Enhancing Patient Safety Education: Cross-Cultural Validation of the APSQ-III in Brazilian Healthcare Students by João Daniel de Souza Menezes, Matheus Querino da Silva, Emerson Roberto dos Santos, Rodrigo Soares Ribeiro, Natália Almeida de Arnaldo Silva Rodriguez Castro, Isabela Amaral de Almeida Bistafa, Alex Bertolazzo Quitério, Eliana Fazuoli Chubaci, Sônia Maria Maciel Lopes, Flávia Cristina Custódio, Stela Regina Pedroso Vilela Torres de Carvalho, Gustavo Schiavinato, Thalissa Catricala, José Nathan Fernandes Rocha, Vânia Maria Sabadoto Brienze, Josimerci Ittavo Lamana Faria, Denise Cristina Mós Vaz Oliani, Antônio Hélio Oliani, Vânia Zaqueu Brandão, Júlio Cesar André, Rita de Cassia Helú Mendonça Ribeiro

“…<b>Background:</b> This study aimed to adapt and validate the Attitudes to Patient Safety Questionnaire (APSQ-III) for Brazilian Portuguese and to compare patient safety attitudes between medical and nursing students. …”
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Ability of soluble TREM2 and PRO-C3 as biomarkers to predict changes in MASLD activity by Charlotte Wilhelmina Wernberg, Vineesh Indira Chandran, Mette Munk Lauridsen, Maria Kløjgaard Skytthe, Camilla Dalby Hansen, Johanne Kragh Hansen, Lea Ladegaard Grønkjær, Birgitte Gade Jacobsen, Tina Di Caterino, Sönke Detlefsen, Maja Thiele, Alejandro Mayorca Guiliani, Ida Falk Villesen, Diana Julie Leeming, Morten Karsdal, Jonas Heilskov Graversen, Aleksander Krag

“…Background &amp; Aims: Diet and weight loss remain the primary treatment for most patients with metabolic dysfunction-associated fatty liver disease (MASLD), with one recent drug therapy approved for severe cases. …”
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An expert patient program for people living with multiple sclerosis improves knowledge and empowerment: a pre-test, post-test multicenter implementation study by Miguel Ángel Robles-Sánchez, Miguel Ángel Robles-Sánchez, Miguel Ángel Robles-Sánchez, Paloma Amil-Bujan, Cristina Bosch-Farré, Clàudia Coll-Martínez, Clàudia Coll-Martínez, María Jesús Arévalo, Elisenda Anglada-Clofent, Rebeca Menéndez-Díaz, Montserrat Aroca-Alsina, Montserrat Aroca-Alsina, Miguel Merchan-Ruiz, Miguel Merchan-Ruiz, Santiago Pérez-Hoyos, Santiago Pérez-Hoyos, Ángel Guillermo Arévalo-Bernabé, Ángel Guillermo Arévalo-Bernabé, Xavier Montalban, Ana Hernando, Sara LLufriú, Silvia Peralta-Moncusí, Lluís Brieva, Cristina Ramo-Tello, Mariona Carabí, Nuria Solà-Valls, Maria Cinta Zabay, Maria Alba Mañé-Martínez, Jaume Sastre-Garriga, Lluís Ramió-Torrentà, Lluís Ramió-Torrentà, Lluís Ramió-Torrentà, Carmen Bertran-Noguer

“…BackgroundMultiple sclerosis (MS) is associated with complex needs and demands, which require patient-centered care. …”
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Pathophysiological and Prognostic Importance of an ExtraCardiac Comorbidity Burden in Patients with Heart Failure with Preserved Ejection Fraction by Yuki Saito, MD, PhD, Tomonari Harada, MD, PhD, Naoki Yuasa, MD, Kazuki Kagami, MD, PhD, Yuta Tani, MSc, Ayami Naito, MD, Fumitaka Murakami, MD, Tomoaki Ishii, RS, Toshimitsu Kato, MD, PhD, Naoki Wada, MD, PhD, Yasuo Okumura, MD, PhD, Hideki Ishii, MD, PhD, Masaru Obokata, MD, PhD

“…Background: Extracardiac comorbidities are highly prevalent in patients with heart failure with preserved ejection fraction (HFpEF). …”
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First-line vs Second-Line Catheter Ablation Therapy for Patients with Atrial Fibrillation—Data from a National Multicentre Registry by Ranin Hilu, MD, Mahmoud Suleiman, MD, Adi Elias, MD, MPH, Ibrahim Marai, MD, Roy Beinart, MD, Eyal Nof, MD, Yoav Michowitz, MD, Michael Glikson, MD, Yuval Konstantino, MD, Moti Haim, MD, David Luria, MD, David Pereg, MD, Avishag Laish-Farkash, MD, PhD, Alexander Omelchenko, MD

“…Background: An early catheter ablation treatment strategy is effective for rhythm control in patients with atrial fibrillation (AF). …”
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Characterization of Malnutrition in Atrial Functional Mitral Regurgitation by Tsukasa Murakami, MD, PhD, Nobuyuki Kagiyama, MD, PhD, Tomohiro Kaneko, MD, PhD, Kazuki Kagami, MD, PhD, Masashi Amano, MD, PhD, Taiji Okada, MD, PhD, Yukio Sato, MD, PhD, Yohei Ohno, MD, PhD, Kimi Sato, MD, PhD, Kojiro Morita, MPH, PhD, RN, PHN, Tomoko Machino-Ohtsuka, MD, PhD, Yukio Abe, MD, PhD, Hideki Ishii, MD, PhD, Masaru Obokata, MD, PhD

“…Methods: This multicentre, observational study included 802 patients diagnosed with AFMR. …”
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Area-level socioeconomic inequalities in hypertension care cascade in China: a nationwide population-based study based on the ChinaHEART projectResearch in context by Wenyao Peng, Siqi Lin, Xuan Liu, Bowang Chen, Xueke Bai, Chaoqun Wu, Xiaoyan Zhang, Yang Yang, Jianlan Cui, Wei Xu, Lijuan Song, Hao Yang, Wenyan He, Yan Zhang, Xi Li, Jiapeng Lu

“…Summary: Background: Socioeconomic status (SES) is one of key social determinants of health. …”
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Interpreting the clinical significance of multiple large-scale mitochondrial DNA deletions (MLSMD) in skeletal muscle tissue in the diagnostic evaluation of primary mitochondrial d... by Jing Wang, Jing Wang, James T. Peterson, Joaquim Diego D. Santos, Ada J. S. Chan, Maria Alejandra Diaz-Miranda, Imon Rahaman, Jean Flickinger, Amy Goldstein, Amy Goldstein, Emily Bogush, Elizabeth M. McCormick, Colleen C. Muraresku, Vernon E. Anderson, Matthew C. Dulik, Matthew C. Dulik, Douglas C. Wallace, Douglas C. Wallace, Rui Xiao, Marni J. Falk, Marni J. Falk, Angela N. Viaene, Angela N. Viaene, Zarazuela Zolkipli-Cunningham, Zarazuela Zolkipli-Cunningham, Zarazuela Zolkipli-Cunningham

“…We sought to evaluate clinical, biochemical, and histopathological phenotypes of a large clinical cohort harboring MLSMD in muscle to better understand their significance across a range of clinical phenotypes.MethodsA single-site retrospective study was performed of 212 diagnostic muscle biopsies obtained from patients referred for Primary Mitochondrial Disease (PMD) evaluation with muscle mitochondrial (mt)DNA sequencing performed at our institution, including electronic medical record (EMR) review of symptoms, biochemical results, and Mitochondrial Myopathy Composite Assessment Tool (MM-COAST) scores.ResultsMLSMD were identified in 50 of 212 (24%) diagnostic tissue biopsies, and were universally present. in subjects ≥50 years (n = 18/18). …”
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Immune-neuroendocrine crosstalk in mood and psychotic disorders: A meta-analysis and systematic review by Minne Van Den Noortgate, Filip Van Den Eede, Violette Coppens, Erik J. Giltay, Livia De Picker, Manuel Morrens

“…Background: Bidirectional interactions between immune and neuroendocrine mechanisms are involved in mood and psychotic disorders, although individual studies report inconsistent and even contradictory findings on the nature of this crosstalk. …”
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Study Design and Protocol for a Randomized Controlled Trial to Assess Long-Term Efficacy and Safety of a Triple Combination of Ezetimibe, Fenofibrate, and Moderate-Intensity Statin... by Nam Hoon Kim, Juneyoung Lee, Suk Chon, Jae Myung Yu, In-Kyung Jeong, Soo Lim, Won Jun Kim, Keeho Song, Ho Chan Cho, Hea Min Yu, Kyoung-Ah Kim, Sang Soo Kim, Soon Hee Lee, Chong Hwa Kim, Soo Heon Kwak, Yong‐ho Lee, Choon Hee Chung, Sihoon Lee, Heung Yong Jin, Jae Hyuk Lee, Gwanpyo Koh, Sang-Yong Kim, Jaetaek Kim, Ju Hee Lee, Tae Nyun Kim, Hyun Jeong Jeon, Ji Hyun Lee, Jae-Han Jeon, Hye Jin Yoo, Hee Kyung Kim, Hyeong-Kyu Park, Il Seong Nam-Goong, Seongbin Hong, Chul Woo Ahn, Ji Hee Yu, Jong Heon Park, Keun-Gyu Park, Chan Ho Park, Kyong Hye Joung, Ohk-Hyun Ryu, Keun Yong Park, Eun-Gyoung Hong, Bong-Soo Cha, Kyu Chang Won, Yoon-Sok Chung, Sin Gon Kim

“…Background Atherogenic dyslipidemia, which is frequently associated with type 2 diabetes (T2D) and insulin resistance, contributes to the development of vascular complications. …”
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Prenatal exposure to organophosphate ester flame retardants and behavioral outcomes in early childhood in the Environmental influences on Child Health Outcomes (ECHO) cohort by Jiwon Oh, Lesliam Quirós-Alcalá, Xuan Li, Kurunthachalam Kannan, Wenjie Lyu, Lyndsay A. Avalos, Emily S. Barrett, Theresa M. Bastain, Jessie P. Buckley, Patricia Cintora, Lisa A. Croen, Anne L. Dunlop, Akhgar Ghassabian, Rima Habre, Julie B. Herbstman, Ixel Hernandez-Castro, Irva Hertz-Picciotto, Donghai Liang, Cindy T. McEvoy, Thomas G. O’Connor, Sheela Sathyanarayana, Susan L. Schantz, Rebecca J. Schmidt, Julie B. Schweitzer, Anne P. Starling, Heather E. Volk, Megan L. Woodbury, Tracey J. Woodruff, Qi Zhao, Yeyi Zhu, Deborah H. Bennett

“…Background: Prenatal exposure to organophosphate esters (OPEs) has been linked to neurotoxic effects in children; however, epidemiological evidence remains inconclusive. …”
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Need for Support: Facilitating Early Transfer of Cardiogenic Shock Patients to Advanced Heart Failure Centres by Vicki N. Wang, MD, Darshan H. Brahmbhatt, MB BChir, MD(Res), Julie K.K. Vishram-Nielsen, MD, PhD, Fernando L. Scolari, MD, PhD, Nicole L. Fung, Madison Otsuki, Vesna Mihajlovic, MD, Narmin Ibrahimova, Filio Billia, MD, PhD, Christopher B. Overgaard, MD, Adriana C. Luk, MD, MSc

“…Background: Cardiogenic shock (CS) is a complex, life-threatening condition that requires timely care of patients. …”
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Adjuvant rituximab and elevated intratumoural CD8 expression are associated with sustained disease control after radiotherapy in a randomised trial of systemic therapy in early-sta... by Michael P. MacManus, John F. Seymour, Hennes Tsang, Richard Fisher, Colm Keane, Muhammed B. Sabdia, Soi C. Law, Jay Gunawardana, Karthik Nath, Stephen H. Kazakoff, Mario L. Marques-Piubelli, Daniela E. Duenas, Michael R. Green, Daniel Roos, Peter O'Brien, Andrew McCann, Richard Tsang, Sidney Davis, David Christie, Chan Cheah, Benhur Amanuel, Tara Cochrane, Jason Butler, Anna Johnston, Mohamed Shanavas, Li Li, Claire Vajdic, Robert Kridel, Victoria Shelton, Samantha Hershenfield, Tara Baetz, David Lebrun, Nathalie Johnson, Marianne Brodtkorb, Maja Ludvigsen, Francesco d’Amore, Ella R. Thompson, Piers Blombery, Maher K. Gandhi, Joshua W.D. Tobin

“…Summary: Background: We report extended follow-up of TROG99.03, a randomised phase III trial in early-stage follicular lymphoma (ESFL) including new information on the role of adjuvant rituximab and translational studies. …”
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Application of a deep learning algorithm for the diagnosis of HCC by Philip Leung Ho Yu, Keith Wan-Hang Chiu, Jianliang Lu, Gilbert C.S. Lui, Jian Zhou, Ho-Ming Cheng, Xianhua Mao, Juan Wu, Xin-Ping Shen, King Ming Kwok, Wai Kuen Kan, Y.C. Ho, Hung Tat Chan, Peng Xiao, Lung-Yi Mak, Vivien W.M. Tsui, Cynthia Hui, Pui Mei Lam, Zijie Deng, Jiaqi Guo, Li Ni, Jinhua Huang, Sarah Yu, Chengzhi Peng, Wai Keung Li, Man-Fung Yuen, Wai-Kay Seto

“…Background &amp; Aims: Hepatocellular carcinoma (HCC) is characterized by a high mortality rate. …”
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Impact of Apolipoprotein A-I Infusions on Cardiovascular Events Post-MI by Neutrophil-Lymphocyte Ratio and LDL-Cholesterol Levels by Sem A.O.F. Rikken, MD, C. Michael Gibson, MD, MS, M. Cecilia Bahit, MD, Danielle Duffy, MD, Gerald Chi, MD, Serge Korjian, MD, Niekbachsh Mohammadnia, MD, Harvey White, DSc, Gaya Anschuetz, MS, Bronwyn A. Kingwell, PhD, Ton Oude Ophuis, MD, PhD, Jose C. Nicolau, MD, PhD, Renato D. Lopes, MD, PhD, Basil S. Lewis, MD, Saloua El Messaoudi, MD, PhD, Dragos Vinereanu, MD, PhD, Jurriën M. ten Berg, MD, PhD, Shaun G. Goodman, MD, MSc, Christoph Bode, MD, PhD, P. Gabriel Steg, MD, Peter Libby, MD, Kevin R. Bainey, MD, Arnoud W.J. van 't Hof, MD, PhD, Paul M. Ridker, MD, Kenneth W. Mahaffey, MD, Stephen J. Nicholls, MD, Roxana Mehran, MD, Robert A. Harrington, MD, Jan H. Cornel, MD, PhD

“…Background: The AEGIS-II (ApoA-I Event Reducing in Ischemic Syndromes-II; NCT03473223) trial evaluated CSL112, a human plasma-derived apolipoprotein A-I therapy, for reducing cardiovascular events after acute myocardial infarction (AMI). …”
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The sodium-glutamate antagonist riluzole improves outcome after acute spinal cord injury: results from the RISCIS randomised controlled trial analysed using a global statistical an... by Michael G. Fehlings, Karlo M. Pedro, Mohammed Ali Alvi, Ali Moghaddamjou, James S. Harrop, Ralph Stanford, Jonathon Ball, Bizhan Aarabi, Paul M. Arnold, James D. Guest, Shekar N. Kurpad, James M. Schuster, Ahmad N. Nassr, Karl M. Schmitt, Jefferson R. Wilson, Darrel S. Brodke, Faiz U. Ahmad, Albert Yee, Wilson Z. Ray, Nathaniel P. Brooks, Jason Wilson, Diana S-L. Chow, Elizabeth G. Toups, Kevin E. Thorpe, Jiaxin Huang, Peng Huang

“…Summary: Background: Spinal cord injury (SCI) clinical trials typically rely on a single primary endpoint to assess drug efficacy. …”
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DOAC Score for Predicting Clinical Outcomes After Left Atrial Appendage Closure by Masahiko Asami, MD, Yu Horiuchi, MD, Jun Tanaka, MD, Daiki Yoshiura, MD, Masanori Taniwaki, MD, Kota Komiyama, MD, PhD, Hitomi Yuzawa, MD, PhD, Kengo Tanabe, MD, PhD, Mitsuru Sago, CE, Shuhei Tanaka, MD, PhD, Ryuki Chatani, MD, Toru Naganuma, MD, Yohei Ohno, MD, PhD, Tomoyuki Tani, MD, Hideharu Okamatsu, MD, Kazuki Mizutani, MD, PhD, Yusuke Watanabe, MD, PhD, Masaki Izumo, MD, PhD, Mike Saji, MD, PhD, Shingo Mizuno, MD, Daisuke Hachinohe, MD, Hiroshi Ueno, MD, PhD, Shunsuke Kubo, MD, Shinichi Shirai, MD, Masaki Nakashima, MD, Masanori Yamamoto, MD, PhD, Kentaro Hayashida, MD, PhD

“…Background: The direct-acting oral anticoagulant (DOAC) score has been validated for assessing the bleeding risk in patients with atrial fibrillation (AF). …”
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Ultra-fast [18F]florbetapir PET imaging using the uMI Panorama PET/CT system by Xueqian Yang, Meiqi Wu, Menglin Liang, Haiqiong Zhang, Bo Li, Chenhui Mao, Liling Dong, Yuan Wang, Haiqun Xing, Chao Ren, Zhenghai Huang, Qingxiang Wen, Qi Ge, Zhengqing Yu, Feng Feng, Jing Gao, Li Huo

“…Abstract Background There is a need for faster amyloid PET scans to reduce patients’ discomfort, minimize movement artifacts, and increase throughput. …”
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Dihydroartemisinin-piperaquine versus sulfadoxine-pyrimethamine for intermittent preventive treatment of malaria in pregnancy: a systematic review and individual participant data m... by Michelle E. Roh, Julie R. Gutman, Maxwell Murphy, Jenny Hill, Mywayiwawo Madanitsa, Abel Kakuru, Hellen C. Barsosio, Simon Kariuki, John P.A. Lusingu, Frank Mosha, Richard Kajubi, Moses R. Kamya, Don Mathanga, Jobiba Chinkhumba, Miriam K. Laufer, Eulambius Mlugu, Appolinary A.R. Kamuhabwa, Eleni Aklillu, Omary Minzi, Roland Nnaemeka Okoro, Ado Danazumi Geidam, John David Ohieku, Meghna Desai, Prasanna Jagannathan, Grant Dorsey, Feiko O. ter Kuile

“…Summary: Background: High-grade Plasmodium falciparum resistance to sulfadoxine-pyrimethamine in east and southern Africa has prompted trials evaluating intermittent preventive treatment in pregnancy (IPTp) with dihydroartemisinin-piperaquine as an alternative to sulfadoxine-pyrimethamine. …”
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The Diagnostic and Prognostic Value of the 12-Lead ECG in Arrhythmogenic Left Ventricular Cardiomyopathy by Leonardo Calò, MD, Cinzia Crescenzi, MD, Andrea Di Marco, MD, PhD, Francesca Fanisio, MD, Fabiana Romeo, MD, Alessio Gargaro, MSc, Annamaria Martino, MD, PhD, Chiara Cappelletto, MD, Marco Merlo, MD, Mattia Targetti, MD, Elisabetta Toso, MD, Federica Toto, MD, Maria Beatrice Musumeci, MD, Giacomo Tini, MD, Michele Ciabatti, MD, Matteo Stefanini, MD, Stefano Canestrelli, MD, Elisa Fedele, MD, Chiara Lanzillo, MD, PhD, Armando Fusco, MD, PhD, Federica Carla Sangiuolo, MD, PhD, Cinzia Radesich, MD, Maria Perotto, MD, Maurizio Pieroni, MD, Ruggiero Mango, MD, PhD, Alessio Gasperetti, MD, PhD, Camillo Autore, MD, Michela Casella, MD, PhD, Antonio Dello Russo, MD, PhD, Davide Stolfo, MD, PhD, Mikael Laredo, MD, PhD, Estelle Gandjbakhch, MD, PhD, Maddalena Graziosi, MD, PhD, Elena Biagini, MD, PhD, Costantina Catalano, MD, Ludovica Barile, MD, Fabrizio Drago, MD, Marianna Cicenia, MD, Anwar Baban, MD, PhD, Gemma Pelargonio, MD, PhD, Maria Lucia Narducci, MD, Federica Re, MD, Giovanni Peretto, MD, Elena Paiotti, MD, Carles Diez Lopez, MD, Iacopo Olivotto, MD, Fiorenzo Gaita, MD, Gianfranco Sinagra, MD, Giuseppe Novelli, MD, PhD

“…Background: Electrocardiographic findings in arrhythmogenic left ventricular cardiomyopathy (ALVC) have been limited to small studies. …”
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