Staged versus immediate complete revascularization for non-culprit arteries in acute myocardial infarction: a post-hoc analysis of FRAME-AMI by Yongwhan Lim, Jaehyuk Jang, Seung Hun Lee, Joon Ho Ahn, Young Joon Hong, Youngkeun Ahn, Myung Ho Jeong, Chan Joon Kim, Joo-Yong Hahn, Joo Myung Lee, Keun Ho Park, Eun Ho Choo, Sung Gyun Ahn, Joon-Hyung Doh, Sang Yeub Lee, Sang Don Park, Hyun-Jong Lee, Min Gyu Kang, Yun-Kyeong Cho, Chang Wook Nam, Sung Hyun Bu, Min Chul Kim

“…Background and objectivesThe optimal timing for complete revascularization (CR) in patients with acute myocardial infarction (AMI) and multivessel disease (MVD) remain uncertain.MethodsThis post-hoc analysis of the FRAME-AMI trial included AMI patients with MVD (n = 549). …”
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One-step diagnosis of infection and lung cancer using metagenomic sequencing by Shaoqiang Li, Yangqing Zhan, Yan Wang, Weilong Li, Xidong Wang, Haoru Wang, Wenjun Sun, Xuefang Cao, Zhengtu Li, Feng Ye

“…Abstract Background Traditional detection methods face challenges in meeting the diverse clinical needs for diagnosing both lung cancer and infections within a single test. …”
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Antibodies against integrin αvβ6 have high diagnostic accuracy for ulcerative colitis by Patrick Bez, Martina Scapolan, Davide Giuseppe Ribaldone, Gian Paolo Caviglia, Silvia Zago, Cristina Trucco, Simone Frara, Antonino Caruso, Marta Ascolani, Michele Campigotto, Stefano Benvenuti, Stefano Martelossi, Lara De Lucchi, Marta Favero, Francesco Cinetto, Francesco Cinetto, Elisabetta Faggin, Laura Ventura, Marcello Rattazzi, Marcello Rattazzi, Tilde Manetta, Giulio Mengozzi, Antonio Antico, Carla Felice, Carla Felice

“…BackgroundAnti-integrin αvβ6 IgG autoantibodies showed good sensitivity and optimal specificity in ulcerative colitis (UC) compared to controls. …”
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Long-term exposure to outdoor fine particulate and physical activity with mortality and cardiovascular events: an analysis of the Prospective Urban Rural Epidemiology (PURE)-China... by Jun Hao, Zhiguang Liu, Bo Hu, Duolao Wang, Sumathy Rangarajan, Yang Wang, Chuangshi Wang, Lap Ah Tse, Weida Liu, Sidong Li, Minghai Yan, Qiujing Cai, Salim Yusuf, Wei Li

“…Summary: Background: Long-term exposure to PM2.5 and low physical activity are independently associated with an increased risk of cardiovascular disease (CVD). …”
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Role of late gadolinium enhancement in the risk stratification of pediatric hypertrophic cardiomyopathy: based on a Chinese cohortResearch in context by Xingrui Chen, Wei Xiangli, Xuan Ma, Yun Tang, Jiaxin Wang, Zhixiang Dong, Kankan Zhao, Zhuxin Wei, Xi Jia, Pengyu Zhou, Yujie Liu, Yanyan Song, Chen Cui, Minjie Lu, Kai Yang, Xiuyu Chen, Shujuan Yang, Shihua Zhao

“…Summary: Background: Recently, late gadolinium enhancement (LGE) has been identified as an important risk factor in pediatric hypertrophic cardiomyopathy (HCM). …”
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Intravenous Administration of sRNA Nanoparticles for Treatment of Osteoporosis in Mice by Xuemeng Mu, Xinyi Du, Huitian Han, Fei Liu, Zhifa Zheng, Jing Hao, Lijin Liu, Su Liu, Ze Wei, Changfa Huang, Annan Liang, Wei Zou, Lina Zhao, Zhihong Wu, Jia Zhang

“…This study explores the potential of LNPs as an effective delivery system to treat osteoporosis. <b>Methods</b>: LNPs were prepared using microfluidic techniques with varying lipid compositions, and characterized in terms of size, zeta potential, and entrapment efficiency (EE%). …”
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Validation of the COAPT risk score in Polish patients undergoing transcatheter edge-to-edge repair of severe, functional mitral regurgitation: a multicenter, observational study by Karolina Jasińska-Gniadzik, Michał Łomiak, Jerzy Pręgowski, Zbigniew Chmielak, Piotr Kasprzyk, Jan Kasprzyk, Rafał Gałąska, Michał Chmielecki, Miłosz J. Jaguszewski, Marcin Fijałkowski, Aleksandra Topolska, Michał Sekuła, Marcin Grabowski, Janusz Kochman, Adam Rdzanek, Piotr Scislo, Agnieszka Kapłon-Cieślicka, Renata Główczyńska, Monika Budnik, Radosław Piątkowski, Łukasz Kołtowski, Arkadiusz Pietrasik, Aleksandra Gąsecka

“…BACKGROUND: The COAPT risk score, developed based on the COAPT trial, is a tool to predict the risk of death or hospitalization for heart failure (HFH) within two years after transcatheter edge-to-edge repair (TEER) of mitral regurgitation using a MitraClip device. …”
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Effects of missed anti-tuberculosis therapy doses on treatment outcome: a multi-center cohort studyResearch in context by Isabella B.B. Ferreira, Rodrigo C. Menezes, Mariana Araújo-Pereira, Valeria C. Rolla, Afrânio L. Kritski, Marcelo Cordeiro-Santos, Timothy R. Sterling, Cody Staats, Gustavo Amorim, Anete Trajman, Bruno B. Andrade, A. Benjamin, Q. Medeiros, F. Ridolfi, A. Gomes-Silva, J. Oliveira, J. Marine, B. Durovni, S. Cavalcante, A. Rezende, A. Bezerra, A. Carvalho, A. Brito, A. Costa, R. Spener-Gomes, M. Rocha, V. Nascimento, B. Nogueira, A. Andrade, E. Silva

“…Summary: Background: Tuberculosis (TB) remains a leading cause of infectious disease mortality globally. …”
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Antiplatelet Therapy in Myocardial Bridge: Insights From the RIALTO Registry by Renzo Laborante, Giuseppe Ciliberti, Gaetano Rizzo, Francesco Canonico, Donato Antonio Paglianiti, Fabio Casamassima, Attilio Restivo, Domenico Cicchella, Francesco Burzotta, Carlo Trani, Cristina Aurigemma, Mattia Galli, Rocco Vergallo, Italo Porto, Gianluca Anastasia, Giuseppe Massimo Sangiorgi, Gianluca Massaro, Marta Cocco, Simone Biscaglia, Gianluca Campo, Daniele Andreini, Antonio Maria Leone, Filippo Crea, Giuseppe Patti, Domenico D'Amario

“…Background Myocardial bridge (MB) is a frequent coronary artery anomaly. …”
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Cardiac arrest while using the toilet: not uncommon and associated with adverse resuscitation profile by Elizabeth D. Paratz, Carl Johann Hansen, Andre La Gerche, Dion Stub, Ziad Nehme, Ashanti Dantanarayana, Kelila Freedman, Andreas Pflaumer, Jodie Ingles, Bo Gregers Winkel, Jacob Tfelt-Hansen

“…Background: Out-of-hospital cardiac arrest (OHCA) on the toilet has been reported to be common and possibly driven by straining or vagal stimulus. …”
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Evidence based QUality Improvement for Prescribing Stewardship in ICU (EQUIPS-ICU): protocol for type III hybrid implementation-effectiveness study by Duncan Wagstaff, John Amuasi, Sumaiya Arfin, Diptesh Aryal, Mohd Basri Mat Nor, Joseph Bonney, Arjen Dondorp, David Dongelmans, Layoni Dullawe, Fathima Fazla, Aniruddha Ghose, Eva Hanciles, Rashan Haniffa, Madiha Hashmi, Adam Hewitt Smith, Bharath Kumar, Yen Lam Minh, Ramani Moonesinghe, Luigi Pisani, Cornelius Sendagire, Mohd Shahnaz Hasan, Maryam Shamal Ghalib, Moses Siaw Frimpong, Otavio Ranzani, Menbeu Sultan, David Thomson, Swagata Tripathy, Louise Thwaites, Rabiul Alam Md. Erfan Uddin, Mohd Zulfakar Mazlan, Wangari Waweru-Siika, Abigail Beane

“…Abstract Background Approximately half of all antimicrobial prescriptions in intensive care units (ICUs) may be inappropriate, including those prescribed when not needed, in unnecessary combinations or for longer durations than needed. …”
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Ovicidal effect of eucalyptus wood vinegar on gastrointestinal nematodes’ eggs from sheep by Yandra Thais Rocha da Mota, Alexandre Santos Pimenta, Moacir Franco de Oliveira, Ana Karolinne de Alencar França, Andressa Marcelly Silvestre Pereira, Rafael Rodolfo de Melo, Thays Vieira da Costa Monteiro, Maíra Fasciotti, Lúcio César Dantas de Medeiros, Ana Carla Diógenes Suassuna Bezerra

“…Background and Aim: Gastrointestinal nematodes (GINs) significantly impair small ruminant production globally, particularly in tropical regions. …”
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Inflammation-based scores predict chronic kidney disease progression in patients with chronic kidney disease and chronic heart failure by Lu Cai, Licong Su, Ying Hu, Endi Cai, Hong Xu, Bicheng Liu, Jianping Weng, Chunbo Chen, Huafeng Liu, Qiongqiong Yang, Hua Li, Yaozhong Kong, Guisen Li, Qijun Wan, Yan Zha, Gang Xu, Yongjun Shi, Yilun Zhou, Guobin Su, Ying Tang, Mengchun Gong

“…Background Inflammation is associated with adverse outcomes of chronic kidney disease (CKD) or chronic heart failure (CHF), but few large data exist. …”
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Prevalence of Variant GTR^I<i>Staphylococcus aureus</i> Isolated from Dairy Cow Milk Samples in the Alpine Grazing System of the Aosta Valley and Its Association with AMR... by Valentina Monistero, Delower Hossain, Sara Fusar Poli, Elizabeth Sampaio de Medeiros, Paola Cremonesi, Bianca Castiglioni, Filippo Biscarini, Hans Ulrich Graber, Giulia Mochettaz, Sandra Ganio, Alessandra Gazzola, Maria Filippa Addis, Claudio Roullet, Antonio Barberio, Silvia Deotto, Lara Biasio, Fernando Ulloa, Davide Galanti, Valerio Bronzo, Paolo Moroni

“…The aim of this study was to provide an overview of <i>S. aureus</i> genotypes associated with antimicrobial resistance (AMR) and virulence profiles in four dairy herds in the Aosta Valley from July 2022 to August 2023. <b>Methods</b>: A total of 468 composite milk samples were collected at three timepoints: T1 (pasture-livestock system), T2 (farm-livestock system), and T3 (pasture-livestock system). …”
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Artificial intelligence-enhanced comprehensive assessment of the aortic valve stenosis continuum in echocardiographyResearch in context by Jiesuck Park, Jiyeon Kim, Jaeik Jeon, Yeonyee E. Yoon, Yeonggul Jang, Hyunseok Jeong, Youngtaek Hong, Seung-Ah Lee, Hong-Mi Choi, In-Chang Hwang, Goo-Yeong Cho, Hyuk-Jae Chang

“…Summary: Background: Transthoracic echocardiography (TTE) is the primary modality for diagnosing aortic stenosis (AS), yet it requires skilled operators and can be resource-intensive. …”
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Predicting brain amyloid load with digital and blood-based biomarkers by Weineng Chen, Yu Liao, Xinchong Shi, Fengjuan Su, Haifan Kong, Yingying Fang, Yifan Zheng, Jiayi Zhou, Ganqiang Liu, Xianbo Zhou, Xiaoli Yao, Curtis B. Ashford, Feng Li, Long Yang, Michael F. Bergeron, J. Wesson Ashford, Xiangsong Zhang, Zhong Pei

“…MemTrax and p-Tau181/Aβ42 composite showed the strongest relationship with CL value among other BBMs. …”
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Role and prognostic value of growth differentiation factor 15 in patient of heart failure with preserved ejection fraction: insights from the PURSUIT-HFpEF registry by Tetsuhisa Kitamura, Shungo Hikoso, Takahisa Yamada, Yoshio Yasumura, Akito Nakagawa, Toshihiro Takeda, Hirota Kida, Akihiro Sunaga, Tomoharu Dohi, Katsuki Okada, Daisaku Nakatani, Yasushi Matsumura, Yasushi Sakata, Shunsuke Tamaki, Takaharu Hayashi, Yoshiharu Higuchi, Masaharu Masuda, Mitsutoshi Asai, Toshiaki Mano, Hisakazu Fuji, Daisaku Masuda, Shizuya Yamashita, Masami Sairyo, Yusuke Nakagawa, Haruhiko Abe, Yasunori Ueda, Kunihiko Nagai, Masamichi Yano, Masami Nishino, Jun Tanouchi, Yoh Arita, Shinji Hasegawa, Takamaru Ishizu, Minoru Ichikawa, Yuzuru Takano, Eisai Rin, Tetsuya Watanabe, Shiro Hoshida, Masahiro Izumi, Hiroyoshi Yamamoto, Hiroyasu Kato, Kazuhiro Nakatani, Mayu Nishio, Keiji Hirooka, Takahiro Yoshimura, Akihiro Tani, Yasushi Okumoto, Yasunaka Makino, Katsuomi Iwakura, Yoshiyuki Kijima, Takashi Kitao, Masashi Fujita, Koichiro Harada, Masahiro Kumada, Osamu Nakagawa, Ryo Araki, Takayuki Yamada, Fusako Sera, Kei Nakamoto, Hidetaka Kioka, Tomohito Ohtani, Nobuyuki Ogasawara, Yukinori Shinoda, Koichi Tachibana, Yohei Sotomi, Taiki Sato, Yuji Yasuga, Toshinari Onishi, Kazunori Kashiwase, Ryu Shutta, Masahiro Seo, Yuki Matsuoka, Yasuhiro Akazawa, Daisuke Sakamoto

“…Background Growth differentiation factor 15 (GDF15) is a cytokine responding to oxidative stress and inflammation, and it regulates appetite and energy balance. …”
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Patient-reported Outcome Measures and Decision Regret After Prostate-specific Membrane Antigen–targeted Radioguided Surgery for Oligorecurrent Prostate Cancer by Fabian Falkenbach, Giovanni Mazzucato, Zhe Tian, Pierre I. Karakiewicz, Markus Graefen, Thomas Steuber, Derya Tilki, Daniel Koehler, Burkhard Beyer, Pierre Tennstedt, Sophie Knipper, Lars Budäus, Tobias Maurer

“…Data on patient-reported outcome measures (PROMs) are lacking. Methods: A retrospective assessment of validated PROMs (12-item Short Form Health Survey [SF-12], 26-item Expanded Prostate Index Composite, and Decision Regret Scale [DRS]) was performed before and after PSMA-RGS for oligorecurrent PCa. …”
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Clinical Features and Outcomes of Pediatric MYH7‐Related Dilated Cardiomyopathy by Fernando de Frutos, Juan Pablo Ochoa, Gregory Webster, Mark Jansen, Paloma Remior, Torsten B. Rasmussen, Maria Sabater‐Molina, Roberto Barriales‐Villa, Francesca Girolami, Sergi Cesar, M. Eugenia Fuentes‐Cañamero, Reyes Alvarez García‐Rovés, Karim Wahbi, Javier Limeres, Milos Kubanek, Martijn G. Slieker, Georgia Sarquella‐Brugada, Dominic J. Abrams, Dennis Dooijes, Fernando Domínguez, Pablo Garcia‐Pavia

“…Background Although genetic variants in MYH7 are the most frequent cause of pediatric genetic dilated cardiomyopathy (DCM), there are no studies available describing this entity. …”
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Tolerability for older, persistence for younger: a real-world evidence on sacubitril/valsartan in an Asian heart failure cohort across age by Po-Kai Chan, Po-Kai Chan, Chu-Yu Hsu, Chao-Chin Lee, Chao-Chin Lee, Fan-Han Yu, Fa-Po Chung, Fa-Po Chung, Chia-Te Liao, Chia-Te Liao, Jin-Long Huang, Jin-Long Huang, Huai-Wen Liang, Ying-Hsiang Lee, Ying-Hsiang Lee, Ying-Hsiang Lee, Po-Lin Lin, Po-Lin Lin, Po-Lin Lin, Wei-Ru Chiou, Wei-Ru Chiou, Wei-Ru Chiou, Chien-Yi Hsu, Chien-Yi Hsu, Hung-Yu Chang, Wen-Yu Lin, Wen-Yu Lin

“…BackgroundSacubitril/Valsartan (S/V) benefits patients with heart failure with reduced ejection fraction (HFrEF), but its tolerability and clinical outcomes across age groups, especially the elderly, remain unclear. …”
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