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141
Refining management strategies for Lennox–Gastaut syndrome: Updated algorithms and practical approaches
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142
Post-Translational Modifications of Proteins Orchestrate All Hallmarks of Cancer
Published 2025-01-01“…Post-translational modifications (PTMs) of proteins dynamically build the buffering and adapting interface between oncogenic mutations and environmental stressors, on the one hand, and cancer cell structure, functioning, and behavior. Aberrant PTMs can be considered as enabling characteristics of cancer as long as they orchestrate all malignant modifications and variability in the proteome of cancer cells, cancer-associated cells, and tumor microenvironment (TME). …”
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Volt/VAr Regulation of the West Mediterranean Regional Electrical Grids Using SVC/STATCOM Devices With Neural Network Algorithms
Published 2025-02-01“…Many researchers have focused on the behavior of voltage in the unbalanced state, and the majority of the studies have been done with STATCOM. …”
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145
Endothelial and neuronal engagement by AAV-BR1 gene therapy alleviates neurological symptoms and lipid deposition in a mouse model of Niemann-Pick type C2
Published 2025-01-01“…Composite phenotype scores and behavioral tests were assessed for the following 6 weeks and visually documented. …”
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146
A randomized, placebo-controlled, cross-over trial of ketamine in Rett syndrome
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147
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Gene mutation, clinical characteristics and pathology in resectable lung adenocarcinoma
Published 2025-01-01“…Pathological examination and genetic testing have become a routine procedure for lung adenocarcinoma following radical resection. …”
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149
CD2AP deficiency aggravates Alzheimer’s disease phenotypes and pathology through p38 MAPK activation
Published 2024-12-01“…Abstract Background Alzheimer’s disease (AD) is the most common form of neurodegenerative disorder, which is characterized by a decline in cognitive abilities. Genome-wide association and clinicopathological studies have demonstrated that the CD2-associated protein (CD2AP) gene is one of the most important genetic risk factors for AD. …”
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150
Role of physical activity in cardiovascular disease prevention: impact of epigenetic modifications
Published 2025-01-01“…Exercise is a potent epigenetic modulator that induces direct and long-lasting genetic changes and activates biological signals associated with cardiovascular health. …”
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151
A Case of Rafiq Syndrome (MAN1B1-CDG) in a Palestinian Child, With Brief Literature Review of 44 Cases
Published 2025-01-01“…Rafiq syndrome, MAN1B1-CDG, was described in 2010 and associated with genetic mutation in MAN1B1 gene in 2011. …”
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152
Loss of MEF2C function by enhancer mutation leads to neuronal mitochondria dysfunction and motor deficits in mice
Published 2025-02-01“…However, the mechanism behind genetic mutations in the non-coding region of genes that affect epigenetic modifications remains unclear. …”
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153
Developmental and Epileptic Encephalopathy: Pathogenesis of Intellectual Disability Beyond Channelopathies
Published 2025-01-01“…Developmental and epileptic encephalopathies (DEEs) are a group of neuropediatric diseases associated with epileptic seizures, severe delay or regression of psychomotor development, and cognitive and behavioral deficits. …”
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154
A Case of Physically Abused OCD Patient Who Physically Abused Her own Child
Published 2013-08-01“…It was suggested that along with genetic factors various psychosocial factors may play a role in the development of Obsessive Compulsive Disorder (OCD). …”
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155
FTO effects the proliferation, invasion, and glycolytic metabolism of colon cancer by regulating PKM2
Published 2025-01-01“…The Fat mass and obesity-associated protein (FTO), a genetic variant associated with obesity, significantly impact the energetic metabolism of mechanical tumors. …”
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156
Oral health-related conditions in Ecuador: A temporal trend analysis of hospital discharges from 2000-2023.
Published 2025-01-01“…Many of the oral conditions identified in the study were malignancies, which are caused by a complex relationship between genetic, environmental, and behavioral factors. Conducting early detection analysis is essential to reduce their occurrence.…”
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157
New Paradigm in Cell Therapy Using Sperm Head to Restore Brain Function and Structure in Animal Model of Alzheimer’s Disease: Support for Boosting Constructive Inflammation vs. Ant...
Published 2022-01-01“…Alzheimer’s is characterized by accumulation of amyloid-β (Aβ) associated with insufficient clearance of toxicants from the brain establishing a chronic inflammation and other abnormalities in the brain. …”
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158
Linking altered neuronal and synaptic properties to nicotinic receptor Alpha5 subunit gene dysfunction: a translational investigation in rat mPFC and human cortical layer 6
Published 2025-01-01“…Abstract Genetic variation in the α5 nicotinic acetylcholine receptor (nAChR) subunit of mice results in behavioral deficits linked to the prefrontal cortex (PFC). rs16969968 is the primary Single Nucleotide Polymorphism (SNP) in CHRNA5 strongly associated with nicotine dependence and schizophrenia in humans. …”
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159
Exposure to major coronary heart disease events reduces lung cancer risk: a mendelian randomization study based on a European population
Published 2025-01-01“…Relevant single nucleotide polymorphisms (SNPs) associated with MCHDE and lung cancer were carefully selected, with particular attention given to mitigating potential confounders, such as smoking behaviors and statin use. …”
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160
Current and Novel Therapies for Cluster Headache: A Narrative Review
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