Prognostic value of global coronary flow reserve before and after elective percutaneous coronary intervention in patients with chronic coronary syndrome by Kai Nogami, Masahiro Hoshino, Eisuke Usui, Yoshihisa Kanaji, Tomoyo Sugiyama, Masahiro Hada, Tatsuhiro Nagamine, Hiroki Ueno, Mirei Setoguchi, Tomohiro Tahara, Tatsuya Sakamoto, Takashi Mineo, Tsunekazu Kakuta

“…ABSTRACT: Background: Impaired global coronary flow reserve (G-CFR), evaluated through phase-contrast cine cardiovascular magnetic resonance (PC-CMR), has been linked to worse outcomes in patients with cardiovascular disease. …”
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Clinical Features and Outcomes of Primary Sclerosing Cholangitis in the Highly Admixed Brazilian Population by Mateus Jorge Nardelli, Paulo Lisboa Bittencourt, Guilherme Grossi Lopes Cançado, Luciana Costa Faria, Cristiane Alves Villela-Nogueira, Vivian Rotman, Eliabe Silva de Abreu, Fernanda Maria Farage Osório, Andreia Silva Evangelista, Liliana Sampaio Costa Mendes, Daniel Ferraz de Campos Mazo, Elodie Bonfim Hyppolito, Adrielly de Souza Martins, Liana Codes, Izabelle Venturini Signorelli, Geisa Perez Medina Gomide, Luciana Agoglia, Claudia Alexandra Pontes Ivantes, Valéria Ferreira de Almeida e Borges, Gabriela Perdomo Coral, Rosamar Eulira Fontes Rezende, Maria Lucia Gomes Ferraz, Debora Raquel Benedita Terrabuio, Eduardo Luiz Rachid Cançado, Claudia Alves Couto

“…Background. Primary sclerosing cholangitis (PSC) is associated with a broad phenotypic spectrum in different populations from diverse ethnic and racial backgrounds. …”
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Utility of serum cytokine testing to differentiate complicated common variable immunodeficiency in resource limited settings by Aditi Jogdand, BS, Karen M. Gilbert, PhD, Joseph S. Hong, BS, Andrew J. Pak, BS, Katherine Liu, BA, Uhuru Kamau, MS, Neha V. Khairnar, MS, MBA, Henry C. Ssemaganda, MD, MS, Daniel DiGiacomo, MD, MPH, Sara Barmettler, MD, MPH, Mei-Sing Ong, PhD, Jocelyn R. Farmer, MD, PhD

“…Background: Common variable immunodeficiency (CVID) is the most common, symptomatic inborn error of immunity (IEI) worldwide. …”
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Deep Learning-Based Identification of Echocardiographic Abnormalities From Electrocardiograms by Goro Fujiki, MD, Satoshi Kodera, MD, PhD, Naoto Setoguchi, MD, Kengo Tanabe, MD, PhD, Kotaro Miyaji, MD, PhD, Shunichi Kushida, MD, PhD, Mike Saji, MD, PhD, Mamoru Nanasato, MD, PhD, Hisataka Maki, MD, PhD, Hideo Fujita, MD, PhD, Nahoko Kato, MD, PhD, Hiroyuki Watanabe, MD, PhD, Minami Suzuki, MD, Masao Takahashi, MD, PhD, Naoko Sawada, MD, PhD, Jiro Ando, MD, Masataka Sato, MD, Shinnosuke Sawano, MD, PhD, Susumu Katsushika, MD, PhD, Hiroki Shinohara, MD, PhD, Norifumi Takeda, MD, PhD, Katsuhito Fujiu, MD, PhD, Hiroshi Akazawa, MD, PhD, Hiroyuki Morita, MD, PhD, Issei Komuro, MD, PhD

“…Background: Heart failure should be diagnosed as early as possible. …”
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Clinical outcomes and genomic profiles of MAP2K1-mutated primary cutaneous melanocytic tumoursResearch in context by Chiel F. Ebbelaar, Anne M.L. Jansen, Leonie C.M. Speet, Frans Schutgens, Sietske Zoetemeyer, Anne-Marie Cleton-Jansen, Marijke R. van Dijk, Gerben E. Breimer, Lourens T. Bloem, Wendy W.J. de Leng, Remco van Doorn, Karijn P.M. Suijkerbuijk, Anne M.R. Schrader, Willeke A.M. Blokx

“…Summary: Background: Primary cutaneous melanocytic tumours harbouring MAP2K1 mutations without second-hit genomic alterations represent a subclass of neoplasms with poorly understood biological behaviour. …”
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α-Glucosidase Inhibition Mechanism and Anti-Hyperglycemic Effects of Flavonoids from Astragali Radix and Their Mixture Effects by Xing Han, Pengpu Wang, Jing Zhang, Yang Lv, Zhigao Zhao, Fengxian Zhang, Mingying Shang, Guangxue Liu, Xuan Wang, Shaoqing Cai, Feng Xu

“…<b>Background</b>: Inhibition of intestinal α-glucosidase is a key strategy for controlling postprandial hyperglycemia in diabetes. …”
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Efficacy of immune checkpoint inhibitors for in-transit melanoma by Victoria Atkinson, Shahneen Sandhu, Georgina V Long, David E Gyorki, George Au-Yeung, Grant A McArthur, Euan Walpole, Mark Smithers, Alexander Menzies, Robyn Saw, Tavis Read, Julia Lai-Kwon, Lumine Na, Emilia Nan Tie, Michael Alexander Rtshiladze, James Bozzi

“…Background The efficacy of immune checkpoint inhibitors (ICI) in metastatic melanoma is well established. …”
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Low-Density Lipoprotein Cholesterol Level, the Lower the Better? Analysis of Korean Patients in the Treat Stroke to Target Trial by Hanim Kwon, Jae-Chan Ryu, Jae-Kwan Cha, Sang Min Sung, Tae-Jin Song, Kyung Bok Lee, Eung-Gyu Kim, Yong-Won Kim, Ji Hoe Heo, Man Seok Park, Kyusik Kang, Byung-Chul Lee, Keun-Sik Hong, Oh Young Bang, Jei Kim, Jong S. Kim

“…However, whether these results can be applied to Asian patients with different ischemic stroke subtypes remains unclear. Methods Patients from 14 South Korean centers were analyzed separately. …”
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Association between inflammatory score, healthy lifestyle, and cardiovascular disease: a national cohort study by Han-Qing Zhao, Han-Qing Zhao, Jia-Le Lv, Jia-Le Lv, Yuan-Zhi Gao, Bo Hu, Zong-Da Du, Zong-Da Du, Zong-Da Du, Yan Wang, Mei-Lin Wang, Mei-Lin Wang, Meng-Di Hou, Fang Li, Xue Xing, Ming-Hui Sun

“…BackgroundThe inflammation score is currently regarded as a reliable composite index for comprehensive assessment of inflammatory status. …”
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Prior metabolic surgery attenuates the weight-loss efficacy of liraglutide in patients with mild obesity by Yuqin Ouyang, Yuqin Ouyang, Xinyue Xiang, Xinyue Xiang, Xinyun Hu, Xinyun Hu, Xuehui Chu, Wenjuan Tang, Wenjuan Tang, Wenhuan Feng, Wenhuan Feng, Wenhuan Feng

“…BackgroundLiraglutide effectively manages mild obesity, but individual weight loss outcomes vary significantly. …”
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Associations between triglyceride glucose-body mass index and 30-day mortality in patients with hemorrhagic stroke: analysis of the MIMIC-IV database by Yuexin Lu, Yuexin Lu, Enjie Song, Enjie Song, Ruilin Chen, Ruilin Chen, Long Jing, Long Jing, Jiahao Tang, Jiahao Tang, Shunan Shi, Shunan Shi, Ming Wang, Ming Wang, Ming Wang, Ming Wang, Shu Wan, Shu Wan, Shu Wan, Shu Wan

“…BackgroundHemorrhagic stroke (HS), accounting for over 40% of stroke-related deaths, imposes a severe global health burden due to high mortality and disability rates. …”
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Very low urinary marinobufagenin excretion reflects a high risk of disease progression in non-advanced CKD by Davide Bolignano, Davide Bolignano, Marta Greco, Marta Greco, Loredana Tripodi, Mario D’Agostino, Paola Cianfrone, Roberta Misiti, Roberta Misiti, Sara Pugliese, Mariateresa Zicarelli, Michela Musolino, Michela Musolino, Daniela Patrizia Foti, Daniela Patrizia Foti, Michele Andreucci, Michele Andreucci, Giuseppe Coppolino, Giuseppe Coppolino

“…BackgroundChronic kidney disease (CKD) has now reached pandemic proportions but risk prediction towards end-stage kidney disease (ESKD) remains challenging. …”
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Deprescribing anticholinergics to preserve brain health: reducing the risk of dementia through deprescribing (R2D2): study protocol for a randomized clinical trial by Noll L. Campbell, Richard J. Holden, Sujuan Gao, Frederick W. Unverzagt, Kathleen A. Lane, Allie Carter, Addison B. Harrington, Sneha Manoharan, Neha Manoharan, Danielle L. Rosenthal, Christopher Pitts, Kathryn Pelkey, Emily Papineau, David M. Lauck, Noha Keshk, Khalid Alamer, Hussein Khalil, Malaz A. Boustani

“…Abstract Background Older adults commonly experience chronic medical conditions and are at risk of cognitive impairment as a result of age, chronic comorbidity, and medications prescribed to manage multiple chronic conditions. …”
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Platelet-rich plasma and dextrose prolotherapy in osteoarthritis knee by Yagya Parna Vohra, Afroz Ahmed Khan, Yesh Veer Singh, Abhishek Pandey, Abhinav Srivastava, Imran Shakeel Khan, Neeraj Singh

“…Background: A prevalent but little-understood ailment is osteoarthritis (OA) knee. …”
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Microbiome profiling reveals gut bacterial species associated with rapid lung function decline in people with HIV by Xiangning Bai, Xiangning Bai, Xiangning Bai, Sajan C. Raju, Sajan C. Raju, Andreas Dehlbæk Knudsen, Rebekka Faber Thudium, Nicoline Stender Arentoft, Marco Gelpi, Marco Gelpi, Safura-Luise Heidari, Ken M. Kunisaki, Ken M. Kunisaki, Karsten Kristiansen, Karsten Kristiansen, Johannes Roksund Hov, Johannes Roksund Hov, Susanne Dam Nielsen, Susanne Dam Nielsen, Susanne Dam Nielsen, Marius Trøseid, Marius Trøseid, Marius Trøseid

“…BackgroundPeople with HIV (PWH) have an increased risk of pulmonary comorbidities compared to people without HIV. …”
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Prognostic Implication of Computational Angiography–Derived Fractional Flow Reserve in Patients With Nonobstructive Coronary Artery Disease by Yik‐Ming Hung, Hao‐Chen Xuan, Qing‐Wen Ren, Jia‐Yi Huang, Si‐Yeung Yu, Yi‐Kei Tse, Jing‐Nan Zhang, Wen‐Li Gu, Ran Guo, Calvin Ka‐Lam Leung, Kai‐Hang Yiu

“…Background Risk stratification of patients with symptomatic nonobstructive coronary artery disease remains uncertain. …”
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Predictive value of the systemic inflammation grade for overall survival in patients with colorectal cancer after surgery: outperforming NLR and mGPS by Jianing Wang, Yujun Liu, Wenliang Jiang, Dongli Zhang, Chao Cheng, Cuixia Liu, Zhibin Zhao, Honggang Wang

“…The Systemic Inflammation Grade (SIG), integrating neutrophil-to-lymphocyte ratio (NLR) and modified Glasgow Prognostic Score (mGPS), was proposed as a composite marker to refine risk assessment.MethodsThis retrospective study analyzed 263 CRC patients undergoing R0 resection (2015–2019). …”
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Clinical outcomes of cancer-associated isolated distal deep vein thrombosis: a comparison between asymptomatic and symptomatic thrombosis—findings from the ONCO DVT Study by Yoshito Ogihara, Yugo Yamashita, Takeshi Morimoto, Nao Muraoka, Michihisa Umetsu, Yuji Nishimoto, Takuma Takada, Tatsuya Nishikawa, Nobutaka Ikeda, Kazunori Otsui, Daisuke Sueta, Yukari Tsubata, Masaaki Shoji, Ayumi Shikama, Yutaka Hosoi, Yasuhiro Tanabe, Ryuki Chatani, Kengo Tsukahara, Naohiko Nakanishi, Kitae Kim, Satoshi Ikeda, Toru Sato, Takeshi Kimura, Kaoru Dohi

“…Background: The risk of recurrent venous thromboembolism (VTE) in patients with isolated distal deep vein thrombosis (IDDVT) is generally low, particularly when IDDVT is asymptomatic. …”
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Cancer-associated fibroblasts-derived exosomal piR-35462 promotes the progression of oral squamous cell carcinoma via FTO/Twist1 pathway by Yushan Ye, Fan Wu, Bowen Li, Hanyu Ma, Lianxi Mai, Yu Peng, Xiaodi Feng, Xiao Tan, Min Fu, Yongmei Tan, Tianjun Lan, Ruixin Wang, Siqi Ren, Jinsong Li, Shaohai Chang, Shule Xie

“…Abstract Background Cancer-associated fibroblasts (CAFs) represent a crucial component of tumor stroma and play critical roles in cancer progression. …”
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Comparison of right ventricular function and clinical outcomes in type 2 diabetes patients with and without obstructive coronary artery disease: insights from a CMR study by Jin Wang, Wei-Feng Yan, Ke Shi, Hua-Yan Xu, Shi-Qin Yu, Ying-Kun Guo, Li Jiang, Yue Gao, Yu-Jiang, Xue-Ming Li, Yuan Li, Zhi-Gang Yang

“…Abstract Background Obstructive coronary artery disease (OCAD) marks a high-risk group within patients with type 2 diabetes mellitus (T2DM), underscoring the need for tailored prevention and management strategies. …”
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