Gypenosides Alleviate Hyperglycemia by Regulating Gut Microbiota Metabolites and Intestinal Permeability by Rong Wang, Xue-Feng Liu, Kuan Yang, Li-Li Yu, Shao-Jing Liu, Na-Na Wang, Yun-Mei Chen, Ya-Qi Hu, Bei Qin

“…<b>Background/Objectives</b>: Gypenosides (Gps) are the main active compounds of <i>Gynostemma</i> and show promise in managing diabetes; nevertheless, the mechanism by which Gps exert anti-diabetic effects is still not fully understood. …”
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Prevalence and risk factors of self-medication with antibiotics in the general population of Tehran—a population-based study by Keyvan Karimi, Yosra Azizpour, Maryam Shafaati, Erta Rajabi, Maryam Zare, Arash Seifi, Ozra Tabatabaei-Malazy, Samaneh Akbarpour, Mahnaz Khalafehnilsaz

“…Abstract Background Given the ongoing global threat of antimicrobial resistance (AMR), largely fueled by self-medication with antibiotics (SMA), this study offers important insights from southern Tehran—an underrepresented region in national data—regarding the prevalence and determinants of SMA. …”
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The cross-sectional association between cardiometabolic index and abdominal aortic calcification in U.S. adults: evidence from NHANES 2013–2014 by Jiawei Peng, Jijun Wu, Xitu Luo, Chengyu Yang, Shian Wu, Wenjun Liu, Wenjun Liu, Yuanhao Feng

“…BackgroundThe cardiometabolic index (CMI) is a novel composite measure that integrates assessments of abdominal adiposity and lipid profiles. …”
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Total bilirubin as a marker for hemolysis and outcome in patients with severe ARDS treated with veno-venous ECMO by Victoria Bünger, Mario Menk, Oliver Hunsicker, Alexander Krannich, Felix Balzer, Claudia D. Spies, Wolfgang M. Kuebler, Steffen Weber-Carstens, Jan A. Graw

“…Abstract Background Hemolysis is a common complication in critically ill patients with sepsis, acute respiratory distress syndrome (ARDS) or therapy with extracorporeal membrane oxygenation (ECMO). …”
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Prognostic value of a lncRNA signature in early-stage invasive breast cancer patients by Rong Guo, Xiting Wang, Yinju Yang, Jiaying Zou, Ming Li, Zeying Li, Yuan Yan, Nan Lan, JianYun Nie, Yiyin Tang, Guojun Zhang

“…Abstract Background Existing staging approaches fall short in precisely forecasting the likelihood of recurrence and survival outcomes among patients undergoing surgery for early-stage breast cancer (EBC). …”
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Non-high density lipoprotein cholesterol/high density lipoprotein cholesterol is L-shaped associated with all-cause mortality and U-shaped with cardiovascular mortality in hyperten... by Meiqian Chen, Meiqian Chen, Li Zhang, Qian Liu, Qingxin Gu, Shuhui Yu, Guanzhen Lu, Guanzhen Lu

“…The relationship between the novel composite lipid metric, NHHR, and all-cause and cardiovascular mortality in hypertensive patients remains unknown and warrants further investigation.MethodsWe analyzed data from 5,561 hypertensive participants in the National Health and Nutrition Examination Survey (NHANES) spanning from 1999 to 2018. …”
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Vitrectomy, subretinal Tissue plasminogen activator and Intravitreal Gas for submacular haemorrhage secondary to Exudative Age-Related macular degeneration (TIGER): study protocol... by Timothy L. Jackson, Catey Bunce, Riti Desai, Jost Hillenkamp, Chan Ning Lee, Noemi Lois, Tunde Peto, Barnaby C. Reeves, David H. Steel, Rhiannon T. Edwards, Jan C. van Meurs, Hatem Wafa, Yanzhong Wang

“…Abstract Background Neovascular (wet) age-related macular degeneration (AMD) can be associated with large submacular haemorrhage (SMH). …”
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Plasma and Fecal Metabolites Combined with Gut Microbiome Reveal Systemic Metabolic Shifts in ⁶⁰Co Gamma-Irradiated Rats by Jie Zong, Haiyang Wu, Xuan Hu, Ami Yao, Wenhua Zhu, Guifang Dou, Shuchen Liu, Xiaoxia Zhu, Ruolan Gu, Yunbo Sun, Zhuona Wu, Shanshan Wang, Hui Gan

“…<b>Background</b>: High-dose γ-ray exposure (≥7 Gy) in nuclear emergencies induces life-threatening acute radiation syndrome, characterized by rapid hematopoietic collapse (leukocytes <0.5 × 10⁹/L) and gastrointestinal barrier failure. …”
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Anthropogenic influences on Rhodnius ecuadoriensis populations and nesting behaviors in sylvatic areas of southern Ecuador by Jazive Esparza-Carate, Soledad Santillán-Guayasamín, César A. Yumiseva, Juan José Bustillos, Mario J. Grijalva, Sereno Denis, Anita G. Villacís

“…Abstract Background Chagas disease, caused by the parasite Trypanosoma cruzi, remains a major public health concern. …”
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To MRAs treatment or not? evidence from a meta-analysis of randomized controlled trials of different MRAs on cardiovascular health in heart failure by Jinyu He, Gang Chen, Yujia Huo, Chunyu Zhang, Haojie Xue, Jing Wang, Yi Zhong, Juan Xiao, Hongping Shen, Jian Feng, Jian Feng

“…BackgroundMineralocorticoid receptor antagonists (MRAs) are pivotal in heart failure (HF) management.ObjectivesThis study evaluates their impact on adverse cardiovascular events and left ventricular ejection fraction (LVEF) in HF patients.MethodsA comprehensive literature search was conducted across PubMed, Embase, Cochrane Library, Web of Science, and ClinicalTrials databases, with a cutoff date of September 30, 2024. …”
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The association of HDL-cholesterol levels with incident major adverse cardiovascular events and mortality in 0.6 million individuals with type 2 diabetes: a population-based retros... by David Tak Wai Lui, Lanlan Li, Xiaodong Liu, Xi Xiong, Eric Ho Man Tang, Chi Ho Lee, Yu Cho Woo, Brian Hung Hin Lang, Carlos King Ho Wong, Kathryn Choon Beng Tan

“…Abstract Background High levels of high-density lipoprotein cholesterol (HDL-C) are previously considered protective against cardiovascular diseases (CVD), but recent studies suggest an increased risk of adverse events at very high HDL-C levels in the general population. …”
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Right Ventricular–Pulmonary Artery Uncoupling and Strain in Acute Heart Failure by Alberto Palazzuoli, Frank Loyd Dini, Nicola Riccardo Pugliese, Gaetano Ruocco, Paolo Severino, Dario Vizza, Rosa Carbonara, Andrea Passantino, Erberto Carluccio

“…Background Assessment of right ventricular–pulmonary artery coupling plays a crucial role in risk stratification, monitoring efficacy, and predicting outcomes in chronic heart failure patients. …”
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Development and Validation of a Machine Learning Prediction Model for Textbook Outcome in Liver Surgery: Results From a Multicenter, International Cohort by Jane Wang, MD, Amir Ashraf Ganjouei, MD, MPH, Taizo Hibi, MD, PhD, Nuria Lluis, MD, PhD, Camilla Gomes, MD, Fernanda Romero-Hernandez, MD, Han Yin, BA, Lucia Calthorpe, MD, Yukiyasu Okamura, MD, PhD, Yuta Abe, MD, PhD, Shogo Tanaka, MD, PhD, Minoru Tanabe, MD, PhD, Zeniche Morise, MD, PhD, Horacio Asbun, MD, PhD, David Geller, MD, Mohammed Abu Hilal, MD, PhD, Mohamed Adam, MD, Adnan Alseidi, MD, EdM, International Hepatectomy Study Group, Alison Baskin, Annie Wong-On-Wing, Annie Yang, Devesh Sharma, Taisuke Imamura, Masanori Nakamura, Yuya Miura, Koki Hayashi, Masatsugu Ishii, Keita Shimata, Kazuya Hirukawa, Hiroki Ueda, June S. Peng, Lucas Thornblade, Kenzo Hirose, Kimberly Kirkwood, Eric Nakakura, Carlos Corvera, Ajay Maker

“…This study aimed to (1) develop a machine learning (ML) model that predicts the textbook outcome in liver surgery (TOLS) using preoperative variables and (2) validate the TOLS criteria by determining whether TOLS is associated with long-term survival after hepatectomy. Background:. Textbook outcome is a composite measure that combines several favorable outcomes into a single metric and represents the optimal postoperative course. …”
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Assessment of the German Version of Brief Assessment of Cognition in Schizophrenia (BACS) by Matin Mortazavi, Jakob Amon, Iris Jäger, Genc Hasanaj, Zahra Aminifarsani, Kristin Fischer, Matthias Gamer, Alkomiet Hasan, Richard S.E. Keefe, Gabriele Sachs, Peter Falkai, Daniel Keeser, Florian Raabe, Elias Wagner

“…Background: Cognitive impairments are a hallmark of schizophrenia-spectrum disorders (SSD), contributing to poor treatment outcomes and a key treatment target. …”
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A Data‐Driven Epigenetic Characterization of Morning Fatigue Severity in Oncology Patients Receiving Chemotherapy: Associations With Epigenetic Age Acceleration, Blood Cell Types,... by Caroline Le, Maureen Lewis, Carolyn S. Harris, Liam Berger, Esther Chavez‐Iglesias, Lisa Morse, Anatol Sucher, Ritu Roy, Adam Olshen, Marilyn J. Hammer, Steve Paul, Margaret Wallhagen, Raymond Chan, Michael Sayer, Sue Yom, Nam‐Woo Cho, Alexandre Chan, Jon Levine, Anand Dhruva, Christine Miaskowski, Yvette P. Conley, Kord M. Kober

“…ABSTRACT Background Moderate‐to‐severe fatigue commonly occurs in patients with cancer. …”
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Impact of a Chronic Total Coronary Occlusion on the Incidence of Appropriate Implantable Cardioverter‐Defibrillator Shocks and Mortality: A Substudy of the Dutch Outcome in ICD The... by Anna van Veelen, Tom E. Verstraelen, Yvemarie B. O. Somsen, Joëlle Elias, Ivo M. van Dongen, Peter Paul H. M. Delnoy, Marcoen F. Scholten, Lucas V. A. Boersma, Alexander H. Maass, Sipke Strikwerda, Mehran Firouzi, Cornelis P. Allaart, Kevin Vernooy, Robert W. Grauss, Raymond Tukkie, Paul Knaapen, Aeilko H. Zwinderman, Marcel G. W. Dijkgraaf, Bimmer E. P. M. Claessen, Marit van Barreveld, Arthur A. M. Wilde, José P. S. Henriques

“…Background Chronic total coronary occlusions (CTO) substantially increase the risk for sudden cardiac death. …”
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Knowledge, Attitudes, and Perceptions of Chronic Patients in Saudi Arabia Regarding the Use of Artificial Intelligence to Improve Medication Adherence by Alsanosi SM, Aldajani AQ, Gheliwi HA, Alotibi MM, Bokhari GS, Almatrafi OA, Alqawlaq AK, Abujamai JZ, Shaikhomer M, Alhindi YZ, Alshanberi AM

“…This study explores knowledge, attitudes, and perceptions (KAP) regarding AI in medication adherence among chronic patients in Makkah region, Saudi Arabia.Methods: A cross-sectional study was conducted among patients with chronic diseases in the Makkah region, Saudi Arabia, from 1 July to 31 December 2024. …”
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Is There a Sex Difference in the Prognosis of Hypertrophic Cardiomyopathy? A Systematic Review and Meta‐Analysis by Huilei Zhao, Ziqi Tan, Menglu Liu, Peng Yu, Jianyong Ma, Xiaozhong Li, Jingfeng Wang, Yujie Zhao, Wengen Zhu, Xiao Liu

“…Background It is still unclear whether there is a sex difference in the prognosis of patients with hypertrophic cardiomyopathy (HCM). …”
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Evaluation of the Arabin cervical pessary for prevention of preterm birth in women with a twin pregnancy and short cervix (STOPPIT-2): An open-label randomised trial and updated me... by Jane E Norman, John Norrie, Graeme MacLennan, David Cooper, Sonia Whyte, Sue Chowdhry, Sarah Cunningham-Burley, Xue W Mei, Joel B E Smith, Andrew Shennan, Stephen C Robson, Steven Thornton, Mark D Kilby, Neil Marlow, Sarah J Stock, Phillip R Bennett, Jane Denton, STOPPIT-2 collaborative group

“…<h4>Background</h4>Preterm-labour-associated preterm birth is a common cause of perinatal mortality and morbidity in twin pregnancy. …”
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Impact of Primary Health Care Data Quality on Infectious Disease Surveillance in Brazil: Case Study by Pilar Tavares Veras Florentino, Juracy Bertoldo Junior, George Caique Gouveia Barbosa, Thiago Cerqueira-Silva, Vinicius de Araújo Oliveira, Marcio Henrique de Oliveira Garcia, Gerson Oliveira Penna, Viviane Boaventura, Pablo Ivan Pereira Ramos, Manoel Barral-Netto, Izabel Marcilio

“…ObjectiveWe aimed to evaluate the impact of data completeness and timeliness on the performance of an EWS for ILI outbreaks and establish optimal thresholds for a suitable DQI, thereby improving the accuracy of outbreak detection and supporting public health surveillance. MethodsA composite DQI was established to measure the completeness and timeliness of PHC data from the Brazilian National Information System on Primary Health Care. …”
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