The Single Nucleotide Polymorphism PPARG2 Pro12Ala Affects Body Mass Index, Fat Mass, and Blood Pressure in Severely Obese Patients by Ana Paula dos Santos Rodrigues, Lorena Pereira Souza Rosa, Hugo Delleon da Silva, Elisângela de Paula Silveira-Lacerda, Erika Aparecida Silveira

“…Background. The PPARG2 Pro12Ala (rs1801282) and IL6 -174G >C (rs1800795) have important function in body weight regulation and a potential role in obesity risk. …”
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Molecular endotypes in sepsis: integration of multicohort transcriptomics based on RNA sequencing by Kengo Mekata, Michihito Kyo, Modong Tan, Nobuaki Shime, Nobuyuki Hirohashi

“…Abstract Background The heterogeneity of host responses in sepsis has hindered efforts to develop targeted therapies for this large patient population. …”
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Aminoguanidine hemisulfate improves mitochondrial autophagy, oxidative stress, and muscle force in Duchenne muscular dystrophy via the AKT/FOXO1 pathway in mdx mice by Shiyue Sun, Tongtong Yu, Joo Young Huh, Yujie Cai, Somy Yoon, Hafiz Muhammad Ahmad Javaid

“…Abstract Background Duchenne muscular dystrophy (DMD) is a prevalent, fatal degenerative muscle disease with no effective treatments. …”
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Lipophilic Extracts of <i>Portulaca oleracea</i> L.: Analysis of Bioactive Fatty Acids Targeting Microbial and Cancer Pathways by Dejan Stojković, Jelena Živković, Stefani Bolevich, Gokhan Zengin, Mehmet Veysi Cetiz, Sergey Bolevich, Marina Soković

“…<b>Methods:</b> Chemical analysis was conducted to determine the fatty acid composition of the extracts. …”
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In vitro and in vivo investigations of selected varieties of Areca catechu L - Phytochemical analysis, antiulcer, and wound healing activity by R. Deveswaran, D.J. Madhu Kumar, V. Madhavan, Soma Chaki, Misbah Khan, Govind R. Kadambi, B.V. Basavaraj, J. Anbu

“…Background: This study investigated the phytochemical composition and potential medicinal properties of arecanut grown in various regions of Karnataka. …”
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Effect of perioperative probiotic intervention on postoperative cognitive dysfunction in elderly patients: a randomized double- blinded and placebo-controlled trial by Sunan Gao, Hongyu Dai, Qian Hao, Jiale Song, Kang Ji, Hongwei Xu, Gang Chen, Jian Lu

“…Abstract Background Postoperative cognitive dysfunction (POCD) may last for days, months or even years, leading to prolonged hospitalization and increased costs, increased mortality, and poor quality of life. …”
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Patterns of Immune Infiltration in Breast Cancer and Their Clinical Implications: A Gene-Expression-Based Retrospective Study. by H Raza Ali, Leon Chlon, Paul D P Pharoah, Florian Markowetz, Carlos Caldas

“…<h4>Background</h4>Immune infiltration of breast tumours is associated with clinical outcome. …”
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Associations of MIND and DI-GM dietary scores with depression, anxiety, and gut microbiota in patients with colon cancer: a cross-sectional study by Yaqin Meng, Jing Tian, Xiu Xiu Li, Zhou Xu

“…BackgroundDietary patterns influence psychological health, systemic inflammation, and gut microbiota composition in colon cancer patients. …”
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NT2-derived astrocyte–neuron co-culture reflects physiological relevance and offers research validity by Sylwia Kedracka-Krok, Ewelina Fic, Zuzanna Cepil, Piotr Rybczyński, Agata Szlaga, Radosław Cacała, Sławomir Lasota, Anna Blasiak, Marta Dziedzicka-Wasylewska

“…Ntera-2 cells and NT2 cells are used interchangeably in this publication. Methods Using an advanced proteomic approach, we assessed the protein composition and abundance of neuron and astrocyte co-cultures and discovered that the astrocytic protein profile in co-culture with neurons was more representative compared with that in pure astrocyte cultures. …”
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Integrating gut microbiome and neuroplasticity genomics in alcohol use disorder therapy by Ilias Koutromanos, Evangelia Legaki, Nikolas Dovrolis, Efthimios Vassilopoulos, Arthur Stem, Vasilis Vasiliou, Elias Tzavellas, Maria Gazouli

“…Abstract Background Alcohol Use Disorder (AUD) is a chronic neuropsychiatric condition with substantial public health impact. …”
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Characterization of vaginal microbiota across female reproductive phases by Qingzhi Zhai, Yuan Gao, Mingyang Wang, Li Li, Lian Li, Jianghua Li, Ying Ma, Ke Niu, Mingxia Ye

“…BackgroundThe vaginal microbiota plays a crucial role in women’s reproductive health, but its composition and function throughout different female reproductive phases remain poorly understood. …”
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Offline to online: a systematic mapping review of evidence to inform nutrition-related policies applicable to online food delivery platforms by Si Si Jia, Allyson R. Todd, Lana Vanderlee, Penny Farrell, Margaret Allman-Farinelli, Gary Sacks, Alice A. Gibson, Stephanie R. Partridge

“…Abstract Background Online food delivery (OFD) platforms offer easy access to an abundance of energy-dense and nutrient-poor takeaway foods and may exacerbate existing unhealthy food environments. …”
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Changes in the fatty acid profile of fish oil derived from Pangasius catfish (Pangasianodon hypophthalmus) processing waste due to variations in fish size and heating temperatures... by Andarini Diharmi, Edison Edison, Netti Aryani, Benny Heltonika, Indra Suharman

“…Background During the last decade, the demand for fish oil as a feed component has increased. …”
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Multi-omics insights into beagle dog fed with a sucking-rewarded automatic feeding device by Yang Jiao, Xin Wang, Aizhen Yu, Li Wu, Hongping Li

“…BackgroundFacilitating the development of the sucking function in early stages of preterm infants holds substantial potential for influencing their long-term outcomes. …”
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The effects of probiotic treatment with Bifidobacterium breve, Bif195 for small intestinal Crohn’s disease and the gut microbiome: results from a randomised, double-blind, placebo-... by Ida Marie Bruun Grønbæk, Sofie Ingdam Halkjær, Sarah Mollerup, Esben Holm Hansen, Sarah Juel Paulsen, Sara Engel, Klaus Theede, Rune Wilkens, Trine Boysen, Andreas Munk Petersen

“…Abstract Background The aetiology of Crohn’s disease, a chronic inflammatory bowel disease, is multifactorial and not completely understood. …”
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Qing-Re-Hua-Shi Decoction ameliorates DSS-induced colitis by modulating multiple signaling pathways and remodeling the gut microbiota and metabolite profile by Wei Chen, Lin Xu, Long Wang, Yu-nan Shan, Yan Li, Jin-shui Zhu

“…However, its molecular mechanisms remain unclear.PurposeThis study investigates the effects of QRHSD on DSS-induced colitis in mice, employing multi-omics analyses, including RNA-seq transcriptomics, 16S rRNA microbiomics, non-targeted metabolomics, and network pharmacology analysis.MethodsThe chemical composition of QRHSD was analyzed using quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS). …”
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Investigating potential links between gut microbiome, clinical parameters, and mortality in long-living male patients receiving multi-drug therapy by Quanxin Wu, Hui Pan, Xianghua Zeng, Fei Xiong, Yongling Lv, Zhiwei Jiang, Jiahuan Li, Li Wang, Xiao Wang

“…Background and aimsMultimorbidity and polypharmacy are common in long-living patients and have been linked to alterations in gut microbiota. …”
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Osteogenic Potential and Bone Matrix Maturity: Comparison of Demineralized Bone Matrix and P15 Polypeptide iFactor^® in an In Vitro Study by Anell Olivos-Meza, Monica Maribel Mata-Miranda, Marcelo Robles-Rodríguez, Gustavo Jesús Vázquez-Zapién, Melissa Guerrero-Ruiz, Carlos Landa-Solís

“…<i>Background and Objectives:</i> Demineralized bone matrix (DBM) is a widely used bone graft substitute due to its osteoconductive and osteoinductive properties. …”
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Effect of perioperative individualized nutrition intervention on pancreatic surgery outcomes: a prospective single-center study by Qing Chen, Chunhong Xiao, Xusangni Li, Qian Li, Huishuang Wu, Meiping Wang, Weixuan Hong, Aiwen Huang

“…Abstract Background There is currently a lack of reports on prospective randomized controlled trials (RCTs) focused on personalized nutritional support in pancreatic surgery. …”
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Deciphering cellular heterogeneity and pathway dynamics in urinary samples: a UMAP-Based approach to understanding acute kidney injury by Cheng Yuan, Cheng Yuan, Cheng Yuan, Juan Wu, Yuandi Xiang, Lihua Ni

“…Understanding the cellular heterogeneity in urine samples during AKI may provide insights into the underlying pathophysiological mechanisms and potential therapeutic targets.ObjectivesTo explore the cellular composition and gene expression patterns in urine samples from AKI and non-AKI conditions using Uniform Manifold Approximation and Projection (UMAP) to identify key cellular interactions and pathway activations related to AKI.MethodsWe utilized publicly available the dataset GSE180595 from the Gene Expression Omnibus (GEO) database. …”
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