Prognostic Impact of Anemia in Patients with Significant Mitral Regurgitation: A Multicenter Cohort Study by Lv J, Lu Q, Li Z, Ye Y, Zhang B, Wang W, Zhao Q, Zhang H, Zhao Z, Wang B, Liu Q, Guo S, Yu Z, Duan Z, Zhao Y, Gao R, Xu H, Ge J, Wu Y

“…During a median follow-up of 732 (704– 748) days, 426 (9.8%) patients died and 686 (15.8%) experienced the composite endpoint. Both anemia and hemoglobin were independently associated with two-year outcomes (all P < 0.001). …”
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The effect of α-lipoic acid treatment on plasma asymmetric dimethylarginine, a biomarker of endothelial dysfunction in diabetic neuropathy by Ferenc Sztanek, Hajnalka Lőrincz, Ágnes Molnár, Anita Szentpéteri, Eszter Zöld, Ildikó Seres, Dénes Páll, Mariann Harangi, Péter Kempler, György Paragh

“…Introduction Diabetic neuropathy may develop on a background of hyperglycaemia and is associated with increased oxidative stress. …”
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Oxidative balance score predicts chronic kidney disease risk in overweight adults: a NHANES-based machine learning study by Leying Zhao, Leying Zhao, Cong Zhao, Cong Zhao, Yuchen Fu, Yuchen Fu, Xiaochang Wu, Xiaochang Wu, Xuezhe Wang, Xuezhe Wang, Yaoxian Wang, Yaoxian Wang, Yaoxian Wang, Huijuan Zheng

“…BackgroundOxidative stress plays a pivotal role in the pathogenesis of chronic kidney disease (CKD), particularly in overweight and obese populations where adipose tissue dysfunction exacerbates systemic inflammation and metabolic derangements. …”
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Short- and mid-term outcomes after redo surgical valve replacement by Pardis Sadeghi, Ali Hosseinsabet, Reza Mohseni-Badalabadi, Arash Jalali, Ahmad Vakili-Basir, Mina Pashang, Negar Omidi, Jamshid Bagheri, Mohammadjavad Mehrabanian

“…Abstract Background While previous studies have indicated comparable outcomes for redo surgical valve replacement (SVR) and primary SVR, there is limited information regarding the long-term follow-up of these patients. …”
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Diastolic function and cardiovascular events in patients with preserved left ventricular ejection fraction. Improving risk stratification with left atrial strain by Ibon Rodriguez-Sanchez, Inaki Villanueva-Benito, Urko Agirre, Jose Juan Onaindia, Alazne Urkullu, Angela Cacicedo, Alberto Ullate, Idoia Bravo, Josu Florido, Alberto Salcedo, Sonia Velasco

“…BackgroundA limited number of studies have examined the prognostic significance of diastolic function in patients with preserved left ventricular ejection fraction (LVEF) in a general population referred for transthoracic echocardiography. …”
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Effect of Frailty on Cardiovascular Clinical Trials by Haowen Jiang, MBBS, Jie Jun Wong, MBBS, Ru-San Tan, MBBS, Fei Gao, PhD, Louis LY. Teo, MBBS, Jordan B. Strom, MD, MSc, Chim C. Lang, MD, PhD, Angela S. Koh, MBBS, MPH, PhD

“…Background: Patients with cardiovascular (CV) diseases are increasingly frail but rarely represented in trials. …”
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Comparative assessment of line probe assays and targeted next-generation sequencing in drug-resistant tuberculosis diagnosisResearch in context by Giovanna Carpi, Marva Seifert, Andres De la Rossa, Swapna Uplekar, Camilla Rodrigues, Nestani Tukvadze, Shaheed V. Omar, Anita Suresh, Timothy C. Rodwell, Rebecca E. Colman

“…Summary: Background: Rapid and accurate detection of drug-resistant tuberculosis (DR-TB) is crucial for ensuring effective treatment, halting transmission and preventing the amplification of resistance. …”
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Retrospective assessment of clinical global impression of severity and change in GM1 gangliosidosis: a tool to score natural history data in rare disease cohorts by Connor J. Lewis, Jean M. Johnston, Silvia Zaragoza Domingo, Gilbert Vezina, Precilla D’Souza, William A. Gahl, David A. Adams, Cynthia J. Tifft, Maria T. Acosta

“…Abstract Background Clinical trials for rare diseases pose unique challenges warranting alternative approaches in demonstrating treatment efficacy. …”
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Long-term cancer risk in users of GLP-1 agonists in Denmark: a nationwide emulated trialResearch in context by Mads Gamborg, Mia Klinten Grand, Kathrine Grell, Susanne Rosthøj, Ulrik Pedersen-Bjergaard, Christian Torp-Pedersen, Lina Steinrud Mørch

“…Summary: Background: The long-term cancer safety of glucagon-like peptide-1 receptor agonists (GLP-1RAs) in real-world settings remains unclear, with limited long-term clinical and observational studies. …”
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Spatial distribution and urban–rural disparity of unmet need for family planning among married/in-union women in Ethiopia: a spatial and decomposition analysis by Shimels Derso Kebede, Daniel Niguse Mamo, Jibril Bashir Adem, Agmasie Damtew Walle, Yawkal Tsega, Elsabeth Addisu, Zinabu Bekele Tadese, Ermias Bekele Enyew

“…BackgroundHigh unmet need for family planning combined with other factors, such as high early marriage and teenage pregnancy, increases the risk of developing obstetric fistula and other complications. …”
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Risk of mental health conditions in bereavement: a population-based analysis of lung cancer spouses by Djin L. Tay, Kline Dubose, Kline Dubose, Jonathan Chipman, Jonathan Chipman, Lee Ellington, Malek Alnajar, Eli Iacob, Caroline Stephens, Katherine A. Ornstein

“…BackgroundCaregiving to lung cancer patients is distressing, isolating, and associated with a high burden of anxiety and depression. …”
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Mammographic density and ageing: A collaborative pooled analysis of cross-sectional data from 22 countries worldwide. by Anya Burton, Gertraud Maskarinec, Beatriz Perez-Gomez, Celine Vachon, Hui Miao, Martín Lajous, Ruy López-Ridaura, Megan Rice, Ana Pereira, Maria Luisa Garmendia, Rulla M Tamimi, Kimberly Bertrand, Ava Kwong, Giske Ursin, Eunjung Lee, Samera A Qureshi, Huiyan Ma, Sarah Vinnicombe, Sue Moss, Steve Allen, Rose Ndumia, Sudhir Vinayak, Soo-Hwang Teo, Shivaani Mariapun, Farhana Fadzli, Beata Peplonska, Agnieszka Bukowska, Chisato Nagata, Jennifer Stone, John Hopper, Graham Giles, Vahit Ozmen, Mustafa Erkin Aribal, Joachim Schüz, Carla H Van Gils, Johanna O P Wanders, Reza Sirous, Mehri Sirous, John Hipwell, Jisun Kim, Jong Won Lee, Caroline Dickens, Mikael Hartman, Kee-Seng Chia, Christopher Scott, Anna M Chiarelli, Linda Linton, Marina Pollan, Anath Arzee Flugelman, Dorria Salem, Rasha Kamal, Norman Boyd, Isabel Dos-Santos-Silva, Valerie McCormack

“…<h4>Background</h4>Mammographic density (MD) is one of the strongest breast cancer risk factors. …”
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Association between red blood cell distribution width-to-albumin ratio and all-cause mortality in intracerebral hemorrhage by Jia Xu, Guangdong Wang, Xinran Chen, Xinyi Xu, Yun Wang, Li Wang, Yaxin Zhang

“…BackgroundIntracerebral hemorrhage (ICH) remains a devastating cerebrovascular condition, marked by high fatality and limited availability of prognostic tools. …”
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Impact of Medical Conditions and Area Deprivation on Fundraising Success in Online Crowdfunding: Cross-Sectional Study by Steven S Doerstling, Matthew M Engelhard, Dennis Akrobetu, Caroline E Sloan, Ada Campagna, Thuy-Vi Nguyen, Farrah Madanay, Felicia Chen, Peter A Ubel

“… Abstract BackgroundWeb-based crowdfunding is commonly used to defray medical expenses, but it is not fully known which factors determine fundraising success. …”
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Impact of Additional Active Treatment for Prostate Cancer on Health-related Quality of Life of Men: Results from the EUPROMS 2.0 1-year Follow-up Survey by Lionne D.F. Venderbos, Sebastiaan Remmers, André Deschamps, John Dowling, Ernst-Günter Carl, Nuno Pereira-Azevedo, Monique J. Roobol

“…Background and objective: In 2019 and 2021, Europa Uomo initiated the Europa Uomo Patient Reported Outcome Study (EUPROMS) and the EUPROMS 2.0 survey, with the goal of collecting data on patients’ self-reported perspective on physical and mental well-being outside of a clinical trial setting, to be able to investigate the burden of prostate cancer (PCa) treatment from a patient-to-patient perspective. …”
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Systematic proteomic and small RNA profiling of extracellular vesicles from cattle infected with a naturally occurring buparvaquone-resistant strain of Theileria annulata and from... by Yijun Chai, Jin Che, Jinming Wang, Guiquan Guan, Hong Yin

“…Abstract Background Extracellular vesicles (EVs) play a pivotal role in host-parasite interactions, particularly in facilitating parasite pathogenesis and immune modulation, and are crucial mediators of intercellular communication. …”
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Impact of systemic immune inflammation index and systemic inflammation response index on all-cause and cardiovascular mortality in cardiovascular-kidney-metabolic syndrome by Yongwei Huang, Xiaoshuang Yin, Zongping Li

“…Abstract Background The cardiovascular-kidney-metabolic (CKM) syndrome is a systemic condition defined by multifaceted interactions among metabolic risk factors, chronic kidney disorder, and cardiovascular diseases. …”
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Atrial fibrillation or flutter in patients undergoing stem cell transplantation, in-hospital and post-discharge outcomes in a large nationwide sample across the United States by Raja Zaghlol, Elena Deych, Nina Manian, Ahmed Altibi, Joshua D. Mitchell

“…Abstract Background Stem Cell Transplantation (SCT) is a cornerstone therapy in managing several malignant and benign hematological conditions. …”
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Comparative cardiovascular outcomes of aripiprazole vs. risperidone in patients with type 2 diabetes and schizophrenia: a retrospective cohort study by Yi-Ting Yeh, Shih-Chang Lo, Chien-Ning Huang, Chien-Ning Huang, Chien-Ning Huang, Yi-Sun Yang, Yi-Sun Yang, Pei-Lun Liao, Edy Kornelius, Edy Kornelius

“…BackgroundIndividuals with schizophrenia have substantially elevated cardiovascular morbidity and mortality, a disparity further exacerbated by coexisting type 2 diabetes mellitus (T2DM). …”
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Correlation of changes in inflammatory and collagen biomarkers with durable guselkumab efficacy through 2 years in participants with active psoriatic arthritis: results from a phas... by Stefan Siebert, Georg Schett, Siba P. Raychaudhuri, Monica Guma, Warner Chen, Sheng Gao, Soumya D. Chakravarty, Frederic Lavie, Proton Rahman

“…Guselkumab-randomized participants with available serum biomarker data (randomly selected to reflect demographic and disease characteristics of the DISCOVER-2 population) comprised inflammatory ( N  = 100) and collagen ( N  = 178) biomarker cohorts. Methods: Pharmacodynamic effects of guselkumab through 2 years on inflammatory and collagen biomarker levels (general linear model) and associations between biomarkers and improvements in composite measures of joint, skin, and overall disease activity (Spearman linear regression) through 2 years were assessed. …”
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