Suicide and suicide attempt in users of GLP-1 receptor agonists: a nationwide case-time-control studyResearch in context by Julien Bezin, Anne Bénard-Laribière, Emilie Hucteau, Marie Tournier, François Montastruc, Antoine Pariente, Jean-Luc Faillie

“…Summary: Background: Glucagon-like peptide-1 receptor agonists (GLP-1 RA) are extensively evaluated for the risk of suicidal behaviors or ideation; the influence of psychiatric history or obesity on this potential effect remains to be investigated. …”
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Hyssopus cuspidatus volatile oil: a potential treatment for steroid-resistant asthma via inhibition of neutrophil extracellular traps by Xu Wang, Hui-Ming Peng, Meng-Ru Zhang, Jing-Jing Li, Chuan-Peng Zhao, Ya-Li Zhang, Si-Yu Wang, Si-Ying Zhu, Jian-Kang Lu, Hai-Long Yin, Qiang Yin, Jin-Bo Fang

“…Abstract Background Steroid-resistant asthma (SRA) is a form of asthma resistant to corticosteroid therapy, which is characterized by the presence of neutrophil-predominant inflammatory response and neutrophil extracellular traps (NETs) formation. …”
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Association Between Size of Left Ventricle and Long‐Term Cardiovascular Events by Yun‐Jiu Cheng, Zi‐Li Liao, Li‐Juan Liu, Yue‐Dong Ma, Xu‐Miao Chen, Ze‐Xuan Wu, Hui‐Qiang Wei, Wei‐Dong Lin, Yi‐Jian Liao, Su‐Hua Wu, Yu‐Mei Xue, Li‐Chun Wang, Yang Wu

“…Background The prognostic significance of small left ventricle (LV) in the general population and its association with cardiovascular disease remain elusive. …”
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Prognostic value of global coronary flow reserve before and after elective percutaneous coronary intervention in patients with chronic coronary syndrome by Kai Nogami, Masahiro Hoshino, Eisuke Usui, Yoshihisa Kanaji, Tomoyo Sugiyama, Masahiro Hada, Tatsuhiro Nagamine, Hiroki Ueno, Mirei Setoguchi, Tomohiro Tahara, Tatsuya Sakamoto, Takashi Mineo, Tsunekazu Kakuta

“…ABSTRACT: Background: Impaired global coronary flow reserve (G-CFR), evaluated through phase-contrast cine cardiovascular magnetic resonance (PC-CMR), has been linked to worse outcomes in patients with cardiovascular disease. …”
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Clinical Features and Outcomes of Primary Sclerosing Cholangitis in the Highly Admixed Brazilian Population by Mateus Jorge Nardelli, Paulo Lisboa Bittencourt, Guilherme Grossi Lopes Cançado, Luciana Costa Faria, Cristiane Alves Villela-Nogueira, Vivian Rotman, Eliabe Silva de Abreu, Fernanda Maria Farage Osório, Andreia Silva Evangelista, Liliana Sampaio Costa Mendes, Daniel Ferraz de Campos Mazo, Elodie Bonfim Hyppolito, Adrielly de Souza Martins, Liana Codes, Izabelle Venturini Signorelli, Geisa Perez Medina Gomide, Luciana Agoglia, Claudia Alexandra Pontes Ivantes, Valéria Ferreira de Almeida e Borges, Gabriela Perdomo Coral, Rosamar Eulira Fontes Rezende, Maria Lucia Gomes Ferraz, Debora Raquel Benedita Terrabuio, Eduardo Luiz Rachid Cançado, Claudia Alves Couto

“…Background. Primary sclerosing cholangitis (PSC) is associated with a broad phenotypic spectrum in different populations from diverse ethnic and racial backgrounds. …”
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Utility of serum cytokine testing to differentiate complicated common variable immunodeficiency in resource limited settings by Aditi Jogdand, BS, Karen M. Gilbert, PhD, Joseph S. Hong, BS, Andrew J. Pak, BS, Katherine Liu, BA, Uhuru Kamau, MS, Neha V. Khairnar, MS, MBA, Henry C. Ssemaganda, MD, MS, Daniel DiGiacomo, MD, MPH, Sara Barmettler, MD, MPH, Mei-Sing Ong, PhD, Jocelyn R. Farmer, MD, PhD

“…Background: Common variable immunodeficiency (CVID) is the most common, symptomatic inborn error of immunity (IEI) worldwide. …”
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Serum NT-ProBNP/Chloride Ratio Predicts Adverse Cardiovascular Outcomes in Patients with Acute Heart Failure by Victor José Leal-Alcántara, Eder González-Macedo, Ana Cristina Maldonado-May, Alberto Santiago-Hernández, Eder Jonathan Amaro-Palomo, Sarai Hernandez-Pastrana, Anna Elisa Adib-Gracia, Rodrigo Gopar-Nieto, Daniel Sierra-Lara Martínez, José Luis Briseño-De la Cruz, Héctor González-Pacheco, Alexandra Arias-Mendoza, Diego Araiza-Garaygordobil

“…<b>Background:</b> Heart failure (HF) is a public health issue. …”
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α-Glucosidase Inhibition Mechanism and Anti-Hyperglycemic Effects of Flavonoids from Astragali Radix and Their Mixture Effects by Xing Han, Pengpu Wang, Jing Zhang, Yang Lv, Zhigao Zhao, Fengxian Zhang, Mingying Shang, Guangxue Liu, Xuan Wang, Shaoqing Cai, Feng Xu

“…<b>Background</b>: Inhibition of intestinal α-glucosidase is a key strategy for controlling postprandial hyperglycemia in diabetes. …”
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Efficacy of immune checkpoint inhibitors for in-transit melanoma by Victoria Atkinson, Shahneen Sandhu, Georgina V Long, David E Gyorki, George Au-Yeung, Grant A McArthur, Euan Walpole, Mark Smithers, Alexander Menzies, Robyn Saw, Tavis Read, Julia Lai-Kwon, Lumine Na, Emilia Nan Tie, Michael Alexander Rtshiladze, James Bozzi

“…Background The efficacy of immune checkpoint inhibitors (ICI) in metastatic melanoma is well established. …”
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Low-Density Lipoprotein Cholesterol Level, the Lower the Better? Analysis of Korean Patients in the Treat Stroke to Target Trial by Hanim Kwon, Jae-Chan Ryu, Jae-Kwan Cha, Sang Min Sung, Tae-Jin Song, Kyung Bok Lee, Eung-Gyu Kim, Yong-Won Kim, Ji Hoe Heo, Man Seok Park, Kyusik Kang, Byung-Chul Lee, Keun-Sik Hong, Oh Young Bang, Jei Kim, Jong S. Kim

“…Background and Purpose The Treat Stroke to Target (TST) was a randomized clinical trial involving French and Korean patients demonstrating that a lower low-density lipoprotein cholesterol (LDL-C, <70 mg/dL) target group (LT) experienced fewer cerebro-cardiovascular events than a higher target (90–110 mg/dL) group (HT). …”
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Association between inflammatory score, healthy lifestyle, and cardiovascular disease: a national cohort study by Han-Qing Zhao, Han-Qing Zhao, Jia-Le Lv, Jia-Le Lv, Yuan-Zhi Gao, Bo Hu, Zong-Da Du, Zong-Da Du, Zong-Da Du, Yan Wang, Mei-Lin Wang, Mei-Lin Wang, Meng-Di Hou, Fang Li, Xue Xing, Ming-Hui Sun

“…BackgroundThe inflammation score is currently regarded as a reliable composite index for comprehensive assessment of inflammatory status. …”
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Prior metabolic surgery attenuates the weight-loss efficacy of liraglutide in patients with mild obesity by Yuqin Ouyang, Yuqin Ouyang, Xinyue Xiang, Xinyue Xiang, Xinyun Hu, Xinyun Hu, Xuehui Chu, Wenjuan Tang, Wenjuan Tang, Wenhuan Feng, Wenhuan Feng, Wenhuan Feng

“…BackgroundLiraglutide effectively manages mild obesity, but individual weight loss outcomes vary significantly. …”
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Associations between triglyceride glucose-body mass index and 30-day mortality in patients with hemorrhagic stroke: analysis of the MIMIC-IV database by Yuexin Lu, Yuexin Lu, Enjie Song, Enjie Song, Ruilin Chen, Ruilin Chen, Long Jing, Long Jing, Jiahao Tang, Jiahao Tang, Shunan Shi, Shunan Shi, Ming Wang, Ming Wang, Ming Wang, Ming Wang, Shu Wan, Shu Wan, Shu Wan, Shu Wan

“…BackgroundHemorrhagic stroke (HS), accounting for over 40% of stroke-related deaths, imposes a severe global health burden due to high mortality and disability rates. …”
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Very low urinary marinobufagenin excretion reflects a high risk of disease progression in non-advanced CKD by Davide Bolignano, Davide Bolignano, Marta Greco, Marta Greco, Loredana Tripodi, Mario D’Agostino, Paola Cianfrone, Roberta Misiti, Roberta Misiti, Sara Pugliese, Mariateresa Zicarelli, Michela Musolino, Michela Musolino, Daniela Patrizia Foti, Daniela Patrizia Foti, Michele Andreucci, Michele Andreucci, Giuseppe Coppolino, Giuseppe Coppolino

“…BackgroundChronic kidney disease (CKD) has now reached pandemic proportions but risk prediction towards end-stage kidney disease (ESKD) remains challenging. …”
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Deprescribing anticholinergics to preserve brain health: reducing the risk of dementia through deprescribing (R2D2): study protocol for a randomized clinical trial by Noll L. Campbell, Richard J. Holden, Sujuan Gao, Frederick W. Unverzagt, Kathleen A. Lane, Allie Carter, Addison B. Harrington, Sneha Manoharan, Neha Manoharan, Danielle L. Rosenthal, Christopher Pitts, Kathryn Pelkey, Emily Papineau, David M. Lauck, Noha Keshk, Khalid Alamer, Hussein Khalil, Malaz A. Boustani

“…Abstract Background Older adults commonly experience chronic medical conditions and are at risk of cognitive impairment as a result of age, chronic comorbidity, and medications prescribed to manage multiple chronic conditions. …”
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Platelet-rich plasma and dextrose prolotherapy in osteoarthritis knee by Yagya Parna Vohra, Afroz Ahmed Khan, Yesh Veer Singh, Abhishek Pandey, Abhinav Srivastava, Imran Shakeel Khan, Neeraj Singh

“…Background: A prevalent but little-understood ailment is osteoarthritis (OA) knee. …”
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Randomized trial of ultraviolet irradiation units installed in homes of children and adolescents with asthma by Jonathan A. Bernstein, MD, Anand Seth, PhD, Marepalli Rao, PhD, Janyce C. Katz, JD, Umesh Singh, MD, PhD, William Greisner, MD, Michelle Lierl, MD, Benjamin Prince, MD, Kunjana Mavunda, MD, MPH, Cheryl K. Bernstein, RN, BS, CRCC, Tianyuan Guan, PhD, Amy J. Nation, DO, Amanda K. Rudman Spergel, MD, Alkis Togias, MD, Mark Glazman, PhD

“…Background: Asthma management involves medications with environmental control, but patient adherence to the latter is poor. …”
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Prognostic Implication of Computational Angiography–Derived Fractional Flow Reserve in Patients With Nonobstructive Coronary Artery Disease by Yik‐Ming Hung, Hao‐Chen Xuan, Qing‐Wen Ren, Jia‐Yi Huang, Si‐Yeung Yu, Yi‐Kei Tse, Jing‐Nan Zhang, Wen‐Li Gu, Ran Guo, Calvin Ka‐Lam Leung, Kai‐Hang Yiu

“…Background Risk stratification of patients with symptomatic nonobstructive coronary artery disease remains uncertain. …”
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Predictive value of the systemic inflammation grade for overall survival in patients with colorectal cancer after surgery: outperforming NLR and mGPS by Jianing Wang, Yujun Liu, Wenliang Jiang, Dongli Zhang, Chao Cheng, Cuixia Liu, Zhibin Zhao, Honggang Wang

“…The Systemic Inflammation Grade (SIG), integrating neutrophil-to-lymphocyte ratio (NLR) and modified Glasgow Prognostic Score (mGPS), was proposed as a composite marker to refine risk assessment.MethodsThis retrospective study analyzed 263 CRC patients undergoing R0 resection (2015–2019). …”
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mHealth intervention "ImTeCHO" to improve delivery of maternal, neonatal, and child care services-A cluster-randomized trial in tribal areas of Gujarat, India. by Dhiren Modi, Nishith Dholakia, Ravi Gopalan, Sethuraman Venkatraman, Kapilkumar Dave, Shobha Shah, Gayatri Desai, Shamim A Qazi, Anju Sinha, Ravindra Mohan Pandey, Ankit Anand, Shrey Desai, Pankaj Shah

“…<h4>Background</h4>The coverage of community-based maternal, neonatal, and child health (MNCH) services remains low, especially in hard-to-reach areas. …”
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