Temporal trends in the planetary health diet index and its association with cardiovascular, kidney, and metabolic diseases: A comprehensive analysis from global and individual pers... by Haoxian Tang, Xuan Zhang, Nan Luo, Jingtao Huang, Qinglong Yang, Hanyuan Lin, Mengyue Lin, Shiwan Wu, Jiasheng Wen, Jianan Hong, Pan Chen, Liwen Jiang, Yequn Chen, Xuerui Tan

“…Background: Diet plays a critical role in human health and environmental sustainability, particularly in cardiovascular, kidney, and metabolic (CKM) diseases. …”
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ZEB1 transcription factor promotes immune escape in melanoma by Christophe Caux, Stephane Dalle, Arnaud de la Fouchardière, Laurie Tonon, Maud Plaschka, Valentin Benboubker, Maxime Grimont, Justine Berthet, Jonathan Lopez, Myrtille Le-Bouar, Brigitte Balme, Garance Tondeur, Lionel Larue, Alain Puisieux, Yenkel Grinberg-Bleyer, Nathalie Bendriss-Vermare, Bertrand Dubois, Julie Caramel

“…We thus wondered whether ZEB1 signaling in melanoma cells may promote immune evasion and resistance to immunotherapy.Methods We evaluated the putative correlation between ZEB1 expression in melanoma cells and the composition of the immune infiltrate in a cohort of 60 human melanoma samples by combining transcriptomic (RNA-sequencing) and seven-color spatial multi-immunofluorescence analyses. …”
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Relationship between dietary fiber physicochemical properties and feedstuff fermentation characteristics and their effects on nutrient utilization, energy metabolism, and gut micro... by Feng Yong, Bo Liu, Huijuan Li, Houxu Hao, Yueli Fan, Osmond Datsomor, Rui Han, Hailong Jiang, Dongsheng Che

“…Abstract Background There is a growing focus on using various plant-derived agricultural by-products to increase the benefits of pig farming, but these feedstuffs are fibrous in nature. …”
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Comparative genomic insights into adaptation, selection signatures, and population dynamics in indigenous Indian sheep and foreign breeds by Malarmathi Muthusamy, Oludayo Michael Akinsola, Oludayo Michael Akinsola, Pritam Pal, Chitra Ramasamy, Saravanan Ramasamy, Abdulraheem Arome Musa, Aranganoor Kannan Thiruvenkadan

“…BackgroundIndia’s indigenous sheep breeds have evolved under extreme and diverse agro‐ecological pressures, yet the genomic basis of their resilience and local adaptation remains poorly understood.MethodThis study combines genomic inbreeding estimates, runs of homozygosity (ROH), population structure analyses, and composite selection scans to investigate three native Indian breeds—Changthangi, Deccani, and Garole—within a panel of nine breeds that also includes populations from Africa (Ethiopian Menz), East and South Asia (Tibetan, Chinese Merino, Bangladesh Garole, Bangladesh East), and Europe (Suffolk).ResultsROH and heterozygosity estimates revealed strong contrasts: Bangladesh East sheep exhibited high genomic inbreeding (FROH≈14.4%) and low observed heterozygosity (∼30.6%), whereas Deccani sheep showed low inbreeding (FROH≈1.1%) and high observed heterozygosity (∼35.6%), consistent with broader gene flow and larger flock sizes. …”
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Spicy food consumption and biological aging across multiple organ systems: a longitudinal analysis from the China Multi-Ethnic cohort by Ning Zhang, Feng Hong, Yi Xiang, Yuan Zhang, Wen Qian, Xuehui Zhang, Liling Chen, Zhuoma Duoji, Xiong Xiao, Xing Zhao

“…We constructed comprehensive BA and organ-specific BAs based on composite indicators using the widely validated Klemera-Doubal method. …”
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Impact of early versus conventional kidney replacement therapy initiation in tumor lysis syndrome: a target trial emulation by Justine Serre, Guillaume Mulier, Charlotte Boud’hors, Marie Lemerle, Moustafa Abdel-Nabey, Corentin Orvain, Anis Chaba, Lucie Biard, Julien Demiselle, Lara Zafrani

“…The design criteria of a clinical trial were mimicked by using the cloning, censoring and weighting method. The primary outcome was the MAKE30 composite outcome, considering only KRT requirement between day 7 and day 30 for the dialysis criteria. …”
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Association between changes in the triglyceride glucose-body roundness Index and cardiovascular disease risk in middle-aged and elderly Chinese adults: a nationwide longitudinal st... by Yu Yang, Yu Yang, Jinfeng Cao, Jie Lyu

“…This study examines the association between long-term changes in the TyG-BRI composite index and CVD incidence in middle-aged and older Chinese adults.MethodsData were obtained from the China Health and Retirement Longitudinal Study, which included 4,446 middle-aged and elderly from 2011 to 2015. …”
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Primary prevention cardiovascular disease risk prediction model for contemporary Chinese (1°P-CARDIAC): Model derivation and validation using a hybrid statistical and machine-learn... by Yekai Zhou, Celia Jiaxi Lin, Qiuyan Yu, Joseph Edgar Blais, Eric Yuk Fai Wan, Emmanuel Wong, Kathryn Tan, David Chung-Wah Siu, Kai Hang Yiu, Esther Wai Yin Chan, Doris Yu, William Wong, Tak-Wah Lam, Ian Chi Kei Wong, Ruibang Luo, Celine S L Chui

“…<h4>Background</h4>Cardiovascular disease (CVD) is the leading cause of mortality and morbidity in China and worldwide while we are lacking in validated primary prevention model specifically for Chinese. …”
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Effects of Fermentation on Proximate, Mineral Elements and Total Antioxidant Activity of Cloves-Cinnamon Formulated Cereal Gruels by T. Ozabor, M. Makanjuola, M. Jejeniwa, I. Adekomi, G. Oni, O. Oluwajide, J. Olaitan

“…The fermenting organisms were isolated from the spontaneously formulated fermented blends using standard microbiological methods. Physicochemical parameters, such as temperature, pH, and Titratable Acidity, as well as proximate and mineral compositions, were assessed using standard procedures. …”
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Carotid plaque thickness predicts cardiovascular events and death in patients with chronic kidney disease by Sasha S. Bjergfelt, Ida M. H. Sørensen, Laerke Urbak, Klaus F. Kofoed, Theis Lange, Bo Feldt-Rasmussen, Henrik Sillesen, Christina Christoffersen, Susanne Bro

“…Abstract Background Classical risk scoring systems underestimate the risk of cardiovascular disease in chronic kidney disease (CKD). …”
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The shared genetic landscape of polycystic ovary syndrome and breast cancer: convergence on ER + breast cancer but not ER- breast cancer by Kaixin Bi, Miaoran Chen, Qianru Zhao, Tongtong Yang, Wenjia Xie, Wenqi Ma, Hongyan Jia

“…Abstract Background The clinically high comorbidity between polycystic ovary syndrome (PCOS) and breast cancer (BC) has been extensively reported. …”
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Deciphering cholangiocarcinoma heterogeneity and specific progenitor cell niche of extrahepatic cholangiocarcinoma at single-cell resolution by Chunliang Liu, Xiang Wang, Erdong Liu, Yali Zong, Wenlong Yu, Youhai Jiang, Jianan Chen, Mingye Gu, Zhengyuan Meng, Jingfeng Li, Yang Liu, Yongjie Zhang, Jing Tang, Hongyang Wang, Jing Fu

“…Abstract Background Cholangiocarcinoma (CCA) is a highly heterogeneous malignancy, primarily comprising intrahepatic (iCCA) and extrahepatic (eCCA) subtypes. …”
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Conserving biodiversity, carbon, and community values in a fragmented landscape by A. Susilowati, Y. Lisnawati, H.H. Rachmat, H. Kurniawan, W.C. Adinugroho, R. Imanuddin, D.J. Sudrajat, I.W.S. Dharmawan, M. Iqbal, S. Fahmi, L.M. Nugraha, E. Novriyanti, E. Sutrisno, A.B. Siswanto

“…BACKGROUND AND OBJECTIVES: Fragmenting forests into small and isolated areas due to deforestation increases the risk of species loss. …”
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SLIT3-mediated intratumoral crosstalk induces neuroblastoma differentiation via a spontaneous regression-like program by Meiling Liu, Dekang Lv, Wenjing Yan, Yi Wu, Shulan Wang, Luoxuan Wang, Jie Lei, Deshun Zeng, Zifeng Wang, Fang Liu, Bing Deng, Quentin Liu, Bin He, Min Yan

“…Spontaneous regression is often accompanied by tumor differentiation, but the mechanisms underlying this process remain largely unclear. Methods Single-nucleus transcriptomics (snRNA-seq) data of neuroblastoma samples were obtained from the Synapse repository to investigate the composition of heterogeneous tumor cell clusters. …”
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Interplay between the gut microbiome and typhoid fever: insights from endemic countries and a controlled human infection model by Philip M. Ashton, Leonardos Mageiros, James E. Meiring, Angeziwa Chunga-Chirambo, Farhana Khanam, Sabina Dongol, Happy Banda, Abhilasha Karkey, Lorena Preciado-Llanes, Helena Thomaides-Brears, Malick Gibani, Nazmul Hasan Rajib, Nazia Rahman, Prasanta Kumar Biswas, Md Amirul Islam Bhuiyan, Sally Kay, Kate Auger, Olivier Seret, Nicholas R. Thomson, Andrew J. Pollard, Stephen Baker, Buddha Basnyat, John D. Clemens, Christiane Dolecek, Sarah J. Dunstan, Gordon Dougan, Robert S. Heyderman, Virginia E. Pitzer, Firdausi Qadri, Melita A. Gordon, Kathryn E. Holt, Thomas C. Darton, STRATAA Study Group

“…Abstract Background Typhoid fever is a systemic infection caused by Salmonella enterica serovar Typhi (S. …”
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Klf9 Loss of Function Protects Against Glucocorticoids Induced Skeletal Muscle Wasting by Yujie Zhang, Jingran Hao, Yueyao Feng, Tongtong Qiu, Jinjin Wu, Xuenan Zhou, Heng Fan, Yongsheng Chang

“…ABSTRACT Background Glucocorticoids (GCs) are the most important and frequently used class of anti‐inflammatory drugs. …”
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Intervention effect and mechanism of Dracocephalum moldavica L. extract on bleomycin-induced pulmonary fibrosis in rats by Xiaoyu SUN, Li CHEN, Ruifang GAO, Hui YU, Min JIN

“…ObjectiveTo elucidate the targets and potential mechanism underlying the anti-pulmonary fibrosis efficacy of Dracocephalum moldavica L. extract by employing an amalgamation of network pharmacology and empirical verification. MethodsThe chemical composition of the extract of Dracocephalum moldavica L. was retrieved with the help of China National Knowledge Infrastructure (CNKI) and Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). …”
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Metabolome Profiling and Predictive Modeling of Dark Green Leaf Trait in Bunching Onion Varieties by Tetsuya Nakajima, Mari Kobayashi, Masato Fuji, Kouei Fujii, Mostafa Abdelrahman, Yasumasa Matsuoka, Jun’ichi Mano, Muneo Sato, Masami Yokota Hirai, Naoki Yamauchi, Masayoshi Shigyo

“…<b>Background:</b> The dark green coloration of bunching onion leaf blades is a key determinant of market value, nutritional quality, and visual appeal. …”
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Effects of five cannabis oils with different CBD: THC ratios and terpenes on hypertension, dyslipidemia, hepatic steatosis, oxidative stress, and CB1 receptor in an experimental mo... by Valentina Degrave, Michelle Berenice Vega Joubert, Camila Filippa, Paola Ingaramo, Lucía Torregiani, Yamile Soledad Caro, María Mercedes De Zan, María Eugenia D’Alessandro, María Eugenia Oliva

“…Abstract Background Non-alcoholic fatty liver disease (NAFLD) is a common liver disorder caused by oxidative stress and dysregulation of lipid metabolism. …”
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Synergic prognostic value of 3D CT scan subcutaneous fat and muscle masses for immunotherapy-treated cancer by Caroline Robert, Aurélien Marabelle, Fabrice Barlesi, Samy Ammari, David Planchard, Siham Farhane, Paul-Henry Cournède, Pierre Decazes, Younes Belkouchi, Léo Mottay, Littisha Lawrance, Antoine de Prévia, Hugues Talbot, Florian Guisier, Tony Ibrahim, Pierre Vera, Nathalie Lassau

“…Background Our aim was to explore the prognostic value of anthropometric parameters in a large population of patients treated with immunotherapy.Methods We retrospectively included 623 patients with advanced non-small cell lung cancer (NSCLC) (n=318) or melanoma (n=305) treated by an immune-checkpoint-inhibitor having a pretreatment (thorax-)abdomen-pelvis CT scan. …”
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