Persistent Beta‐Blocker Therapy Reduces Long‐Term Mortality in Patients With Acute Ischemic Stroke With Elevated Heart Rates by Keon‐Joo Lee, Seong‐Eun Kim, Hyung Seok Guk, Do Yeon Kim, Beom Joon Kim, Moon‐Ku Han, Joon‐Tae Kim, Kang‐Ho Choi, Dong‐Ick Shin, Jae‐Kwan Cha, Dae‐Hyun Kim, Dong‐Eog Kim, Jong‐Moo Park, Kyusik Kang, Soo Joo Lee, Jae Guk Kim, Mi‐Sun Oh, Kyung‐Ho Yu, Byung‐Chul Lee, Keun‐Sik Hong, Yong‐Jin Cho, Jay Chol Choi, Tai Hwan Park, Sang‐Soon Park, Jee‐Hyun Kwon, Wook‐Joo Kim, Jun Lee, Kyung Bok Lee, Sung Il Sohn, Jeong‐Ho Hong, Wi‐Sun Ryu, Seung‐Young Roh, Ji Sung Lee, Juneyoung Lee, Philip B. Gorelick, Hee‐Joon Bae

“…Background Elevated heart rate in patients with acute ischemic stroke is associated with increased risk of mortality. …”
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Outcome Prediction After Tetralogy of Fallot Repair: A Prospective Clinical and Cardiovascular Magnetic Resonance Study by Rachel M. Wald, George Tomlinson, Christopher A. Caldarone, Nagib Dahdah, Frederic Dallaire, Christian Drolet, Michael E. Farkouh, Jasmine Grewal, Camille Hancock‐Friesen, Edward J. Hickey, Gauri Rani Karur, Michelle Keir, Adrienne H. Kovacs, Benedetta Leonardi, Brian W. McCrindle, Syed Najaf Nadeem, Ming‐Yen Ng, Michelle Samuel, Ashish Shah, Edythe B. Tham, Judith Therrien, Alexander Van De Bruaene, Isabelle F. Vonder Muhll, Andrew E. Warren, Kenichiro Yamamura, Paul Khairy

“…Background Identification of individuals at risk for major adverse cardiovascular events is essential for contemporary management of patients with repaired tetralogy of Fallot. …”
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Associations of metabolic status with all-cause mortality among individuals with osteoarthritis: A prospective cohort study by Hao Yang, Muhui Zeng, Tianxiang Fan, Haowei Chen, Xiaofeng Fang, Zhong Alan Li, Xiaoshuai Wang, David J. Hunter, Changhai Ding, Zhaohua Zhu

“…Background: Individuals with osteoarthritis (OA) often experience significant changes in their metabolic status and have a higher risk of mortality compared to the general population. …”
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A nationwide analysis of resource utilization and safety in patients undergoing mitral transcatheter edge-to-edge repair by Tharusan Thevathasan, Sophie Berlinghof, Daniel Elschenbroich, Julia M. Wiedenhofer, Sêhnou Degbeon, Luise Holzhauser, Fabian Barbieri, Mario Kasner, Anna Brand, Henryk Dreger, Steffen Desch, Ulf Landmesser, Markus Reinthaler, Carsten Skurk

“…Background: Transcatheter edge-to-edge repair (TEER) for mitral regurgitation has rapidly progressed. …”
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Metabonomic Biomarkers of Plaque Burden and Instability in Patients With Coronary Atherosclerotic Disease After Moderate Lipid‐Lowering Therapy by Zhendong Mei, Lili Xu, Qingxia Huang, Chenhao Lin, Mengyao Yu, Shalaimaiti Shali, Hongyi Wu, Yijing Lu, Runda Wu, Zhen Wang, Lingfeng Luo, Zhonghan Sun, Liang Sun, Juying Qian, Guochong Chen, Huiru Tang, Kang Yao, Yan Zheng, Yuxiang Dai, Junbo Ge

“…Background Contemporary risk assessment in patients with coronary atherosclerotic disease (CAD) often relies on invasive angiography. …”
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Prediction of Major Adverse Cardiovascular Events in Patients with Peripheral Artery Disease Using Circulating Immunomodulatory Proteins by Ben Li, Farah Shaikh, Houssam Younes, Batool Abuhalimeh, Jason Chin, Khurram Rasheed, Abdelrahman Zamzam, Rawand Abdin, Mohammad Qadura

“…<b>Background/Objectives:</b> The leading cause of death for people with peripheral artery disease (PAD) is major adverse cardiovascular events (MACE), including heart attacks and strokes. …”
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Characterizing ECOPD Phenotypes: Associations with In-Hospital Outcomes and Immunoinflammatory Mechanisms by Wang Q, Wang L, Zhang L, Zhao C, Liu Y, Liu L, Yuan L, Feng M, Wang G, Li L, Zhang S, Yuan Y, Kang D, Zhang X

“…We sought to explore the underlying mechanisms that contribute to the relationship between ECOPD phenotypes and these outcomes.Methods: A k-means cluster analysis was conducted on 20,890 recruited patients hospitalized for ECOPD. …”
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Adherence to the ABC (atrial fibrillation better care) pathway and risk of adverse outcomes in patients with chronic kidney disease: a report from the prospective APHRS-AF registry... by Tommaso Bucci, Katarzyna Nabradalik, Krysztof Irlik, Alena Shantsila, Giulio Francesco Romiti, Marco Proietti, Wee-Siong Teo, Hyung-Wook Park, Wataru Shimizu, Hung-Fat Tse, Tze-Fan Chao, Gregory Y.H. Lip, Hung-Fat Tse, Chun-Wah David Siu, Wataru Shimizu, Kenji Yodogawa, Hiroyuki Tsutsui, Yasushi Mukai, Hirofumi Tomita, Daisuke Horiuchi, Joji Hagii, Kazutaka Aonuma, Yasuo Okumura, Masahiko Goya, Kenzo Hirao, Ajioka Masayoshi, Nobuhisa Hagiwara, Atsushi Suzuki, Teiichi Yamane, Takanori Ikeda, Hitomi Yuzawa, Kazuhiro Satomi, Yoshinao Yazaki, Keiichi Fukuda, Yoshinori Kobayashi, Norishige Morita, Toyoaki Murohara, Eiichi Watanabe, Masahide Harada, Satoru Sakagami, Takahiro Saeki, Kengo Kusano, Koji Miyamoto, Shinsuke Miyazaki, Hiroshi Tada, Koichi Inoue, Nobuaki Tanaka, Yukihiro Koretsune, Haruhiko Abe, Yasuki Kihara, Yukiko Nakano, Akihiko Shimizu, Yasuhiro Yoshiga, Tomohiro Sakamoto, Ken Okumura, Naohiko Takahashi, Tetsuji Shinohara, Kyoko Soejima, Masahiko Takagi, Mitsuharu Kawamura, Yumi Munetsugu, Hyung-Wook Park, Jae-Min Shim, Jae Sun Uhm, Sung Il Im, Hyoung-Seob Par, Jun Hyung Kim, Young Keun On, Il-Young Oh, Seung Yong Shin, Jum Suk Ko, Jun Beom Park, Wee-Siong Teo, Kelvin Cheok-Keng Wong, Toon-Wei Lim, David Foo, Shih-Ann Chen, Tze-Fan Chao, YennJiang Lin, Fa-Po Chung, Yu-Feng Hu, Shil-Lin Chang, Ta-Chuan Tuan, Jo-Nan Liao, Cheng-Hung Li, Jin-Long Huang, Yu-Cheng Hsieh, Tsu-Juey Wu, Ying-Chieh Liao, Cheng-Hung Chiang, Hsiang-Chiang Hsiao, Tung-Chen Yeh, Wei-Siang Lin, Wen-Yu Lin, Jen-Yuan Kuo, Chong-Lie Hong, Yih-Je Wu, Ying-Siang Li, Jui-Peng Tsai, Kuo-Tzu Sung, Sheng-Hsiung Chang

“…Methods: A post-hoc analysis of the prospective APHRS AF Registry. …”
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Plasma extracellular vesicle cargo microRNAs are associated with heart failure and cardiovascular death following acute coronary syndrome by Worawan B. Limpitikul, Michael G. Silverman, Nedyalka Valkov, Jeong-Gun Park, Ashish Yeri, Fernando Camacho Garcia, Guoping Li, Priyanka Gokulnath, Marta Garcia-Contreras, Eric Alsop, Elizabeth Hutchins, Michail Spanos, Claire Lin, Kriti Bomb, Anthony Rosenzweig, Raymond Kwong, Kendall van-Keuren Jensen, James L. Januzzi, Jr., Ravi Shah, David A. Morrow, Marc S. Sabatine, Saumya Das

“…Background and aims: Patients with acute coronary syndromes (ACS) are at risk for long-term sequelae related to adverse ventricular remodeling including heart failure (HF) and cardiovascular death. …”
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Integration of genomics, clinical characteristics and baseline biological profiles to predict the risk of liver injury induced by high-dose methotrexate by Chenquan Lin, Chenquan Lin, Chenquan Lin, Rui Ma, Rui Ma, Rui Ma, Xiao Zeng, Xiao Zeng, Xiao Zeng, Bikui Zhang, Bikui Zhang, Bikui Zhang, Ting Cao, Ting Cao, Ting Cao, Shimeng Jiao, Shimeng Jiao, Shimeng Jiao, Hui Chen, Hui Chen, Hui Chen, Yifang He, Yifang He, Yifang He, Mouze Liu, Mouze Liu, Mouze Liu, Hualin Cai, Hualin Cai, Hualin Cai

“…BackgroundHigh-dose methotrexate (HD-MTX) is commonly employed in the treatment of malignant tumors in children and young adults due to its distinctive therapeutic efficacy. …”
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Association of Left Atrial Dysfunction with Pulmonary Hemodynamics and Cardiovascular Outcomes in Patients with Systemic Sclerosis by Kazutoshi Hirose, MD, Koki Nakanishi, MD, Masao Daimon, MD, Hikari Seki, MD, Yuriko Yoshida, MD, Megumi Hirokawa, MD, Tomoko Nakao, MD, Koichi Kimura, MD, Shun Minatsuki, MD, Masaru Hatano, MD, Hiroyuki Morita, MD, Marco R. Di Tullio, MD, Shunichi Homma, MD, Makoto Kurano, MD, Norihiko Takeda, MD

“…Background: Left atrial (LA) reservoir strain (LARS) is emerging as an early marker of cardiac remodelling, providing significant prognostic information. …”
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Impact of metagenomics next-generation sequencing on etiological diagnosis and early outcomes in sepsis by Feixiang Xu, Chen Chen, Su Lu, Mingming Xue, Hailin Ding, Yanli Song, Yun Zhang, Keyu Sun, Lunxian Tang, Wei Wang, Meitang Wang, Yan Tang, Dingyu Tan, Chenling Yao, Dongwei Shi, Enqiang Mao, Mian Shao, Youguo Ying, Chunmei Zhou, Lihong Huang, Hu Peng, Zhongshu Kuang, Sanqiang Wang, Qingbian Ma, Si Sun, Dongfeng Guo, Tianwen Gu, Bin Yang, Linhao Ma, Chengjin Gao, Xiaoye Lu, Hong Zhang, Ruilan Wang, Chaoyang Tong, Zhenju Song

“…Abstract Background Clinical implications of metagenomics next-generation sequencing (mNGS) in sepsis have not been fully evaluated. …”
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Remote myocardial fibrosis predicts adverse outcome in patients with myocardial infarction on clinical cardiovascular magnetic resonance imaging by Nicholas Black, Joshua Bradley, Erik B. Schelbert, Laura J. Bonnett, Gavin A. Lewis, Jakub Lagan, Christopher Orsborne, Pamela F. Brown, Fardad Soltani, Fredrika Fröjdh, Martin Ugander, Timothy C. Wong, Miho Fukui, Joao L. Cavalcante, Josephine H. Naish, Simon G. Williams, Theresa McDonagh, Matthias Schmitt, Christopher A. Miller

“…ABSTRACT: Background: Heart failure (HF) most commonly occurs in patients who have had a myocardial infarction (MI), but factors other than MI size may be deterministic. …”
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Unraveling the Oncogenic Characteristics of the Cytolinker, Plectin, in Esophageal Squamous Cell CarcinomaSummary by Lili Qiao, Yuanyuan Hu, Lei Xu, Guodong Deng, Xiaohong Yu, Wei Zheng, Yanan Yang, Hui Yuan, Wei Jiang, Xiying Yu

“…Background &amp; Aims: Tissue mechanics involved in carcinogenesis by regulating cell morphology and structure, cell-cell, and cell-extracellular matrix (ECM) interactions are not fully understood. …”
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Trends and inequalities in physical fitness and nutritional status among 0.72 million Chinese adults aged 20–59 years: an analysis of five successive national surveillance surveys,... by Chenyuan Qin, Chaoqun Fan, Jingjing Wang, Qin Li, Jue Liu, Haijun Wang, Qiang Feng

“…Summary: Background: Few comprehensive studies have assessed the long-term trends in physical fitness and nutritional status among Chinese adults, along with the socioeconomic inequalities. …”
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Spatiotemporal variation of the association between climate dynamics and HFRS outbreaks in Eastern China during 2005-2016 and its geographic determinants. by Junyu He, George Christakos, Jiaping Wu, Bernard Cazelles, Quan Qian, Di Mu, Yong Wang, Wenwu Yin, Wenyi Zhang

“…<h4>Background</h4>Hemorrhagic fever with renal syndrome (HFRS) is a rodent-associated zoonosis caused by hantavirus. …”
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Association of stress hyperglycemia ratio with short-term and long-term prognosis in patients undergoing coronary artery bypass grafting across different glucose metabolism states:... by Zhongchen Li, Runze Chen, Zhiwei Zeng, Peng Wang, Chunyu Yu, Shuo Yuan, Xiaoting Su, Yan Zhao, Heng Zhang, Zhe Zheng

“…Abstract Background Stress hyperglycemia ratio (SHR) is recognized as a reliable indicator of acute hyperglycemia during stress. …”
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Interferon Gamma and Tumor Necrosis Factor Alpha Are Inflammatory Biomarkers for Major Adverse Cardiovascular Events in Patients with Peripheral Artery Disease by Ben Li, Eva Lindner, Raghad Abuhalimeh, Farah Shaikh, Houssam Younes, Batool Abuhalimeh, Abdelrahman Zamzam, Rawand Abdin, Mohammad Qadura

“…<b>Background/Objectives:</b> Major adverse cardiovascular events (MACE)—including heart attacks and strokes—are the leading cause of death in patients with peripheral artery disease (PAD), yet biomarker research for MACE prediction in PAD patients remains limited. …”
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SGLT2-inhibitors in diabetic patients with severe aortic stenosis and cardiac damage undergoing transcatheter aortic valve implantation (TAVI) by Pasquale Paolisso, Marta Belmonte, Emanuele Gallinoro, Roberto Scarsini, Luca Bergamaschi, Leonardo Portolan, Matteo Armillotta, Giuseppe Esposito, Elisabetta Moscarella, Giovanni Benfari, Claudio Montalto, Monika Shumkova, Elayne Kelen de Oliveira, Francesco Angeli, Mateusz Orzalkiewicz, Margherita Fabroni, Nurcan Baydaroglu, Andrea Raffaele Munafò, Daniele Oreste D’Atri, Matteo Casenghi, Lucia Scisciola, Michelangela Barbieri, Raffaele Marfella, Felice Gragnano, Edoardo Conte, Dario Pellegrini, Alfonso Ielasi, Daniele Andreini, Martin Penicka, Jacopo Andrea Oreglia, Paolo Calabrò, Antonio Bartorelli, Carmine Pizzi, Tullio Palmerini, Marc Vanderheyden, Francesco Saia, Flavio Ribichini, Emanuele Barbato

“…Abstract Background A substantial number of patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI) experience adverse events after TAVI, with health care expenditure. …”
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Influence of Worsening Renal Function and Baseline Chronic Kidney Disease on Clinical Outcomes in Patients With Chronic Coronary Syndromes: Insights From the REAL‐CAD Study by Yu Yoshiki, Yukio Ozaki, Mitsuru Abe, Tevfik F. Ismail, Hiroshi Takahashi, Masaharu Akao, Hideki Kawai, Takashi Muramatsu, Masahide Harada, Masaya Ohta, Yosuke Hashimoto, Yuichiro Shiki, Masayuki Koshikawa, Keiichi Miyajima, Hidemaro Takatsu, Yudai Niwa, Naoyuki Kawashima, Reina Ozaki, Naotake Tsuboi, Satoshi Iimuro, Hiroshi Iwata, Ichiro Sakuma, Yoshihisa Nakagawa, Kiyoshi Hibi, Takafumi Hiro, Yoshihiro Fukumoto, Seiji Hokimoto, Katsumi Miyauchi, Hisao Ogawa, Hiroyuki Daida, Hiroaki Shimokawa, Hideo Izawa, Takeshi Kimura, Ryozo Nagai

“…Background The effect of worsening renal function and baseline chronic kidney disease (CKD) on outcomes in patients with chronic coronary syndrome in the setting of optimal medical therapy remains unknown. …”
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