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2641
SETD2 loss-of-function uniquely sensitizes cells to epigenetic targeting of NSD1-directed H3K36 methylation
Published 2025-02-01“…Conclusions These findings unify genome-wide screening approaches with the latest genetic and pharmacologic modeling methodologies to reveal an entirely novel epigenetic approach to individualize therapies against a challenging loss-of-function SETD2 mutation in cancer.…”
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2642
Diagnostics and Treatment of Esophageal Achalasia (Clinical Guidelines of the Russian Gastroenterological Association, Russian Scientific Medical Society of Internal Medicine, Russ...
Published 2025-02-01“…The following hypotheses have been proposed as the main mechanisms for the development of achalasia: genetic predisposition, exposure to viral infections, and idiopathic autoimmune triggers. …”
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2643
Are horned cows in loose housing more stressed than hornless cows? a cross-sectional study in organic dairy farms
Published 2025-02-01“…In commercial dairy farming, the majority of cows are dehorned or genetically hornless. It is argued that this reduces the risk of injurious and stressful social conflicts. …”
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2644
Qual o lugar da branquitude na educação cearense? Percepções discente e docente de ser branca/o nesse lugar
Published 2024-09-01“…Entretanto, o movimento de pensar o outro personagem das relações raciais – o branco – tem se tornado uma tônica presente nos estudos étnico-raciais, a fim de viabilizá-lo e problematizá-lo nesse debate, campo esse denominado de estudos críticos da branquitude (Ramos, 1995; Cardoso, 2008; Bento, 2002). Nesse sentido, a fim de contribuir com a discussão, o presente artigo tem como objetivo pensar como estudantes brancos de duas escolas públicas de ensino médio do estado do Ceará compreendem sua raça nesse espaço. …”
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2645
Developing a master of science in health research ethics program in Northern Nigeria: a needs assessment
Published 2025-02-01“…Strengthening the health research ethics skills and knowledge of Nigerian researchers across the country is necessary given the growing genetics research infrastructure. Methods To inform the creation of a Master of Science in Health Research Ethics program in northern Nigeria, we conducted a needs assessment comprised of semi-structured interviews with nine Nigerian bioethics experts. …”
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2646
Modeling, evaluation and forecasting of suspended sediment load in Kal-e Shur River, Sabzevar Basin, in northeast of Iran
Published 2025-02-01“…The study employs ensemble Bagging algorithms, the gradient boosting machine (GBM), genetic algorithm, Naïve Bayes algorithm, gradient boosting decision trees, and extremely randomized trees. …”
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2647
Exploration of the molecular mechanism behind a novel natural genic male-sterile mutation of 1205A in Brassica napus
Published 2025-02-01“…This study not only offers valuable insights into the research and practical application of plant male sterility but also serves as a case study on the genetic regulatory mechanisms governing male sterility.…”
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2648
The Shaping of New Ethnic Clusters in Kalmykia, 1957–1991
Published 2024-05-01“…The study employs the historical/comparative and historical/genetic methods to examine materials from the National Archive of Kalmykia, published documents and statistical tables, republican newspaper articles. …”
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2649
Symbiotic diversity of Portunus pelagicus (Linnaeus, 1758) in Vietnam - implication for species and geographic variations
Published 2025-01-01“…Symbiont species of the crabs were determined using morphological and genetic characters, and the temporal and spatial variation pattern in the symbiont were examined. …”
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2650
Implications of parental lifestyle changes and education level on adolescent offspring weight: a population based cohort study - The HUNT Study, Norway
Published 2018-08-01“…Objective Obesity tends to cluster in families reflecting both common genetics and shared lifestyle patterns within the family environment. …”
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2651
The Analysis of the Fetal Abdominal Wall and Gastrointestinal Tract Abnormalities in a Single Tertiary Center
Published 2024-12-01“…The most common anterior abdominal wall malformations were omphalocele (n=29, 43.3%) and gastroschisis (6 cases, 9.0%), and the most common fetal gastrointestinal tract anomalies were duodenal atresia (n=10, 14.9%), dilated bowel (n=5, 7.4%), and intestinal atresia (n=4, 5.9%). While genetic testing was carried out in 18 cases (27%), chromosomal abnormality was found in 6 (9.0%) cases. …”
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2652
Leveraging Quantum LSTM for High-Accuracy Prediction of Viral Mutations
Published 2025-01-01“…In response to these challenges, this study introduces a novel quantum-enhanced LSTM (QLSTM) model designed to predict genetic mutations, specifically focusing on viral protein sequences. …”
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2653
Legume-derived phenolic acids influence Fusarium oxysporum f.sp. strigae compatibility and biocontrol potential in a Striga push–pull system
Published 2025-03-01“…Biological control of Striga hermonthica (Del.) Benth. includes push–pull, intercropping using legumes, and soil-borne fungi such as Fusarium oxysporum f.sp. strigae (FOS). …”
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2654
Analysis of a mouse germ cell tumor model establishes pluripotency-associated miRNAs as conserved serum biomarkers for germ cell cancer detection
Published 2025-02-01“…We previously developed a genetically engineered mouse model featuring malignant mixed TGCTs consisting of pluripotent embryonal carcinoma (EC) and differentiated teratoma that, like the corresponding human malignancies, originate in utero and are highly chemosensitive. …”
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2655
The link between spreading depolarization and innate immunity in the central nervous system
Published 2025-02-01“…Inflammation extends beyond the central nervous system to peripheral structures, including the meninges and trigeminovascular system, which are critical for headache initiation. Genetic factors, particularly familial hemiplegic migraine (FHM), exacerbate neuroinflammatory responses to SD, leading to increased susceptibility and prolonged headache behaviors. …”
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2656
Heterochrony in orthodenticle expression is associated with ommatidial size variation between Drosophila species
Published 2025-02-01“…However, very little is known about the genetic and developmental bases of differences in eye size. …”
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2657
Characterization of environmental and clinical surveillance inputs to support prospective integrated modeling of the polio endgame.
Published 2025-01-01“…In addition, the development and expansion of genetic testing technologies create new opportunities for poliovirus surveillance system designs. …”
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2658
Saturated Transposon Analysis in Yeast as a one-step method to quantify the fitness effects of gene disruptions on a genome-wide scale.
Published 2025-01-01“…Notably, it has been demonstrated that data obtained from TIS experiments can be used for fitness quantification and the construction of genetic interaction maps, but this potential is only sporadically exploited. …”
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2659
Incidence of extended spectrum beta-lactamase (ESBL) producing Escherichia coli isolated from women with urinary tract infections in Jordan
Published 2025-02-01“…The blaCTX-M gene was genetically confirmed in 20 (10.1%) of the isolates. …”
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2660
Metabarcoding the night sky: Monitoring landscape-scale insect diversity through bat diet
Published 2025-03-01“…Our study shows that genetic analysis of bat feces provides an efficient and promising approach to assess insect diversity patterns at the landscape level, and highlights the potential of widespread bat species for the monitoring of terrestrial insects at large scales.…”
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