Single-cell transcriptome analysis revealed a suppressive tumor immune microenvironment in EGFR mutant lung adenocarcinoma by Lei Yang, Qing Zhou, Bo Zhang, Yi-Long Wu, Zhi-Hong Chen, Wen-zhao Zhong, Fen Wang, Yun-Ting He, Song Dong, Xue-Wu Wei, Wei-Dong Chen, Xiao-Rong Yang, Xue-Meng Shang

“…Hence, we initiated this study to describe the specific TME of EGFR-mutant lung adenocarcinoma (LUAD) from cellular compositional and functional perspectives to better understand the immune landscape of this most common subtype of NSCLC.Methods We used single-cell transcriptome sequencing and multiplex immunohistochemistry to investigate the immune microenvironment of EGFR-mutant and EGFR wild-type LUADs and determined the efficacy of immunotherapy. …”
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Outcomes After Noncardiac Surgery Performed Within 2 Years of Percutaneous Coronary Intervention by Neel M. Butala, Annika Hebbe, Binita Shah, Nathaniel R. Smilowitz, Bilal Aijaz, Anezi Uzendu, Peter Boulos, Stephen W. Waldo

“…Background Limited data exist on noncardiac surgery patients with prior percutaneous coronary intervention (PCI) in the contemporary era. …”
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Trends in Complications Among Patients Undergoing Aortic Valve Replacement in the United States by James E. Harvey, Samir R. Kapadia, David J. Cohen, Ankur Kalra, William Irish, Candace Gunnarsson, Michael Ryan, Soumya G. Chikermane, Christin Thompson, Rishi Puri

“…Background The treatment of severe aortic stenosis has evolved considerably since the introduction of transcatheter aortic valve replacement (TAVR), yet trends in complications for patients undergoing TAVR or surgical aortic valve replacement (SAVR) at a national level have yet to be evaluated. …”
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Proteomics‐Based Soluble Urokinase Plasminogen Activator Receptor Levels and Long‐Term Cardiovascular Outcomes in Survivors of Breast Cancer: A UK Biobank Study by Adithya K. Yadalam, Chang Liu, Yan V. Sun, Anant Mandawat, Arshed A. Quyyumi, Salim S. Hayek

“…Background Breast cancer is associated with increased risk for cardiovascular disease. suPAR (soluble urokinase plasminogen activator receptor) is an immune‐derived signaling glycoprotein implicated in the pathogenesis of atherosclerosis, as well as cancer, representing a shared risk factor for these conditions. …”
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Identification of Plasma Metabolites Responding to Oxycodone Exposure in Rats by Thao Vu, Suneeta Godbole, Lieselot L. G. Carrette, Lisa Maturin, Olivier George, Laura M. Saba, Katerina Kechris

“…Background: Oxycodone has an elevated abuse liability profile compared to other prescription opioid medications. …”
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Prognostic Implications of Resistive Reserve Ratio in Patients With Nonobstructive Coronary Artery Disease With Myocardial Bridging by Negin Mahmoudi Hamidabad, Yoshihisa Kanaji, Ilke Ozcan, Jaskanwal Deep Singh Sara, Ali Ahmad, Lilach O. Lerman, Amir Lerman

“…Background Myocardial bridging (MB) is accompanied by the dynamic extravascular compression of epicardial coronary arteries, leading to intracoronary hemodynamic disturbance with abnormal coronary flow profiles. …”
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Association of the comorbidity of gestational diabetes mellitus and hypertension disorders of pregnancy with birth outcomes by Xingxi Lin, Xingxi Lin, Luhan Zhou, Luhan Zhou, Shuting Si, Haoyue Cheng, Haoyue Cheng, Xialidan Alifu, Xialidan Alifu, Yiwen Qiu, Yiwen Qiu, Yan Zhuang, Yan Zhuang, Ye Huang, Ye Huang, Libi Zhang, Libi Zhang, Diliyaer Ainiwan, Diliyaer Ainiwan, Hui Liu, Yunxian Yu, Yunxian Yu

“…BackgroundsMany pregnant women suffer from more than one pregnancy complication. …”
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Implications of Tricuspid Regurgitation Severity in Patients Undergoing Mitral Transcatheter Edge‐to‐Edge Repair by Alon Shechter, Homa Taheri, Takashi Nagasaka, Aakriti Gupta, Danon Kaewkes, Vivek Patel, Kazuki Suruga, Manvir Dhillon, Keita Koseki, Ofir Koren, Moody Makar, Sabah Skaf, Dhairya Patel, Tarun Chakravarty, Robert J. Siegel, Raj R. Makkar

“…We aimed to explore the prevalence, correlates, and consequences of TR grades and postprocedural trends in this setting. Methods and Results A single‐center registry of isolated, first‐time interventions was retrospectively assessed for pre‐, intra‐, and postprocedural aspects up to 1 year, of them the primary composite outcome of all‐cause deaths or heart failure (HF) hospitalizations, all according to TR severity at baseline and at 1 month following mitral transcatheter edge‐to‐edge repair. …”
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Association of Systemic Inflammatory Response Syndrome With Cardiovascular Events After Mitral Transcatheter Edge‐to‐Edge Repair by Carlo Mannina, Akarsh Sharma, Andreina Carbone, Eduardo Bossone, Antonino Tuttolomondo, Edgar Argulian, Eric Neibart, Michael B. Hadley, Jonathan Halperin, George Dangas, Samin K. Sharma, Annapoorna Kini, Stamatios Lerakis

“…Background Systemic inflammatory response syndrome (SIRS) following cardiovascular interventions is associated with adverse events during hospitalization and follow‐up. …”
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Intracerebral haemorrhage laterality and associations with mood and pain: a MISTIE III substudy by Issam Awad, Daniel Hanley, Wendy C Ziai, Matthew L Flaherty, Mario Zuccarello, Radhika Avadhani, Noeleen Ostapkovich, Dawson C Cooper, Efrat Abramson, Vishank A Shah, Lourdes Carhuapoma, Lauren H Sansing

“…Background The prognostic significance of the affected hemisphere in haemorrhagic stroke remains uncertain. …”
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Allostatic Load/Chronic Stress and Cardiovascular Outcomes in Patients Diagnosed With Breast, Lung, or Colorectal Cancer by Nickolas Stabellini, Jennifer Cullen, Marcio S. Bittencourt, Justin X. Moore, Arnethea Sutton, Priyanshu Nain, Nelson Hamerschlak, Neal L. Weintraub, Susan Dent, Meng‐Han Tsai, Amitava Banerjee, Arjun K Ghosh, Diego Sadler, Steven S. Coughlin, Ana Barac, John Shanahan, Alberto J. Montero, Avirup Guha

“…Background Cardiovascular disease and cancer share a common risk factor: chronic stress/allostatic load (AL). …”
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Plasma Polyamines and Short‐Term Adverse Outcomes Among Patients With Ischemic Stroke: A Prospective Cohort Study by Pinni Yang, Mengyao Shi, Yiming Jia, Chongke Zhong, Hao Peng, Lulu Sun, Daoxia Guo, Jing Chen, Aili Wang, Tan Xu, Zhengbao Zhu, Yonghong Zhang, Jiang He

“…Background Polyamines have been reported to be associated with neurological function, but the associations between polyamines and the prognosis of ischemic stroke remain unclear. …”
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Angiographic Quantitative Flow Ratio–Guided Treatment of Patients With Physiologically Intermediate Coronary Lesions by Jiannan Dai, Changdong Guan, Xueming Xu, Jingbo Hou, Haibo Jia, Huai Yu, Zening Jin, Guosheng Fu, Xiaofan Wu, Liansheng Wang, Rongchong Huang, Zhujun Shen, Yanyan Zhao, Yuanzhe Jin, Lei Song, Shengxian Tu, Shubin Qiao, Bo Yu, Bo Xu, Gregg W. Stone

“…Background The FAVOR III (Comparison of Quantitative Flow Ratio Guided and Angiography Guided Percutaneous Intervention in Patients With Coronary Artery Disease) China trial reported improved clinical outcomes with percutaneous coronary intervention guided by quantitative flow ratio (QFR) compared with angiography. …”
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Impact of Atrial Fibrillation in Patients With Severe Mitral Regurgitation Undergoing Transcatheter Edge‐to‐Edge Repair by Carlo Mannina, Akarsh Sharma, Yash Prakash, Andreina Carbone, Eduardo Bossone, Antonino Tuttolomondo, Edgar Argulian, Sahil Khera, Parasuram Melarcode‐Krishnamoorthy, George Dangas, Jonathan Halperin, Gilbert H. L. Tang, Samin Sharma, Annapoorna Kini, Gregg W. Stone, Stamatios Lerakis

“…Background Atrial fibrillation (AF) and mitral regurgitation (MR) are closely linked, and one may worsen the other. …”
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Associations Between Gene Variants of Lipid‐Lowering Drug Targets and Adverse Outcomes After Ischemic Stroke by Lulu Sun, Qilu Zhang, Mengyao Shi, Yang Liu, Zhengbao Zhu, Jing Zhang, Hao Peng, Aili Wang, Jing Chen, Tan Xu, Yonghong Zhang, Jiang He

“…Background The association of lipid‐lowering drug targets and their gene variants with cardiovascular diseases has been previously clarified. …”
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Association Between Caregiver Strain and Self‐Care Among Caregivers With Hypertension: Findings From the REGARDS Study by Asia Gobourne, Joanna Bryan Ringel, Alexandra King, Monika Safford, Catherine Riffin, Ronal Adelman, Adam Bress, Tracy K. Paul, Raegan W. Durant, David L. Roth, Madeline R. Sterling

“…Background Self‐care for adults with hypertension includes adherence to lifestyle behaviors and medication. …”
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Effect of early tranexamic acid treatment on fatigue in patients with mild traumatic brain injury: data from the CRASH-3 clinical trial [version 3; peer review: 2 approved, 1 not a... by Temitayo Shokunbi, Haleema Shakur-Still, Raoul Mansukhani, Antonio Belli, Rizwana Chaudhri, Sabariah Faizah Jamaluddin, Amy Brenner, Lauren Frimley, Rashid Jooma, Ian Roberts

“…Background Each year world-wide about 65 million people sustain a mild traumatic brain injury (mTBI). …”
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Identifying optimal primary prevention interventions for major cardiovascular disease events and all-cause mortality: a systematic review and hierarchical network meta-analysis of... by Olalekan A Uthman, Rachel Court, Jodie Enderby, Chidozie Nduka, Lena Al-Khudairy, Seun Anjorin, Hema Mistry, G J Melendez-Torres, Sian Taylor-Phillips, Aileen Clarke

“…Background Cardiovascular disease accounts for substantial mortality and healthcare costs worldwide. …”
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Safety and Efficacy of Different Stent Strategies in Percutaneous Coronary Intervention by Waqas Ullah, MD, RPVI, Harigopal Sandhyavenu, MD, Syeda Ramsha Zaidi, MD, Mileydis Alonso, MD, Muhammad Atif Khan, MD, Irfan Ullah, MBBS, Farah Yasmin, MD, Aravind Reddy Polam, MD, Salman Zahid, MD, Arnav Kumar, MD, MSCR, Ewout W. Steyerberg, MSc, PhD, Mohammad Murtaza, MD, Chadi Alraiesm, MD, MPH, Jeffrey J. Rade, MD

“…Background: The utility of polymer-permanent, polymer-absorbable, and polymer-free drug-eluting stents (DES) in the context of different eluting drugs in patients undergoing percutaneous coronary intervention (PCI) remains controversial. …”
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Educational Attainment Level and Risk of Mortality and Cardiopulmonary Outcomes in High‐Risk Patients With Cardiovascular Disease: The INVESTED Trial by Mats C. H. Lassen, Nicholas Howell, Brian L. Claggett, Tor Biering‐Sørensen, Orly Vardeny, Scott D. Solomon, Jacob Udell, Jacob Joseph, Sheila M. Hegde

“…Background Educational attainment level (EAL) is an indicator of socioeconomic status and has been shown to be inversely related with adverse health outcomes. …”
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