primary care medical records before, during and after the first wave of the COVID-19 pandemic; describe the content of ReSPECT forms; and analyse outcomes for those patients who died with a ReSPECT form.Methods and analysis We will perform an observational retrospective study on data, collected from October 2019 for 12 months. …”
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Blockchain-Based Value-Added Tax System: A Systematic Review by Vahideh Ghanooni Shishavan, Shaban Elahi, Sadegh Dorri Nogoorani, Ali Yazdian Varjani

“…The extant literature points to the benefits of employing blockchain in the tax system. …”
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Analisis Penerimaan Sistem Informasi Manajemen BPJS Kesehatan Layanan Primary Care di UPTD Puskesmas Kabupaten Banyumas by Yusmedi Nurfaizal, Rizki Wahyudi

“…The results of the analysis of the data show that the complexity and perceived ease of use variables have an impact on the perception of benefits with a constant value of 5.633. Second, perceived usefulness and perceived ease of use can determine the level of attitude of use with a constant value of 3.970. …”
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Current trends of unicompartmental knee arthroplasty (UKA): choosing between robotic-assisted and conventional surgeries and timing of procedures by Kelvin S. C. Cheung, Kai Chun Augustine Chan, Amy Cheung, Ping Keung Chan, Michelle Hilda Luk, Kwong Yuen Chiu, Henry Fu

“…Abstract Background With robotic advancements in UKA technology, we sought to explore if robotic-assisted UKA could translate to clinical benefits such as reduced hospital stays and lowered emergency readmissions. …”
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Sports and Games Union Policy by Kabale University

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De macrostructuur van het boek Samuël en de theologische implicaties daarvan by HJ Koorevaar

“…A. 1.1:1-2:11. Introduction. The begetting of Samuel and its function. a. 1.1. The begetting of Samuel. b. 1.2:1-11. …”
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The dose–effect relationship between acupuncture and its effect on primary insomnia: a systematic review and meta-analysis by Xiaoni Zhang, Xiaoni Zhang, Yue Wang, Chengyong Liu, Shan Qin, Liyu Lin, Liyu Lin, Can Dong, Wenzhong Wu, Wenzhong Wu, Zhaoming Chen

“…BackgroundThe benefits of acupuncture on primary insomnia (PI) have been well established in previous studies. …”
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Quantitative Performance Analysis of Respiratory Facemasks Using Atmospheric and Laboratory Generated Aerosols Following with Gamma Sterilization by Amit Kumar, D. N. Sangeetha, Ramani Yuvaraj, M. Menaka, Venkatesan Subramanian, Balasubramanian Venkatraman

“…However, FE reduced to about 70% for most penetrating particle size after sterilisation. Further, FE reduced to 84% for the particle > 0.3 µm and to 87% for the particle < 0.3 µm after sterilisation. …”
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Low-activity [18F]-somatostatin receptor (SSTR) imaging using [18F]SiTATE on a long axial field-of-view PET/CT scanner by Nils F. Trautwein, Eduardo Calderón, Pia M. Linder, Gerald Reischl, Philippe Driessen, Wenhong Lan, Andreas S. Brendlin, Thorben Groß, Helmut Dittmann, Martina Hinterleitner, Christian la Fougère, Fabian P. Schmidt, Lena S. Kiefer

“…Furthermore, in low activity [18F]SiTATE PET/CT, the UHS mode improves image quality and noise as well as lesion detectability compared to HS mode, further reinforcing the clinical benefits of this recently introduced reconstruction mode.…”
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Comparison of clinical and pharmacodynamic features of proton pump inhibitors efficacy in gastroesophageal reflux disease by O. A. Storonova, A. S. Trukhmanov

“…Intensity of acid-suppressive action of PPI depends on drug metabolic pathways and genetically determined features of cytochrome P450 system. …”
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Health Canada's use of its priority review process for new drugs: a cohort study by Joel Lexchin

“…The purpose of this study is to compare Health Canada's use of priority reviews to therapeutic ratings from two independent organisations, the Patented Medicine Prices Review Board (PMPRB) and the French drug bulletin Prescrire International, over the period 1 January 1997–31 December 2012.Design Cohort study.Data sources Annual reports of the Therapeutic Products Directorate, and the Biologics and Genetic Therapies Directorate; evaluations of therapeutic innovation from PMPRB and Prescrire International; WHO Collaborating Centre for Drug Statistics Methodology.Interventions Assessments by PMPRB and Prescrire International treated as a gold standard for postmarket therapeutic value.Primary and secondary outcome measures Drug-by-drug comparison between the review status from Health Canada and the therapeutic status from PMPRB/Prescrire using κ values, and positive and negative predictive values. …”
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