Cardiovascular risk in childhood and young adulthood is associated with the hemodynamic response function in midlife: The Bogalusa Heart Study by Kai-Cheng Chuang, Maryam Naseri, Sreekrishna Ramakrishnapillai, Kaitlyn Madden, Julia St Amant, Kevin McKlveen, Kathryn Gwizdala, Ramasudhakar Dhullipudi, Lydia Bazzano, Owen Carmichael

“…Background: In functional MRI, a hemodynamic response function (HRF) describes how neural events are translated into a blood oxygenation response detected through imaging. …”
Get full text

Effectiveness of biomarker-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection: the BATCH RCT by Cherry-Ann Waldron, Philip Pallmann, Simon Schoenbuchner, Debbie Harris, Lucy Brookes-Howell, Céu Mateus, Jolanta Bernatoniene, Katrina Cathie, Saul N Faust, Josie Henley, Lucy Hinds, Kerry Hood, Chao Huang, Sarah Jones, Sarah Kotecha, Sarah Milosevic, Helen Nabwera, Sanjay Patel, Stéphane Paulus, Colin VE Powell, Jenny Preston, Huasheng Xiang, Emma Thomas-Jones, Enitan D Carrol

“…Background Procalcitonin is a biomarker specific for bacterial infection, with a more rapid response than other commonly used biomarkers, such as C-reactive protein, but it is not routinely used in the National Health Service. …”
Get full text

Tumor mutational burden and survival on immune checkpoint inhibition in >8000 patients across 24 cancer types by Vivek Subbiah, Samuel J Klempner, Neeraj Agarwal, David P Carbone, Amit Mahipal, Shilpa Gupta, David Fabrizio, Jeffrey S Ross, Gerald Li, David R Gandara, Miles C Andrews, Jonathan W Riess, Ramez N Eskander, Ryon P Graf, Geoffrey R Oxnard, Sarah Sammons, Jeremy Snider, Lilia Bouzit, Cheryl Cho-Phan, Megan Price, Julia C F Quintanilha, Richard Sheng Poe Huang

“…Background There is uncertainty around clinical applicability of tumor mutational burden (TMB) across cancer types, in part because of inconsistency between TMB measurements from different platforms. …”
Get full text

Protocol and Statistical Analysis Plan for a Multicenter Randomized Trial of Ketamine vs Etomidate for Emergency Tracheal IntubationTake-Home Points by Stephanie C. DeMasi, MD, Brant Imhoff, MS, Ariel A. Lewis, BSN, RN, MPH, Kevin P. Seitz, MD, Brian E. Driver, MD, Kevin W. Gibbs, MD, Adit A. Ginde, MD, MPH, Stacy A. Trent, MD, MPH, Derek W. Russell, MD, Amelia L. Muhs, MD, Matthew E. Prekker, MD, MPH, John P. Gaillard, MD, Daniel Resnick-Ault, MD, L. Jane Stewart, MD, JD, MPH, Micah R. Whitson, MD, Graham W.W. Van Schaik, MD, MBA, Aaron E. Robinson, MD, MPH, Jessica A. Palakshappa, MD, Neil R. Aggarwal, MD, MHSc, Jason C. Brainard, MD, David J. Douin, MD, Carolynn Lyle, PA-C, MPH, Sheetal Gandotra, MD, Aaron J. Lacy, MD, Kristen C. Sherlin, PharmD, Greta K. Carlson, MD, J. Maycee Cain, BS, Brianne Redman, MD, Carrie Higgins, BSN, Cori Withers, BS, Logan L. Beach, MD, Barbara Gould, Jasmine McIntosh, Bradley D. Lloyd, RRT-ACCS, Tiffany L. Israel, MSSW, Li Wang, MS, Todd W. Rice, MD, Wesley H. Self, MD MPH, Jin H. Han, MD, Jonathan D. Casey, MD, Matthew W. Semler, MD

“…Background: Emergency tracheal intubation is a common and high-risk procedure. …”
Get full text

poetics of Eevhen Hrebinka’s poem “Bohdan”: (anti)colonial strategies of the art CONSCIOUSNESS by Olga V. Shaf, Oleksandra V. Goniuk

“…It is important to recognize the influence of psychical and mental backgrounds in the author’s consciousness and literary aesthetics onto the juxtaposition of anti-colonial and colonial art thinking in the 19th century Ukrainian literature in general, and Hrebinka’s works in particular. …”
Get full text

Evaluation of prognostic models to improve prediction of metastasis in patients following potentially curative treatment for primary colorectal cancer: the PROSPECT trial by Vicky Goh, Susan Mallett, Manuel Rodriguez-Justo, Victor Boulter, Rob Glynne-Jones, Saif Khan, Sarah Lessels, Dominic Patel, Davide Prezzi, Stuart Taylor, Steve Halligan

“…Background Despite apparently curative treatment, many patients with colorectal cancer develop subsequent metastatic disease. …”
Get full text

Influenza vaccination and myocarditis among patients receiving immune checkpoint inhibitors by Anju Nohria, Stephane Ederhy, Franck Thuny, Michael Mahmoudi, Alexander R. Lyon, Ryan J. Sullivan, Javid J. Moslehi, Justine V. Cohen, Magid Awadalla, Doll Lauren Alexandra Golden, Syed S. Mahmood, Raza M. Alvi, Nathaniel D. Mercaldo, Malek Z. O. Hassan, Dahlia Banerji, Adam Rokicki, Connor Mulligan, Sean P. T. Murphy, Maeve Jones-O’Connor, Lucie M. Heinzerling, Merna Armanious, Rongras Damrongwatanasuk, Carol L. Chen, Dipti Gupta, Michael C. Kirchberger, Sachin P. Shah, Sarju Ganatra, Paaladinesh Thavendiranathan, Muhammad A. Rizvi, Gagan Sahni, Carlo G. Tocchetti, Valentina Mercurio, Donald P. Lawrence, John D. Groarke, Michael G. Fradley, Kerry L. Reynolds, Tomas G. Neilan

“…Background Influenza vaccination (FV) is recommended for patients with cancer. …”
Get full text

Impact of short-term aircraft noise on cardiovascular disease risk in the area surrounding London Heathrow airport: the RISTANCO epidemiological study by Xiangpu Gong, Nicole Itzkowitz, Calvin Jephcote, Kathryn Adams, Glory O Atilola, John Gulliver, Marta Blangiardo, Anna Hansell

“…Background Long-term exposure to aircraft noise has been associated with small increases in cardiovascular disease risk, but there are almost no short-term exposure studies. …”
Get full text

Development of Women Resilience in the Workplace: A Solution to Break the Glass Ceiling by Farajallah Rahimi, Maral Ahmadi Arpanahi

“…In this research, library method was used to collect information related to theoretical literature and research background, and questionnaire was used to collect data related to research variables. …”
Get full text

Outcomes for older people with screening-detected versus existing chronic kidney disease: a cohort study with data linkage by Anna K Forbes, José M Ordóñez-Mena, Winnie Mei, Clare J Taylor, Nicholas Jones, Jennifer A Hirst, FD Richard Hobbs

“…Design & setting: Prospective cohort study of 892 primary care patients aged ≥60 years with CKD (existing and screening detected) in Oxfordshire, with data linkage to civil death registry and secondary care. Method: Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazard models to compare the risk of all-cause mortality, hospitalisation, CVD, ESKD separately, and as a composite between CKD groups, as well as to identify factors associated with mortality. …”
Get full text

Comparison of antimicrobial efficacy and therapeutic index properties for common wound cleansing solutions, focusing on solutions containing PHMB by Watson, Fergus, Chen, Rui, Saint Bezard, Jeanne, Percival, Steven

“…The optimal solution would have minimal cytotoxicity to the patient while maintaining a minimum concentration required for antimicrobial activity necessary to prevent opportunistic pathogens and biofilm formation.Method: A variety of common wound irrigation products, including polyhexanide in various concentrations and compositions, iodine and hypochlorous acid-based solutions, were tested and compared for their activity against pathogens according to the ESKAPE group of nosocomial relevant microbes. …”
Get full text