Registry for Evaluating Healthy Life Expectancy and Long-Term Outcomes after Catheter Ablation of Atrial Fibrillation in the Very Elderly (REHEALTH AF) study: rationale and design... by Kengo Kusano, Ayako Okada, Koji Miyamoto, Eizo Tachibana, Wataru Shimizu, Masato Murakami, Tomoo Harada, Kojiro Tanimoto, Takeshi Kato, Satoru Sakagami, Katsuhito Fujiu, Tatsuya Hayashi, Yasuo Okumura, Kazuhiro Satomi, Tomoyuki Shiozawa, Hideki Kobayashi, Michifumi Tokuda, Teiichi Yamane, Ryohsuke Narui, Seigo Yamashita, Satoru Miyanaga, Ikutaro Nakajima, Hidehira Fukaya, Hajime Kihara, Shiro Nakahara, Koichi Nagashima, Kenta Murotani, Shinya Suzuki, Ryuta Watanabe, Katsuaki Yokoyama, Hidemori Hayashi, Yu-ki Iwasaki, Yuhi Fujimoto, Yasushi Mukai, Koichiro Ejima, Takayuki Otsuka, Masaomi Kimura, Masahide Harada, Junjiroh Koyama, Hideharu Okamatsu, Mitsuru Takami, Morio Shoda, Kenichi Hiroshima, Tadashi Fujino, Keijiro Nakamura, Koji Kumagai, Yuji Watari, Mina Hatsuno, Kazuki Iso, Kazumasa Sonoda, Yoshiyasu Aizawa, Akio Chikata, Masaru Inoue, Hitoshi Minamiguchi, Nobuhiko Makino, Yoshinao Yazaki, Hideshi Aoyagi, Makoto Ichikawa, Hironori Haruta, Takafumi Hiro, Kimie Okubo, Ken Arima, Taiki Tojo, Yoshiaki Fukuda, Koji Oiwa, Tamami Fujiishi, Masashi Akabane, Norikazu Ishikawa, Haruna Tabuchi, Kenjiro Miyamoto, Hiroshi Mase

“…The primary endpoint will be the composite incidence of stroke/transient ischaemic attack (TIA) or systemic embolism (SE), another cardiovascular event, major bleeding and/or death from any cause. …”
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Estimation of Genetic Parameters for Growth and Acute Hepatopancreatic Necrosis Resistance in Different Strains of Penaeus vannamei by Guixian HUANG, Xupeng LI, Jiteng TIAN, Sheng LUAN, Jie KONG, Baoxiang CAO, Ning LIU, Kun LUO, Jian TAN, Jiawang CAO, Ping DAI, Baolong CHEN, Guangfeng QIANG, Mianyu LIU, Yang LIU, Hongjie WANG, Xuehui LIU, Juan SUI, Xianhong MENG

“…Due to the complex genetic background of existing P. vannamei germplasm resources in China, genetic parameters are influenced considerably by the tested population, infection methods, and other factors. …”
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Early detection to improve outcome in people with undiagnosed psoriatic arthritis: the PROMPT research programme including RCT by Neil McHugh, Laura Bojke, Mel Brooke Turfrey, Rachel Charlton, Myka Ransom, Laura C Coates, Howard Collier, Claire Davies, Emma Dures, Philip Helliwell, Jana James, Anya Lissina, Vishnu B Madhok, Alison L Nightingale, Jonathan Packham, Catherine Smith, Eldon Spackman, Cerys Tassinari, William Tillett, Sarah T Brown

“…Background Longitudinal observational studies suggest that patients who present early to secondary care with psoriatic arthritis have a better outcome. …”
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Evaluation of mobile health technology combining telemonitoring and teleintervention versus usual care in vulnerable-phase heart failure management (HERMeS): a multicentre, randomi... by Sergi Yun, MD, ProfPhD Josep Comín-Colet, MD, Esther Calero-Molina, RN, Encarnación Hidalgo, RN, Núria José-Bazán, RN, Marta Cobo Marcos, MD, Teresa Soria, RN, Pau Llàcer, PhD, Cristina Fernández, MSc, José Manuel García-Pinilla, PhD, Concepción Cruzado, RN, Álvaro González-Franco, MD, Eva María García-Marina, RN, José Luis Morales-Rull, PhD, Cristina Solé, MD, Elena García-Romero, MD, Julio Núñez, PhD, José Civera, RN, Coral Fernández, RN, Mercedes Faraudo, RN, Pedro Moliner, PhD, Francesc Formiga, PhD, Javier de-Juan Bagudá, MD, Isabel Zegri-Reiriz, PhD, José María Verdú-Rotellar, PhD, Emili Vela, PhD, David Monterde, MSc, Jordi Piera-Jiménez, PhD, Gerard Carot-Sans, PhD, Cristina Enjuanes, PhD, Santiago Jiménez-Marrero, Alberto Garay, Raúl Ramos-Polo, Alexandra Pons-Riverola, Herminio Morillas, Sílvia Jovells-Vaqué, Marta Tajes, Rafael de la Espriella, Elisa Esther Rodríguez, Jessica Paola Rugeles, Maria del Carmen Moreno, Carla Castillo, Ainhoa Robles-Mezcua, Ramon Bascompte, Paola Macarena Beltran Troncoso, Rocío Rodríguez, Román Freixa Pamias, Olga Guri, Cristina Delso Gafarot, Sònia Sarret Vila, Angelique-Casas Thomsen, Jordi Fernández

“…Summary: Background: The potential of mobile health (mHealth) technology combining telemonitoring and teleintervention as a non-invasive intervention to reduce the risk of cardiovascular events in patients with heart failure during the early post-discharge period (ie, the vulnerable phase) has not been evaluated to our knowledge. …”
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Effectiveness of biomarker-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection: the BATCH RCT by Cherry-Ann Waldron, Philip Pallmann, Simon Schoenbuchner, Debbie Harris, Lucy Brookes-Howell, Céu Mateus, Jolanta Bernatoniene, Katrina Cathie, Saul N Faust, Josie Henley, Lucy Hinds, Kerry Hood, Chao Huang, Sarah Jones, Sarah Kotecha, Sarah Milosevic, Helen Nabwera, Sanjay Patel, Stéphane Paulus, Colin VE Powell, Jenny Preston, Huasheng Xiang, Emma Thomas-Jones, Enitan D Carrol

“…Background Procalcitonin is a biomarker specific for bacterial infection, with a more rapid response than other commonly used biomarkers, such as C-reactive protein, but it is not routinely used in the National Health Service. …”
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A Standardized Validation Framework for Clinically Actionable Healthcare Machine Learning with Knee Osteoarthritis Grading as a Case Study by Daniel Nasef, Demarcus Nasef, Michael Sher, Milan Toma

“…Background: High in-domain accuracy in healthcare machine learning (ML) models does not guarantee reliable clinical performance, especially when training and validation protocols are insufficiently robust. …”
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Platelet-bound C4d, low C3 and lupus anticoagulant associate with thrombosis in SLE by John Conklin, Thierry Dervieux, Tyler O'Malley

“…Background Low C3 and lupus anticoagulant (LAC) are known risk factors for thrombosis in SLE. …”
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Effectiveness of dolutegravir-based vs boosted darunavir-based first-line 3-drug regimens in people with HIV with advanced disease: A trial emulation by Roberta Gagliardini, Andrea Giacomelli, Cristina Mussini, Stephen R. Cole, Jessie K. Edwards, Carmela Pinnetti, Alessandro Raimondi, Spinello Antinori, Silvia Nozza, Valentina Mazzotta, Giulia Carla Marchetti, Sergio Lo Caputo, Alessandro Tavelli, Antonella d'Arminio Monforte, Andrea Antinori, Alessandro Cozzi-Lepri

“…Background: No randomized comparisons exist between dolutegravir (DTG) and boosted-darunavir (DRV/b) for people initiating treatment with advanced HIV. …”
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Hyperkalemia and the Risks of Adverse Cardiovascular Outcomes in Patients With Chronic Kidney Disease by Abiy Agiro, Fan Mu, Erin Cook, Alexandra Greatsinger, Jingyi Chen, Angela Zhao, Elaine Louden, Ellen Colman, Pooja Desai, Glenn M. Chertow

“…Background This real‐world evidence study compared risks of cardiovascular events in hospital settings among patients with chronic kidney disease (CKD) with and without hyperkalemia. …”
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Adverse Childhood Experiences and Cardiovascular Outcomes in Adult Congenital Heart Disease by David J. Harrison, MD, Rania A. Mekary, PhD, MS, MSc, Shilpa Vijayakumar, MD, Erin Lake, ScD, MS, Joseph Kay, MD, Roni M. Jacobsen, MD, Camila Londono-Obregon, MD, Elizabeth Yeung, MD, Sarah Kelly, PsyD, Ann Poteet, NP, MS, Michael J. Landzberg, MD, Molly Wallrich, RN, Amber D. Khanna, MD

“…Background: Adverse childhood experiences (ACEs) are linked with poor physical and psychosocial health outcomes in adulthood, including cardiovascular disease. …”
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Transcatheter Aortic Valve Replacement and Surgical Aortic Valve Replacement Outcomes in Left Ventricular Assist Device Patients with Aortic Insufficiency by Aniket S Rali, Siva S Taduru, Lena E Tran, Sagar Ranka, Kelly H Schlendorf, Colin M Barker, Ashish S Shah, JoAnn Lindenfeld, Sandip K Zalawadiya

“…Background: Worsening aortic insufficiency (AI) is a known sequela of prolonged continuous-flow left ventricular assist device (LVAD) support with a significant impact on patient outcomes. …”
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Association Between Neighborhood-Level Social Vulnerability and Hypertension Outcomes by John E. Brush, Jr., MD, Chungsoo Kim, PharmD, PhD, Yuntian Liu, MPH, Xin Xin, MS, Chenxi Huang, PhD, Iris J. Lundy, BSN, Jordan R. Asher, MD, MS, Mitsuaki Sawano, MD, Patrick Young, PhD, Jacob McPadden, MD, Mark Anderson, AS, John S. Burrows, MBA, Harlan M. Krumholz, MD, SM, Yuan Lu, ScD

“…Objectives: The aim of the study was to examine how the neighborhood-level social vulnerability index (SVI) influences cardiovascular outcomes in a large, diverse cohort of patients with hypertension. Methods: We used electronic health data to examine the association between census tract-level rankings for the SVI with a composite endpoint of incident myocardial infarction, congestive heart failure, or stroke. …”
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Differences in wait-list mortality: Temporary vs durable circulatory support devices by Mahwash Kassi, MD, Salma Zook, MD, Duc Nguyen, MD, PhD, Katelyn Ingram, BS, Sapna Legha, MD, Rayan Yousefzai, MD, Ju Kim, MD, Imad Hussain, MD, Cindy M. Martin, MD, Janardhana Gorthi, MD, Adeel Ahsan Syed, MD, Nadia Fida, MD, Arvind Bhimaraj, MD, Edward A. Graviss, PhD, Ashrith Guha, MD

“…HM3 had the lowest risk of composite outcomes.…”
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Educational Attainment and the Effect of Intensive Blood Pressure Reduction: A Post Hoc Analysis of the SPRINT Study by Joshua Garfein, Akira Sekikawa, Andrew Mrkva, Djhenne Dalmacy, Jarett D. Berry, Yordanos M. Tiruneh, Jared W. Magnani

“…Background Hypertension is a major risk factor for cardiovascular disease (CVD). …”
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Effects of Intensive Systolic Blood Pressure Lowering on Cardiovascular Events and Mortality in Patients With Type 2 Diabetes Mellitus on Standard Glycemic Control and in Those Wit... by Srinivasan Beddhu, Glenn M. Chertow, Tom Greene, Paul K. Whelton, Walter T. Ambrosius, Alfred K. Cheung, Jeffrey Cutler, Lawrence Fine, Robert Boucher, Guo Wei, Chong Zhang, Holly Kramer, Adam P. Bress, Paul L. Kimmel, Suzanne Oparil, Cora E. Lewis, Mahboob Rahman, William C. Cushman

“…Methods and Results SPRINT tested the effects of intensive (<120 mm Hg) versus standard (<140 mm Hg) SBP goals on CVD events and all‐cause mortality. …”
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Effectiveness of the GRACE risk score according to troponin elevation in patients admitted with non-ST elevation acute coronary syndrome: a post hoc analysis of the UKGRIS parallel... by Chris P Gale, Derek P Chew, Andrew T Yan, David B Brieger, Ramesh Nadarajah, Catherine Reynolds, Catherine Fernandez, Linda Sharples, Kathryn Carruthers, Keith A A Fox, Rachael Gilberts, Shaun Goodman, Deborah Stocken, Suleman Aktaa

“…Background The effectiveness of risk stratification using the Global Registry of Acute Coronary Events (GRACE) Risk Score (GRS) for patients presenting to hospital with suspected non-ST elevation acute coronary syndrome (NSTEACS) according to troponin elevation is unknown.Methods Post hoc analysis of a phase 3 parallel group cluster randomised controlled trial (UK GRACE Risk Score, UKGRIS) of adult patients presenting with suspected NSTEACS to 42 hospitals in England between 9 March 2017 and 30 December 2019, with hospitals randomised (1:1) to standard care or according to the GRS and associated guidelines. …”
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Evaluation of prognostic models to improve prediction of metastasis in patients following potentially curative treatment for primary colorectal cancer: the PROSPECT trial by Vicky Goh, Susan Mallett, Manuel Rodriguez-Justo, Victor Boulter, Rob Glynne-Jones, Saif Khan, Sarah Lessels, Dominic Patel, Davide Prezzi, Stuart Taylor, Steve Halligan

“…Background Despite apparently curative treatment, many patients with colorectal cancer develop subsequent metastatic disease. …”
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Prevalence, Characteristics, and Outcomes of Children With Congenital Heart Disease Undergoing Noncardiac Surgery in the Presence or Absence of COVID‐19 Infection During the Pandem... by David Faraoni, James A. DiNardo, Viviane G. Nasr

“…Background Children with congenital heart disease undergoing noncardiac surgery are at increased risk of perioperative complications. …”
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Prognostic Value of Hospital Frailty Risk Score and Clinical Outcomes in Critical Limb‐Threatening Ischemia and End‐Stage Kidney Disease by Monil Majmundar, Wan‐Chi Chan, Vivek Bhat, Kunal N. Patel, Kirk A. Hance, Georges Hajj, Axel Thors, Kamal Gupta

“…Background End‐stage kidney disease (ESKD) is commonly associated with critical limb‐threatening ischemia (CLTI) and frailty. …”
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Identifying high-risk Fontan phenotypes using K-means clustering of cardiac magnetic resonance-based dyssynchrony metrics by Addison Gearhart, Sunakshi Bassi, Rahul H. Rathod, Rebecca S. Beroukhim, Stuart Lipsitz, Maxwell P. Gold, David M. Harrild, Audrey Dionne, Sunil J. Ghelani

“…Background: Individuals with a Fontan circulation encompass a heterogeneous group with adverse outcomes linked to ventricular dilation, dysfunction, and dyssynchrony. …”
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