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    Post-Translational Modifications of Proteins Orchestrate All Hallmarks of Cancer by Pathea Shawnae Bruno, Aneeta Arshad, Maria-Raluca Gogu, Natalie Waterman, Rylie Flack, Kimberly Dunn, Costel C. Darie, Anca-Narcisa Neagu

    Published 2025-01-01
    “…Post-translational modifications (PTMs) of proteins dynamically build the buffering and adapting interface between oncogenic mutations and environmental stressors, on the one hand, and cancer cell structure, functioning, and behavior. Aberrant PTMs can be considered as enabling characteristics of cancer as long as they orchestrate all malignant modifications and variability in the proteome of cancer cells, cancer-associated cells, and tumor microenvironment (TME). …”
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  3. 143
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    Volt/VAr Regulation of the West Mediterranean Regional Electrical Grids Using SVC/STATCOM Devices With Neural Network Algorithms by H. Feza Carlak, Ergin Kayar

    Published 2025-02-01
    “…Many researchers have focused on the behavior of voltage in the unbalanced state, and the majority of the studies have been done with STATCOM. …”
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    Gene mutation, clinical characteristics and pathology in resectable lung adenocarcinoma by Ji’an Zou, Wei Han, Yan Hu, Chao Zeng, Jina Li, Weixuan Lei, Jieming Cao, Quanming Fei, Mengqi Shao, Junqi Yi, Zeyu Cheng, Li Wang, Fang Wu, Wenliang Liu

    Published 2025-01-01
    “…Pathological examination and genetic testing have become a routine procedure for lung adenocarcinoma following radical resection. …”
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  9. 149

    CD2AP deficiency aggravates Alzheimer’s disease phenotypes and pathology through p38 MAPK activation by Yan-Yan Xue, Zhe-Sheng Zhang, Rong-Rong Lin, Hui-Fen Huang, Ke-Qing Zhu, Dian-Fu Chen, Zhi-Ying Wu, Qing-Qing Tao

    Published 2024-12-01
    “…Abstract Background Alzheimer’s disease (AD) is the most common form of neurodegenerative disorder, which is characterized by a decline in cognitive abilities. Genome-wide association and clinicopathological studies have demonstrated that the CD2-associated protein (CD2AP) gene is one of the most important genetic risk factors for AD. …”
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  10. 150

    Role of physical activity in cardiovascular disease prevention: impact of epigenetic modifications by Yi Sun, Zuoying Peng, Hua Liang

    Published 2025-01-01
    “…Exercise is a potent epigenetic modulator that induces direct and long-lasting genetic changes and activates biological signals associated with cardiovascular health. …”
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  11. 151

    A Case of Rafiq Syndrome (MAN1B1-CDG) in a Palestinian Child, With Brief Literature Review of 44 Cases by Reema Iskafi MD, Bahaa AbuRahmeh MD, Roa’a Aljuneidi MD, Hidaya AlShweiki MD, Siraj Abdelnabi MD, Anas Abukhalaf MBBS, Bara’ Maraqa PBoS

    Published 2025-01-01
    “…Rafiq syndrome, MAN1B1-CDG, was described in 2010 and associated with genetic mutation in MAN1B1 gene in 2011. …”
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    Developmental and Epileptic Encephalopathy: Pathogenesis of Intellectual Disability Beyond Channelopathies by Alexandra D. Medyanik, Polina E. Anisimova, Angelina O. Kustova, Victor S. Tarabykin, Elena V. Kondakova

    Published 2025-01-01
    “…Developmental and epileptic encephalopathies (DEEs) are a group of neuropediatric diseases associated with epileptic seizures, severe delay or regression of psychomotor development, and cognitive and behavioral deficits. …”
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  14. 154

    A Case of Physically Abused OCD Patient Who Physically Abused Her own Child by Tuðba AYAZ, Ayþe Gül YILMAZ ÖZPOLAT, Damla YÜCEL, Umut ALTUNÖZ

    Published 2013-08-01
    “…It was suggested that along with genetic factors various psychosocial factors may play a role in the development of Obsessive Compulsive Disorder (OCD). …”
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  15. 155

    FTO effects the proliferation, invasion, and glycolytic metabolism of colon cancer by regulating PKM2 by Kongyan Zhang, Fei Zhang, Jiahe Wang

    Published 2025-01-01
    “…The Fat mass and obesity-associated protein (FTO), a genetic variant associated with obesity, significantly impact the energetic metabolism of mechanical tumors. …”
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  16. 156

    Oral health-related conditions in Ecuador: A temporal trend analysis of hospital discharges from 2000-2023. by Verónica Baldeón, Adriana Hernández, Sthephany Tapia, Alejandro Rodriguez

    Published 2025-01-01
    “…Many of the oral conditions identified in the study were malignancies, which are caused by a complex relationship between genetic, environmental, and behavioral factors. Conducting early detection analysis is essential to reduce their occurrence.…”
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  17. 157

    New Paradigm in Cell Therapy Using Sperm Head to Restore Brain Function and Structure in Animal Model of Alzheimer’s Disease: Support for Boosting Constructive Inflammation vs. Ant... by Nafiseh Pakravan, Ardeshir Abbasi, Zuhair Mohammad Hassan

    Published 2022-01-01
    “…Alzheimer’s is characterized by accumulation of amyloid-β (Aβ) associated with insufficient clearance of toxicants from the brain establishing a chronic inflammation and other abnormalities in the brain. …”
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  18. 158

    Linking altered neuronal and synaptic properties to nicotinic receptor Alpha5 subunit gene dysfunction: a translational investigation in rat mPFC and human cortical layer 6 by Danqing Yang, Guanxiao Qi, Daniel Delev, Uwe Maskos, Dirk Feldmeyer

    Published 2025-01-01
    “…Abstract Genetic variation in the α5 nicotinic acetylcholine receptor (nAChR) subunit of mice results in behavioral deficits linked to the prefrontal cortex (PFC). rs16969968 is the primary Single Nucleotide Polymorphism (SNP) in CHRNA5 strongly associated with nicotine dependence and schizophrenia in humans. …”
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  19. 159

    Exposure to major coronary heart disease events reduces lung cancer risk: a mendelian randomization study based on a European population by Dongming He, Hongting Lu, Xinhuai Ou, Tiaozhan Zheng, Zhiwen Zheng, Zhanyu Xu, Xiaohong Duan, Shikang Li

    Published 2025-01-01
    “…Relevant single nucleotide polymorphisms (SNPs) associated with MCHDE and lung cancer were carefully selected, with particular attention given to mitigating potential confounders, such as smoking behaviors and statin use. …”
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